PH26263A - Anticoagulant peptides - Google Patents

Anticoagulant peptides Download PDF

Info

Publication number: PH26263A
Authority: PH; Philippines
Prior art keywords: asp; glu; pro; peptide derivative; tyr
Prior art date: 1987-01-23

Application number

PH36388A

Other languages

English (en)

Inventor

John L Krstenansku

Simon J Y Mao

Original Assignee

Merrell Dow Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-01-23

Filing date

1988-01-22

Publication date

1992-04-01

1988-01-22 Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma

1992-04-01 Publication of PH26263A publication Critical patent/PH26263A/en

Links

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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Hematology (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Diabetes (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Tropical Medicine & Parasitology (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Toxicology (AREA)
Zoology (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Steroid Compounds (AREA)

PH36388A 1987-01-23 1988-01-22 Anticoagulant peptides PH26263A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US641787A	1987-01-23	1987-01-23
US5316287A	1987-05-21	1987-05-21

Publications (1)

Publication Number	Publication Date
PH26263A true PH26263A (en)	1992-04-01

Family

ID=26675603

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PH36388A PH26263A (en)	1987-01-23	1988-01-22	Anticoagulant peptides

Country Status (19)

Country	Link
EP (1)	EP0276014B1 (de)
JP (1)	JP2709817B2 (de)
KR (1)	KR960014105B1 (de)
CN (1)	CN88100260A (de)
AR (1)	AR245140A1 (de)
AT (1)	ATE110743T1 (de)
AU (1)	AU601801B2 (de)
CA (1)	CA1341032C (de)
DE (1)	DE3851238T2 (de)
DK (1)	DK173757B1 (de)
ES (1)	ES2063740T3 (de)
FI (1)	FI89060C (de)
HU (1)	HU199159B (de)
IE (1)	IE63547B1 (de)
IL (1)	IL85159A (de)
NO (1)	NO174105C (de)
NZ (1)	NZ223236A (de)
PH (1)	PH26263A (de)
PT (1)	PT86600B (de)

