OA13294A - Molécules duales contenant un dérivé peroxydique, leur synthèse et leurs applications thérapeutiques. - Google Patents

Molécules duales contenant un dérivé peroxydique, leur synthèse et leurs applications thérapeutiques. Download PDF

Info

Publication number: OA13294A
Authority: OA; OAPI
Prior art keywords: formula; mmol; molecules according; radical; trioxaquine
Prior art date: 2000-04-06

Application number

OA1200200308A

Other languages

English (en)

French (fr)

Inventor

Bernard Meunier

Anne Robert

Odile Dechy-Cabaret

Francoise Benoit-Vical

Original Assignee

Centre Nat Rech Scient

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-04-06

Filing date

2001-04-04

Publication date

2007-04-13

2001-04-04 Application filed by Centre Nat Rech Scient filed Critical Centre Nat Rech Scient

2007-04-13 Publication of OA13294A publication Critical patent/OA13294A/fr

Links

230000009977 dual effect Effects 0.000 title claims abstract description 13
230000015572 biosynthetic process Effects 0.000 title description 16
238000003786 synthesis reaction Methods 0.000 title description 16
230000001225 therapeutic effect Effects 0.000 title description 3
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims abstract description 64
-1 cyclic peroxide Chemical class 0.000 claims abstract description 51
230000008878 coupling Effects 0.000 claims abstract description 27
238000010168 coupling process Methods 0.000 claims abstract description 27
238000005859 coupling reaction Methods 0.000 claims abstract description 27
230000000078 anti-malarial effect Effects 0.000 claims abstract description 18
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150000001412 amines Chemical class 0.000 claims abstract description 7
150000003839 salts Chemical class 0.000 claims abstract description 7
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150000007513 acids Chemical class 0.000 claims abstract description 4
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125000001424 substituent group Chemical group 0.000 claims description 25
150000001875 compounds Chemical class 0.000 claims description 21
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238000006243 chemical reaction Methods 0.000 claims description 13
238000006268 reductive amination reaction Methods 0.000 claims description 13
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239000004480 active ingredient Substances 0.000 claims description 9
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FTVLMFQEYACZNP-UHFFFAOYSA-N trimethylsilyl trifluoromethanesulfonate Chemical compound C[Si](C)(C)OS(=O)(=O)C(F)(F)F FTVLMFQEYACZNP-UHFFFAOYSA-N 0.000 description 6
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ZQKMYPACOGVMAD-UHFFFAOYSA-N n-(6,7a-diphenylspiro[4a,7-dihydrocyclopenta[e][1,2,4]trioxine-3,4'-cyclohexane]-1'-yl)-n'-(7-chloroquinolin-4-yl)ethane-1,2-diamine;2-hydroxypropane-1,2,3-tricarboxylic acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O.OC(=O)CC(O)(C(O)=O)CC(O)=O.C=1C=NC2=CC(Cl)=CC=C2C=1NCCNC(CC1)CCC1(OC1C=2)OOC1(C=1C=CC=CC=1)CC=2C1=CC=CC=C1 ZQKMYPACOGVMAD-UHFFFAOYSA-N 0.000 description 5
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D323/00—Heterocyclic compounds containing more than two oxygen atoms as the only ring hetero atoms
- C07D323/04—Six-membered rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Tropical Medicine & Parasitology (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)
Medicinal Preparation (AREA)

OA1200200308A 2000-04-06 2001-04-04 Molécules duales contenant un dérivé peroxydique, leur synthèse et leurs applications thérapeutiques. OA13294A (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR0004422A FR2807433B1 (fr)	2000-04-06	2000-04-06	Molecules duales contenant un derives peroxydique, leur synthese et leurs applications therapeutiques

Publications (1)

Publication Number	Publication Date
OA13294A true OA13294A (fr)	2007-04-13

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OA1200200308A OA13294A (fr)	2000-04-06	2001-04-04	Molécules duales contenant un dérivé peroxydique, leur synthèse et leurs applications thérapeutiques.

Country Status (27)

Country	Link
US (2)	US6949569B2 (de)
EP (1)	EP1268470B1 (de)
JP (1)	JP2004521855A (de)
KR (1)	KR100832047B1 (de)
CN (1)	CN1193028C (de)
AP (1)	AP1399A (de)
AR (1)	AR041773A1 (de)
AT (1)	ATE387441T1 (de)
AU (2)	AU4846301A (de)
BR (1)	BR0109885A (de)
CA (1)	CA2405076C (de)
CY (1)	CY1108071T1 (de)
DE (1)	DE60132981T2 (de)
DK (1)	DK1268470T3 (de)
ES (1)	ES2302727T3 (de)
FR (1)	FR2807433B1 (de)
HU (1)	HUP0300428A2 (de)
IL (2)	IL151918A0 (de)
IS (1)	IS6579A (de)
MX (1)	MXPA02009856A (de)
MY (1)	MY128443A (de)
NO (1)	NO329526B1 (de)
NZ (1)	NZ521774A (de)
OA (1)	OA13294A (de)
PT (1)	PT1268470E (de)
WO (1)	WO2001077105A1 (de)
ZA (1)	ZA200207851B (de)

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* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2862304A1 (fr) *	2003-11-14	2005-05-20	Centre Nat Rech Scient	Molecules duales racemiques ou achirales contenant un derive peroxydique, leur synthese et leurs applications therapeutiques
TW200728315A (en) *	2005-12-06	2007-08-01	Nippon Chemical Ind	Phosphorus transition-metal complex, method of producing the same, and anticancer agent forming the same
FR2902100A1 (fr) *	2006-06-13	2007-12-14	Sanofi Aventis Sa	Molecules duales contenant un derive peroxydique, leur synthese et leurs applications en therapeutique
FR2924343A1 (fr) *	2007-12-04	2009-06-05	Palumed Sa	Nouvelles utilisations therapeutiques de molecules duales contenant un derive peroxydique.
WO2012055946A1 (fr) *	2010-10-27	2012-05-03	Meurice R&D Asbl	Procede de fonctionnalisation de composes insatures

