PH23819A - Morpholinoethylester of mycophenolic acid and derivatives thereof - Google Patents

Morpholinoethylester of mycophenolic acid and derivatives thereof

Info

Publication number: PH23819A
Authority: PH; Philippines
Prior art keywords: agents; morpholinoethylester; derivatives; mycophenolic acid; chem
Prior art date: 1987-01-30

Application number

PH36232A

Other languages

English (en)

Inventor

Peter H Nelson

Chee-Liang Leo Gu

Anthony C Allison

Elsie M Eugui

William A Lee

Original Assignee

Syntex Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-01-30

Filing date

1987-12-15

Publication date

1989-11-23

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21733252&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PH23819(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1987-12-15 Application filed by Syntex Inc filed Critical Syntex Inc

1989-11-23 Publication of PH23819A publication Critical patent/PH23819A/en

Links

HPNSFSBZBAHARI-UHFFFAOYSA-N micophenolic acid Natural products OC1=C(CC=C(C)CCC(O)=O)C(OC)=C(C)C2=C1C(=O)OC2 HPNSFSBZBAHARI-UHFFFAOYSA-N 0.000 title 1
HPNSFSBZBAHARI-RUDMXATFSA-N mycophenolic acid Chemical compound OC1=C(C\C=C(/C)CCC(O)=O)C(OC)=C(C)C2=C1C(=O)OC2 HPNSFSBZBAHARI-RUDMXATFSA-N 0.000 title 1
229960000951 mycophenolic acid Drugs 0.000 title 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
239000002260 anti-inflammatory agent Substances 0.000 abstract 1
229940121363 anti-inflammatory agent Drugs 0.000 abstract 1
230000002682 anti-psoriatic effect Effects 0.000 abstract 1
239000002246 antineoplastic agent Substances 0.000 abstract 1
239000003443 antiviral agent Substances 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
229940125721 immunosuppressive agent Drugs 0.000 abstract 1
239000003018 immunosuppressive agent Substances 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
- C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Communicable Diseases (AREA)
Virology (AREA)
Immunology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Dermatology (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Furan Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Saccharide Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

PH36232A 1987-01-30 1987-12-15 Morpholinoethylester of mycophenolic acid and derivatives thereof PH23819A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/008,717 US4753935A (en)	1987-01-30	1987-01-30	Morpholinoethylesters of mycophenolic acid and pharmaceutical compositions

Publications (1)

Publication Number	Publication Date
PH23819A true PH23819A (en)	1989-11-23

Family

ID=21733252

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PH36232A PH23819A (en)	1987-01-30	1987-12-15	Morpholinoethylester of mycophenolic acid and derivatives thereof

Country Status (26)

Country	Link
US (7)	US4753935A (fr)
EP (1)	EP0281713B1 (fr)
JP (1)	JPS63188672A (fr)
KR (1)	KR940003758B1 (fr)
AT (1)	ATE68180T1 (fr)
AU (1)	AU599728B2 (fr)
CA (1)	CA1333285C (fr)
DE (2)	DE3773660D1 (fr)
DK (1)	DK166675B1 (fr)
ES (1)	ES2038190T3 (fr)
FI (1)	FI85141C (fr)
GE (1)	GEP20094816B (fr)
GR (1)	GR3002866T3 (fr)
HK (1)	HK125893A (fr)
HU (2)	HU201927B (fr)
IE (1)	IE60750B1 (fr)
IL (1)	IL84833A (fr)
LU (1)	LU88795I2 (fr)
LV (1)	LV5748B4 (fr)
MX (1)	MX9203163A (fr)
NL (1)	NL960019I2 (fr)
NO (2)	NO171680C (fr)
NZ (1)	NZ222922A (fr)
PH (1)	PH23819A (fr)
PT (1)	PT86343B (fr)
ZA (1)	ZA879414B (fr)