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US5789540A (en) *	1987-01-23	1998-08-04	Merrell Pharmaceuticals Inc.	Anticoagulant peptides
US6005071A (en) *	1987-01-23	1999-12-21	Merrell Pharmaceuticals Inc.	Anticoagulant peptides
US5192745A (en) *	1987-05-21	1993-03-09	Merrell Dow Pharmaceuticals Inc.	Cyclic anticoagulant peptides
US5236898A (en) *	1987-05-21	1993-08-17	Merrell Dow Pharmaceuticals Inc.	Cyclic anticoagulant peptides
US5256559A (en) *	1988-03-04	1993-10-26	Biogen, Inc.	Methods and compositions for inhibiting platelet aggregation
NZ228995A (en) *	1988-05-10	1992-03-26	Merrell Dow Pharma	Hirudin peptide derivatives and pharmaceutical compositions
WO1990006128A1 (en) *	1988-12-05	1990-06-14	Biogen, Inc.	Methods and compositions for inhibiting platelet aggregation
US5232912A (en) *	1988-12-07	1993-08-03	Merrell Dow Pharmaceuticals Inc.	Anticoagulant peptides
AU630132B2 (en) *	1988-12-07	1992-10-22	Merrell Dow Pharmaceuticals Inc.	Anticoagulant peptides
US5196404B1 (en) *	1989-08-18	1996-09-10	Biogen Inc	Inhibitors of thrombin
US5240913A (en) *	1989-08-18	1993-08-31	Biogen, Inc.	Inhibitors of thrombin
CA2026376C (en) *	1989-10-03	2002-01-01	John L. Krstenansky	Anticoagulant peptides
US5192747A (en) *	1989-10-03	1993-03-09	Merrell Dow Pharmaceuticals Inc.	Anticoagulant peptides
ZA907743B (en) *	1989-10-03	1991-07-31	Merrell Dow Pharma	Radiolabeled anticoagulant peptides
AU641215B2 (en) *	1990-02-13	1993-09-16	Merrell Dow Pharmaceuticals Inc.	Stabilized sulfonate, sulfate, phosphonate and phosphate derivatives of hirudin
DE4005591A1 (de) *	1990-02-22	1991-09-05	Behringwerke Ag	Die blutgerinnung inhibierende peptide, verfahren zu ihrer herstellung und ihre verwendung
US6060451A (en) *	1990-06-15	2000-05-09	The National Research Council Of Canada	Thrombin inhibitors based on the amino acid sequence of hirudin
US5574012A (en) *	1990-07-24	1996-11-12	Merrell Pharmaceuticals Inc.	Analogs of hirudin having anti-platelet activity
ZA915658B (en) *	1990-07-24	1992-05-27	Merrell Dow Pharma	Analogs of hirudin having antiplatelet activity
FI930265A0 (fi) *	1990-07-24	1993-01-22	Merrell Dow Pharma	Antikoagulantpeptider
US5242810A (en) *	1990-12-07	1993-09-07	Biogen, Inc.	Bifunctional inhibitors of thrombin and platelet activation
DE4103649A1 (de) *	1991-02-07	1992-08-13	Basf Ag	Neue antikoagulatorisch wirksame peptide
DE69213628T2 (de) *	1991-03-05	1997-04-24	Fuji Yakuhin Kogyo Kk	Hirudinanalog oder dessen salz, dessen herstellung und das als aktiven bestandteil enthaltende antikoagulanz
US5767235A (en) *	1991-03-05	1998-06-16	Nippon Mining Company Limited	Anticoagulant hirudin variants and methods for their production
IT1250689B (it) *	1991-07-22	1995-04-21	Marco Gerna	Analoghi dell'irudina e procedimento per la loro preparazione
AU2442792A (en) *	1991-07-31	1993-03-02	Institut Pasteur	Polypeptides capable of (in vivo) induction of antibodies themselves capable of inhibiting the invasion of red blood corpuscles by merozoites of (p.falciparum), related products and their use in producing vaccine compositions
KR100330465B1 (ko) *	1993-06-11	2002-11-23	메렐 파마슈티칼스 인크.	삼관능성항트롬빈및항혈소판펩티드
GB9426038D0 (en)	1994-12-22	1995-02-22	Iaf Biochem Int	Low molecular weight bicyclic thrombin inhibitors
US6057314A (en) *	1995-12-21	2000-05-02	Biochem Pharma Inc.	Low molecular weight bicyclic thrombin inhibitors
US5831003A (en) *	1996-06-28	1998-11-03	Bayer Corporation	Peptides which bind to prothrombin and thrombin
GB0209249D0 (en) *	2002-04-23	2002-06-05	Evolutec Ltd	Anticoagulants
GB0711779D0 (en)	2007-06-18	2007-07-25	Univ Singapore	Thrombin inhibitor
CN102757479B (zh) *	2012-05-09	2014-04-30	北京林业大学	高活性降血压肽及其制备方法

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* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3445517C2 (de) *	1984-12-13	1993-11-18	Ciba Geigy	Für ein Hirudin-ähnliches Protein codierende DNA-Sequenz und Verfahren zur Herstellung eines Hirudin-ähnlichen Proteins
DE3445532A1 (de) *	1984-12-13	1986-06-19	Plantorgan Werk Heinrich G.E. Christensen, KG, 2903 Bad Zwischenahn	Hirudin-pa, desulfatohirudine-pa, verfahren zur herstellung und pharmazeutische mittel, die diese wirkstoffe enthalten
DE3506992A1 (de) *	1985-02-27	1986-08-28	Plantorgan Werk Heinrich G.E. Christensen, KG, 2903 Bad Zwischenahn	Modifizierte hirudine, verfahren zu deren herstellung und pharmazeutische mittel, die diese wirkstoffe enthalten
MY101203A (en) *	1985-12-12	1991-08-17	Ucp Gen Pharma Ag	Production of thrombin iinhibitors.

