PH27229A - Tenidap as an inhibitor of the release of elastase by neutrophils - Google Patents

Tenidap as an inhibitor of the release of elastase by neutrophils

Info

Publication number: PH27229A
Authority: PH; Philippines
Prior art keywords: tenidap; elastase; neutrophils; release; salts
Prior art date: 1990-03-19

Application number

PH42109A

Other languages

English (en)

Inventor

Leland David Loose

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-03-19

Filing date

1991-03-08

Publication date

1993-05-04

1991-03-08 Application filed by Pfizer filed Critical Pfizer

1993-05-04 Publication of PH27229A publication Critical patent/PH27229A/en

Links

LXIKEPCNDFVJKC-QXMHVHEDSA-N tenidap Chemical compound C12=CC(Cl)=CC=C2N(C(=O)N)C(=O)\C1=C(/O)C1=CC=CS1 LXIKEPCNDFVJKC-QXMHVHEDSA-N 0.000 title abstract 4
229960003676 tenidap Drugs 0.000 title abstract 4
102000016387 Pancreatic elastase Human genes 0.000 title abstract 3
108010067372 Pancreatic elastase Proteins 0.000 title abstract 3
210000000440 neutrophil Anatomy 0.000 title abstract 2
239000003112 inhibitor Substances 0.000 title 1
241000124008 Mammalia Species 0.000 abstract 3
150000003839 salts Chemical class 0.000 abstract 3
IGPDWKCUDHIIRL-UHFFFAOYSA-N 5-chloro-2-oxo-3-[oxo(thiophen-2-yl)methyl]-3H-indole-1-carboxamide Chemical compound C12=CC(Cl)=CC=C2N(C(=O)N)C(=O)C1C(=O)C1=CC=CS1 IGPDWKCUDHIIRL-UHFFFAOYSA-N 0.000 abstract 1
206010014561 Emphysema Diseases 0.000 abstract 1
206010003230 arteritis Diseases 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
230000004064 dysfunction Effects 0.000 abstract 1
230000001404 mediated effect Effects 0.000 abstract 1
201000001474 proteinuria Diseases 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Pulmonology (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicines Containing Plant Substances (AREA)

PH42109A 1990-03-19 1991-03-08 Tenidap as an inhibitor of the release of elastase by neutrophils PH27229A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/495,888 US5006547A (en)	1990-03-19	1990-03-19	Tenidap as an inhibitor of the release of elastase by neutrophils

Publications (1)

Publication Number	Publication Date
PH27229A true PH27229A (en)	1993-05-04

Family

ID=23970396

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PH42109A PH27229A (en)	1990-03-19	1991-03-08	Tenidap as an inhibitor of the release of elastase by neutrophils

Country Status (17)

Country	Link
US (1)	US5006547A (he)
EP (1)	EP0448261B1 (he)
JP (1)	JPH0678230B2 (he)
KR (1)	KR960016511B1 (he)
AT (1)	ATE133071T1 (he)
AU (1)	AU629109B2 (he)
CA (1)	CA2038410C (he)
DE (1)	DE69116404T2 (he)
DK (1)	DK0448261T3 (he)
HU (1)	HU212492B (he)
IE (1)	IE70732B1 (he)
IL (1)	IL97520A (he)
MY (1)	MY107227A (he)
NZ (1)	NZ237450A (he)
PH (1)	PH27229A (he)
PT (1)	PT97062B (he)
ZA (1)	ZA911980B (he)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5008283A (en) *	1990-03-19	1991-04-16	Pfizer Inc.	Use of tenidap to inhibit activation of collagenase and to inhibit the activity of myeloperoxidase
US5122534A (en) *	1991-02-08	1992-06-16	Pfizer Inc.	Use of tenidap to reduce total serum cholesterol, ldl cholesterol and triglycerides
US5545656A (en) *	1995-04-05	1996-08-13	Pfizer Inc.	2-Oxidole-1-carboxamide pharmaceutical agents for the treatment of alzheimer's disease
US6544556B1 (en)	2000-09-11	2003-04-08	Andrx Corporation	Pharmaceutical formulations containing a non-steroidal antiinflammatory drug and a proton pump inhibitor
EP1390062A4 (en) *	2001-05-02	2005-09-14	Blood Res Center	MODULATORS OF ELASTASE INHIBITOR SECRETION
DK2026651T3 (da)	2006-03-08	2013-07-08	Cortria Corp	Kombinationsterapi med ikke-selektive COX-inhibitorer til forebyggelse af COX-relaterede maveskader
EP2886541A1 (en) *	2013-12-19	2015-06-24	Sanofi	Oxindole derivatives, preparation thereof and therapeutic use in the treatment of AMPK-related diseases

