OA12806A - Novel perindopril salt and pharmaceutical compositions containing same. - Google Patents

Novel perindopril salt and pharmaceutical compositions containing same. Download PDF

Info

Publication number: OA12806A
Authority: OA; OAPI
Prior art keywords: pharmaceutical compositions; compositions containing; containing same; pharmaceutical composition; salt
Prior art date: 2002-04-18

Application number

OA1200400279A

Other languages

English (en)

Inventor

Gerard Damien

Francois Lefoulon

Bernard Marchand

Original Assignee

Servier Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-04-18

Filing date

2003-02-17

Publication date

2006-07-11

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8871521&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=OA12806(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2003-02-17 Application filed by Servier Lab filed Critical Servier Lab

2006-07-11 Publication of OA12806A publication Critical patent/OA12806A/en

Links

239000008194 pharmaceutical composition Substances 0.000 title claims description 7
IPVQLZZIHOAWMC-QXKUPLGCSA-N perindopril Chemical class C1CCC[C@H]2C[C@@H](C(O)=O)N(C(=O)[C@H](C)N[C@@H](CCC)C(=O)OCC)[C@H]21 IPVQLZZIHOAWMC-QXKUPLGCSA-N 0.000 title claims 4
150000004677 hydrates Chemical class 0.000 claims abstract 3
125000000637 arginyl group Chemical class N[C@@H](CCCNC(N)=N)C(=O)* 0.000 claims description 5
229960002582 perindopril Drugs 0.000 claims 3
206010019280 Heart failures Diseases 0.000 claims 1
206010020772 Hypertension Diseases 0.000 claims 1
239000004480 active ingredient Substances 0.000 claims 1
239000003814 drug Substances 0.000 claims 1
239000012729 immediate-release (IR) formulation Substances 0.000 claims 1
239000000546 pharmaceutical excipient Substances 0.000 claims 1
RYCSJJXKEWBUTI-YDYAIEMNSA-N perindopril arginine Chemical class OC(=O)[C@@H](N)CCCNC(N)=N.C1CCC[C@H]2C[C@@H](C(O)=O)N(C(=O)[C@H](C)N[C@@H](CCC)C(=O)OCC)[C@H]21 RYCSJJXKEWBUTI-YDYAIEMNSA-N 0.000 abstract 1
230000015556 catabolic process Effects 0.000 description 2
238000006731 degradation reaction Methods 0.000 description 2
YBRBMKDOPFTVDT-UHFFFAOYSA-N tert-butylamine Chemical class CC(C)(C)N YBRBMKDOPFTVDT-UHFFFAOYSA-N 0.000 description 2
238000004806 packaging method and process Methods 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Cardiology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Indole Compounds (AREA)
Peptides Or Proteins (AREA)

OA1200400279A 2002-04-18 2003-02-17 Novel perindopril salt and pharmaceutical compositions containing same. OA12806A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR0204847A FR2838648B1 (fr)	2002-04-18	2002-04-18	Nouveau sel de perindopril et les compositions pharmaceutiques qui le contiennent

Publications (1)

Publication Number	Publication Date
OA12806A true OA12806A (en)	2006-07-11

Family

ID=8871521

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
OA1200400279A OA12806A (en)	2002-04-18	2003-02-17	Novel perindopril salt and pharmaceutical compositions containing same.

Country Status (37)