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DE69033342T2 (de) *	1989-02-23	2000-05-11	University Of North Carolina At Chapel Hill, Chapel Hill	Etoposidanaloge
US5219851A (en) *	1991-03-05	1993-06-15	Warner-Lambert Company	Tetrahydroisoquinoline-type renin inhibiting peptides
US5247083A (en) *	1992-07-10	1993-09-21	Syntex (U.S.A.) Inc.	Direct esterification of mycophenolic acid
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US5455045A (en) *	1993-05-13	1995-10-03	Syntex (U.S.A.) Inc.	High dose formulations
WO1995000157A1 (fr) *	1993-06-25	1995-01-05	Mobius Consultancy Pty. Ltd.	Agent therapeutique
PL178522B1 (pl) *	1993-09-15	2000-05-31	Syntex Inc	Krystaliczny, bezwodny związek, mykofenolan mofetylu, kompozycja odpowiednia do sporządzania wodnego preparatu dożylnego, sposób wytwarzania kompozycji odpowiedniej do sporządzania preparatu dożylnego i zestaw użyteczny do sporządzania dożylnego preparatu
CZ301771B6 (cs) *	1993-10-01	2010-06-16	Syntex (U.S.A.) Llc.	Farmaceutický prostredek ve forme suchého granulátu obsahující mofetil mykofenolát nebo kyselinu mykofenolovou a zpusob jeho prípravy
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US5512568A (en) *	1994-02-18	1996-04-30	Syntex (U.S.A.) Inc.	Method of using 4-amino derivatives of 5-substituted mycophenolic acid
US6225073B1 (en)	1994-07-07	2001-05-01	Dade Behring Marburg Gmbh	Immunoassay for mycophenolic acid
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US6596747B2 (en)	1998-10-29	2003-07-22	Bristol-Myers Squibb Company	Compounds derived from an amine nucleus and pharmaceutical compositions comprising same
AU764479B2 (en)	1998-10-29	2003-08-21	Bristol-Myers Squibb Company	Compounds derived from an amine nucleus that are inhibitors of IMPDH enzyme
EP1127054A4 (fr) *	1998-10-29	2006-11-02	Bristol Myers Squibb Co	Nouveaux inhibiteurs de l'enzyme impdh
US6420403B1 (en)	1998-10-29	2002-07-16	Edwin J. Iwanowicz	Inhibitors of IMPDH enzyme
IN188985B (fr)	1998-12-09	2002-11-30	Biocon Ltd
US6514979B1 (en)	1999-03-03	2003-02-04	University Of Maryland Biotechnology Institute	Synergistic combinations of guanosine analog reverse transcriptase inhibitors and inosine monophosphate dehydrogenese inhibitors and uses therefor
US6107052A (en) *	1999-06-09	2000-08-22	Roche Diagnostics Corporation	Enzymatic measurement of mycophenolic acid
EP1276739A2 (fr) *	2000-04-24	2003-01-22	Bristol-Myers Squibb Company	Heterocycles utiles en tant qu'inhibiteurs de l'enzyme impdh
US6471980B2 (en)	2000-12-22	2002-10-29	Avantec Vascular Corporation	Intravascular delivery of mycophenolic acid
US7179791B2 (en) *	2001-01-11	2007-02-20	Duke University	Inhibiting GS-FDH to modulate NO bioactivity
GB0124953D0 (en) *	2001-10-17	2001-12-05	Novartis Ag	Organic Compounds
TW200301698A (en) *	2001-12-21	2003-07-16	Bristol Myers Squibb Co	Acridone inhibitors of IMPDH enzyme
IL163666A0 (en)	2002-02-22	2005-12-18	New River Pharmaceuticals Inc	Active agent delivery systems and methods for protecting and administering active agents
US20040127435A1 (en) *	2002-08-02	2004-07-01	Regents Of The University Of California	Uses for inhibitors of inosine monophosphate dehydrogenase
TWI221414B (en) *	2003-02-21	2004-10-01	Chunghwa Chemical Synthesis &	Method of making mycophenolate mofetil using transesterification
GB0307553D0 (en) *	2003-04-01	2003-05-07	Novartis Ag	Organic compounds
AU2003231924A1 (en) *	2003-04-07	2004-11-01	Biocon Limited	Microwave synthesis of mycophenolate
US20070082947A1 (en) *	2003-05-14	2007-04-12	D Orazio Daniel	Use of phthalide derivatives for the treatment and prevention of diabetes mellitus