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4556672A (en) *	1984-03-19	1985-12-03	Pfizer Inc.	3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents
US4678802A (en) *	1985-07-09	1987-07-07	Pfizer Inc.	1-acylcarbamoyloxindole-3-carboxamides as antiinflammatory agents
RO105052B1 (en) *	1987-02-02	1994-12-01	Pfizer	Producing process for the crystalline sodium salt, anhydre, of 5-chlorine-3-(2-tenoil)-2-oxindol-1-carboxamide
DE3852145T2 (de) *	1987-02-18	1995-04-06	Beecham Group Plc	Indolderivate, Verfahren zu deren Herstellung und pharmazeutische Präparate, die diese enthalten.
US4861794A (en) *	1988-04-13	1989-08-29	Pfizer Inc.	3-substituted-2-oxindole-1-carboxamides as inhibitors of interleukin-1 biosynthesis
US4853409A (en) *	1988-04-13	1989-08-01	Pfizer Inc.	3-substituted-2-oxindole-1-carboxamides for suppressing T-cell function
DE3814504A1 (de) *	1988-04-29	1989-11-09	Bayer Ag	(alpha)-substituierte 4-(chinolin-2-yl-methoxy)phenylessigsaeuren und -ester, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln

1990
- 1990-03-19 US US07/495,888 patent/US5006547A/en not_active Expired - Lifetime
1991
- 1991-03-08 AT AT91301963T patent/ATE133071T1/de not_active IP Right Cessation
- 1991-03-08 DK DK91301963.4T patent/DK0448261T3/da active
- 1991-03-08 PH PH42109A patent/PH27229A/en unknown
- 1991-03-08 DE DE69116404T patent/DE69116404T2/de not_active Expired - Fee Related
- 1991-03-08 EP EP91301963A patent/EP0448261B1/en not_active Expired - Lifetime
- 1991-03-12 IL IL9752091A patent/IL97520A/he not_active IP Right Cessation
- 1991-03-15 IE IE86191A patent/IE70732B1/en not_active IP Right Cessation
- 1991-03-15 NZ NZ237450A patent/NZ237450A/en unknown
- 1991-03-15 CA CA002038410A patent/CA2038410C/en not_active Expired - Fee Related
- 1991-03-18 PT PT97062A patent/PT97062B/pt not_active IP Right Cessation
- 1991-03-18 ZA ZA911980A patent/ZA911980B/xx unknown
- 1991-03-18 KR KR1019910004237A patent/KR960016511B1/ko not_active Expired - Fee Related
- 1991-03-18 HU HU91871A patent/HU212492B/hu not_active IP Right Cessation
- 1991-03-18 AU AU73586/91A patent/AU629109B2/en not_active Ceased
- 1991-03-18 MY MYPI91000439A patent/MY107227A/en unknown
- 1991-03-19 JP JP3130751A patent/JPH0678230B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
JPH04234814A (ja)	1992-08-24
EP0448261A3 (en)	1992-04-08
JPH0678230B2 (ja)	1994-10-05
NZ237450A (en)	1997-02-24
ZA911980B (en)	1992-10-28
CA2038410C (en)	1995-01-24
KR910016327A (ko)	1991-11-05
US5006547A (en)	1991-04-09
IL97520A (he)	1995-12-31
PT97062B (pt)	1998-07-31
PT97062A (pt)	1991-10-31
EP0448261B1 (en)	1996-01-17
HUT60622A (en)	1992-10-28
DK0448261T3 (da)	1996-02-12
DE69116404T2 (de)	1996-05-30
HU212492B (en)	1996-07-29
IL97520A0 (en)	1992-06-21
AU7358691A (en)	1992-08-06
DE69116404D1 (de)	1996-02-29
IE70732B1 (en)	1996-12-11
ATE133071T1 (de)	1996-02-15
MY107227A (en)	1995-10-31
KR960016511B1 (ko)	1996-12-14
EP0448261A2 (en)	1991-09-25
IE910861A1 (en)	1991-09-25
AU629109B2 (en)	1992-09-24
HU910871D0 (en)	1991-09-30

