PE20070109A1 - Procesos para la sintesis de 5-(4-metil-1h-imidazol-1-il)-3-(trifluorometil)-bencenamina - Google Patents

Procesos para la sintesis de 5-(4-metil-1h-imidazol-1-il)-3-(trifluorometil)-bencenamina

Info

Publication number: PE20070109A1
Authority: PE; Peru
Prior art keywords: methyl; imidazol; trifluoromethyl; benzenamine; synthesis
Prior art date: 2005-06-09

Application number

PE2006000628A

Other languages

English (en)

Spanish (es)

Inventor

Stephan Abel

Murat Acemoglu

Christoph Krell

Mark Meisenbach

Wen-Chung Shieh

Song Xue

Mahavir Prashad

Joseph Sclafani

Bernhard Erb

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-06-09

Filing date

2006-06-07

Publication date

2007-04-02

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37149980&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20070109(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2006-06-07 Application filed by Novartis Ag filed Critical Novartis Ag

2007-04-02 Publication of PE20070109A1 publication Critical patent/PE20070109A1/es

Links

238000000034 method Methods 0.000 title abstract 2
230000015572 biosynthetic process Effects 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1
XLSZMDLNRCVEIJ-UHFFFAOYSA-N 4-methylimidazole Chemical compound CC1=CNC=N1 XLSZMDLNRCVEIJ-UHFFFAOYSA-N 0.000 abstract 2
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical group 0.000 abstract 2
JMLCVCGQBRZYOZ-UHFFFAOYSA-N 4-methyl-1-[3-nitro-5-(trifluoromethyl)phenyl]imidazole Chemical compound C1=NC(C)=CN1C1=CC([N+]([O-])=O)=CC(C(F)(F)F)=C1 JMLCVCGQBRZYOZ-UHFFFAOYSA-N 0.000 abstract 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical group O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 abstract 1
JXLHNMVSKXFWAO-UHFFFAOYSA-N azane;7-fluoro-2,1,3-benzoxadiazole-4-sulfonic acid Chemical group N.OS(=O)(=O)C1=CC=C(F)C2=NON=C12 JXLHNMVSKXFWAO-UHFFFAOYSA-N 0.000 abstract 1
229940054066 benzamide antipsychotics Drugs 0.000 abstract 1
229910052792 caesium Inorganic materials 0.000 abstract 1
TVFDJXOCXUVLDH-UHFFFAOYSA-N caesium atom Chemical compound [Cs] TVFDJXOCXUVLDH-UHFFFAOYSA-N 0.000 abstract 1
239000003054 catalyst Substances 0.000 abstract 1
XGZVUEUWXADBQD-UHFFFAOYSA-L lithium carbonate Chemical compound [Li+].[Li+].[O-]C([O-])=O XGZVUEUWXADBQD-UHFFFAOYSA-L 0.000 abstract 1
229910052808 lithium carbonate Inorganic materials 0.000 abstract 1
239000002798 polar solvent Substances 0.000 abstract 1
229910052700 potassium Inorganic materials 0.000 abstract 1
239000011591 potassium Substances 0.000 abstract 1
NTTOTNSKUYCDAV-UHFFFAOYSA-N potassium hydride Chemical compound [KH] NTTOTNSKUYCDAV-UHFFFAOYSA-N 0.000 abstract 1
229910000105 potassium hydride Inorganic materials 0.000 abstract 1
229910052708 sodium Inorganic materials 0.000 abstract 1
239000011734 sodium Substances 0.000 abstract 1
229910052723 transition metal Inorganic materials 0.000 abstract 1
150000003624 transition metals Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/07—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms
- C07C205/11—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to carbon atoms of six-membered aromatic rings
- C07C205/12—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to carbon atoms of six-membered aromatic rings the six-membered aromatic ring or a condensed ring system containing that ring being substituted by halogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C07D233/61—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms not forming part of a nitro radical, attached to ring nitrogen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Plural Heterocyclic Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

