PH24845A - Bioadhesive extruded film for intra-oral drug delivery - Google Patents

Bioadhesive extruded film for intra-oral drug delivery

Info

Publication number
PH24845A
PH24845A PH35405A PH35405A PH24845A PH 24845 A PH24845 A PH 24845A PH 35405 A PH35405 A PH 35405A PH 35405 A PH35405 A PH 35405A PH 24845 A PH24845 A PH 24845A
Authority
PH
Philippines
Prior art keywords
bioadhesive
intra
drug delivery
extruded film
oral drug
Prior art date
Application number
PH35405A
Other languages
English (en)
Inventor
Michael Thomas Schiraldi
Howard Rubin
Martin Monroe Perl
Original Assignee
Johnson & Johnson Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Johnson & Johnson Prod Inc filed Critical Johnson & Johnson Prod Inc
Publication of PH24845A publication Critical patent/PH24845A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Laminated Bodies (AREA)
PH35405A 1986-06-16 1987-06-15 Bioadhesive extruded film for intra-oral drug delivery PH24845A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/874,904 US4713243A (en) 1986-06-16 1986-06-16 Bioadhesive extruded film for intra-oral drug delivery and process

Publications (1)

Publication Number Publication Date
PH24845A true PH24845A (en) 1990-10-30

Family

ID=25364834

Family Applications (1)

Application Number Title Priority Date Filing Date
PH35405A PH24845A (en) 1986-06-16 1987-06-15 Bioadhesive extruded film for intra-oral drug delivery

Country Status (13)

Country Link
US (1) US4713243A (de)
EP (1) EP0250187B1 (de)
JP (2) JP2540332B2 (de)
KR (1) KR940011243B1 (de)
AT (1) ATE95058T1 (de)
AU (1) AU7415587A (de)
CA (1) CA1297408C (de)
DE (1) DE3787573T2 (de)
GR (1) GR870935B (de)
IE (1) IE61785B1 (de)
NZ (1) NZ220573A (de)
PH (1) PH24845A (de)
ZA (1) ZA874294B (de)