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ATE330606T1 (de)	2006-07-15	Verfahren zur vorbeugung von nmda-rezeptor vermittelten neuronalen schäden
ATE148130T1 (de)	1997-02-15	Typ-iv-dipeptidyl-aminopeptidase-inhibitoren
DE69224712D1 (de)	1998-04-16	Verschleissfeste, flammhemmende Zusammensetzungen
EP0313305A3 (en)	1990-02-07	Photoprotection compositions comprising chelating agents
ATE179173T1 (de)	1999-05-15	2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy 1,3-propandiol-derivate
ZA911980B (en)	1992-10-28	Tenidap as an inhibitor of the release of elastage by neutrophils
DE69003379D1 (de)	1993-10-21	Chip für Spieltische.
SE9101142L (sv)	1992-10-17	Inblaasning av en gas i en granulaer filterbaedd
FI961380L (fi)	1996-03-26	Koostumuksia virusten aiheuttamien kasvainten ehkäisemiseksi ja hoitamiseksi
FI941040L (fi)	1994-03-04	U-lukon turvaväliosa
CA2078700A1 (en)	1993-03-24	Imidazolylmethyl-pyridines
CH686469GA3 (fr)	1996-04-15	Piece d'horlogerie permettant de faire le point.
FI902238A0 (fi)	1990-05-04	Synergistisk soetningskomposition och foerfarande foer des framstaellning.
FI921456A0 (fi)	1992-04-02	Substituerade 2',3'-didesoxi-5- trifluormetyluridiner foerfaranden foer deras framstaellning och deras anvaendning i laekemedel.
ITTO910901A1 (it)	1993-05-22	Procedimento per l'incollaggio di pezzi di lamiera.
ITTV910116A1 (it)	1993-06-06	Perfezionata custodia di bilie per giochi di biliardo o simili che puo' chiudersi solo se tutte le bilie vengono rimesse nella medesima
IT9022058V0 (it)	1990-11-06	Orologio da polso, in coperchio per l'accesso al meccanismo del movimento
RU96103806A (ru)	1998-05-27	Удобрительный состав
KR940026283U (ko)	1994-12-08	다목적 당구대
KR950000540U (ko)	1995-01-03	당구큐우의 선단면 수평깎기 장치
OA09211A (fr)	1992-06-30	"Composition antifongique adaptée aux traitements des mycoses superficielles".
IT9050807U1 (it)	1992-06-24	Bowling big strike o simile.
IT8920529V0 (it)	1989-02-06	Regolo dosatore per 48 cocktails delle nazioni partecipanti ai campionati del mondo di calcio 1990.
IT8132842U1 (it)	1983-04-20	Dispositivo per la compilazione di schedine di concorso-pronostici (tipo totocalcio, totip, enalotto, ecc.) basato sulla pre-selezione delle tre possibili varianti in rapporto alle percentuali di probabilita' di ogni singolo risultato.
ES1011421U (es)	1990-04-01	Caja envase con juego incorporado.