OA12933A - Novel method for the industrial synthesis of the methyl diester of 5-amino-3-carboxymethyl-4-cyano-2-thiophenecarboxylic acid and application of divalent salts of ranelic acid and the hydrates thereofin said synthesis. - Google Patents

Novel method for the industrial synthesis of the methyl diester of 5-amino-3-carboxymethyl-4-cyano-2-thiophenecarboxylic acid and application of divalent salts of ranelic acid and the hydrates thereofin said synthesis. Download PDF

Info

Publication number: OA12933A
Authority: OA; OAPI
Prior art keywords: formula; synthesis; compound; acid; cyano
Prior art date: 2002-09-24

Application number

OA1200500082A

Other languages

English (en)

Inventor

Lucile Vaysse-Ludot

Pascal Langlois

Jean-Pierre Lecouve

Original Assignee

Servier Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-09-24

Filing date

2003-09-22

Publication date

2006-10-13

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=29415190&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=OA12933(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2003-09-22 Application filed by Servier Lab filed Critical Servier Lab

2006-10-13 Publication of OA12933A publication Critical patent/OA12933A/en

Links

230000015572 biosynthetic process Effects 0.000 title claims abstract description 21
238000003786 synthesis reaction Methods 0.000 title claims abstract description 20
DJSXNILVACEBLP-UHFFFAOYSA-N ranelic acid Chemical class OC(=O)CN(CC(O)=O)C=1SC(C(O)=O)=C(CC(O)=O)C=1C#N DJSXNILVACEBLP-UHFFFAOYSA-N 0.000 title claims abstract description 11
229950003464 ranelic acid Drugs 0.000 title claims abstract description 11
238000000034 method Methods 0.000 title claims description 16
150000003839 salts Chemical class 0.000 title claims description 7
150000004677 hydrates Chemical class 0.000 title claims description 6
KNPBNTMMZCNVIE-UHFFFAOYSA-N 5-amino-3-(carboxymethyl)-4-cyanothiophene-2-carboxylic acid Chemical compound NC=1SC(C(O)=O)=C(CC(O)=O)C=1C#N KNPBNTMMZCNVIE-UHFFFAOYSA-N 0.000 title description 3
-1 methyl diester Chemical class 0.000 title description 2
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims abstract description 8
229910052791 calcium Inorganic materials 0.000 claims abstract description 8
239000011575 calcium Substances 0.000 claims abstract description 8
229910052712 strontium Inorganic materials 0.000 claims abstract description 8
CIOAGBVUUVVLOB-UHFFFAOYSA-N strontium atom Chemical compound [Sr] CIOAGBVUUVVLOB-UHFFFAOYSA-N 0.000 claims abstract description 8
238000006243 chemical reaction Methods 0.000 claims abstract description 5
150000002148 esters Chemical class 0.000 claims abstract description 5
BLYLWUDQKYBGJD-UHFFFAOYSA-N methyl 5-amino-4-cyano-3-(2-methoxy-2-oxoethyl)thiophene-2-carboxylate Chemical compound COC(=O)CC1=C(C(=O)OC)SC(N)=C1C#N BLYLWUDQKYBGJD-UHFFFAOYSA-N 0.000 claims abstract description 4
WBJINCZRORDGAQ-UHFFFAOYSA-N ethyl formate Chemical compound CCOC=O WBJINCZRORDGAQ-UHFFFAOYSA-N 0.000 claims abstract 3
150000001875 compounds Chemical class 0.000 claims description 26
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 15
YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 claims description 12
238000010992 reflux Methods 0.000 claims description 8
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 6
239000005864 Sulphur Substances 0.000 claims description 6
229940079488 strontium ranelate Drugs 0.000 claims description 6
FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical class [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 5
RNJOKCPFLQMDEC-UHFFFAOYSA-N 4(R),8-dimethyl-trans-2-nonenoyl-CoA Chemical compound COC(=O)CC(=O)CC(=O)OC RNJOKCPFLQMDEC-UHFFFAOYSA-N 0.000 claims description 4