Families Citing this family (332)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62169723A (ja) * 1986-01-22 1987-07-25 Teisan Seiyaku Kk 徐放化製剤
JPH0759496B2 (ja) * 1986-03-25 1995-06-28 ロ−ト製薬株式会社 歯周病治療剤
JPS62223112A (ja) * 1986-03-25 1987-10-01 Rooto Seiyaku Kk 歯周病治療剤
US5196202A (en) * 1986-09-01 1993-03-23 Teikoku Seiyaku Kabushiki Kaisha Sustained release dosage form
US5213615A (en) * 1986-10-11 1993-05-25 Ivoclar Ag Dental material and method for the control of caries and paradentitis
GB8712518D0 (en) * 1987-05-28 1987-07-01 Univ Belfast Unit-dose film composition
US4808410A (en) * 1987-12-16 1989-02-28 Richardson-Vicks Inc. Pharmaceutical compositions containing dyclonine HC1 and phenol
US4906475A (en) 1988-02-16 1990-03-06 Paco Pharmaceutical Services Estradiol transdermal delivery system
US5234957A (en) * 1991-02-27 1993-08-10 Noven Pharmaceuticals, Inc. Compositions and methods for topical administration of pharmaceutically active agents
US5719197A (en) * 1988-03-04 1998-02-17 Noven Pharmaceuticals, Inc. Compositions and methods for topical administration of pharmaceutically active agents
US5446070A (en) * 1991-02-27 1995-08-29 Nover Pharmaceuticals, Inc. Compositions and methods for topical administration of pharmaceutically active agents
GB8810951D0 (en) * 1988-05-09 1988-06-15 Innovata Biomed Ltd Buccal local anaesthetic
IT1217628B (it) * 1988-05-18 1990-03-30 Neo Abello Spa Forma farmaceutica e supporto per la somministrazione di estratti ellergenici
US5085866A (en) * 1988-12-02 1992-02-04 Southern Research Institute Method of producing zero-order controlled-released devices
US4992276A (en) * 1988-12-14 1991-02-12 Warner-Lambert Company Antiseptic compositions containing hexahydro-5-pyrimidinamine compounds and thymol and methods for preparing same
DK254289D0 (da) * 1989-05-25 1989-05-25 Dumex Ltd As Middel til behandling af svampeinfektioner
US5021053A (en) * 1989-07-14 1991-06-04 Alza Corporation Oral osmotic device with hydrogel driving member
US5776493A (en) * 1989-07-14 1998-07-07 Alza Corporation Oral osmotic device for delivery of nystatin with hydrogel driving member
US5198220A (en) * 1989-11-17 1993-03-30 The Procter & Gamble Company Sustained release compositions for treating periodontal disease
US5059123A (en) * 1990-05-14 1991-10-22 Jernberg Gary R Periodontal barrier and method for aiding periodontal tissue regeneration
US5197882A (en) * 1990-05-14 1993-03-30 Gary R. Jernberg Periodontal barrier and method for aiding periodontal tissue regeneration agents
US5290271A (en) * 1990-05-14 1994-03-01 Jernberg Gary R Surgical implant and method for controlled release of chemotherapeutic agents
US5634943A (en) * 1990-07-12 1997-06-03 University Of Miami Injectable polyethylene oxide gel implant and method for production
US5147654A (en) * 1990-07-23 1992-09-15 Alza Corporation Oral osmotic device for delivering nicotine
US5332576A (en) * 1991-02-27 1994-07-26 Noven Pharmaceuticals, Inc. Compositions and methods for topical administration of pharmaceutically active agents
IL97930A (en) * 1991-04-23 1996-06-18 Perio Prod Ltd Preparations for whitening two controlled release products that contain a super-oxygen compound
IT1250421B (it) * 1991-05-30 1995-04-07 Recordati Chem Pharm Composizione farmaceutica a rilascio controllato con proprieta' bio-adesive.
US5340581A (en) 1991-08-23 1994-08-23 Gillette Canada, Inc. Sustained-release matrices for dental application
US5906834A (en) * 1992-06-15 1999-05-25 The Gillette Company Color changing matrix as wear indicator
CA2116115C (en) * 1991-08-23 2000-05-16 Mingchih M. Tseng Sustained-release matrices for dental application
US5571533A (en) * 1992-02-07 1996-11-05 Recordati, S.A., Chemical And Pharmaceutical Company Controlled-release mucoadhesive pharmaceutical composition for the oral administration of furosemide
US5248310A (en) * 1992-03-27 1993-09-28 Alza Corporation Oral osmotic device with hydrogel driving member
US5512299A (en) * 1992-03-30 1996-04-30 Alza Corporation Method of treating oral inflammatory disease
US5242910A (en) * 1992-10-13 1993-09-07 The Procter & Gamble Company Sustained release compositions for treating periodontal disease
AU679937B2 (en) * 1992-11-18 1997-07-17 Johnson & Johnson Consumer Products, Inc. Extrudable compositions for topical or transdermal drug delivery
US5573776A (en) * 1992-12-02 1996-11-12 Alza Corporation Oral osmotic device with hydrogel driving member
US6015844A (en) * 1993-03-22 2000-01-18 Johnson & Johnson Medical, Inc. Composite surgical material
US5447725A (en) * 1993-06-11 1995-09-05 The Procter & Gamble Company Methods for aiding periodontal tissue regeneration
US5489437A (en) * 1993-08-17 1996-02-06 Applied Extrusion Technologies, Inc. Hydrogel products and methods of producing same
CN1134163A (zh) * 1993-08-19 1996-10-23 辛勒斯治疗系统公司 水溶性压敏粘膜粘合剂和配备该粘合剂用于放置在有粘膜衬里的体腔内的器具
US5578315A (en) * 1993-12-01 1996-11-26 Rutgers, The State University Of New Jersey Mucosal adhesive device for long-acting delivery of pharmaceutical combinations in oral cavity
US5458879A (en) * 1994-03-03 1995-10-17 The Procter & Gamble Company Oral vehicle compositions
AU2703795A (en) * 1994-06-23 1996-01-19 Procter & Gamble Company, The Treatment of nicotine craving and/or smoking withdrawal symptoms with a transdermal or transmucosal composition containing nicotine and caffeine or xanthine
US5614578A (en) * 1994-10-28 1997-03-25 Alza Corporation Injection-molded dosage form
AU5299996A (en) * 1995-02-23 1996-09-11 Cygnus, Inc. Water-soluble pressure-sensitive mucoadhesive
US5713852A (en) * 1995-06-07 1998-02-03 Alza Corporation Oral dosage and method for treating painful conditions of the oral cavity
CA2184316A1 (en) * 1995-09-12 1997-03-13 Wei-Chi Liao Buccal delivery system for therapeutic agents
US20050152950A1 (en) * 1995-11-13 2005-07-14 Saffran Bruce N. Method and apparatus for macromolecular delivery using a coated membrane
US5906814A (en) * 1995-12-07 1999-05-25 The Andrew Jergens Company Topical film-forming compositions
JP2791317B2 (ja) * 1995-12-26 1998-08-27 株式会社三和化学研究所 多層フィルム製剤
EP2272536B1 (de) * 1996-06-26 2016-05-04 Board of Regents, The University of Texas System Extrudierbare pharmazeutische Schmelzklebstoffformulierung
US6500777B1 (en) 1996-06-28 2002-12-31 Ethicon, Inc. Bioresorbable oxidized cellulose composite material for prevention of postsurgical adhesions
US5993787A (en) * 1996-09-13 1999-11-30 Johnson & Johnson Consumer Products, Inc. Composition base for topical therapeutic and cosmetic preparations
SE9603667D0 (sv) * 1996-10-08 1996-10-08 Astra Ab Pharmaceutical compositions
US5800832A (en) * 1996-10-18 1998-09-01 Virotex Corporation Bioerodable film for delivery of pharmaceutical compounds to mucosal surfaces
US5955097A (en) 1996-10-18 1999-09-21 Virotex Corporation Pharmaceutical preparation applicable to mucosal surfaces and body tissues