PE2006000628A 2005-06-09 2006-06-07 Procesos para la sintesis de 5-(4-metil-1h-imidazol-1-il)-3-(trifluorometil)-bencenamina PE20070109A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US68897605P	2005-06-09	2005-06-09

Publications (1)

Publication Number	Publication Date
PE20070109A1 true PE20070109A1 (es)	2007-04-02

Family

ID=37149980

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
PE2006000628A PE20070109A1 (es)	2005-06-09	2006-06-07	Procesos para la sintesis de 5-(4-metil-1h-imidazol-1-il)-3-(trifluorometil)-bencenamina
PE2010000468A PE20100716A1 (es)	2005-06-09	2006-06-07	Proceso para la sintesis de 1-bromo-3-nitro-5-trifluorometil-benceno
PE2010000467A PE20100715A1 (es)	2005-06-09	2006-06-07	Proceso para la sintesis de 5-(4-metil-1h-imidazol-1-il)-3-(trifluorometil)-bencenamina

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
PE2010000468A PE20100716A1 (es)	2005-06-09	2006-06-07	Proceso para la sintesis de 1-bromo-3-nitro-5-trifluorometil-benceno
PE2010000467A PE20100715A1 (es)	2005-06-09	2006-06-07	Proceso para la sintesis de 5-(4-metil-1h-imidazol-1-il)-3-(trifluorometil)-bencenamina

Country Status (25)

Country	Link
US (2)	US7781597B2 (da)
EP (3)	EP2292607B1 (da)
JP (2)	JP5225078B2 (da)
KR (2)	KR101249199B1 (da)
CN (6)	CN102180796A (da)
AR (1)	AR057056A1 (da)
AT (1)	ATE540931T1 (da)
AU (3)	AU2006258050B2 (da)
BR (1)	BRPI0611683A2 (da)
CA (4)	CA2833394C (da)
DK (2)	DK2292607T3 (da)
ES (3)	ES2380489T3 (da)
GT (1)	GT200600202AA (da)
HU (1)	HUE028024T2 (da)
IN (2)	IN2014DN08588A (da)
JO (1)	JO2758B1 (da)
MX (1)	MX2007015609A (da)
MY (1)	MY146795A (da)
PE (3)	PE20070109A1 (da)
PL (3)	PL1896426T3 (da)
PT (3)	PT2292607E (da)
RU (1)	RU2446162C2 (da)
SI (2)	SI2292607T1 (da)
TW (1)	TWI380981B (da)
WO (1)	WO2006135640A2 (da)

