NO20034237L - Ny fremgangsmate for den industrielle syntese av metyldiesteren av 5-amino-3-karboksymetyl-4-cyano-2-tiofenkarboksylsyre, og anvendelse i syntesen av bivalente salter av ranelinsyre og deres hydrater - Google Patents

Ny fremgangsmate for den industrielle syntese av metyldiesteren av 5-amino-3-karboksymetyl-4-cyano-2-tiofenkarboksylsyre, og anvendelse i syntesen av bivalente salter av ranelinsyre og deres hydrater

Info

Publication number: NO20034237L
Authority: NO; Norway
Prior art keywords: synthesis; acid; hydrates; carboxymethyl; cyano
Prior art date: 2002-09-24

Application number

NO20034237A

Other languages

English (en)

Other versions

NO328697B1 (no

NO20034237D0 (no

Inventor

Jean-Pierre Lecouve

Lucile Vaysse-Ludot

Pascal Langlois

Original Assignee

Servier Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-09-24

Filing date

2003-09-23

Publication date

2004-03-25

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=29415190&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20034237(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2003-09-23 Application filed by Servier Lab filed Critical Servier Lab

2003-09-23 Publication of NO20034237D0 publication Critical patent/NO20034237D0/no

2004-03-25 Publication of NO20034237L publication Critical patent/NO20034237L/no

2010-04-26 Publication of NO328697B1 publication Critical patent/NO328697B1/no

Links

230000015572 biosynthetic process Effects 0.000 title 2
238000003786 synthesis reaction Methods 0.000 title 2
KNPBNTMMZCNVIE-UHFFFAOYSA-N 5-amino-3-(carboxymethyl)-4-cyanothiophene-2-carboxylic acid Chemical compound NC=1SC(C(O)=O)=C(CC(O)=O)C=1C#N KNPBNTMMZCNVIE-UHFFFAOYSA-N 0.000 title 1
150000004677 hydrates Chemical class 0.000 title 1
238000000034 method Methods 0.000 title 1
-1 methyl diester Chemical class 0.000 title 1
DJSXNILVACEBLP-UHFFFAOYSA-N ranelic acid Chemical class OC(=O)CN(CC(O)=O)C=1SC(C(O)=O)=C(CC(O)=O)C=1C#N DJSXNILVACEBLP-UHFFFAOYSA-N 0.000 title 1
229950003464 ranelic acid Drugs 0.000 title 1
150000003839 salts Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/23—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same unsaturated acyclic carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

NO20034237A 2002-09-24 2003-09-23 Ny fremgangsmate for den industrielle syntese av metyldiesteren av 5-amino-3-karboksymetyl-4-cyano-2-tiofenkarboksylsyre, og anvendelse i syntesen av bivalente salter av ranelinsyre og deres hydrater NO328697B1 (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR0211764A FR2844796A1 (fr)	2002-09-24	2002-09-24	Nouveau procede de synthese industrielle du diester methylique de l'acide 5-amino-3-carboxymethyl-4-cyano-2- thiophenecarboxylique, et application a la synthese des sels bivalents de l'acide ranelique et de leurs hydrates

Publications (3)

Publication Number	Publication Date
NO20034237D0 NO20034237D0 (no)	2003-09-23
NO20034237L true NO20034237L (no)	2004-03-25
NO328697B1 NO328697B1 (no)	2010-04-26

Family

ID=29415190

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20034237A NO328697B1 (no)	2002-09-24	2003-09-23	Ny fremgangsmate for den industrielle syntese av metyldiesteren av 5-amino-3-karboksymetyl-4-cyano-2-tiofenkarboksylsyre, og anvendelse i syntesen av bivalente salter av ranelinsyre og deres hydrater

Country Status (38)