Country	Link
US (1)	US6696481B2 (sr)
EP (1)	EP1354873B1 (sr)
JP (1)	JP3737488B2 (sr)
KR (1)	KR100542468B1 (sr)
CN (1)	CN1211365C (sr)
AP (1)	AP1787A (sr)
AR (1)	AR039428A1 (sr)
AT (1)	ATE271036T1 (sr)
AU (2)	AU2003222921A1 (sr)
BR (1)	BR0300709A (sr)
CA (1)	CA2423825C (sr)
CR (1)	CR7576A (sr)
DE (1)	DE60300011T2 (sr)
DK (1)	DK1354873T3 (sr)
EA (1)	EA005676B1 (sr)
EC (1)	ECSP045441A (sr)
ES (1)	ES2224092T3 (sr)
FR (1)	FR2838648B1 (sr)
GE (1)	GEP20074211B (sr)
HR (1)	HRP20041079B1 (sr)
IL (1)	IL164424A (sr)
IS (1)	IS2842B (sr)
MA (1)	MA27115A1 (sr)
ME (1)	ME00454B (sr)
MX (1)	MXPA03002346A (sr)
NO (1)	NO324323B1 (sr)
NZ (1)	NZ524478A (sr)
OA (1)	OA12806A (sr)
PL (1)	PL359321A1 (sr)
PT (1)	PT1354873E (sr)
RS (1)	RS51694B (sr)
SI (1)	SI1354873T1 (sr)
TN (1)	TNSN04206A1 (sr)
TR (1)	TR200401793T4 (sr)
UA (1)	UA79463C2 (sr)
WO (1)	WO2003087050A2 (sr)
ZA (1)	ZA200301395B (sr)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2395195A (en) *	2002-11-18	2004-05-19	Cipla Ltd	Preparation of perindopril from carboxy-protected precursor, & perindopril monohydrates for use as angiotensin converting enzyme (ACE) inhibitors
PT1729739T (pt)	2004-03-29	2016-12-01	Servier Lab	Processo para a preparação de uma composição farmacêutica sólida
SI21800A (sl)	2004-05-14	2005-12-31	Krka, Tovarna Zdravil, D.D., Novo Mesto	Nov postopek sinteze perindoprila
PT1679072E (pt) *	2005-01-06	2008-12-22	Ipca Lab Ltd	Processo para a síntese de derivados de ácido (2s,3as,7as)-1-(s)-alanil-octa-hidro-1h-indole-2-carboxílico e utilização na síntese de perindopril
DK1861367T3 (da) *	2005-03-14	2009-11-02	Servier Lab	Forbedret fremgangsmåde til oprensning af perindopril
FR2894825B1 (fr) *	2005-12-21	2010-12-03	Servier Lab	Nouvelle association d'un inhibiteur du courant if sinusal et d'un inhibiteur de l'enzyme de conversion et les compositions pharmaceutiques qui la contiennent
FR2897866B1 (fr)	2006-02-28	2008-04-18	Servier Lab	Forme cristalline alpha du sel d'arginine du perindopril, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
FR2897865B1 (fr) *	2006-02-28	2008-04-18	Servier Lab	Forme cristalline beta du sel d'arginine du perindopril, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
GB0624084D0 (en) *	2006-12-01	2007-01-10	Selamine Ltd	Ramipril amino acid salts
GB0624087D0 (en) *	2006-12-01	2007-01-10	Selamine Ltd	Ramipril combination salt
GB0624090D0 (en) *	2006-12-01	2007-01-10	Selamine Ltd	Ramipril amine salts
SI22542A (sl) *	2007-06-04	2008-12-31	Diagen D.O.O.	Stabilna formulacija amorfnih soli perindoprila, postopek za njeno pripravo v industrijskem merilu in njena uporaba za zdravljenje hipertenzije
US8686161B2 (en) *	2008-06-24	2014-04-01	Mylan Laboratories Limited	Polymorphic forms of perindopril (L)-arginine and process for the preparation thereof
AU2009212902A1 (en) *	2008-09-03	2010-03-18	Apotex Pharmachem Inc.	Amorphous form of an L-arginine salt of perindopril and processes of preparation thereof
CN101766598A (zh) *	2008-12-31	2010-07-07	东英（江苏）药业有限公司	含有培哚普利的药物组合物
GB0910692D0 (en)	2009-06-20	2009-08-05	Teva Pharma	Compound
SI23149A (sl)	2009-09-21	2011-03-31	Silverstone Pharma	Nove benzatinske soli ACE inhibitorjev, postopek za njihovo pripravo in njihova uporaba za zdravljenje kardiovaskularnih bolezni
FR2961105B1 (fr) *	2010-06-15	2013-02-08	Servier Lab	Utilisation de l'association d'un inhibiteur du courant if sinusal et d'un inhibiteur de l'enzyme de conversion de l'angiotensine pour le traitement de l'insuffisance cardiaque
FR2985511B1 (fr)	2012-01-05	2014-01-03	Servier Lab	Forme cristalline delta du sel d'arginine du perindopril, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
FR2985512B1 (fr) *	2012-01-05	2014-06-20	Servier Lab	Procede de preparation du sel de l-arginine du perindopril
CN103172696B (zh) *	2012-12-19	2014-12-17	宁波美诺华药业股份有限公司	一种γ晶型的培哚普利精氨酸盐的制备方法
FR3040303B1 (fr) *	2015-08-27	2019-04-05	Les Laboratoires Servier Suivi Par Sabine Goudeau-Wenger	Composition pharmaceutique comprenant un inhibiteur de la hmg-coa reductase et un inhibiteur eca
PH12018502155B1 (en)	2016-04-20	2024-03-27	Servier Lab	Pharmaceutical composition comprising a beta blocker, a converting enzyme inhibitor and an antihypertensive or an nsaid
EP3842035A1 (en)	2019-12-23	2021-06-30	KRKA, d.d., Novo mesto	Composition for the preparation of perindopril arginine granules, a method for their preparation and pharmaceutical composition comprising the granules
SI26268A (sl)	2021-11-18	2023-05-31	Zupet Rok	Postopek za pripravo hidratirane oblike perindopril l-arginina

