PE20180927A1 - Moleculas de union a lag-3 y metodos de uso de las mismas - Google Patents

Moleculas de union a lag-3 y metodos de uso de las mismas

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Publication number
PE20180927A1
PE20180927A1 PE2017002549A PE2017002549A PE20180927A1 PE 20180927 A1 PE20180927 A1 PE 20180927A1 PE 2017002549 A PE2017002549 A PE 2017002549A PE 2017002549 A PE2017002549 A PE 2017002549A PE 20180927 A1 PE20180927 A1 PE 20180927A1
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PE
Peru
Prior art keywords
domain
seq
lag
antibodies
methods
Prior art date
Application number
PE2017002549A
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English (en)
Inventor
Motte-Mohs Ross La
Kalpana Shah
Douglas H Smith
Lesile S Johnson
Paul A Moore
Ezio Bonvini
Scott Koenig
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Macrogenics Inc
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Application filed by Macrogenics Inc filed Critical Macrogenics Inc
Publication of PE20180927A1 publication Critical patent/PE20180927A1/es

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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/35—Valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/522—CH1 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/626—Diabody or triabody
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE REFIERE A ANTICUERPOS ANTI-LAG-3 TALES COMO: A) EL ANTICUERPO mAb 1 DE LAG-3 QUE COMPRENDE UN DOMINIO CDRH1 DE SEQ ID N°: 8, UN DOMINIO CDRH2 DE SEQ ID N°: 9 Y UN DOMINIO CDRH3 DE SEQ ID N°: 10 EN SU DOMINIO DE CADENA PESADA VARIABLE, Y UN DOMINIO CDRL1 DE SEC ID N°: 13, UN DOMINIO CDRL2 DE SEC ID N°: 14 Y UN DOMINIO CDRL3 DE SEC ID N°: 15 EN SU DOMINIO DE CADENA LIGERA VARIABLE; B) EL ANTICUERPO mAb 2 DE LAG-3 QUE COMPRENDE UN DOMINIO CDRH1 DE SEQ ID N°: 31, UN DOMINIO CDRH2 DE SEQ ID N°: 32 Y UN DOMINIO CDRH3 DE SEQ ID N°: 33 EN SU DOMINIO DE CADENA PESADA VARIABLE, Y UN DOMINIO CDRL1 DE SEC ID N°: 36, UN DOMINIO CDRL2 DE SEC ID N°: 37 Y UN DOMINIO CDRL3 DE SEC ID N°: 38 EN SU DOMINIO DE CADENA LIGERA VARIABLE; ENTRE OTROS ANTICUERPOS. TAMBIEN SE REFIERE A INMUNOCONJUGADOS. DICHOS ANTICUERPOS SON UTILES EN EL TRATAMIENTO DE CANCER O UNA INFECCION
PE2017002549A 2015-06-08 2016-06-07 Moleculas de union a lag-3 y metodos de uso de las mismas PE20180927A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562172277P 2015-06-08 2015-06-08
US201562255094P 2015-11-13 2015-11-13

Publications (1)

Publication Number Publication Date
PE20180927A1 true PE20180927A1 (es) 2018-06-08

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PE2017002549A PE20180927A1 (es) 2015-06-08 2016-06-07 Moleculas de union a lag-3 y metodos de uso de las mismas

Country Status (20)

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US (3) US11072653B2 (es)
EP (2) EP3302562A4 (es)
KR (1) KR102826081B1 (es)
CN (1) CN107614013B (es)
AU (1) AU2016274485B2 (es)
CL (2) CL2017003132A1 (es)
CO (1) CO2017012553A2 (es)
CR (1) CR20170550A (es)
EA (1) EA201792657A1 (es)
EC (1) ECSP17080639A (es)
GE (2) GEP20207162B (es)
HK (1) HK1252827A1 (es)
IL (1) IL256179B2 (es)
MX (2) MX390920B (es)
MY (1) MY187967A (es)
PE (1) PE20180927A1 (es)
PH (1) PH12017502222B1 (es)
TW (1) TWI773646B (es)
UA (1) UA123310C2 (es)
WO (1) WO2016200782A1 (es)

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