Country	Link
US (3)	US7105683B2 (no)
EP (1)	EP1403264B1 (no)
JP (1)	JP4136865B2 (no)
KR (1)	KR100551503B1 (no)
CN (2)	CN1280285C (no)
AP (1)	AP1942A (no)
AR (1)	AR041356A1 (no)
AT (1)	ATE286041T1 (no)
AU (2)	AU2003282178A1 (no)
BR (1)	BR0304194A (no)
CA (1)	CA2442875C (no)
DE (1)	DE60300252T2 (no)
DK (1)	DK1403264T3 (no)
EA (1)	EA007496B1 (no)
EC (1)	ECSP055742A (no)
ES (1)	ES2235144T3 (no)
FR (1)	FR2844796A1 (no)
GE (1)	GEP20074140B (no)
HR (1)	HRP20050360B1 (no)
IL (1)	IL167314A (no)
IS (1)	IS2136B (no)
MA (1)	MA26101A1 (no)
ME (1)	ME00451B (no)
MX (1)	MXPA03008645A (no)
MY (1)	MY131939A (no)
NI (1)	NI200500065A (no)
NO (1)	NO328697B1 (no)
NZ (1)	NZ528400A (no)
OA (1)	OA12933A (no)
PL (1)	PL214414B1 (no)
PT (1)	PT1403264E (no)
RS (1)	RS50929B (no)
SG (1)	SG110070A1 (no)
SI (1)	SI1403264T1 (no)
TN (1)	TNSN05089A1 (no)
UA (1)	UA79991C2 (no)
WO (1)	WO2004029035A1 (no)
ZA (1)	ZA200307410B (no)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2844795B1 (fr) *	2002-09-24	2004-10-22	Servier Lab	Nouveau procede de synthese industriel du ranelate de strontium et de ses hydrates
FR2844796A1 (fr) *	2002-09-24	2004-03-26	Servier Lab	Nouveau procede de synthese industrielle du diester methylique de l'acide 5-amino-3-carboxymethyl-4-cyano-2- thiophenecarboxylique, et application a la synthese des sels bivalents de l'acide ranelique et de leurs hydrates
PT1534305E (pt) *	2003-05-07	2007-02-28	Osteologix As	Tratamento de afecções cartilagineas / osseas com sais de estroncio hidrosoluveis
PT1622630E (pt) *	2003-05-07	2012-10-11	Osteologix As	Combinações de estrôncio para a profilaxia/tratamento de patologias da cartilagem e/ou do osso
US20050085531A1 (en) *	2003-10-03	2005-04-21	Hodge Carl N.	Thiophene-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof
US20080167513A1 (en) *	2004-02-26	2008-07-10	Osteologlx A/S	Strontium-Containing Compounds for Use in the Prevention or Treatment of Necrotic Bone Conditions
DK1768748T4 (da)	2004-06-25	2019-06-11	Mokwalo Spf S A	Sammensætninger omfattende strontium og vitamin D og anvendelser deraf
FR2875807B1 (fr) *	2004-09-30	2006-11-17	Servier Lab	Forme cristalline alpha du ranelate de strontium, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
US20070292529A1 (en) *	2006-06-19	2007-12-20	Tabbiner Philip S	Strontium compositions and methods of treating osteoporotic conditions
CN101665483B (zh) *	2008-09-01	2013-01-23	河北医科大学	一种雷尼酸锶中间体化合物ⅱ的合成方法
WO2011110597A1 (de)	2010-03-11	2011-09-15	Azad Pharmaceutical Ingredients Ag	Verfahren zur herstellung von strontiumranelat
CN103319454B (zh) *	2013-06-14	2014-06-18	广东众生药业股份有限公司	一种高纯度雷尼酸四乙酯及其中间体的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR415850A (fr)	1909-07-22	1910-10-05	Gustave Auguste Ferrie	Dispositif de mesure permettant de lire directement la valeur d'une grandeur fonction de deux variables
FR2651497B1 (fr) *	1989-09-01	1991-10-25	Adir	Nouveaux sels de metaux bivalents de l'acide n, n-di (carboxymethyl)amino-2 cyano-3 carboxymethyl-4 carboxy-5 thiophene, leur procede de preparation et les compositions pharmaceutiques les renfermant.
FR2844796A1 (fr) *	2002-09-24	2004-03-26	Servier Lab	Nouveau procede de synthese industrielle du diester methylique de l'acide 5-amino-3-carboxymethyl-4-cyano-2- thiophenecarboxylique, et application a la synthese des sels bivalents de l'acide ranelique et de leurs hydrates
FR2844797B1 (fr) *	2002-09-24	2004-10-22	Servier Lab	Nouveau procede de synthese industriel des tetraesters de l'acide 5-[bis (carboxymethyl)]-3-carboxymethyl-4-cyano-2- thiophenecarboxylique, et application a la synthese des sels bivalents de l'acide ranelique et de leurs hydrates

