PH27554A - Prodrugs of antiinflammatory-3-acyl-2-oxindole-1-carboxamides - Google Patents

Prodrugs of antiinflammatory-3-acyl-2-oxindole-1-carboxamides

Info

Publication number: PH27554A
Authority: PH; Philippines
Prior art keywords: oxindole; carboxamides; antiinflammatory; prodrugs; acyl
Prior art date: 1988-10-18

Application number

PH39329A

Other languages

English (en)

Inventor

Thomas Charles Crawford

Lawrence Alan Reiter

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-10-18

Filing date

1989-10-04

Publication date

1993-08-18

1989-10-04 Application filed by Pfizer filed Critical Pfizer

1993-08-18 Publication of PH27554A publication Critical patent/PH27554A/en

Links

229940002612 prodrug Drugs 0.000 title 1
239000000651 prodrug Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Rheumatology (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pain & Pain Management (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

PH39329A 1988-10-18 1989-10-04 Prodrugs of antiinflammatory-3-acyl-2-oxindole-1-carboxamides PH27554A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/US1988/003658 WO1990004393A1 (fr)	1988-10-18	1988-10-18	Promedicaments de 3-acyle-2-indoxyle-1-carboxamides anti-inflammatoires

Publications (1)

Publication Number	Publication Date
PH27554A true PH27554A (en)	1993-08-18

Family

ID=22208957

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PH39329A PH27554A (en)	1988-10-18	1989-10-04	Prodrugs of antiinflammatory-3-acyl-2-oxindole-1-carboxamides

Country Status (33)

Country	Link
US (1)	US5118703A (fr)
JP (1)	JPH07597B2 (fr)
KR (1)	KR910007237B1 (fr)
CN (1)	CN1022241C (fr)
AP (1)	AP118A (fr)
AR (1)	AR246519A1 (fr)
AT (1)	ATE125794T1 (fr)
AU (1)	AU606819B2 (fr)
BG (1)	BG50834A3 (fr)
CA (1)	CA1339558C (fr)
CZ (1)	CZ278983B6 (fr)
DD (1)	DD285604A5 (fr)
DK (1)	DK514989A (fr)
EG (1)	EG19887A (fr)
FI (1)	FI95253C (fr)
HU (1)	HU208421B (fr)
IE (1)	IE66586B1 (fr)
IL (1)	IL91960A (fr)
IS (1)	IS1598B (fr)
MA (1)	MA21657A1 (fr)
MX (1)	MX18021A (fr)
MY (1)	MY104238A (fr)
NO (1)	NO178027C (fr)
NZ (1)	NZ231044A (fr)
OA (1)	OA09140A (fr)
PH (1)	PH27554A (fr)
PL (2)	PL163112B1 (fr)
PT (1)	PT92000B (fr)
RO (1)	RO109195B1 (fr)
RU (1)	RU2036905C1 (fr)
SK (1)	SK278175B6 (fr)
WO (1)	WO1990004393A1 (fr)
YU (1)	YU48070B (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5059693A (en) *	1989-10-06	1991-10-22	Pfizer Inc.	Process for making 3-aroyl-2-oxindole-1-carboxamides
ATE146181T1 (de) *	1992-11-23	1996-12-15	Pfizer	Regioselektive synthese von 4-chlor-2- thiophencarbonsäure
US5270331A (en) *	1993-01-26	1993-12-14	Pfizer, Inc.	Prodrugs of antiinflammatory 3-acyl-2-oxindole-1-carboxamides
WO1994018194A1 (fr) *	1993-02-09	1994-08-18	Pfizer Inc.	Oxindole 1-[n-(alcoxycarbonyl)] carboxamides et 1-(n-carboxamido)carboxamides utilises comme agents anti-inflammatoires.
US5449788A (en) *	1994-01-28	1995-09-12	Catalytica, Inc.	Process for preparing 2-oxindole-1-carboxamides
CN1094819C (zh) *	1997-04-30	2002-11-27	大兴株式会社	环状坯料之制造装置
EP0984012A3 (fr) *	1998-08-31	2001-01-10	Pfizer Products Inc.	Promedicaments d'oxindole liberant du monoxyde d'azote avec propriétés analgesiques et antiinflammatoires
MXPA02004010A (es) *	1999-10-26	2002-10-23	Univ Texas Southwestern Med Ct	Metodos para tratamiento de perdida capilar que consisten en administrar compuesto de indolina.