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ES2308226T3 (es) *	2003-09-11	2008-12-01	Sandoz Ag	Proceso para la produccion de micofenolato mofetil.
KR20060121887A (ko) *	2003-09-23	2006-11-29	디에스엠 아이피 어셋츠 비.브이.	진성 당뇨병의 치료 및 예방용 조성물
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US20080188653A1 (en) *	2007-02-04	2008-08-07	Formosa Laboratories, Inc.	Process for Preparation of Mycophenolate Mofetil
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US20090076000A1 (en) *	2007-09-15	2009-03-19	Protia, Llc	Deuterium-enriched mycophenolate mofetil
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CN102952105A (zh) *	2011-08-26	2013-03-06	中国科学院上海药物研究所	一类霉酚酸衍生物、其制备方法和用途
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US10603299B2 (en)	2016-06-02	2020-03-31	Steven Baranowitz	Prevention and treatment of viral infections
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US10835489B2 (en) *	2018-03-09	2020-11-17	University Of Saskatchewan	Modified release formulations of mycophenolate mofetil
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1987
- 1987-01-30 US US07/008,717 patent/US4753935A/en not_active Expired - Lifetime
- 1987-09-04 US US07/093,459 patent/US4808592A/en not_active Expired - Lifetime
- 1987-12-11 PT PT86343A patent/PT86343B/pt active IP Right Revival
- 1987-12-15 FI FI875502A patent/FI85141C/fi not_active IP Right Cessation
- 1987-12-15 EP EP87311021A patent/EP0281713B1/fr not_active Expired - Lifetime
- 1987-12-15 LU LU88795C patent/LU88795I2/fr unknown
- 1987-12-15 DK DK658787A patent/DK166675B1/da not_active IP Right Cessation
- 1987-12-15 IL IL84833A patent/IL84833A/xx not_active IP Right Cessation
- 1987-12-15 ZA ZA879414A patent/ZA879414B/xx unknown
- 1987-12-15 PH PH36232A patent/PH23819A/en unknown
- 1987-12-15 KR KR1019870014353A patent/KR940003758B1/ko not_active Expired - Lifetime
- 1987-12-15 HU HU875663A patent/HU201927B/hu unknown
- 1987-12-15 NZ NZ222922A patent/NZ222922A/xx unknown
- 1987-12-15 NO NO875240A patent/NO171680C/no not_active IP Right Cessation
- 1987-12-15 DE DE8787311021T patent/DE3773660D1/de not_active Expired - Lifetime
- 1987-12-15 CA CA000554352A patent/CA1333285C/fr not_active Expired - Lifetime
- 1987-12-15 DE DE1996175020 patent/DE19675020I2/de active Active
- 1987-12-15 AT AT87311021T patent/ATE68180T1/de active
- 1987-12-15 IE IE339787A patent/IE60750B1/en not_active IP Right Cessation
- 1987-12-15 AU AU82540/87A patent/AU599728B2/en not_active Expired
- 1987-12-15 JP JP62320066A patent/JPS63188672A/ja active Granted
- 1987-12-15 ES ES198787311021T patent/ES2038190T3/es not_active Expired - Lifetime
1988
- 1988-01-22 US US07/146,883 patent/US4786637A/en not_active Expired - Lifetime
- 1988-08-17 US US07/233,200 patent/US4868153A/en not_active Expired - Lifetime
- 1988-11-14 US US07/272,161 patent/US4952579A/en not_active Expired - Lifetime
1989
- 1989-06-29 US US07/373,413 patent/US4948793A/en not_active Expired - Lifetime
1990
- 1990-03-28 US US07/500,439 patent/US4992467A/en not_active Expired - Lifetime
1991
- 1991-10-10 GR GR91400377T patent/GR3002866T3/el unknown
1992
- 1992-06-23 MX MX9203163A patent/MX9203163A/es unknown
1993
- 1993-11-11 HK HK1258/93A patent/HK125893A/en not_active IP Right Cessation
1994
- 1994-07-01 HU HU94P/P00008P patent/HU210350A9/hu unknown
1996
- 1996-07-05 LV LV960221A patent/LV5748B4/xx unknown
- 1996-07-12 NL NL960019C patent/NL960019I2/nl unknown
1997
- 1997-07-01 NO NO1997007C patent/NO1997007I1/no unknown
2006
- 2006-07-17 GE GEAP19879526A patent/GEP20094816B/en unknown

