PH30228A - Reduction products of rapamycin as immuno-suppressants anti-inflammatory or antifungal agents - Google Patents

Reduction products of rapamycin as immuno-suppressants anti-inflammatory or antifungal agents

Info

Publication number: PH30228A
Authority: PH; Philippines
Prior art keywords: rapamycin; suppressants; immuno; inflammatory; antifungal agents
Prior art date: 1991-05-07

Application number

PH44299A

Other languages

English (en)

Inventor

Craig Eugene Caufield

Philip Floyd Hughes

John Henry Musser

Original Assignee

American Home Prod

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-05-07

Filing date

1992-04-30

Publication date

1997-02-05

1991-05-07 Priority claimed from US07/696,692 external-priority patent/US5102876A/en

1991-08-07 Priority claimed from US07/741,714 external-priority patent/US5138051A/en

1992-04-30 Application filed by American Home Prod filed Critical American Home Prod

1997-02-05 Publication of PH30228A publication Critical patent/PH30228A/en

Links

ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 title abstract 2
229960002930 sirolimus Drugs 0.000 title abstract 2
QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 title abstract 2
229940121363 anti-inflammatory agent Drugs 0.000 title 1
239000002260 anti-inflammatory agent Substances 0.000 title 1
230000003110 anti-inflammatory effect Effects 0.000 title 1
229940121375 antifungal agent Drugs 0.000 title 1
239000003429 antifungal agent Substances 0.000 title 1
229960003444 immunosuppressant agent Drugs 0.000 title 1
230000001861 immunosuppressant effect Effects 0.000 title 1
239000003018 immunosuppressive agent Substances 0.000 title 1
208000023275 Autoimmune disease Diseases 0.000 abstract 1
206010007134 Candida infections Diseases 0.000 abstract 1
206010061218 Inflammation Diseases 0.000 abstract 1
SIPUZPBQZHNSDW-UHFFFAOYSA-N bis(2-methylpropyl)aluminum Chemical compound CC(C)C[Al]CC(C)C SIPUZPBQZHNSDW-UHFFFAOYSA-N 0.000 abstract 1
239000003638 chemical reducing agent Substances 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
230000004054 inflammatory process Effects 0.000 abstract 1
125000000468 ketone group Chemical group 0.000 abstract 1
230000000144 pharmacologic effect Effects 0.000 abstract 1
238000006722 reduction reaction Methods 0.000 abstract 1
-1 sodium triacetoxyborohydride Chemical compound 0.000 abstract 1
239000012321 sodium triacetoxyborohydride Substances 0.000 abstract 1
238000002054 transplantation Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Bioinformatics & Cheminformatics (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Diabetes (AREA)
Rheumatology (AREA)
Biochemistry (AREA)
Endocrinology (AREA)
Hematology (AREA)
Obesity (AREA)
Pain & Pain Management (AREA)
Transplantation (AREA)
Emergency Medicine (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

PH44299A 1991-05-07 1992-04-30 Reduction products of rapamycin as immuno-suppressants anti-inflammatory or antifungal agents PH30228A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US07/696,692 US5102876A (en)	1991-05-07	1991-05-07	Reduction products of rapamycin
US07/741,714 US5138051A (en)	1991-08-07	1991-08-07	Rapamycin analogs as immunosuppressants and antifungals

Publications (1)

Publication Number	Publication Date
PH30228A true PH30228A (en)	1997-02-05

Family

ID=27105845

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PH44299A PH30228A (en)	1991-05-07	1992-04-30	Reduction products of rapamycin as immuno-suppressants anti-inflammatory or antifungal agents

Country Status (15)

Country	Link
EP (1)	EP0512754B1 (de)
JP (1)	JP3108192B2 (de)
KR (1)	KR100230877B1 (de)
AT (1)	ATE194352T1 (de)
AU (1)	AU647616B2 (de)
DE (1)	DE69231215T2 (de)
DK (1)	DK0512754T3 (de)
ES (1)	ES2147724T3 (de)
FI (1)	FI97472C (de)
GR (1)	GR3034033T3 (de)
HU (1)	HU217868B (de)
MX (1)	MX9202031A (de)
NZ (1)	NZ242616A (de)
PH (1)	PH30228A (de)
PT (1)	PT512754E (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5776943A (en) *	1991-05-14	1998-07-07	American Home Products Corporation	Rapamycin metabolites
US5118677A (en) *	1991-05-20	1992-06-02	American Home Products Corporation	Amide esters of rapamycin
GB9302567D0 (en) *	1993-02-10	1993-03-24	Smithkline Beecham Plc	Novel compound
CH686761A5 (de)	1993-05-27	1996-06-28	Sandoz Ag	Galenische Formulierungen.
JP3480624B2 (ja)	1995-06-09	2003-12-22	シャープ株式会社	強誘電体薄膜被覆基板、その製造方法、及びキャパシタ構造素子
JP3133922B2 (ja)	1995-06-09	2001-02-13	シャープ株式会社	強誘電体薄膜被覆基板、その製造方法、及びキャパシタ構造素子
US6258823B1 (en) *	1996-07-12	2001-07-10	Ariad Pharmaceuticals, Inc.	Materials and method for treating or preventing pathogenic fungal infection
GB9826882D0 (en)	1998-12-07	1999-01-27	Novartis Ag	Organic compounds