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* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE69614149T2 (de) *	1995-11-16	2002-03-14	F. Hoffmann-La Roche Ag, Basel	Chinolinderivate als antimalariamittel

2000
- 2000-04-06 FR FR0004422A patent/FR2807433B1/fr not_active Expired - Fee Related
2001
- 2001-04-04 US US10/240,929 patent/US6949569B2/en not_active Expired - Fee Related
- 2001-04-04 PT PT01921476T patent/PT1268470E/pt unknown
- 2001-04-04 WO PCT/FR2001/001013 patent/WO2001077105A1/fr not_active Ceased
- 2001-04-04 JP JP2001575578A patent/JP2004521855A/ja active Pending
- 2001-04-04 OA OA1200200308A patent/OA13294A/fr unknown
- 2001-04-04 DK DK01921476T patent/DK1268470T3/da active
- 2001-04-04 CN CNB018088066A patent/CN1193028C/zh not_active Expired - Fee Related
- 2001-04-04 KR KR1020027013363A patent/KR100832047B1/ko not_active Expired - Fee Related
- 2001-04-04 AU AU4846301A patent/AU4846301A/xx active Pending
- 2001-04-04 BR BR0109885-3A patent/BR0109885A/pt not_active IP Right Cessation
- 2001-04-04 AU AU2001248463A patent/AU2001248463B2/en not_active Ceased
- 2001-04-04 MX MXPA02009856A patent/MXPA02009856A/es active IP Right Grant
- 2001-04-04 CA CA2405076A patent/CA2405076C/fr not_active Expired - Fee Related
- 2001-04-04 EP EP01921476A patent/EP1268470B1/de not_active Expired - Lifetime
- 2001-04-04 HU HU0300428A patent/HUP0300428A2/hu unknown
- 2001-04-04 NZ NZ521774A patent/NZ521774A/en not_active IP Right Cessation
- 2001-04-04 ES ES01921476T patent/ES2302727T3/es not_active Expired - Lifetime
- 2001-04-04 DE DE60132981T patent/DE60132981T2/de not_active Expired - Lifetime
- 2001-04-04 AT AT01921476T patent/ATE387441T1/de active
- 2001-04-04 AP APAP/P/2002/002646A patent/AP1399A/en active
- 2001-04-04 IL IL15191801A patent/IL151918A0/xx unknown
- 2001-04-06 MY MYPI20011659A patent/MY128443A/en unknown
- 2001-04-06 AR ARP010101655A patent/AR041773A1/es not_active Application Discontinuation
2002
- 2002-09-25 IL IL151918A patent/IL151918A/en not_active IP Right Cessation
- 2002-09-30 ZA ZA200207851A patent/ZA200207851B/en unknown
- 2002-10-03 IS IS6579A patent/IS6579A/is unknown
- 2002-10-04 NO NO20024795A patent/NO329526B1/no not_active IP Right Cessation
2005
- 2005-08-04 US US11/196,979 patent/US7566710B2/en not_active Expired - Fee Related
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Also Published As

Publication number	Publication date
HUP0300428A2 (hu)	2003-06-28
WO2001077105A1 (fr)	2001-10-18
PT1268470E (pt)	2008-06-05
BR0109885A (pt)	2003-06-03
IS6579A (is)	2002-10-03
DE60132981T2 (de)	2009-03-19
EP1268470A1 (de)	2003-01-02
US20040038957A1 (en)	2004-02-26
EP1268470B1 (de)	2008-02-27
ZA200207851B (en)	2004-01-26
ES2302727T3 (es)	2008-08-01
CA2405076C (fr)	2012-03-20
AR041773A1 (es)	2005-06-01
NO20024795L (no)	2002-12-06
NO20024795D0 (no)	2002-10-04
HK1056882A1 (en)	2004-03-05
AP2002002646A0 (en)	2002-12-31
US7566710B2 (en)	2009-07-28
CY1108071T1 (el)	2014-02-12
ATE387441T1 (de)	2008-03-15
AP1399A (en)	2005-04-27
MY128443A (en)	2007-02-28
AU4846301A (en)	2001-10-23
IL151918A0 (en)	2003-04-10
NO329526B1 (no)	2010-11-01
AU2001248463B2 (en)	2006-03-16
US6949569B2 (en)	2005-09-27
JP2004521855A (ja)	2004-07-22
KR100832047B1 (ko)	2008-05-27
MXPA02009856A (es)	2004-02-26
FR2807433A1 (fr)	2001-10-12
DK1268470T3 (da)	2008-06-30
CA2405076A1 (fr)	2001-10-18
CN1426410A (zh)	2003-06-25
NZ521774A (en)	2005-10-28
DE60132981D1 (de)	2008-04-10
IL151918A (en)	2010-04-29
KR20020084294A (ko)	2002-11-04
US20050288315A1 (en)	2005-12-29
CN1193028C (zh)	2005-03-16
FR2807433B1 (fr)	2002-09-20

Publication	Publication Date	Title
FR2669336A1 (fr)	1992-05-22	Nouveaux derives d'oxazolo pyridines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
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CH629194A5 (fr)	1982-04-15	Amino aryl triazines-1,2,4 utilisables dans le traitement d'algies diverses.
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FR2473521A1 (fr)	1981-07-17	2,3-dihydro-3-(1h-imidazol-1-ylmethylene)-4h-1-benzo-thiopyran-4-ones, a action antifongique et antibacterienne