PE20210862A1 - Metodo para preparar 2-[(3r)-3-metilmorfolin-4-il]-4-(1-metil-1h-pirazol-5-il)-8-(1h-pirazol-5-il)-1,7-naftiridina - Google Patents

Metodo para preparar 2-[(3r)-3-metilmorfolin-4-il]-4-(1-metil-1h-pirazol-5-il)-8-(1h-pirazol-5-il)-1,7-naftiridina

Info

Publication number
PE20210862A1
PE20210862A1 PE2021000226A PE2021000226A PE20210862A1 PE 20210862 A1 PE20210862 A1 PE 20210862A1 PE 2021000226 A PE2021000226 A PE 2021000226A PE 2021000226 A PE2021000226 A PE 2021000226A PE 20210862 A1 PE20210862 A1 PE 20210862A1
Authority
PE
Peru
Prior art keywords
pirazol
methyl
formula
compound
preparing
Prior art date
Application number
PE2021000226A
Other languages
English (en)
Inventor
Johannes Platzek
Philipp Rubenbauer
Der Haas Hendricus Nicolaas Sebastiaan Van
Sonja Elisabeth Hoogeveen
Oers Matthijs Cornelis Maria Van
Reinerus Gerardus Gieling
Jeroen Alexander Dekker
Original Assignee
Bayer Ag
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=63405064&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20210862(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Ag, Bayer Pharma AG filed Critical Bayer Ag
Publication of PE20210862A1 publication Critical patent/PE20210862A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE REFIERE A UN PROCEDIMIENTO DE PREPARACION DEL COMPUESTO DE FORMULA (I) QUE COMPRENDE: A) HACER REACCIONAR UN COMPUESTO INTERMEDIO DE LA FORMULA (IXa) TAL COMO (R)-4-(8-CLORO-4-(1-METIL-1H-PIRAZOL-5-IL)-1,7-NAFTIRIDIN-2-IL)-3-METIL-MORFOLINA, CON UN COMPUESTO DE LA FORMULA (IIIa) O (IIIb) TAL COMO ESTER DE PINACOL DEL ACIDO 1-(TETRAHIDRO-2H-PIRAN-2-IL)-1H-PIRAZOL-5-BORONICO EN PRESENCIA DE UN DISOLVENTE ORGANICO COMO ACETATO DE ISOPROPILO, ACETATO DE ETILO, 1,2-DIMETOXIETANO, ENTRE OTROS, PARA OBTENER UN COMPUESTO INTERMEDIO DE LA FORMULA (VIIa) O (VIIb) TAL COMO (3R)-3-METIL-4-(4-(1-METIL-1H-PIRAZOL-5-IL)-8-(1-(TETRAHIDRO-2H-PIRAN-2-IL)-1H-PIRAZOL-5-IL)-1,7-NAFTIRIDIN-2-IL)MORFOLINA; Y B) ELIMINAR EL GRUPO R4 DEL COMPUESTO INTERMEDIO DE LA FORMULA (VIIa) O (VIIb), PROPORCIONANDO ASI UN COMPUESTO DE LA FORMULA (I) O SU TAUTOMERO; EN DONDE R1, R2, R3 Y R4 SON TAL COMO SE DEFINEN EN LA DESCRIPCION.
PE2021000226A 2018-08-24 2019-08-22 Metodo para preparar 2-[(3r)-3-metilmorfolin-4-il]-4-(1-metil-1h-pirazol-5-il)-8-(1h-pirazol-5-il)-1,7-naftiridina PE20210862A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP18190731 2018-08-24
PCT/EP2019/072467 WO2020039025A1 (en) 2018-08-24 2019-08-22 Method for preparing 2-[(3r)-3-methylmorpholin-4-yl]-4-[1-methyl-1h-pyrazol-5-yl)-8-(1h-pyrazol-5-yl)-1,7-naphthyridine

Publications (1)

Publication Number Publication Date
PE20210862A1 true PE20210862A1 (es) 2021-05-18

Family

ID=63405064

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2021000226A PE20210862A1 (es) 2018-08-24 2019-08-22 Metodo para preparar 2-[(3r)-3-metilmorfolin-4-il]-4-(1-metil-1h-pirazol-5-il)-8-(1h-pirazol-5-il)-1,7-naftiridina

Country Status (28)