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5023262A (en)	1990-08-14	1991-06-11	American Home Products Corporation	Hydrogenated rapamycin derivatives

1992
- 1992-04-28 FI FI921893A patent/FI97472C/fi not_active IP Right Cessation
- 1992-04-28 JP JP04109579A patent/JP3108192B2/ja not_active Expired - Fee Related
- 1992-04-30 DK DK92303916T patent/DK0512754T3/da active
- 1992-04-30 PH PH44299A patent/PH30228A/en unknown
- 1992-04-30 MX MX9202031A patent/MX9202031A/es unknown
- 1992-04-30 PT PT92303916T patent/PT512754E/pt unknown
- 1992-04-30 ES ES92303916T patent/ES2147724T3/es not_active Expired - Lifetime
- 1992-04-30 EP EP92303916A patent/EP0512754B1/de not_active Expired - Lifetime
- 1992-04-30 DE DE69231215T patent/DE69231215T2/de not_active Expired - Fee Related
- 1992-04-30 AT AT92303916T patent/ATE194352T1/de not_active IP Right Cessation
- 1992-04-30 HU HU9201468A patent/HU217868B/hu not_active IP Right Cessation
- 1992-05-01 KR KR1019920007431A patent/KR100230877B1/ko not_active Expired - Fee Related
- 1992-05-05 NZ NZ24261692A patent/NZ242616A/en unknown
- 1992-05-05 AU AU16008/92A patent/AU647616B2/en not_active Ceased
2000
- 2000-07-27 GR GR20000401723T patent/GR3034033T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
PT512754E (pt)	2000-11-30
FI97472B (fi)	1996-09-13
HUT62589A (en)	1993-05-28
KR100230877B1 (ko)	1999-11-15
NZ242616A (en)	1994-07-26
AU1600892A (en)	1992-11-12
DE69231215D1 (de)	2000-08-10
AU647616B2 (en)	1994-03-24
JPH05117279A (ja)	1993-05-14
FI921893A0 (fi)	1992-04-28
FI921893L (fi)	1992-11-08
EP0512754B1 (de)	2000-07-05
EP0512754A1 (de)	1992-11-11
KR920021553A (ko)	1992-12-18
ES2147724T3 (es)	2000-10-01
JP3108192B2 (ja)	2000-11-13
HU9201468D0 (en)	1992-07-28
HU217868B (hu)	2000-04-28
DK0512754T3 (da)	2000-09-18
GR3034033T3 (en)	2000-11-30
MX9202031A (es)	1992-11-01
FI97472C (fi)	1996-12-27
ATE194352T1 (de)	2000-07-15
DE69231215T2 (de)	2000-11-09

Publication	Publication Date	Title
DE69223583D1 (de)	1998-01-29	Imidazolidyl-Makrolide mit immunosuppressiver Wirkung
IL109580A0 (en)	1994-08-26	Monomeric bile acid derivatives, processes for their preparation and the use of these compounds as medicaments
MX9205137A (es)	1993-04-01	O-heteroaril, o-alquilheteroaril, o-alquenilheteroaril y o-alquinilheteroarilmacrolidas que tienen actividad inmunosupresora.
CA2260777A1 (en)	1998-02-12	Pentafluorobenzenesulfonamides and analogs
PH30228A (en)	1997-02-05	Reduction products of rapamycin as immuno-suppressants anti-inflammatory or antifungal agents
ES2092500T3 (es)	1996-12-01	Derivados de cyclosporin.
MA22906A1 (fr)	1993-12-31	Derives nouveaux de pyrazole substitues sur l'azote, leur procede de production, compositions les contenant et leur utilisation comme herbicides.
AU1058492A (en)	1992-08-06	Improvements in or relating to organic compounds
GR3037059T3 (en)	2002-01-31	Desosamino derivatives of macrolides as immunosuppressants and antifungal agents.
ES2169272T3 (es)	2002-07-01	Diaminopirimidinas, composiciones farmaceuticas que las contienen y su utilizacion como agente antibacteriano.
ATE154615T1 (de)	1997-07-15	Halbsynthetische glykosaminoglykane, die in 3- position mit nukleophilen radikalen substituierte alpha-l-galakturonsäure enthalten
DK177191D0 (da)	1991-10-23	Heterocyclic compounds and their preparation and use
JPS56154473A (en)	1981-11-30	3,4,5,6-tetrahydro-1,2,4,6- thiatriazine(3,5)dione-1,1-dioxide, its manufacture, herbicide containing it, undesirable plant growth regulation and manufacture of herbicide
HUT59412A (en)	1992-05-28	Thieno/3,2-b/pyran-5,7-dione derivatives, process for their application and for the production of these compounds and their intermediates, as well as endoparasiticidal and herbicidal compositions comprising such compounds
ES2058870T3 (es)	1994-11-01	Nuevos compuestos triazolicos.
IL147223A0 (en)	2002-08-14	The use of the protein uk 114 for inhibiting organ transplant rejection
IT1251229B (it)	1995-05-05	Composizioni utili nella terapia delle affezioni del sistema immunitario e delle anemie