CUONGYYJJVDODC-UHFFFAOYSA-N malononitrile Chemical compound N#CCC#N CUONGYYJJVDODC-UHFFFAOYSA-N 0.000 claims description 4
239000011541 reaction mixture Substances 0.000 claims description 4
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
238000001914 filtration Methods 0.000 claims description 2
ZHEZAQJNZMLYBA-UHFFFAOYSA-J distrontium;5-[bis(carboxylatomethyl)amino]-3-(carboxylatomethyl)-4-cyanothiophene-2-carboxylate;octahydrate Chemical compound O.O.O.O.O.O.O.O.[Sr+2].[Sr+2].[O-]C(=O)CN(CC([O-])=O)C=1SC(C([O-])=O)=C(CC([O-])=O)C=1C#N ZHEZAQJNZMLYBA-UHFFFAOYSA-J 0.000 claims 2
159000000003 magnesium salts Chemical class 0.000 abstract 2
YXGHUSALBGWCAV-UHFFFAOYSA-N 5-amino-4-cyano-3-(2-methoxy-2-oxoethyl)thiophene-2-carboxylic acid Chemical compound COC(=O)CC1=C(C(O)=O)SC(N)=C1C#N YXGHUSALBGWCAV-UHFFFAOYSA-N 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
239000000543 intermediate Substances 0.000 description 4
KVJIIORUFXGTFN-UHFFFAOYSA-L strontium;5-[bis(carboxymethyl)amino]-3-(carboxymethyl)-4-cyanothiophene-2-carboxylate Chemical compound [Sr+2].OC(=O)CN(CC(O)=O)C=1SC(C([O-])=O)=C(CC(O)=O)C=1C#N.OC(=O)CN(CC(O)=O)C=1SC(C([O-])=O)=C(CC(O)=O)C=1C#N KVJIIORUFXGTFN-UHFFFAOYSA-L 0.000 description 4
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 3
239000000203 mixture Substances 0.000 description 3
150000005690 diesters Chemical class 0.000 description 2
239000002244 precipitate Substances 0.000 description 2
239000000126 substance Substances 0.000 description 2
230000001225 therapeutic effect Effects 0.000 description 2
JXPDNDHCMMOJPC-UHFFFAOYSA-N 2-hydroxybutanedinitrile Chemical compound N#CC(O)CC#N JXPDNDHCMMOJPC-UHFFFAOYSA-N 0.000 description 1
208000020084 Bone disease Diseases 0.000 description 1
239000002253 acid Substances 0.000 description 1
230000003262 anti-osteoporosis Effects 0.000 description 1
244000309464 bull Species 0.000 description 1
238000001816 cooling Methods 0.000 description 1
ZSANYRMTSBBUCA-UHFFFAOYSA-N diethyl 3-oxopentanedioate Chemical compound CCOC(=O)CC(=O)CC(=O)OCC ZSANYRMTSBBUCA-UHFFFAOYSA-N 0.000 description 1
HPNMFZURTQLUMO-UHFFFAOYSA-N diethylamine Chemical compound CCNCC HPNMFZURTQLUMO-UHFFFAOYSA-N 0.000 description 1
238000009776 industrial production Methods 0.000 description 1
IXLRCPSVPMSMMM-UHFFFAOYSA-N methyl 3-(dicyanomethylidene)-5-hydroxy-5-methoxypent-4-enoate Chemical compound COC(=O)CC(=C(C#N)C#N)C=C(O)OC IXLRCPSVPMSMMM-UHFFFAOYSA-N 0.000 description 1
230000000144 pharmacologic effect Effects 0.000 description 1
230000035484 reaction time Effects 0.000 description 1
239000007858 starting material Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/23—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same unsaturated acyclic carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

OA1200500082A 2002-09-24 2003-09-22 Novel method for the industrial synthesis of the methyl diester of 5-amino-3-carboxymethyl-4-cyano-2-thiophenecarboxylic acid and application of divalent salts of ranelic acid and the hydrates thereofin said synthesis. OA12933A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR0211764A FR2844796A1 (fr)	2002-09-24	2002-09-24	Nouveau procede de synthese industrielle du diester methylique de l'acide 5-amino-3-carboxymethyl-4-cyano-2- thiophenecarboxylique, et application a la synthese des sels bivalents de l'acide ranelique et de leurs hydrates

Publications (1)

Publication Number	Publication Date
OA12933A true OA12933A (en)	2006-10-13

Family

ID=29415190

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
OA1200500082A OA12933A (en)	2002-09-24	2003-09-22	Novel method for the industrial synthesis of the methyl diester of 5-amino-3-carboxymethyl-4-cyano-2-thiophenecarboxylic acid and application of divalent salts of ranelic acid and the hydrates thereofin said synthesis.