AU769500B2 (en) * 1996-10-18 2004-01-29 Arius Two, Inc. Pharmaceutical carrier device suitable for delivery of pharmaceutical compounds to mucosal surfaces
EP1342548B1 (de) * 1996-10-28 2015-12-23 General Mills, Inc. Einbettung und Einkapselung von Teilchen zur kontrollierten Abgabe und eingekapseltes Produkt
DE19646392A1 (de) 1996-11-11 1998-05-14 Lohmann Therapie Syst Lts Zubereitung zur Anwendung in der Mundhöhle mit einer an der Schleimhaut haftklebenden, Pharmazeutika oder Kosmetika zur dosierten Abgabe enthaltenden Schicht
US6582708B1 (en) 2000-06-28 2003-06-24 The Procter & Gamble Company Tooth whitening substance
US20020018754A1 (en) 1999-03-15 2002-02-14 Paul Albert Sagel Shapes for tooth whitening strips
US6096328A (en) 1997-06-06 2000-08-01 The Procter & Gamble Company Delivery system for an oral care substance using a strip of material having low flexural stiffness
US5894017A (en) * 1997-06-06 1999-04-13 The Procter & Gamble Company Delivery system for an oral care substance using a strip of material having low flexural stiffness
US5879691A (en) 1997-06-06 1999-03-09 The Procter & Gamble Company Delivery system for a tooth whitener using a strip of material having low flexural stiffness
US6045811A (en) * 1997-06-06 2000-04-04 The Procter & Gamble Company Delivery system for an oral care substance using a permanently deformable strip of material
US5989569A (en) * 1997-06-06 1999-11-23 The Procter & Gamble Company Delivery system for a tooth whitener using a permanently deformable strip of material
US6136297A (en) * 1997-06-06 2000-10-24 The Procter & Gamble Company Delivery system for an oral care substance using a strip of material having low flexural stiffness
US20050074495A1 (en) * 1997-06-17 2005-04-07 Fziomed, Inc. Compositions of polyacids and methods for their use in reducing adhesions
US20040096422A1 (en) * 1997-06-17 2004-05-20 Schwartz Herbert E. Compositions of polyacids and polyethers and methods for their use in reducing pain
US5906997A (en) * 1997-06-17 1999-05-25 Fzio Med, Inc. Bioresorbable compositions of carboxypolysaccharide polyether intermacromolecular complexes and methods for their use in reducing surgical adhesions
US7192984B2 (en) * 1997-06-17 2007-03-20 Fziomed, Inc. Compositions of polyacids and polyethers and methods for their use as dermal fillers
US6869938B1 (en) 1997-06-17 2005-03-22 Fziomed, Inc. Compositions of polyacids and polyethers and methods for their use in reducing adhesions
US6123957A (en) * 1997-07-16 2000-09-26 Jernberg; Gary R. Delivery of agents and method for regeneration of periodontal tissues
US6153210A (en) * 1997-08-14 2000-11-28 Periodontix, Inc. Use of locally delivered metal ions for treatment of periodontal disease
US20050048102A1 (en) * 1997-10-16 2005-03-03 Virotex Corporation Pharmaceutical carrier device suitable for delivery of pharmaceutical compounds to mucosal surfaces
US6072100A (en) * 1998-01-28 2000-06-06 Johnson & Johnson Consumer Products, Inc. Extrudable compositions for topical or transdermal drug delivery
US5981499A (en) * 1998-02-20 1999-11-09 Atlantic Biomed Corporation Lesion-directed antibiotics in dry dosage forms for the treatment of shallow ulcers of the oral mucosa
US6103266A (en) * 1998-04-22 2000-08-15 Tapolsky; Gilles H. Pharmaceutical gel preparation applicable to mucosal surfaces and body tissues
AU746339B2 (en) * 1998-04-29 2002-04-18 Arius Two, Inc. Pharmaceutical carrier device suitable for delivery of pharmaceutical compounds to mucosal surfaces
US7662409B2 (en) * 1998-09-25 2010-02-16 Gel-Del Technologies, Inc. Protein matrix materials, devices and methods of making and using thereof
US20050147690A1 (en) * 1998-09-25 2005-07-07 Masters David B. Biocompatible protein particles, particle devices and methods thereof
DE19856101A1 (de) * 1998-12-04 2000-06-08 Labtec Gmbh Mundhöhlen-Matrixpflaster
AU2978400A (en) * 1999-02-02 2000-08-25 Ortho-Mcneil Pharmaceutical, Inc. Method of manufacture for transdermal matrices
US6319510B1 (en) 1999-04-20 2001-11-20 Alayne Yates Gum pad for delivery of medication to mucosal tissues
ATE285220T1 (de) 1999-07-02 2005-01-15 Procter & Gamble Zusammenstzungen enthaltend organosiloxan-harze zur freisetzung von mundpflegewirkstoffen und zur verlängerung der freisetzung
DE19954421A1 (de) 1999-11-12 2001-05-31 Lohmann Therapie Syst Lts Filmförmige Zubereitung zur biphasigen Freisetzung pharmakologisch wirksamer oder anderer Substanzen
US6432415B1 (en) 1999-12-17 2002-08-13 Axrix Laboratories, Inc. Pharmaceutical gel and aerosol formulations and methods to administer the same to skin and mucosal surfaces
US6566345B2 (en) 2000-04-28 2003-05-20 Fziomed, Inc. Polyacid/polyalkylene oxide foams and gels and methods for their delivery
AU2001249214A1 (en) 2000-03-15 2001-09-24 The Brigham And Women's Hospital, Inc. Suppression of vascular disorders by mucosal administration of heat shock protein peptides
US7785572B2 (en) * 2000-03-17 2010-08-31 Lg Household And Health Care Ltd. Method and device for teeth whitening using a dry type adhesive
US6689344B2 (en) 2000-03-17 2004-02-10 Lg Household & Healthcare Ltd. Patches for teeth whitening
CN1232241C (zh) * 2000-03-17 2005-12-21 Lg生活健康株式会社 牙齿增白贴片
US8652446B2 (en) 2000-03-17 2014-02-18 Lg Household & Healthcare Ltd. Apparatus and method for whitening teeth
US7067116B1 (en) * 2000-03-23 2006-06-27 Warner-Lambert Company Llc Fast dissolving orally consumable solid film containing a taste masking agent and pharmaceutically active agent at weight ratio of 1:3 to 3:1
US20020010150A1 (en) * 2000-04-28 2002-01-24 Cortese Stephanie M. Homostatic compositions of polyacids and polyalkylene oxides and methods for their use
CN1311800C (zh) 2000-06-28 2007-04-25 宝洁公司 提高活性过氧化物的稳定性的结构体和组合物
USRE44145E1 (en) 2000-07-07 2013-04-09 A.V. Topchiev Institute Of Petrochemical Synthesis Preparation of hydrophilic pressure sensitive adhesives having optimized adhesive properties
ATE478932T1 (de) 2000-07-07 2010-09-15 Av Topchiev Inst Petrochemical Herstellung von hydrophilen druckempfindlichen klebstoffen mit optimalen hafteigenschaften
DE10038571A1 (de) * 2000-08-03 2002-02-14 Knoll Ag Zusammensetzungen und Dosierungsformen zur Anwendung in der Mundhöhle bei der Bhandlung von Mykosen
US6756051B1 (en) 2000-11-15 2004-06-29 Li-Lan H. Chen Bioadhesive, closed-cell foam film, sustained release, delivery devices and methods of making and using same
US6500408B2 (en) 2001-01-27 2002-12-31 Jc Technologies, Inc. Enamel-safe tooth bleach and method for use
ATE525061T1 (de) * 2001-02-28 2011-10-15 Axiomedic Ltd Feste selbst-haftende zusammensetzungen zur topischen behandlung von störungen der mundschleimhaut
US8980334B2 (en) 2001-02-28 2015-03-17 Axiomedic Ltd. Double-layered absorbable solid compositions for the topical treatment of oral mucosal disorders
US6503486B2 (en) * 2001-03-12 2003-01-07 Colgate Palmolive Company Strip for whitening tooth surfaces
