PL1646613T3 - Chinolinowe i chinazolinowe pochodne mające powinowactwo do receptorów typu 5HT1 - Google Patents
Chinolinowe i chinazolinowe pochodne mające powinowactwo do receptorów typu 5HT1Info
- Publication number
- PL1646613T3 PL1646613T3 PL04763307T PL04763307T PL1646613T3 PL 1646613 T3 PL1646613 T3 PL 1646613T3 PL 04763307 T PL04763307 T PL 04763307T PL 04763307 T PL04763307 T PL 04763307T PL 1646613 T3 PL1646613 T3 PL 1646613T3
- Authority
- PL
- Poland
- Prior art keywords
- quinoline
- affinity
- quinazoline derivatives
- type receptors
- receptors
- Prior art date
Links
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical compound N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 title 2
- 125000002294 quinazolinyl group Chemical class N1=C(N=CC2=CC=CC=C12)* 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
- C04B35/622—Forming processes; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
- C04B35/626—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B
- C04B35/63—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B using additives specially adapted for forming the products, e.g.. binder binders
- C04B35/632—Organic additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Manufacturing & Machinery (AREA)
- Ceramic Engineering (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Inorganic Chemistry (AREA)
- Psychiatry (AREA)
- Materials Engineering (AREA)
- Structural Engineering (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0316915.8A GB0316915D0 (en) | 2003-07-18 | 2003-07-18 | Compounds |
| PCT/EP2004/008000 WO2005014552A1 (en) | 2003-07-18 | 2004-07-15 | Quinoline and quinazoline derivatives having affinity for 5ht1-type receptors |
| EP04763307A EP1646613B1 (en) | 2003-07-18 | 2004-07-15 | Quinoline and quinazoline derivatives having affinity for 5ht1-type receptors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL1646613T3 true PL1646613T3 (pl) | 2008-08-29 |
Family
ID=27764115
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL04763307T PL1646613T3 (pl) | 2003-07-18 | 2004-07-15 | Chinolinowe i chinazolinowe pochodne mające powinowactwo do receptorów typu 5HT1 |
Country Status (28)
| Country | Link |
|---|---|
| US (5) | US7279481B2 (pl) |
| EP (3) | EP1876174B1 (pl) |
| JP (1) | JP2006528146A (pl) |
| KR (1) | KR20060041242A (pl) |
| CN (1) | CN100441571C (pl) |
| AR (1) | AR046394A1 (pl) |
| AT (2) | ATE389637T1 (pl) |
| AU (1) | AU2004263268B2 (pl) |
| BR (1) | BRPI0412695A (pl) |
| CA (1) | CA2532452A1 (pl) |
| CY (1) | CY1107974T1 (pl) |
| DE (2) | DE602004012564T2 (pl) |
| DK (1) | DK1646613T3 (pl) |
| ES (2) | ES2336148T3 (pl) |
| GB (1) | GB0316915D0 (pl) |
| HR (1) | HRP20080226T3 (pl) |
| IL (1) | IL173036A0 (pl) |
| IS (1) | IS2744B (pl) |
| MA (1) | MA27926A1 (pl) |
| MX (1) | MXPA06000716A (pl) |
| NO (1) | NO20060774L (pl) |
| NZ (1) | NZ544586A (pl) |
| PL (1) | PL1646613T3 (pl) |
| PT (1) | PT1646613E (pl) |
| RU (1) | RU2402533C2 (pl) |
| SI (1) | SI1646613T1 (pl) |
| TW (1) | TW200521115A (pl) |
| WO (1) | WO2005014552A1 (pl) |
Families Citing this family (52)
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|---|---|---|---|---|
| ATE424825T1 (de) | 2001-07-20 | 2009-03-15 | Psychogenics Inc | Behandlung von hyperaktivitätsstörungen und aufmerksamkeitsdefiziten |
