PH26030A - Use of benzamide in the treatment of cognitive disorders - Google Patents

Use of benzamide in the treatment of cognitive disorders Download PDF

Info

Publication number: PH26030A
Authority: PH; Philippines
Prior art keywords: treatment; moclobemide; dementia; test; prevention
Prior art date: 1988-01-28

Application number

PH38119A

Other languages

English (en)

Inventor

Roman Dr Amrein

Ravi Dr Anand

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-01-28

Filing date

1989-01-27

Publication date

1992-01-29

1989-01-27 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

1992-01-29 Publication of PH26030A publication Critical patent/PH26030A/en

Links

208000010877 cognitive disease Diseases 0.000 title claims abstract description 5
KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 title claims 4
238000000034 method Methods 0.000 claims description 16
206010012289 Dementia Diseases 0.000 claims description 11
230000002265 prevention Effects 0.000 claims description 7
206010061216 Infarction Diseases 0.000 claims description 3
230000003412 degenerative effect Effects 0.000 claims description 3
230000007574 infarction Effects 0.000 claims 1
YHXISWVBGDMDLQ-UHFFFAOYSA-N moclobemide Chemical compound C1=CC(Cl)=CC=C1C(=O)NCCN1CCOCC1 YHXISWVBGDMDLQ-UHFFFAOYSA-N 0.000 abstract description 26
238000012360 testing method Methods 0.000 description 27
239000003826 tablet Substances 0.000 description 26
229960004644 moclobemide Drugs 0.000 description 24
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 16
STECJAGHUSJQJN-VJQRDGCPSA-N chembl3084722 Chemical compound C1([C@@H](CO)C(=O)O[C@@H]2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-VJQRDGCPSA-N 0.000 description 14
229960002646 scopolamine Drugs 0.000 description 14
229930000680 A04AD01 - Scopolamine Natural products 0.000 description 13
STECJAGHUSJQJN-GAUPFVANSA-N Hyoscine Natural products C1([C@H](CO)C(=O)OC2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-GAUPFVANSA-N 0.000 description 13
STECJAGHUSJQJN-UHFFFAOYSA-N N-Methyl-scopolamin Natural products C1C(C2C3O2)N(C)C3CC1OC(=O)C(CO)C1=CC=CC=C1 STECJAGHUSJQJN-UHFFFAOYSA-N 0.000 description 13
239000004615 ingredient Substances 0.000 description 11
239000000126 substance Substances 0.000 description 10
229920002261 Corn starch Polymers 0.000 description 9
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 9
235000019759 Maize starch Nutrition 0.000 description 9
239000008101 lactose Substances 0.000 description 9
229920000036 polyvinylpyrrolidone Polymers 0.000 description 9
239000001267 polyvinylpyrrolidone Substances 0.000 description 9
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 9
241001465754 Metazoa Species 0.000 description 8
230000000694 effects Effects 0.000 description 8
238000002347 injection Methods 0.000 description 8
239000007924 injection Substances 0.000 description 8
235000019359 magnesium stearate Nutrition 0.000 description 8
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
241000700159 Rattus Species 0.000 description 7
239000008367 deionised water Substances 0.000 description 7
229910021641 deionized water Inorganic materials 0.000 description 7
239000000725 suspension Substances 0.000 description 7
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 6
UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 6
229920002472 Starch Polymers 0.000 description 6
GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 6
239000011248 coating agent Substances 0.000 description 6
238000000576 coating method Methods 0.000 description 6
238000004519 manufacturing process Methods 0.000 description 6
239000011734 sodium Substances 0.000 description 6
229910052708 sodium Inorganic materials 0.000 description 6
239000008107 starch Substances 0.000 description 6
239000002775 capsule Substances 0.000 description 5
230000006735 deficit Effects 0.000 description 5
239000008187 granular material Substances 0.000 description 5
239000000203 mixture Substances 0.000 description 5
239000000843 powder Substances 0.000 description 5
229960004499 scopolamine hydrobromide Drugs 0.000 description 5
WTGQALLALWYDJH-MOUKNHLCSA-N scopolamine hydrobromide (anhydrous) Chemical compound Br.C1([C@@H](CO)C(=O)O[C@H]2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 WTGQALLALWYDJH-MOUKNHLCSA-N 0.000 description 5
239000000243 solution Substances 0.000 description 5
239000000454 talc Substances 0.000 description 5
229910052623 talc Inorganic materials 0.000 description 5
230000001149 cognitive effect Effects 0.000 description 4
239000000902 placebo Substances 0.000 description 4
229940068196 placebo Drugs 0.000 description 4
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
208000035475 disorder Diseases 0.000 description 3
239000003814 drug Substances 0.000 description 3
239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 3
229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 3
235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 3
UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 3