US6419906B1 (en) * 2001-03-12 2002-07-16 Colgate Palmolive Company Strip for whitening tooth surfaces
US6514483B2 (en) * 2001-03-12 2003-02-04 Colgate Palmolive Company Strip for whitening tooth surfaces
US8840918B2 (en) 2001-05-01 2014-09-23 A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences Hydrogel compositions for tooth whitening
US8541021B2 (en) * 2001-05-01 2013-09-24 A.V. Topchiev Institute Of Petrochemical Synthesis Hydrogel compositions demonstrating phase separation on contact with aqueous media
CA2445086C (en) 2001-05-01 2008-04-08 A.V. Topchiev Institute Of Petrochemical Synthesis Hydrogel compositions
US8206738B2 (en) 2001-05-01 2012-06-26 Corium International, Inc. Hydrogel compositions with an erodible backing member
US20050215727A1 (en) 2001-05-01 2005-09-29 Corium Water-absorbent adhesive compositions and associated methods of manufacture and use
EP1390084B1 (de) * 2001-05-01 2011-03-23 A.V. Topchiev Institute of Petrochemical Synthesis Zweiphasige, wasserabsorbierende bioadhäsive zusammenstezung
US20050113510A1 (en) 2001-05-01 2005-05-26 Feldstein Mikhail M. Method of preparing polymeric adhesive compositions utilizing the mechanism of interaction between the polymer components
US6660292B2 (en) 2001-06-19 2003-12-09 Hf Flavoring Technology Llp Rapidly disintegrating flavored film for precooked foods
US6946142B2 (en) 2001-06-23 2005-09-20 Lg Household & Healthcare Ltd. Multi-layer patches for teeth whitening
WO2003003957A1 (en) * 2001-07-06 2003-01-16 Lavipharm Laboratories Inc. Quick dissolving oral mucosal drug delivery device with moisture barrier coating
US20060073174A1 (en) * 2001-08-16 2006-04-06 Access Pharmaceuticals, Inc. Adherent and erodible film to treat a moist surface of a body tissue
US6585997B2 (en) * 2001-08-16 2003-07-01 Access Pharmaceuticals, Inc. Mucoadhesive erodible drug delivery device for controlled administration of pharmaceuticals and other active compounds
US6419903B1 (en) * 2001-08-20 2002-07-16 Colgate Palmolive Company Breath freshening film
US20030124196A1 (en) * 2001-08-22 2003-07-03 Susan Weinbach Pulsatile release compositions and methods for enhanced intestinal drug absorption
US20030083286A1 (en) * 2001-08-22 2003-05-01 Ching-Leou Teng Bioadhesive compositions and methods for enhanced intestinal drug absorption
US8900498B2 (en) 2001-10-12 2014-12-02 Monosol Rx, Llc Process for manufacturing a resulting multi-layer pharmaceutical film
US8900497B2 (en) 2001-10-12 2014-12-02 Monosol Rx, Llc Process for making a film having a substantially uniform distribution of components
US7357891B2 (en) 2001-10-12 2008-04-15 Monosol Rx, Llc Process for making an ingestible film
US8765167B2 (en) 2001-10-12 2014-07-01 Monosol Rx, Llc Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions
US7910641B2 (en) 2001-10-12 2011-03-22 Monosol Rx, Llc PH modulated films for delivery of actives
US8663687B2 (en) 2001-10-12 2014-03-04 Monosol Rx, Llc Film compositions for delivery of actives
US8603514B2 (en) * 2002-04-11 2013-12-10 Monosol Rx, Llc Uniform films for rapid dissolve dosage form incorporating taste-masking compositions
US7425292B2 (en) 2001-10-12 2008-09-16 Monosol Rx, Llc Thin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom
US20070281003A1 (en) 2001-10-12 2007-12-06 Fuisz Richard C Polymer-Based Films and Drug Delivery Systems Made Therefrom
US10285910B2 (en) 2001-10-12 2019-05-14 Aquestive Therapeutics, Inc. Sublingual and buccal film compositions
US7666337B2 (en) 2002-04-11 2010-02-23 Monosol Rx, Llc Polyethylene oxide-based films and drug delivery systems made therefrom
US20190328679A1 (en) 2001-10-12 2019-10-31 Aquestive Therapeutics, Inc. Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions
US11207805B2 (en) 2001-10-12 2021-12-28 Aquestive Therapeutics, Inc. Process for manufacturing a resulting pharmaceutical film
US20110033542A1 (en) 2009-08-07 2011-02-10 Monosol Rx, Llc Sublingual and buccal film compositions
KR20030045473A (ko) * 2001-12-04 2003-06-11 대신제약주식회사 점막부착성을 가지는 의약품 조성물
US20030224090A1 (en) * 2002-02-11 2003-12-04 Edizone, Lc Snacks of orally soluble edible films
GB0205868D0 (en) * 2002-03-13 2002-04-24 Univ Nottingham Polymer composite with internally distributed deposition matter
US8017150B2 (en) 2002-04-11 2011-09-13 Monosol Rx, Llc Polyethylene oxide-based films and drug delivery systems made therefrom
US8623393B2 (en) 2002-04-29 2014-01-07 Gel-Del Technologies, Inc. Biomatrix structural containment and fixation systems and methods of use thereof
US6949240B2 (en) 2002-05-23 2005-09-27 The Procter & Gamble Company Tooth whitening products
US7776314B2 (en) 2002-06-17 2010-08-17 Grunenthal Gmbh Abuse-proofed dosage system
US6937455B2 (en) 2002-07-03 2005-08-30 Kronos Advanced Technologies, Inc. Spark management method and device
US8956160B2 (en) * 2002-07-02 2015-02-17 Ranir, Llc Device and method for delivering an oral care agent
US7053565B2 (en) 2002-07-03 2006-05-30 Kronos Advanced Technologies, Inc. Electrostatic fluid accelerator for and a method of controlling fluid flow
US6921529B2 (en) 2002-07-29 2005-07-26 Joseph C. Maley Treatment modality and method for fungal nail infection
US20040120991A1 (en) * 2002-09-07 2004-06-24 Mars Incorporated Edible films having distinct regions
US20050100515A1 (en) * 2002-09-11 2005-05-12 The Procter & Gamble Company Tooth whitening products
US20040120903A1 (en) * 2002-09-11 2004-06-24 The Procter & Gamble Company Tooth whitening strips
US8524200B2 (en) 2002-09-11 2013-09-03 The Procter & Gamble Company Tooth whitening products
US6916463B2 (en) * 2002-09-24 2005-07-12 The Procter & Gamble Company Oral products having an aesthetic layer
DE10252726B4 (de) 2002-11-13 2008-05-08 Lts Lohmann Therapie-Systeme Ag Mehrschichtiges transmucosales therapeutisches System
SE0302947D0 (sv) 2003-01-24 2003-11-07 Magle Ab A composition material for transmucosal delivery
EA012306B1 (ru) * 2003-01-24 2009-08-28 Магле Холдинг Аб Композиционный материал для доставки через слизистые оболочки
US7041311B2 (en) * 2003-02-28 2006-05-09 International Flavors & Fragrances Inc. Preparation for saliva flow
WO2004096125A2 (en) * 2003-04-14 2004-11-11 Shire Laboratories, Inc. Pharmaceutical compositions releasing their active agents from a buccal or sublingual location to overcome an absorption window problem
AU2003283851A1 (en) * 2003-04-30 2004-12-13 Icure Pharmaceutical Corporation Patch for tooth whitening
US7306812B2 (en) * 2003-05-09 2007-12-11 Cephalon, Inc. Dissolvable backing layer for use with a transmucosal delivery device
US7276246B2 (en) * 2003-05-09 2007-10-02 Cephalon, Inc. Dissolvable backing layer for use with a transmucosal delivery device
EP3210601A1 (de) * 2003-05-28 2017-08-30 MonoSolRX, LLC Polyethylenoxidbasierte folien und daraus hergestellte arzneimittelabgabesysteme