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BRPI0508140B1 (pt)	2004-03-05	2015-03-17	Nissan Chemical Ind Ltd	Composto benzamida substituída por isoxazolina da fórmula (1); da fórmula (2) substituído por 3,5-bis (aril substituído); da fórmula (4) substituída por alquinibenzeno ou um sal do mesmo; "pesticida, agroquímico, inseticida, parasiticida contendo como ingrediente ativo um ou mais composto benzamida substituída por isoxazolina e sal do mesmo"
MY146795A (en) *	2005-06-09	2012-09-28	Novartis Ag	Process for the synthesis of organic compounds
TW200803740A (en)	2005-12-16	2008-01-16	Du Pont	5-aryl isoxazolines for controlling invertebrate pests
TWI412322B (zh)	2005-12-30	2013-10-21	杜邦股份有限公司	控制無脊椎害蟲之異唑啉
WO2008154528A2 (en)	2007-06-13	2008-12-18	E. I. Du Pont De Nemours And Company	Isoxazoline insecticides
TWI430995B (zh)	2007-06-26	2014-03-21	Du Pont	萘異唑啉無脊椎有害動物控制劑
DK2182945T3 (da)	2007-06-27	2015-11-16	Du Pont	Fremgangsmåde til bekæmpelse af skadedyr hos dyr
TWI649303B (zh)	2007-08-17	2019-02-01	杜邦股份有限公司	製備４-乙醯基-ｎ-〔２-側氧基-２-〔（２，２，２-三氟乙基）胺基〕乙基〕-１-萘甲醯胺之化合物及方法
US8367584B2 (en)	2007-10-03	2013-02-05	E.I. Du Pont De Nemours And Company	Naphthalene isoxazoline compounds for control of invertebrate pests
TW201444787A (zh)	2008-04-09	2014-12-01	Du Pont	製備３-三氟甲基查耳酮（ｃｈａｌｃｏｎｅ）之方法
EP2305667A3 (en)	2008-07-17	2011-05-11	Teva Pharmaceutical Industries Ltd.	Nilotinib intermediates and preparation thereof
HRP20120793T1 (hr)	2008-11-05	2012-12-31	Teva Pharmaceutical Industries Ltd.	Kristalni oblici nilotinib hci
WO2010060074A1 (en) *	2008-11-24	2010-05-27	Teva Pharmaceutical Industries Ltd.	Preparation of nilotinib and intermediates thereof
US20110053968A1 (en)	2009-06-09	2011-03-03	Auspex Pharmaceuticals, Inc.	Aminopyrimidine inhibitors of tyrosine kinase
EP2576523B1 (en)	2010-05-27	2016-01-13	E. I. du Pont de Nemours and Company	Crystalline form of 4-[5 - [3 -chloro-5 -(trifluoromethyl)phenyl] -4,5 -dihydro-5 -(trifluoromethyl)-3 - isoxazolyl]-n-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-1- naphthalenecarboxamide
SG11201402765TA (en)	2011-12-30	2014-06-27	Hanmi Pharm Ind Co Ltd	THIENO[3,2-d]PYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY FOR PROTEIN KINASES
CN102592837B (zh) *	2012-03-12	2014-01-15	河北师范大学	制备超级电容器用四氯合金属季铵盐掺杂聚苯胺电极的方法
CN103694176B (zh)	2014-01-07	2015-02-18	苏州立新制药有限公司	尼洛替尼中间体的制备方法
CN104592122B (zh) *	2014-12-09	2018-01-23	凯莱英医药集团（天津）股份有限公司	3‑(4‑甲基‑1h‑咪唑‑1‑基)‑5‑(三氟甲基)苯胺的制备方法
CN105985293B (zh) *	2015-03-04	2018-04-03	埃斯特维华义制药有限公司	尼洛替尼中间体的制备方法
EP3095782A1 (en)	2015-05-18	2016-11-23	Esteve Química, S.A.	New method for preparing 3-(4-methyl-1h-imidazol-1-yl)-5-(trifluoromethyl)benzenamine
CN107201532B (zh) *	2017-05-09	2019-08-27	吉林凯莱英医药化学有限公司	芳香化合物的硝化方法
WO2019130254A1 (en) *	2018-01-01	2019-07-04	Laurus Labs Ltd	An improved process for 3-(4-methyl-1h-imidazol-1-yl)-5-(trifluoromethyl) aniline
CN108530364B (zh)	2018-04-10	2020-01-21	江苏创诺制药有限公司	一种3-(4-甲基-1h-咪唑-1-基)-5-三氟甲基苯胺单盐酸盐的晶型及其应用
TWI787523B (zh)	2018-06-15	2022-12-21	漢達生技醫藥股份有限公司	達沙替尼十二烷基硫酸鹽之結晶
EP3953336A4 (en) *	2019-04-06	2023-05-03	Trinapco, Inc	SULFONYLDIAZOLES AND N-(FLUOROSULFONYL)AZOLES AND PROCESS FOR THEIR PRODUCTION
EP3904342A1 (en)	2020-04-28	2021-11-03	Grindeks, A Joint Stock Company	Process for the preparation of 3-(trifluoromethyl)-5-(4-methyl-1h-imidazole-1-yl)-benzeneamine hydrochloride
CN114751836B (zh) *	2021-02-23	2024-05-31	四川青木制药有限公司	3-(4-甲基-1h-咪唑-1-基)-5-(三氟甲基)苯胺合成方法及其中间体
CN114853734A (zh) *	2022-06-14	2022-08-05	海南鑫开源医药科技有限公司	一种尼洛替尼游离碱的制备方法
CN116478319B (zh) *	2022-11-07	2025-07-01	华北电力大学	一种离子共价有机聚合物的制备方法及其在碱性环境吸附ReO4-的应用
CN115626880B (zh) *	2022-11-15	2023-11-14	常州大学	3-硝基-5-氰基三氟甲苯的合成方法
CN118108670B (zh) *	2023-12-28	2025-07-01	江苏希迪制药有限公司	尼罗替尼中间体3-(4-甲基-1h-咪唑-1-基)-5-(三氟甲基)苯胺的精制纯化方法
CN121517361A (zh) *	2026-01-15	2026-02-13	湖南阿斯迪康药业有限公司	一种基于溴苯类化合物合成1-芳基咪唑类化合物的方法