238000002360 preparation method Methods 0.000 description 3
239000004408 titanium dioxide Substances 0.000 description 3
ZUSPUYXHFZBBBB-SNVBAGLBSA-N (3r)-3-hydroxy-1-(4-methoxybenzoyl)pyrrolidin-2-one Chemical compound C1=CC(OC)=CC=C1C(=O)N1C(=O)[C@H](O)CC1 ZUSPUYXHFZBBBB-SNVBAGLBSA-N 0.000 description 2
208000020401 Depressive disease Diseases 0.000 description 2
ZXNRTKGTQJPIJK-UHFFFAOYSA-N aniracetam Chemical compound C1=CC(OC)=CC=C1C(=O)N1C(=O)CCC1 ZXNRTKGTQJPIJK-UHFFFAOYSA-N 0.000 description 2
229960000793 aniracetam Drugs 0.000 description 2
RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 description 2
YPHMISFOHDHNIV-FSZOTQKASA-N cycloheximide Chemical compound C1[C@@H](C)C[C@H](C)C(=O)[C@@H]1[C@H](O)CC1CC(=O)NC(=O)C1 YPHMISFOHDHNIV-FSZOTQKASA-N 0.000 description 2
238000011156 evaluation Methods 0.000 description 2
JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 2
230000007787 long-term memory Effects 0.000 description 2
238000005259 measurement Methods 0.000 description 2
230000015654 memory Effects 0.000 description 2
239000006186 oral dosage form Substances 0.000 description 2
239000006201 parenteral dosage form Substances 0.000 description 2
230000035484 reaction time Effects 0.000 description 2
230000035939 shock Effects 0.000 description 2
230000006403 short-term memory Effects 0.000 description 2
208000024891 symptom Diseases 0.000 description 2
208000031872 Body Remains Diseases 0.000 description 1
239000001856 Ethyl cellulose Substances 0.000 description 1
ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 1
239000001828 Gelatine Substances 0.000 description 1
LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 description 1
102000010909 Monoamine Oxidase Human genes 0.000 description 1
108010062431 Monoamine oxidase Proteins 0.000 description 1
239000002202 Polyethylene glycol Substances 0.000 description 1
239000013543 active substance Substances 0.000 description 1
239000008280 blood Substances 0.000 description 1
210000004369 blood Anatomy 0.000 description 1
230000037396 body weight Effects 0.000 description 1
210000004556 brain Anatomy 0.000 description 1
229960001948 caffeine Drugs 0.000 description 1
VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 description 1
239000012876 carrier material Substances 0.000 description 1
230000002490 cerebral effect Effects 0.000 description 1
208000026106 cerebrovascular disease Diseases 0.000 description 1
238000000546 chi-square test Methods 0.000 description 1
230000019771 cognition Effects 0.000 description 1
230000007278 cognition impairment Effects 0.000 description 1
230000003931 cognitive performance Effects 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
235000005911 diet Nutrition 0.000 description 1
230000037213 diet Effects 0.000 description 1
239000006185 dispersion Substances 0.000 description 1
239000002552 dosage form Substances 0.000 description 1
239000008298 dragée Substances 0.000 description 1
229920001249 ethyl cellulose Polymers 0.000 description 1
235000019325 ethyl cellulose Nutrition 0.000 description 1
YLRFCQOZQXIBAB-RBZZARIASA-N fluoxymesterone Chemical class C1CC2=CC(=O)CC[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1CC[C@](C)(O)[C@@]1(C)C[C@@H]2O YLRFCQOZQXIBAB-RBZZARIASA-N 0.000 description 1
229920000159 gelatin Polymers 0.000 description 1
235000019322 gelatine Nutrition 0.000 description 1
230000002489 hematologic effect Effects 0.000 description 1
230000010365 information processing Effects 0.000 description 1
238000001802 infusion Methods 0.000 description 1
239000003112 inhibitor Substances 0.000 description 1
230000002401 inhibitory effect Effects 0.000 description 1
238000005304 joining Methods 0.000 description 1
239000007788 liquid Substances 0.000 description 1
239000008297 liquid dosage form Substances 0.000 description 1
230000007774 longterm Effects 0.000 description 1
239000002899 monoamine oxidase inhibitor Substances 0.000 description 1
235000015205 orange juice Nutrition 0.000 description 1
230000002688 persistence Effects 0.000 description 1
239000006187 pill Substances 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
230000000069 prophylactic effect Effects 0.000 description 1
230000004044 response Effects 0.000 description 1
230000002441 reversible effect Effects 0.000 description 1
239000000779 smoke Substances 0.000 description 1
239000007787 solid Substances 0.000 description 1
239000007909 solid dosage form Substances 0.000 description 1
239000000829 suppository Substances 0.000 description 1
239000006188 syrup Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
238000007910 systemic administration Methods 0.000 description 1
238000010998 test method Methods 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
210000002700 urine Anatomy 0.000 description 1
230000000007 visual effect Effects 0.000 description 1
230000003442 weekly effect Effects 0.000 description 1
238000005303 weighing Methods 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