US20050118261A1 (en) * 2003-06-12 2005-06-02 Oien Hal J. Compositions and methods of administering doxepin to mucosal tissue
US8465537B2 (en) 2003-06-17 2013-06-18 Gel-Del Technologies, Inc. Encapsulated or coated stent systems
US7472655B2 (en) * 2003-07-01 2009-01-06 Lu Hao Leng Table top
US20070048228A1 (en) 2003-08-06 2007-03-01 Elisabeth Arkenau-Maric Abuse-proofed dosage form
DE102005005446A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Bruchfeste Darreichungsformen mit retardierter Freisetzung
DE102004032051A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform
DE10361596A1 (de) 2003-12-24 2005-09-29 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
US8075872B2 (en) 2003-08-06 2011-12-13 Gruenenthal Gmbh Abuse-proofed dosage form
DE10336400A1 (de) 2003-08-06 2005-03-24 Grünenthal GmbH Gegen Missbrauch gesicherte Darreichungsform
US20050036958A1 (en) * 2003-08-13 2005-02-17 Jianxun Feng Dental bleaching
US20050038181A1 (en) * 2003-08-15 2005-02-17 Colgate-Palmolive Company Silicone polymer based liquid tooth whitening composition
US8815215B2 (en) * 2003-08-15 2014-08-26 Colgate-Palmolive Company Hydrophobic tooth whitening system and methods of use
US20050069502A1 (en) * 2003-08-15 2005-03-31 Chopra Suman K. Hydrophobic polymer carrier based liquid tooth whitening composition
AU2004264974A1 (en) * 2003-08-15 2005-02-24 Arius Two, Inc. Adhesive bioerodible transmucosal drug delivery system
US20050036957A1 (en) * 2003-08-15 2005-02-17 Michael Prencipe Tooth whitening dental tray and method of use
WO2005034852A2 (en) 2003-08-26 2005-04-21 Gel-Del Technologies, Inc. Protein biomaterials and biocoacervates and methods of making and using thereof
US7666396B2 (en) * 2003-09-11 2010-02-23 Kimberly-Clark Worldwide, Inc. Single-use moisturizing product
DE602004030931D1 (de) * 2003-11-04 2011-02-17 Supernus Pharmaceuticals Inc
US8709476B2 (en) 2003-11-04 2014-04-29 Supernus Pharmaceuticals, Inc. Compositions of quaternary ammonium compounds containing bioavailability enhancers
AU2004289248B2 (en) 2003-11-07 2012-05-03 U.S. Smokeless Tobacco Company Llc Tobacco compositions
US8627828B2 (en) 2003-11-07 2014-01-14 U.S. Smokeless Tobacco Company Llc Tobacco compositions
KR100462465B1 (ko) * 2003-11-20 2004-12-23 정천수 충방전 겸용잭을 갖는 충전지 케이스구조 및 이에연결되는 방수용 잭플러그
WO2005055945A2 (en) * 2003-12-08 2005-06-23 Gel-Del Technologies, Inc. Mucoadhesive drug delivery devices and methods of making and using thereof
US20050126562A1 (en) * 2003-12-15 2005-06-16 Alexza Molecular Delivery Corporation Treatment of breakthrough pain by drug aerosol inhalation
JP4128521B2 (ja) * 2003-12-19 2008-07-30 信越化学工業株式会社 ゲル状シート及びその製造方法
KR20070007299A (ko) 2004-01-30 2007-01-15 코리움 인터네셔널, 인크. 활성제의 전달을 위한 급속 용해 필름
US20070269519A1 (en) * 2004-03-03 2007-11-22 Constantine Georgiades Whitening products
EP1751225B1 (de) * 2004-03-19 2009-08-05 The Tapemark Company Thermoplastische filme und herstellungsverfahren dafür
US20050208108A1 (en) * 2004-03-19 2005-09-22 Jannusch Leonard C Thermoplastic films and methods for making
AU2005235369B2 (en) * 2004-04-22 2010-11-11 Acucort Ab Pharmaceutical compositions for acute glucocorticoid therapy
EP1591106B1 (de) * 2004-04-28 2009-07-22 Shin-Etsu Chemical Co., Ltd. Filmzubereitung und Verfahren zu deren Herstelllung
DK1765292T3 (en) 2004-06-12 2018-01-02 Collegium Pharmaceutical Inc ABUSE PREVENTIONAL PHARMACEUTICAL FORMULATIONS
DE102004032049A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Gegen Missbrauch gesicherte, orale Darreichungsform
AU2005271259B2 (en) 2004-08-05 2012-01-19 A.V. Topchiev Institute Of Petrochemical Synthesis Adhesive composition
US8899976B2 (en) 2004-09-24 2014-12-02 Align Technology, Inc. Release agent receptacle
US20060099550A1 (en) * 2004-11-10 2006-05-11 Ranir/Dcp Corporation Device and method for delivering an oral care agent
US20060115785A1 (en) 2004-11-30 2006-06-01 Chunhua Li Systems and methods for intra-oral drug delivery
US7766658B2 (en) 2004-11-30 2010-08-03 Align Technology, Inc. Systems and methods for intra-oral diagnosis
US7947508B2 (en) 2004-11-30 2011-05-24 Align Technology, Inc. Systems and methods for intra-oral diagnosis
EP1835933A4 (de) 2005-01-04 2015-01-07 Yeda Res & Dev Hsp60, hsp60-peptide und t-zellen-impfstoffe zur immunmodulation
DE102005005449A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
KR100741654B1 (ko) * 2005-02-07 2007-07-23 한웅코텍 주식회사 피부적용 유성 소프트 겔 시트
US9050393B2 (en) 2005-02-08 2015-06-09 Bruce N. Saffran Medical devices and methods for modulation of physiology using device-based surface chemistry
JP5577021B2 (ja) 2005-02-17 2014-08-20 アボット・ラボラトリーズ 動物における障害を治療および予防するための薬剤組成物の経粘膜投与
DE102005011029A1 (de) * 2005-03-08 2006-09-14 Maria Clementine Martin Klosterfrau Vertriebsgesellschaft Mbh Zusammensetzung für die perorale Applikation mit gesteuerter Freisetzung von Wirkstoffen
US7410532B2 (en) 2005-04-04 2008-08-12 Krichtafovitch Igor A Method of controlling a fluid flow
US20060275369A1 (en) * 2005-06-01 2006-12-07 Cao Group, Inc. Orally Therapeutic Plastics and Devices Formed Therefrom
US8623334B1 (en) 2005-09-29 2014-01-07 Alan J. Wickenhauser Topical anesthetic
US8263047B2 (en) * 2005-09-29 2012-09-11 Wickenhauser Alan J Topical anesthetic for dental procedures
WO2007056142A2 (en) * 2005-11-02 2007-05-18 Theraquest Biosciences, Llc Methods of preventing the serotonin syndrome and compositions for use therefor
US9125833B2 (en) * 2005-11-02 2015-09-08 Relmada Therapeutics, Inc. Multimodal abuse resistant and extended release opioid formulations
US20090082466A1 (en) * 2006-01-27 2009-03-26 Najib Babul Abuse Resistant and Extended Release Formulations and Method of Use Thereof
US8329744B2 (en) * 2005-11-02 2012-12-11 Relmada Therapeutics, Inc. Methods of preventing the serotonin syndrome and compositions for use thereof
CN104622700A (zh) * 2005-12-21 2015-05-20 高露洁-棕榄公司 清洁和/或抛光组合物及其使用方法
EP1965774A2 (de) * 2005-12-30 2008-09-10 Cogentus Pharmaceuticals, Inc. Orale pharmazeutische formulierungen mit nichtsteroidalen entzündungshemmern und säurehemmern
AU2007207503A1 (en) * 2006-01-20 2007-07-26 Monosol Rx, Llc Film bandage for mucosal administration of actives
BRPI0709162A2 (pt) 2006-03-24 2011-06-28 Auxilum Pharmaceuticals Inc processo para a preparação de um laminado extrudado fundido a quente
EP3141248A1 (de) 2006-03-24 2017-03-15 Auxilium International Holdings, Inc. Stabilisierte zusammensetzungen mit basischen, labilen wirkstoffen
CN101460154B (zh) 2006-04-04 2015-07-01 Kg艾克维泽生公司 包含抗血小板剂和抑酸剂的口服剂型
GB0613552D0 (en) * 2006-07-07 2006-08-16 Univ Heriot Watt Resorbable insert
US9682256B2 (en) * 2006-07-14 2017-06-20 Colgate-Palmolive Company Methods of making compositions comprising films
SI2054031T1 (sl) 2006-07-21 2016-09-30 Biodelivery Sciences International, Inc. Transmukozne naprave za administracijo z izboljšanim vnosom
US20080075771A1 (en) * 2006-07-21 2008-03-27 Vaughn Jason M Hydrophilic opioid abuse deterrent delivery system using opioid antagonists