| GB0316915D0 (en) | 2003-07-18 | 2003-08-20 | Glaxo Group Ltd | Compounds |
| JP5080970B2 (ja) * | 2004-06-17 | 2012-11-21 | サイトキネティクス・インコーポレーテッド | 心疾患を治療するための置換尿素誘導体 |
| KR100817538B1 (ko) * | 2006-07-05 | 2008-03-27 | 한국화학연구원 | 신규 치환된―１ｈ―퀴나졸린―２,４―디온 유도체, 이의제조방법 및 이를 함유하는 약학적 조성물 |
| JP2010513569A (ja) * | 2006-12-19 | 2010-04-30 | ユニバーシティ オブ バージニア パテント ファウンデーション | アルコール摂取に対するトピラメートおよびオンダンセトロンの併用効果 |
| CA2677205A1 (en) * | 2007-01-31 | 2008-08-07 | University Of Virginia Patent Foundation | Topiramate plus naltrexone for the treatment of addictive disorders |
| EP2016943B1 (en) | 2007-07-19 | 2011-02-23 | Laboratorios del Dr. Esteve S.A. | Substituted tetrahydro-quinoline-sulfonamide compounds, their preparation and use as medicaments |
| WO2009029308A1 (en) * | 2007-08-27 | 2009-03-05 | University Of Virginia Patent Foundation | Medication combinations for the treatment of alcoholism and drug addiction |
| MX2010009509A (es) | 2008-02-28 | 2010-11-30 | Univ Virginia | Gen transportador de serotonina y tratamiento de alcoholismo. |
| WO2009132202A2 (en) | 2008-04-24 | 2009-10-29 | Incyte Corporation | Macrocyclic compounds and their use as kinase inhibitors |
| EP2116205B1 (en) * | 2008-05-06 | 2010-12-29 | BIEDERMANN MOTECH GmbH | Rod-shaped implant, in particular for the dynamic stabilization of the spine |
| US20100298397A1 (en) * | 2009-05-19 | 2010-11-25 | Singh Nikhilesh N | Method of treatment of obsessive compulsive disorder with ondansetron |
| CN101671336B (zh) | 2009-09-23 | 2013-11-13 | 辽宁利锋科技开发有限公司 | 芳杂环并嘧啶衍生物和类似物及其制备方法和用途 |
| EP2308850A1 (en) * | 2009-10-06 | 2011-04-13 | Laboratorios Del. Dr. Esteve, S.A. | Heterocycyl-substituted-alkylamino phenyl derivatives, their preparation and use as medicaments |
| EA024450B1 (ru) | 2010-07-02 | 2016-09-30 | Юниверсити Оф Вирджиния Пэтент Фаундейшн | Молекулярно-генетический подход к лечению и диагностике алкогольной и наркотической зависимости |
| KR20140052018A (ko) | 2011-08-09 | 2014-05-02 | 다케다 야쿠힌 고교 가부시키가이샤 | 시클로프로판아민 화합물 |
| EP2751137A4 (en) | 2011-09-09 | 2015-06-03 | Univ Virginia Patent Found | MOLECULAR GENETIC APPROACH FOR THE TREATMENT AND DIAGNOSIS OF ALCOHOL AND DRUG INDEPENDENCE |
| GB201117313D0 (en) | 2011-10-07 | 2011-11-16 | Gt Biolog Ltd | Bacterium for use in medicine |
| JP6345651B2 (ja) * | 2012-05-09 | 2018-06-20 | サノビオン ファーマシューティカルズ インクＳｕｎｏｖｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． | ヘテロアリール化合物及びその使用方法 |
| CN103508927A (zh) * | 2012-06-25 | 2014-01-15 | 天津药物研究院 | 一种2-甲磺酰氨基二苯醚的制备方法 |
| CN105051005B (zh) | 2012-10-12 | 2017-06-13 | 武田药品工业株式会社 | 环丙胺化合物及其用途 |
| GB201306536D0 (en) | 2013-04-10 | 2013-05-22 | Gt Biolog Ltd | Polypeptide and immune modulation |
| US9663463B2 (en) | 2013-11-20 | 2017-05-30 | Sanwa Kagaku Kenkyusho Co., Ltd. | 3-azabicyclo[3.1.0]hexane derivative and use thereof for medical purpose |
| AR099994A1 (es) | 2014-04-11 | 2016-08-31 | Takeda Pharmaceuticals Co | Compuesto de ciclopropanamina y sus usos |
| WO2016075314A1 (fr) | 2014-11-13 | 2016-05-19 | Institut National De La Recherche Agronomique | Identification de facteurs de transcription de yarrowia lipolytica affectant la production de proteines |
| FR3028527A1 (fr) | 2014-11-13 | 2016-05-20 | Pivert | Identification de facteurs de transcription de yarrowia lipolytica |