PH38119A 1988-01-28 1989-01-27 Use of benzamide in the treatment of cognitive disorders PH26030A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CH29888		1988-01-28

Publications (1)

Publication Number	Publication Date
PH26030A true PH26030A (en)	1992-01-29

Family

ID=4183804

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PH38119A PH26030A (en)	1988-01-28	1989-01-27	Use of benzamide in the treatment of cognitive disorders

Country Status (15)

Country	Link
US (1)	US4906626A (fr)
EP (1)	EP0326023B1 (fr)
JP (1)	JPH07116043B2 (fr)
KR (1)	KR960016203B1 (fr)
AT (1)	ATE113207T1 (fr)
AU (1)	AU620584B2 (fr)
CA (1)	CA1332151C (fr)
DE (1)	DE58908544D1 (fr)
DK (1)	DK171094B1 (fr)
ES (1)	ES2063060T3 (fr)
HU (1)	HU203042B (fr)
IE (1)	IE65409B1 (fr)
IL (1)	IL89031A (fr)
PH (1)	PH26030A (fr)
ZA (1)	ZA89523B (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4985437A (en) *	1986-12-17	1991-01-15	Glaxo Group Limited	Medicaments
FR2645742A1 (fr) *	1989-04-12	1990-10-19	Delagrange Laboratoires	Application de derives de 2-methoxy 4-(4,5-dihydro 2-imidazolyl (ou 2-oxazolyl) amino) 5-chloro benzamide dans le traitement des troubles de la fonction cognitive
JP3172202B2 (ja) *	1990-11-29	2001-06-04	エフ．ホフマン−ラロシュアーゲー	不安の障害の処置剤
US6951884B2 (en) *	2002-06-12	2005-10-04	Hoffmann-La Roche Inc.	Fluorobenzamides and uses thereof
RU2006117366A (ru) *	2003-10-23	2007-12-10	Ф.Хоффманн-Ля Рош Аг (Ch)	Производные бензазепина в качестве ингибиторов мао-в
EP1713486A4 (fr) *	2003-12-02	2009-04-29	Sheldon Leslie James	Therapie combinee pour le traitement de la demence, la depression et l'apathie
ES2537898T3 (es)	2005-10-25	2015-06-15	Shionogi & Co., Ltd.	Derivados de aminotiazolidina y aminotetrahidrotiazepina como inhibidores de BACE 1
EP2151435A4 (fr)	2007-04-24	2011-09-14	Shionogi & Co	Composition pharmaceutique pour le traitement de la maladie d'alzheimer
AU2008245082B8 (en)	2007-04-24	2012-09-13	Shionogi & Co., Ltd.	Aminodihydrothiazine derivatives substituted with a cyclic group
US8637504B2 (en)	2008-06-13	2014-01-28	Shionogi & Co., Ltd.	Sulfur-containing heterocyclic derivative having beta secretase inhibitory activity
WO2010047372A1 (fr) *	2008-10-22	2010-04-29	塩野義製薬株式会社	2-aminopyridin-4-one et dérivé de 2-aminopyridine dont l'activité inhibe la bace1
RU2012129168A (ru)	2009-12-11	2014-01-20	Сионоги Энд Ко. Лтд.	Производные оксазина
CA2816285A1 (fr)	2010-10-29	2012-05-03	Shionogi & Co., Ltd.	Derive de naphtyridine
US9018219B2 (en)	2010-10-29	2015-04-28	Shionogi & Co., Ltd.	Fused aminodihydropyrimidine derivative
WO2012147763A1 (fr)	2011-04-26	2012-11-01	塩野義製薬株式会社	Dérivé d'oxazine et inhibiteur de bace 1 le contenant
JP2016501827A (ja)	2012-10-24	2016-01-21	塩野義製薬株式会社	Ｂａｃｅ１阻害作用を有するジヒドロオキサジンまたはオキサゼピン誘導体
ES2973138T3 (es)	2016-04-12	2024-06-18	E Vision Smart Optics Inc	Lentes electroactivas con puentes resistivos elevados