2002
- 2002-09-24 FR FR0211764A patent/FR2844796A1/fr active Pending
2003
- 2003-09-17 MY MYPI20033534A patent/MY131939A/en unknown
- 2003-09-22 DE DE60300252T patent/DE60300252T2/de not_active Expired - Lifetime
- 2003-09-22 BR BR0304194-8A patent/BR0304194A/pt not_active Application Discontinuation
- 2003-09-22 GE GEAP20038760A patent/GEP20074140B/en unknown
- 2003-09-22 AU AU2003282178A patent/AU2003282178A1/en not_active Abandoned
- 2003-09-22 AT AT03292317T patent/ATE286041T1/de active
- 2003-09-22 WO PCT/FR2003/002776 patent/WO2004029035A1/fr not_active Ceased
- 2003-09-22 DK DK03292317T patent/DK1403264T3/da active
- 2003-09-22 HR HRP20050360AA patent/HRP20050360B1/hr not_active IP Right Cessation
- 2003-09-22 PT PT03292317T patent/PT1403264E/pt unknown
- 2003-09-22 RS YUP-2005/0242A patent/RS50929B/sr unknown
- 2003-09-22 ES ES03292317T patent/ES2235144T3/es not_active Expired - Lifetime
- 2003-09-22 EP EP03292317A patent/EP1403264B1/fr not_active Expired - Lifetime
- 2003-09-22 JP JP2003330438A patent/JP4136865B2/ja not_active Expired - Fee Related
- 2003-09-22 AP AP2005003259A patent/AP1942A/xx active
- 2003-09-22 UA UAA200503859A patent/UA79991C2/uk unknown
- 2003-09-22 ME MEP-2008-685A patent/ME00451B/me unknown
- 2003-09-22 AU AU2003248279A patent/AU2003248279B2/en not_active Ceased
- 2003-09-22 OA OA1200500082A patent/OA12933A/en unknown
- 2003-09-22 SI SI200330013T patent/SI1403264T1/xx unknown
- 2003-09-23 ZA ZA200307410A patent/ZA200307410B/xx unknown
- 2003-09-23 EA EA200300926A patent/EA007496B1/ru not_active IP Right Cessation
- 2003-09-23 PL PL362367A patent/PL214414B1/pl unknown
- 2003-09-23 KR KR1020030065785A patent/KR100551503B1/ko not_active Expired - Fee Related
- 2003-09-23 NO NO20034237A patent/NO328697B1/no not_active IP Right Cessation
- 2003-09-23 NZ NZ528400A patent/NZ528400A/en not_active IP Right Cessation
- 2003-09-23 MX MXPA03008645A patent/MXPA03008645A/es active IP Right Grant
- 2003-09-23 CA CA002442875A patent/CA2442875C/fr not_active Expired - Fee Related
- 2003-09-23 AR ARP030103454A patent/AR041356A1/es not_active Application Discontinuation
- 2003-09-24 US US10/669,738 patent/US7105683B2/en not_active Expired - Fee Related
- 2003-09-24 CN CNB031348076A patent/CN1280285C/zh not_active Expired - Fee Related
- 2003-09-24 SG SG200305554A patent/SG110070A1/en unknown
- 2003-09-24 CN CNB2006100073351A patent/CN100393707C/zh not_active Expired - Fee Related
- 2003-09-24 MA MA27320A patent/MA26101A1/fr unknown
2005
- 2005-03-08 IL IL167314A patent/IL167314A/en not_active IP Right Cessation
- 2005-03-18 NI NI200500065A patent/NI200500065A/es unknown
- 2005-03-23 TN TNP2005000089A patent/TNSN05089A1/fr unknown
- 2005-04-19 IS IS7808A patent/IS2136B/xx unknown
- 2005-04-22 EC EC2005005742A patent/ECSP055742A/es unknown
2006
- 2006-02-21 US US11/358,034 patent/US7462714B2/en not_active Expired - Fee Related
- 2006-02-21 US US11/358,496 patent/US7238815B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US20060142596A1 (en)	2006-06-29
ECSP055742A (es)	2005-07-06
EA007496B1 (ru)	2006-10-27
ME00451B (me)	2011-10-10
RS20050242A (sr)	2007-06-04
AR041356A1 (es)	2005-05-11
AU2003248279A1 (en)	2004-04-08
HK1096661A1 (zh)	2007-06-08
JP4136865B2 (ja)	2008-08-20
NO328697B1 (no)	2010-04-26
CA2442875A1 (fr)	2004-03-24
CN100393707C (zh)	2008-06-11
PL214414B1 (pl)	2013-07-31
CN1280285C (zh)	2006-10-18
CN1500783A (zh)	2004-06-02
SG110070A1 (en)	2005-04-28
IL167314A (en)	2010-04-29
FR2844796A1 (fr)	2004-03-26
EP1403264A1 (fr)	2004-03-31
US20040059135A1 (en)	2004-03-25
MA26101A1 (fr)	2004-04-01
AU2003248279B2 (en)	2009-08-06
EA200300926A1 (ru)	2004-04-29
EP1403264B1 (fr)	2004-12-29
DK1403264T3 (da)	2005-04-04
US7462714B2 (en)	2008-12-09
GEP20074140B (en)	2007-06-25
NI200500065A (es)	2006-01-03
HRP20050360B1 (hr)	2013-08-31
AU2003282178A1 (en)	2004-04-19
US7105683B2 (en)	2006-09-12
AP2005003259A0 (en)	2005-03-31
PL362367A1 (en)	2004-04-05
DE60300252T2 (de)	2005-12-22
US7238815B2 (en)	2007-07-03
ZA200307410B (en)	2004-07-07
ATE286041T1 (de)	2005-01-15
MXPA03008645A (es)	2005-04-19
JP2004269495A (ja)	2004-09-30
CN1817869A (zh)	2006-08-16
WO2004029035A1 (fr)	2004-04-08
PT1403264E (pt)	2005-04-29
NO20034237D0 (no)	2003-09-23
KR100551503B1 (ko)	2006-02-13
HK1061845A1 (en)	2004-10-08
MY131939A (en)	2007-09-28
BR0304194A (pt)	2004-09-08
NZ528400A (en)	2004-06-25
KR20040026627A (ko)	2004-03-31
IS7808A (is)	2005-04-19
ES2235144T3 (es)	2005-07-01
US20060142567A1 (en)	2006-06-29
CA2442875C (fr)	2009-06-02
IS2136B (is)	2006-08-15
DE60300252D1 (de)	2005-02-03
AP1942A (en)	2009-01-28
SI1403264T1 (en)	2005-04-30
HRP20050360A2 (en)	2005-06-30
TNSN05089A1 (fr)	2007-05-14
OA12933A (en)	2006-10-13
RS50929B (sr)	2010-08-31
UA79991C2 (en)	2007-08-10

