PL1668002T3 - 2,4-diokso-3-chinazolinyloarylowe pochodne sulfonylomocznika - Google Patents

2,4-diokso-3-chinazolinyloarylowe pochodne sulfonylomocznika

Info

Publication number: PL1668002T3
Authority: PL; Poland
Prior art keywords: sub; sup; group; alkyl; member selected
Prior art date: 2003-10-03

Application number

PL04789522T

Other languages

English (en)

Inventor

Robert M Scarborough

Wolin Huang

Anjali Pandey

Shawn M Bauer

Xiaoming Zhang

Zhaozhong J Jia

Original Assignee

Portola Pharm Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-10-03

Filing date

2004-09-29

Publication date

2010-02-26

2004-09-29 Application filed by Portola Pharm Inc filed Critical Portola Pharm Inc

2010-02-26 Publication of PL1668002T3 publication Critical patent/PL1668002T3/pl

Links

229940100389 Sulfonylurea Drugs 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 4
229910052799 carbon Inorganic materials 0.000 abstract 4
JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
208000007536 Thrombosis Diseases 0.000 abstract 2
125000003545 alkoxy group Chemical group 0.000 abstract 2
125000001188 haloalkyl group Chemical group 0.000 abstract 2
125000005647 linker group Chemical group 0.000 abstract 2
UHOVQNZJYSORNB-UHFFFAOYSA-N monobenzene Natural products C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 2
CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical group C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000000304 alkynyl group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
230000005764 inhibitory process Effects 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Chemical group COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
208000010110 spontaneous platelet aggregation Diseases 0.000 abstract 1
YROXIXLRRCOBKF-UHFFFAOYSA-N sulfonylurea Chemical class OC(=N)N=S(=O)=O YROXIXLRRCOBKF-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Hematology (AREA)
Surgery (AREA)
Diabetes (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Non-Alcoholic Beverages (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Hydrogenated Pyridines (AREA)

PL04789522T 2003-10-03 2004-09-29 2,4-diokso-3-chinazolinyloarylowe pochodne sulfonylomocznika PL1668002T3 (pl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US50856403P	2003-10-03	2003-10-03
EP04789522A EP1668002B1 (en)	2003-10-03	2004-09-29	2,4-dioxo-3-quinazolinylaryl sulfonylureas
PCT/US2004/032921 WO2005032488A2 (en)	2003-10-03	2004-09-29	2,4-dioxo-3-quinazolinylaryl sulfonylureas

Publications (1)

Publication Number	Publication Date
PL1668002T3 true PL1668002T3 (pl)	2010-02-26

Family

ID=34421757

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL04789522T PL1668002T3 (pl)	2003-10-03	2004-09-29	2,4-diokso-3-chinazolinyloarylowe pochodne sulfonylomocznika

Country Status (15)

Country	Link
US (1)	US7109332B2 (pl)
EP (1)	EP1668002B1 (pl)
JP (1)	JP2007507551A (pl)
KR (1)	KR20060113700A (pl)
CN (1)	CN1863798B (pl)
AT (1)	ATE448222T1 (pl)
AU (1)	AU2004278030C1 (pl)
CA (1)	CA2540214A1 (pl)
DE (1)	DE602004024093D1 (pl)
ES (1)	ES2334795T3 (pl)
IL (1)	IL174446A (pl)
MX (1)	MXPA06003618A (pl)
PL (1)	PL1668002T3 (pl)
PT (1)	PT1668002E (pl)
WO (1)	WO2005032488A2 (pl)