1989
- 1989-01-11 CA CA000587927A patent/CA1332151C/fr not_active Expired - Lifetime
- 1989-01-13 US US07/297,168 patent/US4906626A/en not_active Expired - Lifetime
- 1989-01-19 ES ES89100901T patent/ES2063060T3/es not_active Expired - Lifetime
- 1989-01-19 EP EP89100901A patent/EP0326023B1/fr not_active Expired - Lifetime
- 1989-01-19 AT AT89100901T patent/ATE113207T1/de not_active IP Right Cessation
- 1989-01-19 DE DE58908544T patent/DE58908544D1/de not_active Expired - Lifetime
- 1989-01-23 ZA ZA89523A patent/ZA89523B/xx unknown
- 1989-01-23 IL IL8903189A patent/IL89031A/en unknown
- 1989-01-25 JP JP1014249A patent/JPH07116043B2/ja not_active Expired - Lifetime
- 1989-01-25 HU HU89303A patent/HU203042B/hu unknown
- 1989-01-27 DK DK036889A patent/DK171094B1/da not_active IP Right Cessation
- 1989-01-27 AU AU28836/89A patent/AU620584B2/en not_active Expired
- 1989-01-27 KR KR1019890000867A patent/KR960016203B1/ko not_active Expired - Lifetime
- 1989-01-27 IE IE27389A patent/IE65409B1/en not_active IP Right Cessation
- 1989-01-27 PH PH38119A patent/PH26030A/en unknown

Also Published As

Publication number	Publication date
KR960016203B1 (ko)	1996-12-06
DK171094B1 (da)	1996-06-03
IE890273L (en)	1989-07-28
ES2063060T3 (es)	1995-01-01
AU2883689A (en)	1989-08-03
HUT50042A (en)	1989-12-28
JPH01224318A (ja)	1989-09-07
ATE113207T1 (de)	1994-11-15
IL89031A (en)	1995-07-31
AU620584B2 (en)	1992-02-20
DK36889A (da)	1989-07-29
US4906626A (en)	1990-03-06
EP0326023A3 (en)	1990-09-05
DK36889D0 (da)	1989-01-27
JPH07116043B2 (ja)	1995-12-13
IE65409B1 (en)	1995-10-18
ZA89523B (en)	1989-09-27
KR890011589A (ko)	1989-08-21
HU203042B (en)	1991-05-28
CA1332151C (fr)	1994-09-27
DE58908544D1 (de)	1994-12-01
EP0326023A2 (fr)	1989-08-02
IL89031A0 (en)	1989-08-15
EP0326023B1 (fr)	1994-10-26

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US4906626A (en)	1990-03-06	Method of use for treatment or prevention of cognitive disorders
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