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL96047C (fr) *	1956-06-08
US3564009A (en) *	1966-01-13	1971-02-16	Sumitomo Chemical Co	Process for producing 1-acylindole derivatives
BE756447A (fr) *	1969-10-15	1971-03-22	Pfizer	Oxindolecarboxamides
US3923996A (en) *	1972-07-31	1975-12-02	Sandoz Ag	3-Substituted-oxindoles in compositions and methods of treating obesity
IE53102B1 (en) *	1981-05-12	1988-06-22	Ici Plc	Pharmaceutical spiro-succinimide derivatives
DE3268971D1 (en) *	1981-10-06	1986-03-20	Ici Plc	Biochemical process
US4556672A (en) *	1984-03-19	1985-12-03	Pfizer Inc.	3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents
US4752609A (en) *	1985-06-20	1988-06-21	Pfizer Inc.	Analgesic and antiinflammatory 1,3-diacyl-2-oxindole compounds
US5036099A (en) *	1987-02-02	1991-07-30	Pfizer Inc.	Anhydrous, crystalline sodium salt of 5-chloro-3-(2-thenoyl)-2-oxindole-1-carboxamide
EP0365194B1 (fr) *	1988-10-18	1995-08-02	Pfizer Inc.	Prodrogues de 3-aryl-2-oxindole-1-carboxamide antiinflammatoires
US5047554A (en) *	1989-04-18	1991-09-10	Pfizer Inc.	3-substituted-2-oxindole derivatives
US5059693A (en) *	1989-10-06	1991-10-22	Pfizer Inc.	Process for making 3-aroyl-2-oxindole-1-carboxamides

1988
- 1988-10-18 HU HU886740A patent/HU208421B/hu not_active IP Right Cessation
- 1988-10-18 WO PCT/US1988/003658 patent/WO1990004393A1/fr not_active Ceased
- 1988-10-18 US US07/675,883 patent/US5118703A/en not_active Expired - Lifetime
- 1988-10-18 MX MX1802188A patent/MX18021A/es unknown
- 1988-10-18 SK SK5906-89A patent/SK278175B6/sk unknown
- 1988-10-18 RO RO147347A patent/RO109195B1/ro unknown
1989
- 1989-09-20 IS IS3509A patent/IS1598B/is unknown
- 1989-09-28 CA CA000614317A patent/CA1339558C/fr not_active Expired - Fee Related
- 1989-10-04 PH PH39329A patent/PH27554A/en unknown
- 1989-10-09 AT AT89310319T patent/ATE125794T1/de active
- 1989-10-12 IL IL9196089A patent/IL91960A/xx not_active IP Right Cessation
- 1989-10-16 MY MYPI89001415A patent/MY104238A/en unknown
- 1989-10-16 PT PT92000A patent/PT92000B/pt not_active IP Right Cessation
- 1989-10-16 AP APAP/P/1989/000141A patent/AP118A/en active
- 1989-10-16 BG BG090022A patent/BG50834A3/xx unknown
- 1989-10-16 YU YU200589A patent/YU48070B/sh unknown
- 1989-10-17 AR AR89315179A patent/AR246519A1/es active
- 1989-10-17 JP JP1270174A patent/JPH07597B2/ja not_active Expired - Lifetime
- 1989-10-17 AU AU42956/89A patent/AU606819B2/en not_active Ceased
- 1989-10-17 DD DD89333653A patent/DD285604A5/de not_active IP Right Cessation
- 1989-10-17 PL PL89296831A patent/PL163112B1/pl unknown
- 1989-10-17 MA MA21909A patent/MA21657A1/fr unknown
- 1989-10-17 PL PL89281871A patent/PL162316B1/pl unknown
- 1989-10-17 NZ NZ231044A patent/NZ231044A/en unknown
- 1989-10-17 CN CN89107943A patent/CN1022241C/zh not_active Expired - Fee Related
- 1989-10-17 KR KR1019890014914A patent/KR910007237B1/ko not_active Expired
- 1989-10-17 OA OA59665A patent/OA09140A/fr unknown
- 1989-10-17 DK DK514989A patent/DK514989A/da not_active Application Discontinuation
- 1989-10-17 IE IE333289A patent/IE66586B1/en not_active IP Right Cessation
- 1989-10-18 CZ CS895906A patent/CZ278983B6/cs not_active IP Right Cessation
- 1989-10-18 EG EG49689A patent/EG19887A/xx active
1991
- 1991-04-17 FI FI911855A patent/FI95253C/fi not_active IP Right Cessation
- 1991-04-17 NO NO911512A patent/NO178027C/no unknown
- 1991-04-17 RU SU914895525A patent/RU2036905C1/ru active