Country Status (38)

Country	Link
US (3)	US7105683B2 (de)
EP (1)	EP1403264B1 (de)
JP (1)	JP4136865B2 (de)
KR (1)	KR100551503B1 (de)
CN (2)	CN100393707C (de)
AP (1)	AP1942A (de)
AR (1)	AR041356A1 (de)
AT (1)	ATE286041T1 (de)
AU (2)	AU2003248279B2 (de)
BR (1)	BR0304194A (de)
CA (1)	CA2442875C (de)
DE (1)	DE60300252T2 (de)
DK (1)	DK1403264T3 (de)
EA (1)	EA007496B1 (de)
EC (1)	ECSP055742A (de)
ES (1)	ES2235144T3 (de)
FR (1)	FR2844796A1 (de)
GE (1)	GEP20074140B (de)
HR (1)	HRP20050360B1 (de)
IL (1)	IL167314A (de)
IS (1)	IS2136B (de)
MA (1)	MA26101A1 (de)
ME (1)	ME00451B (de)
MX (1)	MXPA03008645A (de)
MY (1)	MY131939A (de)
NI (1)	NI200500065A (de)
NO (1)	NO328697B1 (de)
NZ (1)	NZ528400A (de)
OA (1)	OA12933A (de)
PL (1)	PL214414B1 (de)
PT (1)	PT1403264E (de)
RS (1)	RS50929B (de)
SG (1)	SG110070A1 (de)
SI (1)	SI1403264T1 (de)
TN (1)	TNSN05089A1 (de)
UA (1)	UA79991C2 (de)
WO (1)	WO2004029035A1 (de)
ZA (1)	ZA200307410B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2844795B1 (fr) *	2002-09-24	2004-10-22	Servier Lab	Nouveau procede de synthese industriel du ranelate de strontium et de ses hydrates
FR2844796A1 (fr) *	2002-09-24	2004-03-26	Servier Lab	Nouveau procede de synthese industrielle du diester methylique de l'acide 5-amino-3-carboxymethyl-4-cyano-2- thiophenecarboxylique, et application a la synthese des sels bivalents de l'acide ranelique et de leurs hydrates
DK1622630T3 (da) *	2003-05-07	2012-12-17	Osteologix As	P009368epdk1
ATE342722T1 (de) *	2003-05-07	2006-11-15	Osteologix As	Behandlung von knorpel/knochen-erkrankungen mit wasserlöslichen strontiumsalzen
US20050085531A1 (en) *	2003-10-03	2005-04-21	Hodge Carl N.	Thiophene-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof
PL1732575T3 (pl)	2004-02-26	2011-05-31	Osteologix As	Związki zawierające stron do stosowania w zapobieganiu lub leczeniu stanów nekrotycznych kości
US8658206B2 (en)	2004-06-25	2014-02-25	Mokwalo SA	Compositions comprising strontium and vitamin D and uses thereof
FR2875807B1 (fr) *	2004-09-30	2006-11-17	Servier Lab	Forme cristalline alpha du ranelate de strontium, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
US20070292529A1 (en) *	2006-06-19	2007-12-20	Tabbiner Philip S	Strontium compositions and methods of treating osteoporotic conditions
CN101665483B (zh) *	2008-09-01	2013-01-23	河北医科大学	一种雷尼酸锶中间体化合物ⅱ的合成方法
WO2011110597A1 (de)	2010-03-11	2011-09-15	Azad Pharmaceutical Ingredients Ag	Verfahren zur herstellung von strontiumranelat
CN103319454B (zh) *	2013-06-14	2014-06-18	广东众生药业股份有限公司	一种高纯度雷尼酸四乙酯及其中间体的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR415850A (fr)	1909-07-22	1910-10-05	Gustave Auguste Ferrie	Dispositif de mesure permettant de lire directement la valeur d'une grandeur fonction de deux variables
FR2651497B1 (fr) *	1989-09-01	1991-10-25	Adir	Nouveaux sels de metaux bivalents de l'acide n, n-di (carboxymethyl)amino-2 cyano-3 carboxymethyl-4 carboxy-5 thiophene, leur procede de preparation et les compositions pharmaceutiques les renfermant.
FR2844797B1 (fr) *	2002-09-24	2004-10-22	Servier Lab	Nouveau procede de synthese industriel des tetraesters de l'acide 5-[bis (carboxymethyl)]-3-carboxymethyl-4-cyano-2- thiophenecarboxylique, et application a la synthese des sels bivalents de l'acide ranelique et de leurs hydrates
FR2844796A1 (fr) *	2002-09-24	2004-03-26	Servier Lab	Nouveau procede de synthese industrielle du diester methylique de l'acide 5-amino-3-carboxymethyl-4-cyano-2- thiophenecarboxylique, et application a la synthese des sels bivalents de l'acide ranelique et de leurs hydrates

