OA13238A - [1,8]Naphthyridin-2-ones and related compounds forthe treatment of schizophrenia. - Google Patents

[1,8]Naphthyridin-2-ones and related compounds forthe treatment of schizophrenia. Download PDF

Info

Publication number: OA13238A
Authority: OA; OAPI
Prior art keywords: piperazin; butoxy; naphthyridin; dihydro; naphthalen
Prior art date: 2003-08-22

Application number

OA1200600052A

Other languages

English (en)

Inventor

Jerry Clark

David Favor

Lloyd Franklin

Douglas Johnson

Ligong Ou

Michael Walters

Jamie Davis

Lorraine Fay

Kevin Henegat

Brian Nichelson

Joseph Thomas Repine

Andrew David White

Zhijian Zhu

Original Assignee

Warner Lambert Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-08-22

Filing date

2004-08-13

Publication date

2006-12-13

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34216117&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=OA13238(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2004-08-13 Application filed by Warner Lambert Co filed Critical Warner Lambert Co

2006-12-13 Publication of OA13238A publication Critical patent/OA13238A/en

Links

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238000004895 liquid chromatography mass spectrometry Methods 0.000 description 1
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SAPNXPWPAUFAJU-UHFFFAOYSA-N lofepramine Chemical compound C12=CC=CC=C2CCC2=CC=CC=C2N1CCCN(C)CC(=O)C1=CC=C(Cl)C=C1 SAPNXPWPAUFAJU-UHFFFAOYSA-N 0.000 description 1
239000007937 lozenge Substances 0.000 description 1
239000000314 lubricant Substances 0.000 description 1
VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
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238000004949 mass spectrometry Methods 0.000 description 1
238000010907 mechanical stirring Methods 0.000 description 1
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230000008018 melting Effects 0.000 description 1
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XMJHPCRAQCTCFT-UHFFFAOYSA-N methyl chloroformate Chemical compound COC(Cl)=O XMJHPCRAQCTCFT-UHFFFAOYSA-N 0.000 description 1
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RNZLTHJOEWPICO-UHFFFAOYSA-N tert-butyl 4-(8-chloronaphthalen-1-yl)piperazine-1-carboxylate Chemical compound C1CN(C(=O)OC(C)(C)C)CCN1C1=CC=CC2=CC=CC(Cl)=C12 RNZLTHJOEWPICO-UHFFFAOYSA-N 0.000 description 1
DQMDVQPLCVJQFB-UHFFFAOYSA-N tert-butyl 4-(8-fluoronaphthalen-1-yl)piperazine-1-carboxylate Chemical compound C1CN(C(=O)OC(C)(C)C)CCN1C1=CC=CC2=CC=CC(F)=C12 DQMDVQPLCVJQFB-UHFFFAOYSA-N 0.000 description 1
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PRDWQFTWRGMKNZ-UHFFFAOYSA-N tert-butyl 4-[7-(1-butoxyethenyl)naphthalen-1-yl]piperazine-1-carboxylate Chemical compound C12=CC(C(=C)OCCCC)=CC=C2C=CC=C1N1CCN(C(=O)OC(C)(C)C)CC1 PRDWQFTWRGMKNZ-UHFFFAOYSA-N 0.000 description 1
ZLDZLJYKUILXOQ-UHFFFAOYSA-N tert-butyl 4-[7-(trifluoromethylsulfonyloxy)naphthalen-1-yl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OC(C)(C)C)CCN1C1=CC=CC2=CC=C(OS(=O)(=O)C(F)(F)F)C=C12 ZLDZLJYKUILXOQ-UHFFFAOYSA-N 0.000 description 1
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125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
150000003512 tertiary amines Chemical class 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
PHTUQLWOUWZIMZ-GZTJUZNOSA-N trans-dothiepin Chemical compound C1SC2=CC=CC=C2C(=C/CCN(C)C)/C2=CC=CC=C21 PHTUQLWOUWZIMZ-GZTJUZNOSA-N 0.000 description 1
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PHLBKPHSAVXXEF-UHFFFAOYSA-N trazodone Chemical compound ClC1=CC=CC(N2CCN(CCCN3C(N4C=CC=CC4=N3)=O)CC2)=C1 PHLBKPHSAVXXEF-UHFFFAOYSA-N 0.000 description 1
CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 1
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ITMCEJHCFYSIIV-UHFFFAOYSA-M triflate Chemical compound [O-]S(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-M 0.000 description 1
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ZSCDBOWYZJWBIY-UHFFFAOYSA-N trimipramine Chemical compound C1CC2=CC=CC=C2N(CC(CN(C)C)C)C2=CC=CC=C21 ZSCDBOWYZJWBIY-UHFFFAOYSA-N 0.000 description 1
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Classifications

