PL1633189T3 - Skrócone fragmenty alfa-synukleiny w chorobie z ciałami lewy'ego - Google Patents
Skrócone fragmenty alfa-synukleiny w chorobie z ciałami lewy'egoInfo
- Publication number
- PL1633189T3 PL1633189T3 PL04776059T PL04776059T PL1633189T3 PL 1633189 T3 PL1633189 T3 PL 1633189T3 PL 04776059 T PL04776059 T PL 04776059T PL 04776059 T PL04776059 T PL 04776059T PL 1633189 T3 PL1633189 T3 PL 1633189T3
- Authority
- PL
- Poland
- Prior art keywords
- synuclein
- alpha
- lewy body
- body disease
- truncated fragments
- Prior art date
Links
- 208000009829 Lewy Body Disease Diseases 0.000 title 1
- 201000002832 Lewy body dementia Diseases 0.000 title 1
- 102000003802 alpha-Synuclein Human genes 0.000 title 1
- 108090000185 alpha-Synuclein Proteins 0.000 title 1
- 239000012634 fragment Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1096—Processes for the isolation, preparation or purification of DNA or RNA cDNA Synthesis; Subtracted cDNA library construction, e.g. RT, RT-PCR
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Crystallography & Structural Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Plant Pathology (AREA)
- Environmental Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Psychology (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Bioinformatics & Computational Biology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47192903P | 2003-05-19 | 2003-05-19 | |
| EP04776059.0A EP1633189B1 (en) | 2003-05-19 | 2004-05-19 | Truncated fragments of alpha-synuclein in lewy body disease |
| PCT/US2004/015836 WO2005013889A2 (en) | 2003-05-19 | 2004-05-19 | Truncated fragments of alpha-synuclein in lewy body disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL1633189T3 true PL1633189T3 (pl) | 2017-12-29 |
Family
ID=34135040
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL04776059T PL1633189T3 (pl) | 2003-05-19 | 2004-05-19 | Skrócone fragmenty alfa-synukleiny w chorobie z ciałami lewy'ego |
| PL10189868T PL2361928T3 (pl) | 2003-05-19 | 2004-05-19 | Skrócone fragmenty alfa-synukleiny w chorobie z ciałami Lewy'ego |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL10189868T PL2361928T3 (pl) | 2003-05-19 | 2004-05-19 | Skrócone fragmenty alfa-synukleiny w chorobie z ciałami Lewy'ego |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US7306945B2 (pl) |
| EP (2) | EP1633189B1 (pl) |
| JP (2) | JP4820291B2 (pl) |
| CA (1) | CA2526900C (pl) |
| CY (2) | CY1119133T1 (pl) |
| DK (2) | DK2361928T3 (pl) |
| ES (2) | ES2640669T3 (pl) |
| HU (2) | HUE035044T2 (pl) |
| PL (2) | PL1633189T3 (pl) |
| PT (2) | PT2361928T (pl) |
| SI (2) | SI2361928T1 (pl) |
| WO (1) | WO2005013889A2 (pl) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040146521A1 (en) * | 1999-06-01 | 2004-07-29 | Schenk Dale B. | Prevention and treatment of synucleinopathic disease |
| TW200509968A (en) * | 2002-11-01 | 2005-03-16 | Elan Pharm Inc | Prevention and treatment of synucleinopathic disease |
| US9034337B2 (en) | 2003-10-31 | 2015-05-19 | Prothena Biosciences Limited | Treatment and delay of outset of synucleinopathic and amyloidogenic disease |
| US8506959B2 (en) | 2002-11-01 | 2013-08-13 | Neotope Biosciences Limited | Prevention and treatment of synucleinopathic and amyloidogenic disease |
| US8697082B2 (en) | 2002-11-01 | 2014-04-15 | Neotope Biosciences Limited | Prevention and treatment of synucleinopathic and amyloidogenic disease |
| US20080014194A1 (en) | 2003-10-31 | 2008-01-17 | Elan Pharmaceuticals, Inc. | Prevention and Treatment of Synucleinopathic and Amyloidogenic Disease |
| US7358331B2 (en) * | 2003-05-19 | 2008-04-15 | Elan Pharmaceuticals, Inc. | Truncated fragments of alpha-synuclein in Lewy body disease |