2002
- 2002-09-24 FR FR0211764A patent/FR2844796A1/fr active Pending
2003
- 2003-09-17 MY MYPI20033534A patent/MY131939A/en unknown
- 2003-09-22 OA OA1200500082A patent/OA12933A/en unknown
- 2003-09-22 HR HRP20050360AA patent/HRP20050360B1/hr not_active IP Right Cessation
- 2003-09-22 AP AP2005003259A patent/AP1942A/xx active
- 2003-09-22 UA UAA200503859A patent/UA79991C2/uk unknown
- 2003-09-22 AU AU2003248279A patent/AU2003248279B2/en not_active Ceased
- 2003-09-22 GE GEAP20038760A patent/GEP20074140B/en unknown
- 2003-09-22 RS YUP-2005/0242A patent/RS50929B/sr unknown
- 2003-09-22 AU AU2003282178A patent/AU2003282178A1/en not_active Abandoned
- 2003-09-22 DK DK03292317T patent/DK1403264T3/da active
- 2003-09-22 ES ES03292317T patent/ES2235144T3/es not_active Expired - Lifetime
- 2003-09-22 JP JP2003330438A patent/JP4136865B2/ja not_active Expired - Fee Related
- 2003-09-22 ME MEP-2008-685A patent/ME00451B/me unknown
- 2003-09-22 PT PT03292317T patent/PT1403264E/pt unknown
- 2003-09-22 SI SI200330013T patent/SI1403264T1/xx unknown
- 2003-09-22 BR BR0304194-8A patent/BR0304194A/pt not_active Application Discontinuation
- 2003-09-22 AT AT03292317T patent/ATE286041T1/de active
- 2003-09-22 DE DE60300252T patent/DE60300252T2/de not_active Expired - Lifetime
- 2003-09-22 WO PCT/FR2003/002776 patent/WO2004029035A1/fr not_active Ceased
- 2003-09-22 EP EP03292317A patent/EP1403264B1/de not_active Expired - Lifetime
- 2003-09-23 PL PL362367A patent/PL214414B1/pl unknown
- 2003-09-23 NZ NZ528400A patent/NZ528400A/en not_active IP Right Cessation
- 2003-09-23 ZA ZA200307410A patent/ZA200307410B/xx unknown
- 2003-09-23 EA EA200300926A patent/EA007496B1/ru not_active IP Right Cessation
- 2003-09-23 KR KR1020030065785A patent/KR100551503B1/ko not_active Expired - Fee Related
- 2003-09-23 MX MXPA03008645A patent/MXPA03008645A/es active IP Right Grant
- 2003-09-23 NO NO20034237A patent/NO328697B1/no not_active IP Right Cessation
- 2003-09-23 CA CA002442875A patent/CA2442875C/fr not_active Expired - Fee Related
- 2003-09-23 AR ARP030103454A patent/AR041356A1/es not_active Application Discontinuation
- 2003-09-24 SG SG200305554A patent/SG110070A1/en unknown
- 2003-09-24 US US10/669,738 patent/US7105683B2/en not_active Expired - Fee Related
- 2003-09-24 MA MA27320A patent/MA26101A1/fr unknown
- 2003-09-24 CN CNB2006100073351A patent/CN100393707C/zh not_active Expired - Fee Related
- 2003-09-24 CN CNB031348076A patent/CN1280285C/zh not_active Expired - Fee Related
2005
- 2005-03-08 IL IL167314A patent/IL167314A/en not_active IP Right Cessation
- 2005-03-18 NI NI200500065A patent/NI200500065A/es unknown
- 2005-03-23 TN TNP2005000089A patent/TNSN05089A1/fr unknown
- 2005-04-19 IS IS7808A patent/IS2136B/xx unknown
- 2005-04-22 EC EC2005005742A patent/ECSP055742A/es unknown
2006
- 2006-02-21 US US11/358,496 patent/US7238815B2/en not_active Expired - Fee Related
- 2006-02-21 US US11/358,034 patent/US7462714B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EA200300926A1 (ru)	2004-04-29
KR100551503B1 (ko)	2006-02-13
PT1403264E (pt)	2005-04-29
IS7808A (is)	2005-04-19
TNSN05089A1 (fr)	2007-05-14
SI1403264T1 (en)	2005-04-30
NO328697B1 (no)	2010-04-26
RS20050242A (sr)	2007-06-04
AP2005003259A0 (en)	2005-03-31
NO20034237L (no)	2004-03-25
HK1096661A1 (zh)	2007-06-08
ME00451B (me)	2011-10-10
CA2442875C (fr)	2009-06-02
US20040059135A1 (en)	2004-03-25
PL214414B1 (pl)	2013-07-31
CN1817869A (zh)	2006-08-16
CN100393707C (zh)	2008-06-11
AP1942A (en)	2009-01-28
HRP20050360B1 (hr)	2013-08-31
PL362367A1 (en)	2004-04-05
IL167314A (en)	2010-04-29
HK1061845A1 (en)	2004-10-08
MXPA03008645A (es)	2005-04-19
US20060142567A1 (en)	2006-06-29
WO2004029035A1 (fr)	2004-04-08
AR041356A1 (es)	2005-05-11
MA26101A1 (fr)	2004-04-01
CN1500783A (zh)	2004-06-02
ECSP055742A (es)	2005-07-06
EP1403264A1 (de)	2004-03-31
DE60300252T2 (de)	2005-12-22
JP4136865B2 (ja)	2008-08-20
FR2844796A1 (fr)	2004-03-26
US7105683B2 (en)	2006-09-12
US7238815B2 (en)	2007-07-03
ATE286041T1 (de)	2005-01-15
ZA200307410B (en)	2004-07-07
NI200500065A (es)	2006-01-03
UA79991C2 (en)	2007-08-10
CA2442875A1 (fr)	2004-03-24
MY131939A (en)	2007-09-28
IS2136B (is)	2006-08-15
US20060142596A1 (en)	2006-06-29
RS50929B (sr)	2010-08-31
DE60300252D1 (de)	2005-02-03
HRP20050360A2 (en)	2005-06-30
GEP20074140B (en)	2007-06-25
NZ528400A (en)	2004-06-25
BR0304194A (pt)	2004-09-08
EA007496B1 (ru)	2006-10-27
AU2003282178A1 (en)	2004-04-19
CN1280285C (zh)	2006-10-18
ES2235144T3 (es)	2005-07-01
EP1403264B1 (de)	2004-12-29
US7462714B2 (en)	2008-12-09
NO20034237D0 (no)	2003-09-23
AU2003248279A1 (en)	2004-04-08
DK1403264T3 (da)	2005-04-04
KR20040026627A (ko)	2004-03-31
AU2003248279B2 (en)	2009-08-06
SG110070A1 (en)	2005-04-28
JP2004269495A (ja)	2004-09-30