Also Published As

Publication number	Publication date
EP0281713B1 (fr)	1991-10-09
EP0281713A1 (fr)	1988-09-14
US4808592A (en)	1989-02-28
DE19675020I2 (de)	2002-11-07
KR940003758B1 (ko)	1994-04-30
JPS63188672A (ja)	1988-08-04
NO875240D0 (no)	1987-12-15
US4786637A (en)	1988-11-22
LV5748B4 (lv)	1997-02-20
DK166675B1 (da)	1993-06-28
PT86343A (en)	1988-01-01
NL960019I2 (nl)	1997-06-02
ATE68180T1 (de)	1991-10-15
GEP20094816B (en)	2009-11-10
LV5748A4 (lv)	1996-10-20
US4948793A (en)	1990-08-14
IE60750B1 (en)	1994-08-10
AU8254087A (en)	1988-08-04
DE3773660D1 (de)	1991-11-14
HK125893A (en)	1993-11-19
ZA879414B (en)	1989-08-30
NL960019I1 (nl)	1996-10-01
MX9203163A (es)	1992-07-31
FI85141B (fi)	1991-11-29
US4868153A (en)	1989-09-19
DK658787A (da)	1988-07-31
NO171680B (no)	1993-01-11
GR3002866T3 (en)	1993-01-25
JPH0571591B2 (fr)	1993-10-07
HU201927B (en)	1991-01-28
KR880009016A (ko)	1988-09-13
DK658787D0 (da)	1987-12-15
US4952579A (en)	1990-08-28
NO1997007I1 (no)	1997-07-01
FI85141C (fi)	1992-03-10
FI875502L (fi)	1988-07-31
LU88795I2 (fr)	1996-11-05
IL84833A0 (en)	1988-06-30
US4992467A (en)	1991-02-12
US4753935A (en)	1988-06-28
IL84833A (en)	1992-03-29
HU210350A9 (en)	1995-03-28
ES2038190T3 (es)	1993-07-16
HUT47567A (en)	1989-03-28
NZ222922A (en)	1990-09-26
FI875502A0 (fi)	1987-12-15
AU599728B2 (en)	1990-07-26
NO171680C (no)	1993-04-21
NO875240L (no)	1988-08-01
PT86343B (pt)	1991-02-08
CA1333285C (fr)	1994-11-29
IE873397L (en)	1988-07-30

Publication	Publication Date	Title
PH23819A (en)	1989-11-23	Morpholinoethylester of mycophenolic acid and derivatives thereof
MY103801A (en)	1993-09-30	Dideoxydidehydrocarbocyclic nucleosides
FI881816A0 (fi)	1988-04-19	Nya bicykliska foereningar, foerfarane foer deras framstaellning och dessa innehaollande farmaceutiska blandningar.
FI893130A0 (fi)	1989-06-27	Menetelmä uusien terapeuttisesti käyttökelpoisten estramustiiniestereiden valmistamiseksi
EP0408044A3 (en)	1991-07-17	Anti-inflammatory and/or anti-allergic composition comprising glutathione derivatives
DE3477380D1 (en)	1989-04-27	Novel benzothiazepine derivatives, processes for preparing the same and pharmaceutical compositions
EP0255164A3 (en)	1990-10-17	Use of a thioester for preparing pharmaceutical compositions for the treatment of ischemia and reperfusion syndromes
DK424888D0 (da)	1988-07-29	Naphthothiazepinderivater, fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende saadanne derivater
LU88449I2 (fr)	1994-09-09	Fleroxacine et ses dérivés pharmaceutiquement acceptables.