Legal Events

Date	Code	Title	Description
2019-04-29	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
DK1347955T3 (da)	2010-06-07	Nye mandelsyrederivater og deres anvendelse som throbin-hæmmere
NO20034236L (no)	2004-03-25	Ny fremgangsmate for den industrielle syntese av tetraestere av 5-[bis(karboksymetyl)amino]-3-karboksymetyl-4-cyano-2-tiofenkarboksylsyre, og anvendelse i syntesen av bivalente salter av ranelinsyre og deres hydrater
NO2017051I1 (no)	2017-10-09	Kariprazin, eventuelt i form av et salt, inkludert kariprazin hydroklorid
DE602005011795D1 (de)	2009-01-29	Inhibitoren von 11-beta-hydroxysteroiddehydrogenase typ 1
DK1261600T3 (da)	2004-08-16	Heteroaromatiske carboxamidderivater og deres anvendelse som inhibitorer af enzymet IKK-2
DK1701946T3 (da)	2008-04-28	1-piperazin- og 1-homopiperazincarboxylatderivater, deres fremstilling og deres terapeutiske anvendelse som inhibitorer af FAAH-enzymet
DK1497266T3 (da)	2008-10-06	Quinolinderivater og deres anvendelse som 5HT6-ligander
ATE361279T1 (de)	2007-05-15	N-[phenyl(piperidin-2-yl)methyl]benzamidderivat , verfahren zu ihrer herstellung und ihre therapeutische anwendung
NO20054969D0 (no)	2005-10-26	2-cyanopropansyreamid- og esterderivater og deres anvendelse
DK1527050T3 (da)	2010-07-19	Quinolin-derivater og deres anvendelse som mycobakterielle inhibitorer
NO20034187D0 (no)	2003-09-19	Nye spirotricykliske derivater og anvendelse derav som fosfodiesterase-7 inhibitorer
NO20055581D0 (no)	2005-11-25	Heltrukket stalror for bruk som et lederor og fremgangsmate for produksjon derav
ATE501135T1 (de)	2011-03-15	Piperidinamino-benzimidazol-derivate al respiratorisches syncytialvirus replikation inhibitoren
DK1342881T3 (da)	2006-10-23	Opskummet syrebehandlingsvæske
NO2015008I2 (no)	2015-03-12	olaparib og salter derav
BRPI0312331A2 (pt)	2016-06-28	composições de ácido hialurônico e métodos de emprego.
ATE333463T1 (de)	2006-08-15	Selektive dipeptidische inhibitoren von kallikrein
EP1639086A4 (en)	2007-07-11	RNA Interferases and method of use thereof
NO20042719L (no)	2004-06-28	Substituerte 2-amino-cykloalkankarboksamider og deres anvendelse som protease-inhibitorer
DK1581518T3 (da)	2011-06-06	Substituerede 1-piperidin-4-yl-4-pyrrolidin-3-yl-piperazin-derivater og deres anvendelse som neurokinin antagonister
NO20034237D0 (no)	2003-09-23	Ny fremgangsmåte for den industrielle syntese av metyldiesteren av 5-amino-3-karboksymetyl-4-cyano-2-tiofenkarboksylsyre, og anvendelse isyntesen av bivalente salter av ranelinsyre og deres hydrater
DK1575951T3 (da)	2014-09-15	Heterocykliske forbindelser, fremgangsmåder til fremstilling deraf og deres anvendelse i terapi
EP1543129A4 (en)	2007-08-15	REPRESSION OF GENE EXPRESSION INDUCED BY VIRUSES IN PLANTS
NO20044321L (no)	2004-10-12	Piperazinyl- eller piperidinylamin-sulfaminsyreamider som inhibitorer av steroid sulfatase
EP1467673A4 (en)	2013-04-17	Irrigation solution and methods for use