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GT200600207A (es) *	2005-06-09	2007-01-15	Novartis Ag	Proceso para la síntesis de compuestos orgánicos

2006
- 2006-05-31 MY MYPI20062506A patent/MY146795A/en unknown
- 2006-06-06 JO JO2006161A patent/JO2758B1/en active
- 2006-06-07 KR KR1020077028642A patent/KR101249199B1/ko not_active Expired - Fee Related
- 2006-06-07 PE PE2006000628A patent/PE20070109A1/es not_active Application Discontinuation
- 2006-06-07 CN CN2011100581769A patent/CN102180796A/zh active Pending
- 2006-06-07 CN CN200680019924XA patent/CN101189212B/zh not_active Expired - Fee Related
- 2006-06-07 IN IN8588DEN2014 patent/IN2014DN08588A/en unknown
- 2006-06-07 SI SI200631789T patent/SI2292607T1/sl unknown
- 2006-06-07 US US11/915,691 patent/US7781597B2/en active Active
- 2006-06-07 PL PL06772447T patent/PL1896426T3/pl unknown
- 2006-06-07 CA CA2833394A patent/CA2833394C/en not_active Expired - Lifetime
- 2006-06-07 DK DK10171942.5T patent/DK2292607T3/da active
- 2006-06-07 CN CN2011100572469A patent/CN102174019B/zh not_active Expired - Fee Related
- 2006-06-07 BR BRPI0611683-3A patent/BRPI0611683A2/pt active Search and Examination
- 2006-06-07 PE PE2010000468A patent/PE20100716A1/es not_active Application Discontinuation
- 2006-06-07 ES ES06772447T patent/ES2380489T3/es not_active Expired - Lifetime
- 2006-06-07 AT AT06772447T patent/ATE540931T1/de active
- 2006-06-07 AU AU2006258050A patent/AU2006258050B2/en not_active Ceased
- 2006-06-07 CA CA2942046A patent/CA2942046A1/en not_active Abandoned
- 2006-06-07 PL PL10171942T patent/PL2292607T3/pl unknown
- 2006-06-07 RU RU2007148238/04A patent/RU2446162C2/ru active
- 2006-06-07 PL PL10171941T patent/PL2266961T3/pl unknown
- 2006-06-07 KR KR1020127011979A patent/KR101283109B1/ko not_active Expired - Fee Related
- 2006-06-07 PT PT101719425T patent/PT2292607E/pt unknown
- 2006-06-07 ES ES10171941.7T patent/ES2558696T3/es not_active Expired - Lifetime
- 2006-06-07 CN CN2011100581788A patent/CN102174021B/zh not_active Expired - Fee Related
- 2006-06-07 ES ES10171942.5T patent/ES2465522T3/es not_active Expired - Lifetime
- 2006-06-07 EP EP10171942.5A patent/EP2292607B1/en not_active Expired - Lifetime
- 2006-06-07 MX MX2007015609A patent/MX2007015609A/es active IP Right Grant
- 2006-06-07 PT PT101719417T patent/PT2266961E/pt unknown
- 2006-06-07 CA CA2886482A patent/CA2886482C/en not_active Expired - Lifetime
- 2006-06-07 IN IN8578DEN2014 patent/IN2014DN08578A/en unknown
- 2006-06-07 CA CA2611280A patent/CA2611280C/en not_active Expired - Lifetime
- 2006-06-07 EP EP06772447A patent/EP1896426B1/en not_active Expired - Lifetime
- 2006-06-07 AR ARP060102367A patent/AR057056A1/es unknown
- 2006-06-07 JP JP2008515880A patent/JP5225078B2/ja not_active Expired - Fee Related
- 2006-06-07 PE PE2010000467A patent/PE20100715A1/es not_active Application Discontinuation
- 2006-06-07 SI SI200632010T patent/SI2266961T1/sl unknown
- 2006-06-07 DK DK10171941.7T patent/DK2266961T3/da active
- 2006-06-07 EP EP10171941.7A patent/EP2266961B1/en not_active Expired - Lifetime
- 2006-06-07 WO PCT/US2006/022154 patent/WO2006135640A2/en not_active Ceased
- 2006-06-07 PT PT06772447T patent/PT1896426E/pt unknown
- 2006-06-07 CN CN2011100574125A patent/CN102180836B/zh not_active Expired - Fee Related
- 2006-06-07 HU HUE10171941A patent/HUE028024T2/en unknown
- 2006-06-07 CN CN2011100581773A patent/CN102174020B/zh not_active Expired - Fee Related
- 2006-06-08 TW TW095120304A patent/TWI380981B/zh not_active IP Right Cessation
2010
- 2010-07-12 US US12/834,295 patent/US8008504B2/en not_active Expired - Fee Related
- 2010-11-11 AU AU2010241374A patent/AU2010241374B2/en not_active Ceased
2011
- 2011-03-09 AU AU2011201044A patent/AU2011201044A1/en not_active Abandoned
2012
- 2012-05-17 GT GT200600202AK patent/GT200600202AA/es unknown
- 2012-09-21 JP JP2012208775A patent/JP2013035855A/ja active Pending