1988
- 1988-01-15 CA CA000556652A patent/CA1341032C/en not_active Expired - Fee Related
- 1988-01-19 NZ NZ223236A patent/NZ223236A/xx unknown
- 1988-01-19 JP JP63007651A patent/JP2709817B2/ja not_active Expired - Fee Related
- 1988-01-21 AR AR88309880A patent/AR245140A1/es active
- 1988-01-21 KR KR1019880000432A patent/KR960014105B1/ko not_active Expired - Fee Related
- 1988-01-21 IL IL85159A patent/IL85159A/xx not_active IP Right Cessation
- 1988-01-22 EP EP88100934A patent/EP0276014B1/de not_active Expired - Lifetime
- 1988-01-22 HU HU88258A patent/HU199159B/hu unknown
- 1988-01-22 NO NO880268A patent/NO174105C/no unknown
- 1988-01-22 DE DE3851238T patent/DE3851238T2/de not_active Expired - Fee Related
- 1988-01-22 ES ES88100934T patent/ES2063740T3/es not_active Expired - Lifetime
- 1988-01-22 DK DK198800310A patent/DK173757B1/da not_active IP Right Cessation
- 1988-01-22 PT PT86600A patent/PT86600B/pt not_active IP Right Cessation
- 1988-01-22 AU AU10729/88A patent/AU601801B2/en not_active Ceased
- 1988-01-22 AT AT88100934T patent/ATE110743T1/de not_active IP Right Cessation
- 1988-01-22 IE IE16788A patent/IE63547B1/en not_active IP Right Cessation
- 1988-01-22 PH PH36388A patent/PH26263A/en unknown
- 1988-01-22 FI FI880286A patent/FI89060C/fi not_active IP Right Cessation
- 1988-01-23 CN CN198888100260A patent/CN88100260A/zh active Pending

Also Published As

Publication number	Publication date
HUT46339A (en)	1988-10-28
JP2709817B2 (ja)	1998-02-04
AU601801B2 (en)	1990-09-20
NO174105C (no)	1994-03-16
CN88100260A (zh)	1988-11-09
AU1072988A (en)	1988-07-28
NO880268D0 (no)	1988-01-22
NZ223236A (en)	1989-11-28
IL85159A (en)	1993-04-04
ATE110743T1 (de)	1994-09-15
PT86600A (pt)	1988-02-01
EP0276014A3 (en)	1990-05-16
DK173757B1 (da)	2001-09-10
EP0276014B1 (de)	1994-08-31
FI880286A0 (fi)	1988-01-22
KR880009045A (ko)	1988-09-13
KR960014105B1 (ko)	1996-10-14
EP0276014A2 (de)	1988-07-27
HU199159B (en)	1990-01-29
IE880167L (en)	1988-07-23
IL85159A0 (en)	1988-06-30
FI880286A7 (fi)	1988-07-24
FI89060B (fi)	1993-04-30
JPS63215698A (ja)	1988-09-08
NO174105B (no)	1993-12-06
AR245140A1 (es)	1993-12-30
IE63547B1 (en)	1995-05-17
NO880268L (no)	1988-07-25
FI89060C (fi)	1993-08-10
DE3851238T2 (de)	1995-03-16
CA1341032C (en)	2000-06-20
DK31088D0 (da)	1988-01-22
PT86600B (pt)	1991-12-31
DK31088A (da)	1988-07-24
DE3851238D1 (de)	1994-10-06
ES2063740T3 (es)	1995-01-16

Publication	Publication Date	Title
PH26263A (en)	1992-04-01	Anticoagulant peptides
DE69026715T2 (de)	1996-10-17	Neue thrombininhibitoren
CA1340646C (en)	1999-07-13	Cyclic anticoagulant peptides
EP0291981B1 (de)	1993-04-14	Zyklisches antikoagulierendes Peptid
CA2035917C (en)	2001-10-02	Stabilized sulfonate, sulfate, phosphonate and phosphate derivatives of hirudin
AU630132B2 (en)	1992-10-22	Anticoagulant peptides
DE69120158T2 (de)	1996-10-31	Hirudin-Analoge mit Antiblutplättchen-Aktivität
EP0655462B1 (de)	1998-05-06	Lineare Adhäsionsinhibitoren
CA2086243C (en)	2001-10-02	Anticoagulant peptides
US5236898A (en)	1993-08-17	Cyclic anticoagulant peptides
US6005071A (en)	1999-12-21	Anticoagulant peptides
US5789540A (en)	1998-08-04	Anticoagulant peptides
US5232912A (en)	1993-08-03	Anticoagulant peptides
US5574012A (en)	1996-11-12	Analogs of hirudin having anti-platelet activity