Country Link
US (1) US12258343B2 (es)
EP (1) EP3841101B1 (es)
JP (1) JP7422741B2 (es)
KR (1) KR102797099B1 (es)
CN (1) CN112823158B (es)
AU (1) AU2019324521B9 (es)
BR (1) BR112021001309A2 (es)
CA (1) CA3110394A1 (es)
CL (1) CL2021000454A1 (es)
CO (1) CO2021001892A2 (es)
DK (1) DK3841101T3 (es)
ES (1) ES2950825T3 (es)
FI (1) FI3841101T3 (es)
HR (1) HRP20230611T1 (es)
HU (1) HUE062332T2 (es)
IL (1) IL280878A (es)
JO (1) JOP20210032A1 (es)
LT (1) LT3841101T (es)
MX (1) MX2021002132A (es)
MY (1) MY201874A (es)
PE (1) PE20210862A1 (es)
PL (1) PL3841101T3 (es)
PT (1) PT3841101T (es)
RS (1) RS64362B1 (es)
SG (1) SG11202101011RA (es)
SI (1) SI3841101T1 (es)
UA (1) UA128407C2 (es)
WO (1) WO2020039025A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI656121B (zh) 2014-08-04 2019-04-11 德商拜耳製藥公司 ２－（嗎啉－４－基）－１，７－萘啶
US11690911B2 (en) 2017-08-04 2023-07-04 Bayer Aktiengesellschaft Combination of ATR kinase inhibitors and PD-1/PD-L1 inhibitors
US11236070B2 (en) 2019-05-16 2022-02-01 Novartis Ag Chemical process

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101405001A (zh) * 2006-03-20 2009-04-08 霍夫曼-拉罗奇有限公司 抑制btk和syk蛋白质激酶的方法
WO2008150827A1 (en) * 2007-05-29 2008-12-11 Smithkline Beecham Corporation Naphthyridine, derivatives as p13 kinase inhibitors
JP5564045B2 (ja) * 2008-09-02 2014-07-30 ノバルティス アーゲー 二環式キナーゼ阻害剤
PL2710018T3 (pl) * 2011-05-19 2022-04-04 Fundación Del Sector Público Estatal Centro Nacional De Investigaciones Oncológicas Carlos III (F.S.P. CNIO) Związki makrocykliczne jako inhibitory kinaz białkowych
KR101366368B1 (ko) * 2011-07-08 2014-02-21 주식회사 두산 신규 유기 전계 발광 화합물 및 이를 포함하는 유기 전계 발광 소자
TWI656121B (zh) * 2014-08-04 2019-04-11 德商拜耳製藥公司 ２－（嗎啉－４－基）－１，７－萘啶
WO2018153970A1 (en) * 2017-02-24 2018-08-30 Bayer Pharma Aktiengesellschaft Solid forms of 2-[(3r)-3-methylmorpholin-4-yl]-4-(1-methyl-1h-pyrazol-5-yl)-8-(1h-pyrazol-5-yl)-1,7-naphthyridine

Also Published As

Publication number Publication date
CN112823158B (zh) 2023-08-15
FI3841101T3 (fi) 2023-07-28
LT3841101T (lt) 2023-06-26
SG11202101011RA (en) 2021-02-25
JP2021535122A (ja) 2021-12-16
HUE062332T2 (hu) 2023-10-28
UA128407C2 (uk) 2024-07-03
US12258343B2 (en) 2025-03-25
PL3841101T3 (pl) 2023-08-21
IL280878A (en) 2021-04-29
AU2019324521B2 (en) 2024-10-31
CO2021001892A2 (es) 2021-03-08
KR20210049845A (ko) 2021-05-06
US20210253573A1 (en) 2021-08-19
CA3110394A1 (en) 2020-02-27
BR112021001309A2 (pt) 2021-04-27
EP3841101A1 (en) 2021-06-30
AU2019324521B9 (en) 2024-11-14
KR102797099B1 (ko) 2025-04-18
CN112823158A (zh) 2021-05-18
DK3841101T3 (da) 2023-07-31
JOP20210032A1 (ar) 2021-02-23
JP7422741B2 (ja) 2024-01-26
ES2950825T3 (es) 2023-10-13
HRP20230611T1 (hr) 2023-09-15
WO2020039025A1 (en) 2020-02-27
PT3841101T (pt) 2023-07-25
MY201874A (en) 2024-03-21
MX2021002132A (es) 2021-04-28
SI3841101T1 (sl) 2023-07-31
AU2019324521A1 (en) 2021-03-11
RS64362B1 (sr) 2023-08-31
EP3841101B1 (en) 2023-05-03
CL2021000454A1 (es) 2021-07-09

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