| JP4613824B2 (ja) * | 2003-10-30 | 2011-01-19 | 大正製薬株式会社 | トランスジェニック非ヒト哺乳動物 |
| WO2005047860A2 (en) | 2003-11-08 | 2005-05-26 | Elan Pharmaceuticals, Inc. | Antibodies to alpha-synuclein |
| MX2007001679A (es) | 2004-08-09 | 2007-05-23 | Elan Pharm Inc | Prevencion y tratamiento de la enfermedad sinucleinopatica y amiloidogenica. |
| US20070214509A1 (en) * | 2005-12-23 | 2007-09-13 | The Parkinson's Institute | Methods and systems for identifying compounds that modulate alpha-synuclein aggregation |
| US20090010894A1 (en) * | 2005-12-23 | 2009-01-08 | The Parkinson's Institute | Methods and systems for identifying compounds that modulate alpha-synuclein aggregation |
| LT3067066T (lt) | 2007-02-23 | 2019-06-25 | Prothena Biosciences Limited | Sinukleopatinių ir amiloidogeninių ligų prevencija ir gydymas |
| PL2118300T3 (pl) | 2007-02-23 | 2015-11-30 | Prothena Biosciences Ltd | Zapobieganie i leczenie synukleinopatii i amyloidozy |
| US8147833B2 (en) | 2007-02-23 | 2012-04-03 | Neotope Biosciences Limited | Prevention and treatment of synucleinopathic and amyloidogenic disease |
| AT506535B1 (de) | 2008-02-22 | 2010-04-15 | Affiris Forschungs & Entwicklungs Gmbh | Vaccine enthaltend alpha-synuclein-mimotope auf basis von peptiden |
| AU2009236583B2 (en) * | 2008-04-17 | 2015-07-16 | Declion Holdings Llc | Design and synthesis of directed sequence polymer compositions and antibodies thereof for the treatment of protein conformational disorders |
| DK2282758T3 (en) * | 2008-04-29 | 2019-02-25 | Bioarctic Ab | ANTIBODIES AND VACCINES FOR USE IN THERAPEUTIC AND DIAGNOSTIC PROCEDURES FOR ALPHA-SYNUCLEIN-RELATED DISORDERS |
| AT508638B1 (de) | 2009-08-21 | 2011-08-15 | Affiris Ag | Verwendung von peptiden und polypeptiden zur behandlung und/oder prävention von synukleinopathien |
| JP6006908B2 (ja) * | 2010-11-05 | 2016-10-12 | ブランダイス ユニバーシティBrandeis University | Ice阻害化合物およびその使用 |
| EP2659908A1 (en) | 2012-05-01 | 2013-11-06 | Affiris AG | Compositions |
| EP2659906A1 (en) | 2012-05-01 | 2013-11-06 | Affiris AG | Compositions |
| EP2659907A1 (en) | 2012-05-01 | 2013-11-06 | Affiris AG | Compositions |
| US12156912B2 (en) | 2012-05-18 | 2024-12-03 | Board Of Regents Of The University Of Nebraska | Methods and compositions for inhibiting diseases of the central nervous system |
| JP2017501848A (ja) | 2013-11-19 | 2017-01-19 | プロセナ バイオサイエンシーズ リミテッド | 便秘症状からのレビー小体病の免疫療法のモニター |
| US9732148B2 (en) | 2014-10-16 | 2017-08-15 | Genentech, Inc. | Anti-α-synuclein antibodies and methods of use |
| GB201512203D0 (en) | 2015-07-13 | 2015-08-19 | Lundbeck & Co As H | Agents,uses and methods |
| CN109475616B (zh) | 2016-06-02 | 2022-10-18 | 麦迪穆有限责任公司 | 针对α-突触核蛋白的抗体及其用途 |
| CA3027350A1 (en) * | 2016-07-06 | 2018-01-11 | Prothena Biosciences Limited | Assay for detecting total and s129 phosphorylated alpha-synuclein |
| MA46836A (fr) | 2016-11-15 | 2019-09-25 | H Lundbeck As | Agents, utilisations et procédés pour le traitement d'une synucléinopathie |
| EP3555127B1 (en) | 2016-12-16 | 2024-12-18 | H. Lundbeck A/S | Agents, uses and methods |
| US10364286B2 (en) | 2016-12-22 | 2019-07-30 | H. Lundbeck A/S | Monoclonal anti-alpha-synuclein antibodies for preventing tau aggregation |
| EA201991720A1 (ru) | 2017-02-17 | 2020-01-20 | Бристол-Маерс Сквибб Компани | Антитела к альфа-синуклеину и их применения |
| GB201720970D0 (en) | 2017-12-15 | 2018-01-31 | Ucb Biopharma Sprl | Antibodies |
| GB201720975D0 (en) | 2017-12-15 | 2018-01-31 | Ucb Biopharma Sprl | Anti-alpha synuclein antibodies |
| US20210032369A1 (en) * | 2018-02-12 | 2021-02-04 | The Scripps Research Institute | Methods related to parkinson?s disease and synucleinopathies |