Publication	Publication Date	Title
JP4136867B2 (ja)	2008-08-20	ラネリック酸ストロンチウム及びその水和物の新規な工業的合成方法
OA12933A (en)	2006-10-13	Novel method for the industrial synthesis of the methyl diester of 5-amino-3-carboxymethyl-4-cyano-2-thiophenecarboxylic acid and application of divalent salts of ranelic acid and the hydrates thereofin said synthesis.
MXPA03008647A (es)	2005-04-19	Nuevo proceso para la sintesis industrial de tetraesteres de acido 5-[bis (carboximetil) amino]-3 -carboximetil-4 -ciano-2- tiofencarboxilico, y aplicacion a la sintesis de sales bivalentes de acido ranelico y sus hidratos.
EP0650963A1 (de)	1995-05-03	Verbessertes Verfahren zur Herstellung von 2-Methylthiazole-5-carboxylaten
HK1096661B (en)	2009-01-23	An intermediate for the industrial synthesis of substituted thiophenecarboxylate
US5880288A (en)	1999-03-09	Process for the preparation of 2-methylthiazole-5-carboxylates
KR970011284B1 (ko)	1997-07-09	개선된 2-메틸티아졸-5-카르복실레이트의 제조방법
JP3085698B2 (ja)	2000-09-11	チオフェン誘導体およびその製造方法
HK1061845B (en)	2007-02-23	New process for the industrial synthesis of substituted thiophene-carboxylates, and application of such compounds