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- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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2004
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- 2004-08-13 KR KR1020067003621A patent/KR100765668B1/ko not_active Expired - Fee Related
- 2004-08-13 AU AU2004266191A patent/AU2004266191B2/en not_active Ceased
- 2004-08-13 EP EP04744287A patent/EP1660497A1/en not_active Withdrawn
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- 2004-08-13 MX MXPA06002070A patent/MXPA06002070A/es active IP Right Grant
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- 2004-08-13 BR BRPI0413860-0A patent/BRPI0413860A/pt not_active IP Right Cessation
- 2004-08-13 WO PCT/IB2004/002665 patent/WO2005019215A1/en not_active Ceased
- 2004-08-13 EA EA200600294A patent/EA009645B1/ru not_active IP Right Cessation
- 2004-08-18 PE PE2004000796A patent/PE20051039A1/es not_active Application Discontinuation
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- 2004-08-20 PA PA20048609701A patent/PA8609701A1/es unknown
- 2004-08-20 TW TW093125196A patent/TWI298327B/zh active
- 2004-08-20 AR ARP040103006A patent/AR045386A1/es not_active Application Discontinuation
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- 2004-08-20 MY MYPI20043415A patent/MY140693A/en unknown
2005
- 2005-01-13 GT GT200500007A patent/GT200500007A/es unknown
2006
- 2006-01-20 NO NO20060324A patent/NO20060324L/no not_active Application Discontinuation
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- 2006-02-10 CU CU20060028A patent/CU23464B7/es not_active IP Right Cessation
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- 2006-02-22 CR CR8254A patent/CR8254A/es unknown
- 2006-02-22 MA MA28828A patent/MA28003A1/fr unknown
- 2006-02-22 EC EC2006006391A patent/ECSP066391A/es unknown
- 2006-02-22 TN TNP2006000063A patent/TNSN06063A1/en unknown
- 2006-08-24 US US11/466,822 patent/US20060287309A1/en not_active Abandoned
- 2006-08-24 US US11/466,828 patent/US20060287310A1/en not_active Abandoned
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Also Published As

Publication number	Publication date
US20050043309A1 (en)	2005-02-24
MY140693A (en)	2010-01-15
PA8609701A1 (es)	2005-05-24
TNSN06063A1 (en)	2007-10-03
AU2004266191B2 (en)	2009-11-26
AR045386A1 (es)	2005-10-26
NL1026892C2 (nl)	2005-11-21
CN100422181C (zh)	2008-10-01
ECSP066391A (es)	2006-08-30
IL173439A0 (en)	2006-06-11
HK1091815A1 (zh)	2007-01-26
NZ545078A (en)	2009-09-25
TW200524938A (en)	2005-08-01
EP1660497A1 (en)	2006-05-31
MXPA06002070A (es)	2006-05-19
NO20060324L (no)	2006-05-18
CA2538915A1 (en)	2005-03-03
HN2004000319A (es)	2010-06-09
KR100801794B1 (ko)	2008-02-05
CR8254A (es)	2006-10-17
RS20060129A (sr)	2008-06-05
KR20070053364A (ko)	2007-05-23
AP2006003525A0 (en)	2006-02-28
KR20060071404A (ko)	2006-06-26
WO2005019215A1 (en)	2005-03-03
AU2004266191A1 (en)	2005-03-03
JP4034811B2 (ja)	2008-01-16
CU23464B7 (es)	2009-12-17
ZA200601526B (en)	2007-04-25
CA2538915C (en)	2010-06-15
BRPI0413860A (pt)	2006-10-24
US20060287309A1 (en)	2006-12-21
JP2007503386A (ja)	2007-02-22
US20060287310A1 (en)	2006-12-21
CR9834A (es)	2008-04-21
EA009645B1 (ru)	2008-02-28
IS8267A (is)	2006-01-26
MEP45308A (en)	2011-02-10
GEP20084447B (en)	2008-08-10
PE20051039A1 (es)	2005-12-12
US7160888B2 (en)	2007-01-09
UA82541C2 (uk)	2008-04-25
NL1026892A1 (nl)	2005-02-28
MA28003A1 (fr)	2006-07-03
CN1839134A (zh)	2006-09-27
TWI298327B (en)	2008-07-01
KR100765668B1 (ko)	2007-10-10
GT200500007A (es)	2005-10-24
EA200600294A1 (ru)	2006-08-25

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