SA07280459B1 (ar) 2006-08-25 2011-07-20 بيورديو فارما إل. بي. أشكال جرعة صيدلانية للتناول عن طريق الفم مقاومة للعبث تشتمل على مسكن شبه أفيوني
WO2008028047A2 (en) * 2006-08-30 2008-03-06 Lab International Srl Bioadhesive film drug delivery system
JP4739452B2 (ja) 2006-09-20 2011-08-03 モノソル アールエックス リミテッド ライアビリティ カンパニー 発泡を減じる風味付与剤を含む喫食可能な水溶性フィルム
RU2453143C2 (ru) * 2006-10-31 2012-06-20 Вм. Ригли, Дж. Компани Способ получения структуры, обеспечивающей высвобождение ароматизатора, и структура
US7731604B2 (en) * 2006-10-31 2010-06-08 Taylor Made Golf Company, Inc. Golf club iron head
CN101754755A (zh) * 2007-02-15 2010-06-23 德尔玛-杨有限公司 促进跨粘膜递送的组合物及方法
DE102007011485A1 (de) * 2007-03-07 2008-09-11 Grünenthal GmbH Darreichungsform mit erschwertem Missbrauch
US20090098192A1 (en) * 2007-10-11 2009-04-16 Fuisz Richard C Extrudable and Extruded Compositions for Delivery of Bioactive Agents, Method of Making Same and Method of Using Same
EA021392B1 (ru) * 2007-10-11 2015-06-30 Филип Моррис Продактс С.А. Бездымный табачный продукт
AU2014202358B2 (en) * 2007-10-11 2016-06-16 Philip Morris Products S.A. Method for making a dosage
US9125434B2 (en) 2007-10-11 2015-09-08 Philip Morris Products S.A. Smokeless tobacco product, smokeless tobacco product in the form of a sheet, extrudable tobacco composition, method for manufacturing a smokeless tobacco product, method for delivering super bioavailable nicotine contained in tobacco to a user, and packaged smokeless tobacco product sheet
US11890371B2 (en) 2007-12-26 2024-02-06 Petvivo Holdings, Inc. Biocompatible protein-based particles and methods thereof
JP5774853B2 (ja) 2008-01-25 2015-09-09 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 医薬投薬形
AU2009223061B2 (en) 2008-03-11 2014-10-09 Depomed Inc. Gastric retentive extended-release dosage forms comprising combinations of a non-opioid analgesic and an opioid analgesic
US8372432B2 (en) 2008-03-11 2013-02-12 Depomed, Inc. Gastric retentive extended-release dosage forms comprising combinations of a non-opioid analgesic and an opioid analgesic
DE102008014533A1 (de) * 2008-03-15 2009-09-17 Lts Lohmann Therapie-Systeme Ag Gingival-Wafer
MX2010012039A (es) 2008-05-09 2010-11-30 Gruenenthal Gmbh Proceso para la preparacion de una formulacion de polvo intermedia y una forma de dosificacion solida final bajo el uso de un paso de congelacion por rocio.
US8172569B2 (en) 2008-06-12 2012-05-08 Align Technology, Inc. Dental appliance
EP2647371A1 (de) * 2008-06-19 2013-10-09 University Of The Witwatersrand Johannesburg Transmukosales Abgabesystem
AU2009271271A1 (en) * 2008-06-23 2010-01-21 Biodelivery Sciences International, Inc. Multidirectional mucosal delivery devices and methods of use
GB0812742D0 (en) * 2008-07-11 2008-08-20 Critical Pharmaceuticals Ltd Process
US10016534B2 (en) 2008-11-17 2018-07-10 Gel-Del Technologies, Inc. Protein biomaterial and biocoacervate vessel graft systems and methods of making and using thereof
CA2751884C (en) 2009-01-14 2018-09-25 Corium International, Inc. Transdermal administration of tamsulosin
PL2403505T3 (pl) 2009-03-04 2017-06-30 Regenera Pharma Ltd. Terapeutyczne zastosowania frakcji gumy mastyksowej
AU2010220057C1 (en) 2009-03-04 2015-10-29 Regenera Pharma Ltd. Compositions of polymeric myrcene
WO2010135053A2 (en) * 2009-05-21 2010-11-25 Bionex Pharmaceuticals Llc Dual and single layer dosage forms
ES2428938T3 (es) 2009-07-22 2013-11-12 Grünenthal GmbH Forma de dosificación resistente a la manipulación y estabilizada frente a la oxidación
BR112012001547A2 (pt) 2009-07-22 2016-03-08 Gruenenthal Gmbh forma de dosagem farmacêutica extrusada por fusão a quente
US8475832B2 (en) 2009-08-07 2013-07-02 Rb Pharmaceuticals Limited Sublingual and buccal film compositions
US9549842B2 (en) 2011-02-04 2017-01-24 Joseph E. Kovarik Buccal bioadhesive strip and method of treating snoring and sleep apnea
US8701671B2 (en) 2011-02-04 2014-04-22 Joseph E. Kovarik Non-surgical method and system for reducing snoring
JP5892940B2 (ja) 2009-11-25 2016-03-23 アリスジェン ソシエテ アノニム クラウン化合物及び／又は対イオンと複合体化されたペプチドを含む粘膜送達組成物
US10610528B2 (en) 2009-12-08 2020-04-07 Intelgenx Corp. Solid oral film dosage forms and methods for making same
US20110136815A1 (en) 2009-12-08 2011-06-09 Horst Zerbe Solid oral film dosage forms and methods for making same
US10668060B2 (en) 2009-12-10 2020-06-02 Collegium Pharmaceutical, Inc. Tamper-resistant pharmaceutical compositions of opioids and other drugs
US8597681B2 (en) 2009-12-22 2013-12-03 Mallinckrodt Llc Methods of producing stabilized solid dosage pharmaceutical compositions containing morphinans
US9198861B2 (en) 2009-12-22 2015-12-01 Mallinckrodt Llc Methods of producing stabilized solid dosage pharmaceutical compositions containing morphinans
CN102821757B (zh) 2010-02-03 2016-01-20 格吕伦塔尔有限公司 通过挤出机制备粉末状药物组合物
CN102892815B (zh) * 2010-03-26 2016-05-18 陶氏环球技术有限责任公司 熔体挤出的膜
US9572773B2 (en) 2010-04-26 2017-02-21 Novartis A.G. Layered drug delivery device
US20110290694A1 (en) * 2010-05-27 2011-12-01 Monosol Rx, Llc Oral film dosage form having indicia thereon
JP5819949B2 (ja) 2010-06-10 2015-11-24 ミダテック リミテッド ナノ粒子フィルム送達システム
DE102010029942A1 (de) * 2010-06-10 2011-12-15 Robert Bosch Gmbh Injektionsnadel
CN103179954A (zh) 2010-09-02 2013-06-26 格吕伦塔尔有限公司 包含阴离子聚合物的抗破碎剂型
CA2808219C (en) 2010-09-02 2019-05-14 Gruenenthal Gmbh Tamper resistant dosage form comprising inorganic salt
KR101910781B1 (ko) 2010-09-07 2018-10-22 레제네라 파마 리미티드 매스틱 검의 산성 추출물을 포함하는 조성물
US9149959B2 (en) 2010-10-22 2015-10-06 Monosol Rx, Llc Manufacturing of small film strips
EP2637631B1 (de) 2010-11-08 2017-01-04 Colgate-Palmolive Company Orale zusammensetzungen mit mikroaggregaten
US9675540B2 (en) 2010-12-13 2017-06-13 Colgate-Palmolive Company Oral compositions and method for producing thereof
BR112013014678A2 (pt) 2010-12-13 2016-08-02 Colgate Palmolive Co composições orais e método para a produção das mesmas
JP2014502594A (ja) 2010-12-13 2014-02-03 コルゲート・パーモリブ・カンパニー 口腔用組成物およびその製造方法
EP2670368A4 (de) 2011-02-03 2015-04-15 Pharmedica Ltd Neue im mund zersetzbare filme zur insulinverabreichung zwecks behandlung von diabetes
US12279989B2 (en) 2011-02-04 2025-04-22 Seed Health, Inc. Method and system for increasing beneficial bacteria and decreasing pathogenic bacteria in the oral cavity
US11844720B2 (en) 2011-02-04 2023-12-19 Seed Health, Inc. Method and system to reduce the likelihood of dental caries and halitosis
US12257272B2 (en) 2015-12-24 2025-03-25 Seed Health, Inc. Method and system for reducing the likelihood of developing depression in an individual
US11951139B2 (en) 2015-11-30 2024-04-09 Seed Health, Inc. Method and system for reducing the likelihood of osteoporosis
US12533312B2 (en) 2011-02-04 2026-01-27 Seed Health, Inc. Method and system for preventing sore throat in humans