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2503155A2 (fr) *	1980-10-02	1982-10-08	Science Union & Cie	Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
FR2811320B1 (fr) *	2000-07-06	2002-08-23	Adir	Nouvelle forme cristalline alpha du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent

2002
- 2002-04-18 FR FR0204847A patent/FR2838648B1/fr not_active Expired - Lifetime
2003
- 2003-02-17 DK DK03290383T patent/DK1354873T3/da active
- 2003-02-17 AP APAP/P/2004/003154A patent/AP1787A/en active
- 2003-02-17 OA OA1200400279A patent/OA12806A/en unknown
- 2003-02-17 ES ES03290383T patent/ES2224092T3/es not_active Expired - Lifetime
- 2003-02-17 DE DE60300011T patent/DE60300011T2/de not_active Expired - Lifetime
- 2003-02-17 PT PT03290383T patent/PT1354873E/pt unknown
- 2003-02-17 RS YU90904A patent/RS51694B/sr unknown
- 2003-02-17 ME MEP-2008-688A patent/ME00454B/me unknown
- 2003-02-17 HR HRP20041079AA patent/HRP20041079B1/hr not_active IP Right Cessation
- 2003-02-17 UA UA20041109440A patent/UA79463C2/uk unknown
- 2003-02-17 AT AT03290383T patent/ATE271036T1/de active
- 2003-02-17 EP EP03290383A patent/EP1354873B1/fr not_active Expired - Lifetime
- 2003-02-17 AU AU2003222921A patent/AU2003222921A1/en not_active Abandoned
- 2003-02-17 WO PCT/FR2003/000507 patent/WO2003087050A2/fr not_active Ceased
- 2003-02-17 TR TR2004/01793T patent/TR200401793T4/xx unknown
- 2003-02-17 GE GEAP8501A patent/GEP20074211B/en unknown
- 2003-02-17 SI SI200330002T patent/SI1354873T1/xx unknown
- 2003-02-20 ZA ZA200301395A patent/ZA200301395B/xx unknown
- 2003-02-21 US US10/371,865 patent/US6696481B2/en not_active Expired - Lifetime
- 2003-02-24 NO NO20030849A patent/NO324323B1/no not_active IP Right Cessation
- 2003-02-27 AU AU2003200700A patent/AU2003200700C1/en not_active Revoked
- 2003-02-28 NZ NZ524478A patent/NZ524478A/en not_active IP Right Cessation
- 2003-03-07 CN CNB031071481A patent/CN1211365C/zh not_active Expired - Lifetime
- 2003-03-18 MX MXPA03002346A patent/MXPA03002346A/es active IP Right Grant
- 2003-03-20 KR KR1020030017434A patent/KR100542468B1/ko not_active Expired - Lifetime
- 2003-03-21 BR BR0300709-0A patent/BR0300709A/pt not_active Application Discontinuation
- 2003-03-24 PL PL03359321A patent/PL359321A1/xx not_active Application Discontinuation
- 2003-03-25 JP JP2003083250A patent/JP3737488B2/ja not_active Expired - Lifetime
- 2003-04-03 CA CA002423825A patent/CA2423825C/fr not_active Expired - Fee Related
- 2003-04-03 EA EA200300334A patent/EA005676B1/ru unknown
- 2003-04-16 AR ARP030101332A patent/AR039428A1/es not_active Application Discontinuation
2004
- 2004-10-05 IL IL164424A patent/IL164424A/en active IP Right Grant
- 2004-10-15 TN TNP2004000206A patent/TNSN04206A1/en unknown
- 2004-10-27 IS IS7516A patent/IS2842B/is unknown
- 2004-11-03 MA MA27926A patent/MA27115A1/fr unknown
- 2004-11-18 EC EC2004005441A patent/ECSP045441A/es unknown
- 2004-11-18 CR CR7576A patent/CR7576A/es unknown