| SG11201704814SA (en) | 2014-12-23 | 2017-07-28 | 4D Pharma Res Ltd | Pirin polypeptide and immune modulation |
| WO2016102950A1 (en) | 2014-12-23 | 2016-06-30 | 4D Pharma Research Limited | Immune modulation |
| MA41010B1 (fr) | 2015-06-15 | 2020-01-31 | 4D Pharma Res Ltd | Compositions comprenant des souches bactériennes |
| HRP20191949T1 (hr) | 2015-06-15 | 2020-01-24 | 4D Pharma Research Limited | Blautia stercosis i wexlerae za upotrebu u liječenju upalnih i autoimunih bolesti |
| ME03511B (me) | 2015-06-15 | 2020-04-20 | 4D Pharma Res Ltd | Kompozicije koje sadrže bakterijske sojeve |
| MA41060B1 (fr) | 2015-06-15 | 2019-11-29 | 4D Pharma Res Ltd | Compositions comprenant des souches bactériennes |
| WO2016203221A1 (en) | 2015-06-15 | 2016-12-22 | 4D Pharma Research Limited | Compositions comprising bacterial strains |
| GB201520497D0 (en) | 2015-11-20 | 2016-01-06 | 4D Pharma Res Ltd | Compositions comprising bacterial strains |
| HK1254843B (zh) | 2015-11-20 | 2020-04-17 | 希杰生物科技株式会社 | 包含细菌菌株的组合物 |
| SG10201913557TA (en) | 2016-03-04 | 2020-02-27 | 4D Pharma Plc | Compositions comprising bacterial blautia strains for treating visceral hypersensitivity |
| GB201612191D0 (en) | 2016-07-13 | 2016-08-24 | 4D Pharma Plc | Compositions comprising bacterial strains |
| TWI802545B (zh) | 2016-07-13 | 2023-05-21 | 英商４Ｄ製藥有限公司 | 包含細菌菌株之組合物 |
| GB201621123D0 (en) | 2016-12-12 | 2017-01-25 | 4D Pharma Plc | Compositions comprising bacterial strains |
| ES2877726T3 (es) | 2017-05-22 | 2021-11-17 | 4D Pharma Res Ltd | Composiciones que comprenden cepas bacterianas |
| EP3630942B1 (en) | 2017-05-24 | 2022-11-30 | 4D Pharma Research Limited | Compositions comprising bacterial strain |
| TWI812624B (zh) | 2017-06-14 | 2023-08-21 | 南韓商希杰生物科技股份有限公司 | 包含細菌品系之組成物 |
| PL3600363T3 (pl) | 2017-06-14 | 2021-06-14 | 4D Pharma Research Limited | Kompozycje zawierające szczepy bakteryjne |
| ES2841902T3 (es) | 2017-06-14 | 2021-07-12 | 4D Pharma Res Ltd | Composiciones que comprenden cepas bacterianas |
| CN108047143A (zh) * | 2017-12-18 | 2018-05-18 | 刘凤娟 | 一种用于治疗功能性胃肠病的5-羟色胺受体拮抗剂的合成方法 |
| CN112654621B (zh) | 2018-06-27 | 2024-05-14 | 百时美施贵宝公司 | 可作为t细胞活化剂的经取代萘啶酮化合物 |
| PT3814347T (pt) | 2018-06-27 | 2023-07-18 | Bristol Myers Squibb Co | Compostos de naftiridinona úteis como ativadores de células t |
| AR119821A1 (es) | 2019-08-28 | 2022-01-12 | Bristol Myers Squibb Co | Compuestos de piridopirimidinonilo sustituidos útiles como activadores de células t |
| AR120823A1 (es) | 2019-12-23 | 2022-03-23 | Bristol Myers Squibb Co | Compuestos bicíclicos sustituidos útiles como activadores de células t |
| EP4081522A1 (en) | 2019-12-23 | 2022-11-02 | Bristol-Myers Squibb Company | Substituted piperazine derivatives useful as t cell activators |
| CN114846007B (zh) | 2019-12-23 | 2024-11-22 | 百时美施贵宝公司 | 可用作t细胞激活剂的经取代的喹唑啉基化合物 |
| CN118308475B (zh) * | 2024-03-18 | 2024-11-26 | 安徽医科大学第一附属医院 | Htr1b作为胚胎发育停滞的诊断标志物和治疗靶点方面的应用 |
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| GB0316915D0 (en) | 2003-07-18 | 2003-08-20 | Glaxo Group Ltd | Compounds |
| US20050124625A1 (en) * | 2003-10-21 | 2005-06-09 | Salvati Mark E. | Piperazine derivatives and their use as modulators of nuclear hormone receptor function |