| CN112105393A (zh) | 2018-05-16 | 2020-12-18 | 爱默蕾大学 | 苯乙烯基苯并噻唑衍生物及在成像中的用途 |
| WO2020132275A1 (en) * | 2018-12-19 | 2020-06-25 | Ubi Ip Holdings | Artificial promiscuous t helper cell epitopes as immune stimulators for synthetic peptide immunogens |
| IL300364A (en) | 2020-08-04 | 2023-04-01 | Ac Immune Sa | immunogenic substances |
| KR102505164B1 (ko) * | 2020-09-29 | 2023-02-28 | 서울대학교산학협력단 | 신경퇴행성 질환의 예방 또는 치료용 펩타이드 및 이를 포함하는 약학 조성물 |
| CA3230055A1 (en) | 2021-09-16 | 2023-03-23 | Josefine Nielsen Soderberg | Compositions and methods for treating synucleinopathies |
| US20250012814A1 (en) | 2021-11-01 | 2025-01-09 | Nitrase Therapeutics, Inc. | Methods of diagnosing a synucleinopathy |
| EP4733299A1 (en) | 2023-05-22 | 2026-04-29 | Shenzhen Braegen Pharmaceutical Co., Ltd. | Sulfur-containing fused ring compound, pharmaceutical composition containing same, and preparation method therefor and use thereof |
| WO2025172592A1 (en) | 2024-02-15 | 2025-08-21 | Ac Immune Sa | Alpha synuclein therapeutic vaccine |
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-
2004
- 2004-05-19 PL PL04776059T patent/PL1633189T3/pl unknown
- 2004-05-19 DK DK10189868.2T patent/DK2361928T3/en active
- 2004-05-19 ES ES04776059.0T patent/ES2640669T3/es not_active Expired - Lifetime
- 2004-05-19 PL PL10189868T patent/PL2361928T3/pl unknown
- 2004-05-19 EP EP04776059.0A patent/EP1633189B1/en not_active Expired - Lifetime
- 2004-05-19 PT PT101898682T patent/PT2361928T/pt unknown
- 2004-05-19 HU HUE10189868A patent/HUE035044T2/en unknown
- 2004-05-19 HU HUE04776059A patent/HUE034320T2/en unknown
- 2004-05-19 PT PT47760590T patent/PT1633189T/pt unknown
- 2004-05-19 SI SI200432398A patent/SI2361928T1/sl unknown
- 2004-05-19 EP EP10189868.2A patent/EP2361928B1/en not_active Expired - Lifetime
- 2004-05-19 DK DK04776059.0T patent/DK1633189T3/en active
- 2004-05-19 ES ES10189868.2T patent/ES2632216T3/es not_active Expired - Lifetime
- 2004-05-19 JP JP2006514909A patent/JP4820291B2/ja not_active Expired - Lifetime
- 2004-05-19 WO PCT/US2004/015836 patent/WO2005013889A2/en not_active Ceased
- 2004-05-19 CA CA2526900A patent/CA2526900C/en not_active Expired - Fee Related
- 2004-05-19 SI SI200432403T patent/SI1633189T1/sl unknown
- 2004-10-19 US US10/969,335 patent/US7306945B2/en not_active Expired - Lifetime
-
2010
- 2010-09-10 JP JP2010203787A patent/JP5766923B2/ja not_active Expired - Fee Related
-
2017
- 2017-07-12 CY CY20171100744T patent/CY1119133T1/el unknown
- 2017-09-20 CY CY20171100989T patent/CY1119556T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20050198694A1 (en) | 2005-09-08 |
| CY1119133T1 (el) | 2018-02-14 |
| JP5766923B2 (ja) | 2015-08-19 |
| WO2005013889A3 (en) | 2005-04-28 |
| SI1633189T1 (sl) | 2017-12-29 |
| EP1633189A2 (en) | 2006-03-15 |
| CA2526900A1 (en) | 2005-02-17 |
| EP1633189A4 (en) | 2006-07-19 |
| EP2361928B1 (en) | 2017-04-26 |
| JP2011033633A (ja) | 2011-02-17 |
| PT1633189T (pt) | 2017-10-04 |
| WO2005013889A2 (en) | 2005-02-17 |
| JP2007525464A (ja) | 2007-09-06 |
| HUE034320T2 (en) | 2018-02-28 |
| PT2361928T (pt) | 2017-07-21 |
| ES2640669T3 (es) | 2017-11-03 |
| SI2361928T1 (sl) | 2017-07-31 |
| HUE035044T2 (en) | 2018-05-02 |
| EP1633189B1 (en) | 2017-07-05 |
| EP2361928A1 (en) | 2011-08-31 |
| DK1633189T3 (en) | 2017-08-21 |
| DK2361928T3 (en) | 2017-07-03 |
| ES2632216T3 (es) | 2017-09-11 |
| CA2526900C (en) | 2015-11-24 |
| CY1119556T1 (el) | 2018-03-07 |
| US7306945B2 (en) | 2007-12-11 |
| JP4820291B2 (ja) | 2011-11-24 |
| PL2361928T3 (pl) | 2017-09-29 |
| WO2005013889A9 (en) | 2005-06-02 |
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