Also Published As

Publication number	Publication date
IS1598B (is)	1996-05-20
AR246519A1 (es)	1994-08-31
HUT58052A (en)	1992-01-28
ATE125794T1 (de)	1995-08-15
SK590689A3 (en)	1996-03-06
IL91960A0 (en)	1990-07-12
FI95253C (fi)	1996-01-10
PT92000B (pt)	1995-06-30
NO911512D0 (no)	1991-04-17
PT92000A (pt)	1990-04-30
AP8900141A0 (en)	1989-10-31
NO911512L (no)	1991-06-12
WO1990004393A1 (fr)	1990-05-03
JPH07597B2 (ja)	1995-01-11
MY104238A (en)	1994-02-28
FI911855A0 (fi)	1991-04-17
CZ590689A3 (en)	1994-04-13
MA21657A1 (fr)	1990-07-01
RO109195B1 (ro)	1994-12-30
NZ231044A (en)	1990-12-21
NO178027B (no)	1995-10-02
AP118A (en)	1991-02-22
EG19887A (en)	1996-03-31
US5118703A (en)	1992-06-02
YU200589A (en)	1991-02-28
HU208421B (en)	1993-10-28
CN1041938A (zh)	1990-05-09
DK514989D0 (da)	1989-10-17
IE66586B1 (en)	1996-01-24
RU2036905C1 (ru)	1995-06-09
OA09140A (fr)	1991-10-31
PL163112B1 (pl)	1994-02-28
HU886740D0 (en)	1991-07-29
IS3509A7 (is)	1990-04-19
IL91960A (en)	1994-04-12
FI95253B (fi)	1995-09-29
DK514989A (da)	1990-04-19
CN1022241C (zh)	1993-09-29
DD285604A5 (de)	1990-12-19
CZ278983B6 (en)	1994-11-16
BG50834A3 (en)	1992-11-16
NO178027C (no)	1996-01-10
YU48070B (sh)	1997-01-08
MX18021A (es)	1993-11-01
CA1339558C (fr)	1997-11-25
AU606819B2 (en)	1991-02-14
KR910007237B1 (ko)	1991-09-24
SK278175B6 (en)	1996-03-06
KR900006285A (ko)	1990-05-07
PL162316B1 (pl)	1993-09-30
IE893332L (en)	1990-04-18
JPH02149559A (ja)	1990-06-08
AU4295689A (en)	1990-04-26

Publication	Publication Date	Title
PL277466A1 (en)	1989-09-04	Ice-breaker
GB2333292B (en)	2000-01-26	Derivatives of hexaazoisowurtzitane
GB8813297D0 (en)	1988-07-13	Tent-iglu
PH27554A (en)	1993-08-18	Prodrugs of antiinflammatory-3-acyl-2-oxindole-1-carboxamides
EP0429436A3 (en)	1991-12-27	Prodrugs of rapamycin
GB2217729B (en)	1991-10-23	Obtenation of scualane
GB8802421D0 (en)	1988-03-02	Set of parts
ZA897854B (en)	1991-05-29	Prodrugs of antiinflammatory 3-acyl-2-oxindole-1-carboxamines
EP0262852A3 (en)	1989-05-03	Prodrugs of antihypercholoesterolemic compounds
ZA895341B (en)	1990-04-25	Allylaminoethylazoles
GB2226327B (en)	1992-03-25	Purification of 1-amino-2-chloro-4-hydroxyanthraquinone
GB8803491D0 (en)	1988-03-16	New type of shinguard
ZA909799B (en)	1991-10-30	Bruting of gem-stones
ZA898265B (en)	1990-08-29	Deur-en/of vensterraamstelsel
GB8818299D0 (en)	1988-09-07	Brolly mate
IE883488L (en)	1989-05-23	Anti-tumor prodrugs
IE881760L (en)	1988-12-12	Derivatives of n-phenylpyrazoles
CS521788A1 (en)	1990-08-14	Derivatives of trimethoprine
YU11688A (en)	1991-02-28	Derivatives of pyridazodiazepine
PL275148A1 (en)	1990-04-17	Anorching set
AU112246S (en)	1991-09-25	A set of tapware
GB8805779D0 (en)	1988-04-13	Fix right
AU104629S (en)	1989-08-16	Section
AU106020S (en)	1989-11-23	Section
AU106540S (en)	1990-01-30	Section