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| JP2007527901A (ja) | 2004-03-10 | 2007-10-04 | アルタナ ファルマ アクチエンゲゼルシャフト | アミド置換された新規のヒドロキシ−６−フェニルフェナントリジン及びｐｄｅ４インヒビターとしてのそれらの使用 |
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-
2003
- 2003-07-18 GB GBGB0316915.8A patent/GB0316915D0/en not_active Ceased
-
2004
- 2004-07-15 CA CA002532452A patent/CA2532452A1/en not_active Abandoned
- 2004-07-15 ES ES07118193T patent/ES2336148T3/es not_active Expired - Lifetime
- 2004-07-15 DE DE602004012564T patent/DE602004012564T2/de not_active Expired - Lifetime
- 2004-07-15 US US10/565,066 patent/US7279481B2/en not_active Expired - Fee Related
- 2004-07-15 MX MXPA06000716A patent/MXPA06000716A/es active IP Right Grant
- 2004-07-15 AT AT04763307T patent/ATE389637T1/de active
- 2004-07-15 AU AU2004263268A patent/AU2004263268B2/en not_active Ceased
- 2004-07-15 SI SI200430699T patent/SI1646613T1/sl unknown
- 2004-07-15 DE DE602004024141T patent/DE602004024141D1/de not_active Expired - Lifetime
- 2004-07-15 RU RU2006104993/04A patent/RU2402533C2/ru not_active IP Right Cessation
- 2004-07-15 NZ NZ544586A patent/NZ544586A/en unknown
- 2004-07-15 DK DK04763307T patent/DK1646613T3/da active
- 2004-07-15 HR HR20080226T patent/HRP20080226T3/xx unknown
- 2004-07-15 AT AT07118193T patent/ATE448205T1/de not_active IP Right Cessation
- 2004-07-15 KR KR1020067001103A patent/KR20060041242A/ko not_active Ceased
- 2004-07-15 EP EP07118193A patent/EP1876174B1/en not_active Expired - Lifetime
- 2004-07-15 PT PT04763307T patent/PT1646613E/pt unknown
- 2004-07-15 EP EP04763307A patent/EP1646613B1/en not_active Expired - Lifetime
- 2004-07-15 WO PCT/EP2004/008000 patent/WO2005014552A1/en not_active Ceased
- 2004-07-15 PL PL04763307T patent/PL1646613T3/pl unknown
- 2004-07-15 JP JP2006520756A patent/JP2006528146A/ja not_active Ceased
- 2004-07-15 EP EP09175186A patent/EP2145622A1/en not_active Withdrawn
- 2004-07-15 CN CNB2004800270575A patent/CN100441571C/zh not_active Expired - Fee Related
- 2004-07-15 ES ES04763307T patent/ES2302543T3/es not_active Expired - Lifetime
- 2004-07-15 BR BRPI0412695-5A patent/BRPI0412695A/pt not_active IP Right Cessation
- 2004-07-16 TW TW093121227A patent/TW200521115A/zh unknown
- 2004-07-16 AR ARP040102527A patent/AR046394A1/es not_active Application Discontinuation
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2006
- 2006-01-09 IL IL173036A patent/IL173036A0/en unknown
- 2006-01-18 MA MA28738A patent/MA27926A1/fr unknown
- 2006-02-15 IS IS8304A patent/IS2744B/is unknown
- 2006-02-17 NO NO20060774A patent/NO20060774L/no not_active Application Discontinuation
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2007
- 2007-03-16 US US11/687,098 patent/US7459456B2/en not_active Expired - Fee Related
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2008
- 2008-05-29 CY CY20081100555T patent/CY1107974T1/el unknown
- 2008-07-02 US US12/166,547 patent/US7592346B2/en not_active Expired - Fee Related
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2009
- 2009-08-13 US US12/540,452 patent/US7732600B2/en not_active Expired - Fee Related
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2010
- 2010-04-23 US US12/766,053 patent/US20100204273A1/en not_active Abandoned
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