Also Published As

Publication number	Publication date
KR20080014010A (ko)	2008-02-13
AR057056A1 (es)	2007-11-14
ES2558696T3 (es)	2016-02-08
ES2465522T3 (es)	2014-06-06
PL1896426T3 (pl)	2012-06-29
US20080200692A1 (en)	2008-08-21
TWI380981B (zh)	2013-01-01
EP1896426B1 (en)	2012-01-11
MX2007015609A (es)	2008-02-25
SI2266961T1 (sl)	2016-02-29
US8008504B2 (en)	2011-08-30
WO2006135640A3 (en)	2007-08-02
BRPI0611683A2 (pt)	2010-09-28
EP2292607A3 (en)	2011-04-27
RU2446162C2 (ru)	2012-03-27
AU2010241374B2 (en)	2011-11-03
PL2292607T3 (pl)	2014-09-30
PT1896426E (pt)	2012-04-12
ES2380489T8 (es)	2012-06-22
TW200716563A (en)	2007-05-01
AU2011201044A1 (en)	2011-03-31
CN102174020A (zh)	2011-09-07
PT2292607E (pt)	2014-06-24
PE20100715A1 (es)	2010-10-25
CN102174019A (zh)	2011-09-07
US20100280257A1 (en)	2010-11-04
ES2380489T3 (es)	2012-05-14
AU2006258050A1 (en)	2006-12-21
DK2292607T3 (da)	2014-06-30
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