PE20190920A1 - Anticuerpos modificados de union a fcrn humano y metodos de utilizacion - Google Patents

Anticuerpos modificados de union a fcrn humano y metodos de utilizacion

Info

Publication number
PE20190920A1
PE20190920A1 PE2019000724A PE2019000724A PE20190920A1 PE 20190920 A1 PE20190920 A1 PE 20190920A1 PE 2019000724 A PE2019000724 A PE 2019000724A PE 2019000724 A PE2019000724 A PE 2019000724A PE 20190920 A1 PE20190920 A1 PE 20190920A1
Authority
PE
Peru
Prior art keywords
polypeptide
region
human
amino acid
mutations
Prior art date
Application number
PE2019000724A
Other languages
English (en)
Inventor
Guido Hartmann
Joerg Thomas Regula
Matthias Rueth
Wolfgang Schaefer
Tilman Schlothauer
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PE20190920A1 publication Critical patent/PE20190920A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Ophthalmology & Optometry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Se refiere a un anticuerpo biespecifico que comprende un primer polipeptido de la region Fc y un segundo polipeptido de la region Fc, ambos son de las subclases IgG1 humana o IgG4 humana y comprenden una o dos de las mutaciones seleccionadas de i) el grupo I253A, H310A y H435A, entre otros en el primer polipeptido, y una o dos de las mutaciones seleccionadas del grupo que comprende las mutaciones L251D, I253, H310A, entre otros en el segundo polipeptido de la region Fc. El primer polipeptido de la region Fc presenta una secuencia de aminoacidos SEQ ID NO: 60, 61, 62, entre otros; el segundo polipeptido de la region Fc presenta una secuencia de aminoacidos SEQ ID NO: 60, 61, 62 entre otros. Dicho anticuerpo comprende un primer sitio de union a antigeno que se une especificamente a VEGF humano y un segundo sitio de union a antigeno que se une especificamente a ANG-2humano caracterizado porque comprende las secuencias de aminoacidos de SEQ ID NO: 102; SEQ ID NO: 103, entre otros. Dicho anticuerpo no se une a FcRn humano. Tambien se refiere a una formulacion farmaceutica y es util en el tratamiento de enfermedades oculares vasculares.
PE2019000724A 2013-04-29 2014-04-25 Anticuerpos modificados de union a fcrn humano y metodos de utilizacion PE20190920A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13165744 2013-04-29
EP14151316 2014-01-15
PCT/EP2014/058417 WO2014177460A1 (en) 2013-04-29 2014-04-25 Human fcrn-binding modified antibodies and methods of use

Publications (1)

Publication Number Publication Date
PE20190920A1 true PE20190920A1 (es) 2019-06-26

Family

ID=50678163

Family Applications (2)

Application Number Title Priority Date Filing Date
PE2015002313A PE20151807A1 (es) 2013-04-29 2014-04-25 Anticuerpos modificados de union a fcrn humano y metodo de utilizacion
PE2019000724A PE20190920A1 (es) 2013-04-29 2014-04-25 Anticuerpos modificados de union a fcrn humano y metodos de utilizacion

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PE2015002313A PE20151807A1 (es) 2013-04-29 2014-04-25 Anticuerpos modificados de union a fcrn humano y metodo de utilizacion

Country Status (23)

Country Link
US (2) US11091541B2 (es)
EP (2) EP3628685A1 (es)
JP (3) JP2016528167A (es)
KR (2) KR20210094669A (es)
CN (1) CN105143262A (es)
AU (3) AU2014261630B2 (es)
BR (1) BR112015027385A2 (es)
CA (1) CA2904806C (es)
CL (3) CL2015003126A1 (es)
CR (1) CR20150512A (es)
EA (1) EA201501063A1 (es)
ES (1) ES2746136T3 (es)
HK (1) HK1213578A1 (es)
IL (1) IL241787B (es)
MX (1) MX365787B (es)
MY (1) MY172430A (es)
PE (2) PE20151807A1 (es)
PH (1) PH12015502470A1 (es)
PL (1) PL2992012T3 (es)
SG (2) SG11201508911PA (es)
TW (1) TWI747803B (es)
UA (1) UA118029C2 (es)
WO (1) WO2014177460A1 (es)

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