US11998479B2 (en) 2011-02-04 2024-06-04 Seed Health, Inc. Method and system for addressing adverse effects on the oral microbiome and restoring gingival health caused by sodium lauryl sulphate exposure
US11951140B2 (en) 2011-02-04 2024-04-09 Seed Health, Inc. Modulation of an individual's gut microbiome to address osteoporosis and bone disease
US9050335B1 (en) 2011-05-17 2015-06-09 Mallinckrodt Llc Pharmaceutical compositions for extended release of oxycodone and acetaminophen resulting in a quick onset and prolonged period of analgesia
US8858963B1 (en) 2011-05-17 2014-10-14 Mallinckrodt Llc Tamper resistant composition comprising hydrocodone and acetaminophen for rapid onset and extended duration of analgesia
US8741885B1 (en) 2011-05-17 2014-06-03 Mallinckrodt Llc Gastric retentive extended release pharmaceutical compositions
PL2736497T3 (pl) 2011-07-29 2018-01-31 Gruenenthal Gmbh Tabletka odporna na ingerencję, zapewniająca natychmiastowe uwalnianie leku
CA2839123A1 (en) 2011-07-29 2013-02-07 Grunenthal Gmbh Tamper-resistant tablet providing immediate drug release
US20140017299A1 (en) * 2011-08-18 2014-01-16 Monosol Rx, Llc Steroid hormone delivery systems and methods of preparing the same
SG10201610097WA (en) 2011-08-18 2017-01-27 Biodelivery Sciences Int Inc Abuse-resistant mucoadhesive devices for delivery of buprenorphine
US9901539B2 (en) 2011-12-21 2018-02-27 Biodelivery Sciences International, Inc. Transmucosal drug delivery devices for use in chronic pain relief
MX356421B (es) 2012-02-28 2018-05-29 Gruenenthal Gmbh Forma de dosificacion resistente a la manipulacion indebida que comprende un compuesto farmacologicamente activo y un polimero anionico.
PL2838512T3 (pl) 2012-04-18 2018-12-31 Grünenthal GmbH Farmaceutyczna postać dawkowania odporna na niewłaściwe użycie i odporna na uderzeniowe uwalnianie dawki
US10064945B2 (en) 2012-05-11 2018-09-04 Gruenenthal Gmbh Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc
AU2013331240B8 (en) 2012-10-17 2016-11-24 The Procter & Gamble Company Strip for the delivery of an oral care active and methods for applying oral care actives
WO2014191396A1 (en) 2013-05-29 2014-12-04 Grünenthal GmbH Tamper resistant dosage form with bimodal release profile
MX371432B (es) 2013-05-29 2020-01-30 Gruenenthal Gmbh Forma de dosificacion resistente al uso indebido que contiene una o mas particulas.
US10624862B2 (en) 2013-07-12 2020-04-21 Grünenthal GmbH Tamper-resistant dosage form containing ethylene-vinyl acetate polymer
RU2638397C2 (ru) * 2013-09-30 2017-12-13 Кимберли-Кларк Ворлдвайд, Инк. Термопластичное изделие с термоактивным средством
WO2015078891A1 (en) 2013-11-26 2015-06-04 Farmaceutici Formenti S.P.A. Preparation of a powdery pharmaceutical composition by means of cryo-milling
US12005085B2 (en) 2013-12-20 2024-06-11 Seed Health, Inc. Probiotic method and composition for maintaining a healthy vaginal microbiome
US11826388B2 (en) 2013-12-20 2023-11-28 Seed Health, Inc. Topical application of Lactobacillus crispatus to ameliorate barrier damage and inflammation
US11839632B2 (en) 2013-12-20 2023-12-12 Seed Health, Inc. Topical application of CRISPR-modified bacteria to treat acne vulgaris
US11980643B2 (en) 2013-12-20 2024-05-14 Seed Health, Inc. Method and system to modify an individual's gut-brain axis to provide neurocognitive protection
US11969445B2 (en) 2013-12-20 2024-04-30 Seed Health, Inc. Probiotic composition and method for controlling excess weight, obesity, NAFLD and NASH
US11998574B2 (en) 2013-12-20 2024-06-04 Seed Health, Inc. Method and system for modulating an individual's skin microbiome
US12246043B2 (en) 2013-12-20 2025-03-11 Seed Health, Inc. Topical application to treat acne vulgaris
US11833177B2 (en) 2013-12-20 2023-12-05 Seed Health, Inc. Probiotic to enhance an individual's skin microbiome
US12329783B2 (en) 2013-12-20 2025-06-17 Seed Health, Inc. Method and system to improve the health of a person's skin microbiome
EP2889030A1 (de) 2013-12-30 2015-07-01 Uluru Inc. Steuerung der Erosionsraten von mukoadhäsiven Vorrichtungen mit Lieferung von Wirkstoffen und anderen Verbindungen und Bereitstellung erhöhter und unterschiedlicher therapeutischer Blutwerte
US20150320690A1 (en) 2014-05-12 2015-11-12 Grünenthal GmbH Tamper resistant immediate release capsule formulation comprising tapentadol
EP3148512A1 (de) 2014-05-26 2017-04-05 Grünenthal GmbH Gegen entsorgung von ethanolischer dosis gesicherte mehrfachpartikel
PT3155050T (pt) * 2014-06-06 2020-11-12 Opes Corp Oy Massa contendo composto funcional e regulador de viscosidade
BR112017021475A2 (pt) 2015-04-24 2018-07-10 Gruenenthal Gmbh forma de dosagem resistente à adulteração (tamper) com liberação imediata e resistência contra extração de solvente
WO2016192924A1 (en) * 2015-06-05 2016-12-08 Unilever Plc Oral care device
AU2016319203A1 (en) 2015-09-10 2018-02-22 Grünenthal GmbH Protecting oral overdose with abuse deterrent immediate release formulations
WO2017085262A1 (en) * 2015-11-19 2017-05-26 Dermtreat Aps A pharmaceutical film composition having improved residence time on the application site
DE102016000541A1 (de) 2016-01-14 2017-07-20 Hofmann & Sommer GmbH und Co.KG Cellulosefaserbasierte Trägermatrices (smartFilms) zur Applikation von Inhaltsstoffen sowie deren Herstellung
US12433850B2 (en) 2016-05-05 2025-10-07 Aquestive Therapeutics, Inc. Enhanced delivery epinephrine and prodrug compositions
US11273131B2 (en) 2016-05-05 2022-03-15 Aquestive Therapeutics, Inc. Pharmaceutical compositions with enhanced permeation
US12427121B2 (en) 2016-05-05 2025-09-30 Aquestive Therapeutics, Inc. Enhanced delivery epinephrine compositions
JP7653218B2 (ja) 2016-05-05 2025-03-28 アクエスティブ セラピューティクス インコーポレイテッド 送達増強エピネフリン組成物
US9737530B1 (en) 2016-06-23 2017-08-22 Collegium Pharmaceutical, Inc. Process of making stable abuse-deterrent oral formulations
EP3634507B1 (de) * 2017-06-07 2025-01-15 EGY-Nano Pharma, LP Orale, verlängerte wirkstofffreisetzungsplattformen
WO2019006122A1 (en) 2017-06-28 2019-01-03 University Of Pittsburgh-Of The Commonwealth System Of Higher Education HOT EXTRUSION FOR VAGINAL FILM PHARMACEUTICAL PRODUCTS
US12274597B2 (en) 2017-08-11 2025-04-15 Align Technology, Inc. Dental attachment template tray systems
DE102017127434A1 (de) * 2017-11-21 2019-05-23 Lts Lohmann Therapie-Systeme Ag Taschenförmige oral auflösende Filme mit hoher Wirkstoffbeladung
JP7243301B2 (ja) * 2018-03-15 2023-03-22 大正製薬株式会社 口腔用組成物
GB2575625A (en) 2018-06-22 2020-01-22 Church & Dwight Co Inc Oral care compositions comprising benzocaine and mucoadhesive thin films formed therefrom
JP7739256B2 (ja) * 2019-07-19 2025-09-16 バイオエクセル セラピューティクス，インコーポレイテッド 鎮静作用のないデクスメデトミジン治療レジメン
US10758329B1 (en) 2019-08-20 2020-09-01 Raymond L. Wright, III Hydrating mouth guard
CN111249328B (zh) * 2020-03-13 2021-06-25 河南护理职业学院 一种复方口腔溃疡贴膜及其制备方法
US12465564B2 (en) 2021-10-25 2025-11-11 Aquestive Therapeutics, Inc. Oral and nasal compositions and methods of treatment

