PE20121065A1 - Compuestos tetraciclicos - Google Patents

Compuestos tetraciclicos

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Publication number
PE20121065A1
PE20121065A1 PE2011002060A PE2011002060A PE20121065A1 PE 20121065 A1 PE20121065 A1 PE 20121065A1 PE 2011002060 A PE2011002060 A PE 2011002060A PE 2011002060 A PE2011002060 A PE 2011002060A PE 20121065 A1 PE20121065 A1 PE 20121065A1
Authority
PE
Peru
Prior art keywords
alkyl
cyane
cycloalkyl
halogen
substituted
Prior art date
Application number
PE2011002060A
Other languages
English (en)
Inventor
Kazutomo Kinoshita
Kohsuke Asoh
Noriyuki Furuichi
Toshiya Ito
Hatsuo Kawada
Nobuya Ishii
Hiroshi Sakamoto
Woosang Hong
Minjeong Park
Yoshiyuki Ono
Yasuharu Kato
Kenji Morikami
Takashi Emura
Nobuhiro Oikawa
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43308919&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20121065(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of PE20121065A1 publication Critical patent/PE20121065A1/es

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    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
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    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
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Abstract

REFERIDA A UN COMPUESTO DE FORMULA I, DONDE UNO DE A1, A2, A3, A4, A7, A8, A9 Y A10 ES N Y LOS RESTANTES C; A5 ES NR5, O, S; R1 Y R10 SON CADA UNO H, CIANO, HALOGENO, HETEROCICLOALQUILO DE 4-10 MIEMBROS SUSTITUIDO O NO; R2 ES H, ALQUILO C1-C8, ALQUENILO C2-C8, CIANO, HALOGENO, ENTRE OTROS; R3 ES H, ALQUILO C1-C8 SUSTITUIDO O NO CON 1 O MAS HALOGENOS, 1 O MAS OH, ARILO C6-C10, CIANO, ENTRE OTROS; R4 ES H, ALQUILO C1-C8, CICLOALQUILO C3-C8, CIANO, HIDROXICARBONILO, HIDROXILO, ENTRE OTROS; R5 ES H, ALQUILO C1-C8, ALQUILSULFONILO C1-C8, ALQUINILO C2-C8, ENTRE OTROS; R6 Y R6' SON CADA UNO ALQUILO C1-C8, ALQUENILO C2-C8, O JUNTOS FORMAN CICLOALQUILO C3-C8, HTEROCICLOALQUILO DE 4-10 MIEMBROS SUSTITUIDO O NO, ENTE OTROS; R7 ES H, HALOGENO, ALCOXILO C1-C8, ALQUILSULFONILO C1-C8, NITRO, ENTRE OTROS; R8 ES H, ALQUILO C1-C8 SUSTITUIDO O NO, ALQUENILO C2-C8, CICLOALQUILO C3-C8, ALCOXICARBONILO C1-C8, OXO, CIANO, ENTRE OTROS; R9 ES H, ALQUILO C1-C8, ALQUINILO C2-C8, CICLOALQUILO C3-C8, HALOGENO, ENTRE OTROS. UN COMPUESTO PREFERIDO ES: 9-(4-ISOPROPIL-PIPERAZIN-1-IL)-6,6-DIMETIL-11-OXO-6,11-DIHIDRO-5H-BENZO[b]CARBAZOL-3-CARBONITRILO. DICHOS COMPUESTOS SON INHIBIDORES DE ALK UTILES EN EL TRATAMIENTO DE CANCER, METASTASIS, DEPRESION
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