Also Published As

Publication number	Publication date
NO20030849L (no)	2003-10-20
CA2423825A1 (fr)	2003-10-18
PL359321A1 (en)	2003-10-20
ME00454B (me)	2011-10-10
AU2003222921A8 (en)	2003-10-27
AU2003200700C1 (en)	2015-04-23
CA2423825C (fr)	2006-02-21
FR2838648B1 (fr)	2004-05-21
JP2003321493A (ja)	2003-11-11
SI1354873T1 (en)	2004-12-31
HRP20041079B1 (hr)	2013-04-30
UA79463C2 (en)	2007-06-25
US6696481B2 (en)	2004-02-24
ES2224092T3 (es)	2005-03-01
PT1354873E (pt)	2004-10-29
IL164424A0 (en)	2005-12-18
DE60300011D1 (de)	2004-08-19
AU2003200700A1 (en)	2003-11-06
KR100542468B1 (ko)	2006-01-11
AP2004003154A0 (en)	2004-12-31
KR20030082902A (ko)	2003-10-23
NO324323B1 (no)	2007-09-24
ATE271036T1 (de)	2004-07-15
AU2003200700B2 (en)	2005-01-20
WO2003087050A2 (fr)	2003-10-23
CN1211365C (zh)	2005-07-20
TNSN04206A1 (en)	2007-03-12
ZA200301395B (en)	2003-09-02
US20030199568A1 (en)	2003-10-23
CR7576A (es)	2008-08-21
EA005676B1 (ru)	2005-04-28
AU2003222921A1 (en)	2003-10-27
IL164424A (en)	2010-12-30
GEP20074211B (en)	2007-10-10
IS2842B (is)	2013-08-15
WO2003087050A3 (fr)	2004-03-25
MA27115A1 (fr)	2004-12-20
EA200300334A1 (ru)	2003-12-25
RS51694B (sr)	2011-10-31
CN1451656A (zh)	2003-10-29
NO20030849D0 (no)	2003-02-24
HRP20041079A2 (en)	2004-12-31
ECSP045441A (es)	2005-03-10
AP1787A (en)	2007-10-04
TR200401793T4 (tr)	2004-08-23
FR2838648A1 (fr)	2003-10-24
EP1354873A1 (fr)	2003-10-22
AR039428A1 (es)	2005-02-16
IS7516A (is)	2004-10-27
RS90904A (sr)	2007-02-05
MXPA03002346A (es)	2005-08-26
DK1354873T3 (da)	2004-11-01
NZ524478A (en)	2004-05-28
BR0300709A (pt)	2004-09-08
HK1057367A1 (en)	2004-04-02
DE60300011T2 (de)	2005-03-17
EP1354873B1 (fr)	2004-07-14
JP3737488B2 (ja)	2006-01-18

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