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5562012A (en) * 1978-11-06 1980-05-10 Teijin Ltd Slow-releasing preparation
GB2042888B (en) * 1979-03-05 1983-09-28 Teijin Ltd Preparation for administration to the mucosa of the oral or nasal cavity
JPS5620513A (en) * 1979-07-31 1981-02-26 Eisai Co Ltd Sugar-coated tablet containing fat-soluble drug
JPS5758615A (en) * 1980-09-26 1982-04-08 Nippon Soda Co Ltd Film agnent and its preparation
JPS5890507A (ja) * 1981-11-24 1983-05-30 Nippon Soda Co Ltd 粘膜粘着性フイルム製剤の製造方法
JPS59222406A (ja) * 1983-06-01 1984-12-14 Teijin Ltd 歯周疾患治療用製剤及びその製造法
HU197847B (en) * 1984-03-01 1989-06-28 Sandoz Ag Process for producing therapeutical preparations suitable for transdermatic treating
JPS62223114A (ja) * 1986-03-25 1987-10-01 Rooto Seiyaku Kk 徐放性歯周病治療剤

Also Published As

Publication number Publication date
ATE95058T1 (de) 1993-10-15
DE3787573D1 (de) 1993-11-04
IE61785B1 (en) 1994-11-30
JP2706064B2 (ja) 1998-01-28
DE3787573T2 (de) 1994-02-10
NZ220573A (en) 1989-11-28
GR870935B (en) 1987-10-19
KR880000087A (ko) 1988-03-23
CA1297408C (en) 1992-03-17
KR940011243B1 (ko) 1994-12-03
US4713243A (en) 1987-12-15
JPH08253414A (ja) 1996-10-01
EP0250187B1 (de) 1993-09-29
AU7415587A (en) 1987-12-17
JPS6319152A (ja) 1988-01-26
IE871583L (en) 1987-12-16
ZA874294B (en) 1989-01-25
JP2540332B2 (ja) 1996-10-02
EP0250187A2 (de) 1987-12-23
EP0250187A3 (en) 1988-06-01

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