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BRPI0418026A (pt) *	2003-12-22	2007-04-17	Ajinomoto Kk	derivados de fenilalanina ou sais farmaceuticamente aceitáveis destes, composição farmacêutica, antagonista de alfa4 integrina, e, agente terapêutico ou agente preventivo para doenças
WO2006039212A2 (en) *	2004-09-29	2006-04-13	Portola Pharmaceuticals, Inc.	Substituted 2h-1,3-benzoxazin-4(3h)-ones
CA2627719C (en) *	2005-11-03	2016-07-12	Portola Pharmaceuticals, Inc.	[4-(6-halo-7-substituted-2,4-dioxo-1,4-dihydro-2h-quinazolin-3-yl)-phenyl]-5-chloro-thiophen-2-yl-sulfonylureas and forms and methods related thereto
US7834023B2 (en)	2006-09-20	2010-11-16	Portola Pharmaceuticals, Inc.	Substituted dihydroquinazolines as platelet ADP receptor inhibitors
CA2682207A1 (en) *	2007-04-05	2008-10-16	Cv Therapeutics, Inc.	Quinazolinone derivatives as aldh-2 inhibitors
WO2008133155A1 (ja)	2007-04-19	2008-11-06	Astellas Pharma Inc.	二環式ヘテロ環化合物
CA2686221A1 (en) *	2007-05-02	2008-11-13	Portola Pharmaceuticals, Inc.	[4-(6-fluoro-7-methylamino-2,4-dioxo-1,4-dihydro-2h-quinazolin-3-yl)-phenyl]-5-chloro-thiophen-2-yl-sulfonylurea salts, forms and methods related thereto
CN101654441B (zh) *	2008-08-19	2012-10-03	信谊药厂	抗凝化合物、组合物及其用途
RU2538965C2 (ru)	2009-01-19	2015-01-10	Эббви Инк.	Вызывающие апоптоз средства для лечения рака и иммунных и аутоиммунных заболеваний
NZ616828A (en)	2009-01-19	2015-03-27	Abbvie Inc	Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
MX2014005304A (es)	2011-10-31	2015-03-20	Xenon Pharmaceuticals Inc	Biaril eter sulfonamidas y su uso como agentes terapeuticos.
ES2586213T3 (es)	2011-10-31	2016-10-13	Xenon Pharmaceuticals Inc.	Compuestos de bencenosulfonamida y su uso como agentes terapéuticos
CA2874621A1 (en)	2012-05-22	2013-11-28	Genentech, Inc.	N-substituted benzamides and their use in the treatment of pain
US10071957B2 (en)	2012-07-06	2018-09-11	Genentech, Inc.	N-substituted benzamides and methods of use thereof
CN105263490B (zh)	2013-03-14	2018-05-22	基因泰克公司	取代的三唑并吡啶及其使用方法
CA2898680A1 (en)	2013-03-15	2014-09-18	Genentech,Inc.	Substituted benzoxazoles and methods of use thereof
JP6383418B2 (ja)	2013-11-27	2018-08-29	ジェネンテック，インコーポレイテッド	置換ベンズアミド及びその使用方法
CN106715418A (zh)	2014-07-07	2017-05-24	基因泰克公司	治疗化合物及其使用方法
JP6929792B2 (ja)	2015-02-16	2021-09-01	ザユニバーシティオブクィーンズランド	スルホニル尿素及び関連化合物並びにその使用
MA42118A (fr)	2015-05-22	2018-03-28	Genentech Inc	Benzamides substitués et leurs méthodes d'utilisation
WO2017035271A1 (en)	2015-08-27	2017-03-02	Genentech, Inc.	Therapeutic compounds and methods of use thereof
JP6987746B2 (ja)	2015-09-28	2022-01-05	ジェネンテック，インコーポレイテッド	治療用化合物及びその使用方法
US10899732B2 (en)	2015-11-25	2021-01-26	Genentech, Inc.	Substituted benzamides useful as sodium channel blockers
US10766858B2 (en)	2016-03-30	2020-09-08	Genentech, Inc.	Substituted benzamides and methods of use thereof
BR112019007763A2 (pt)	2016-10-17	2019-07-02	Genentech Inc	composto de fórmula, composição farmacêutica, métodos para tratar uma doença ou condição, para tratar dores, para diminuir o fluxo de íons e para tratar prurido, uso de um composto e invenção
EP3601273B1 (en)	2017-03-24	2021-12-01	Genentech, Inc.	4-piperidin-n-(pyrimidin-4-yl)chroman-7-sulfonamide derivatives as sodium channel inhibitors
CN110914256A (zh)	2017-07-07	2020-03-24	英夫拉索姆有限公司	新颖磺酰胺羧酰胺化合物
TW201910317A (zh)	2017-08-15	2019-03-16	愛爾蘭商英弗雷佐姆有限公司	新穎化合物
WO2019034693A1 (en)	2017-08-15	2019-02-21	Inflazome Limited	SULFONYLURATES AND SULFONYLTHIOURES AS INHIBITORS OF NLRP3
MX2020001776A (es)	2017-08-15	2020-03-24	Inflazome Ltd	Sulfonilureas y sulfoniltioureas como inhibidores de nlrp3.
CN111315733A (zh)	2017-11-09	2020-06-19	英夫拉索姆有限公司	新颖磺酰胺甲酰胺化合物
WO2019092171A1 (en)	2017-11-09	2019-05-16	Inflazome Limited	Novel sulfonamide carboxamide compounds
AR114263A1 (es)	2018-02-26	2020-08-12	Genentech Inc	Compuestos terapéuticos y métodos para utilizarlos
WO2019166619A1 (en)	2018-03-02	2019-09-06	Inflazome Limited	Novel compounds
WO2019191702A1 (en)	2018-03-30	2019-10-03	F. Hoffmann-La Roche Ag	Substituted hydro-pyrido-azines as sodium channel inhibitors
TW202003490A (zh)	2018-05-22	2020-01-16	瑞士商赫孚孟拉羅股份公司	治療性化合物及其使用方法
CA3116141C (en)	2018-12-06	2023-09-05	Daiichi Sankyo Company, Limited	Cycloalkane-1,3-diamine derivative

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SE9702774D0 (sv)	1997-07-22	1997-07-22	Astra Pharma Prod	Novel compounds
CA2318199A1 (en)	1998-01-15	1999-07-22	Cor Therapeutics, Inc.	Platelet adp receptor inhibitors
WO2001057037A1 (en) *	2000-02-04	2001-08-09	Cor Therapeutics, Inc.	Platelet adp receptor inhibitors
US6906063B2 (en)	2000-02-04	2005-06-14	Portola Pharmaceuticals, Inc.	Platelet ADP receptor inhibitors

2004
- 2004-09-29 PL PL04789522T patent/PL1668002T3/pl unknown
- 2004-09-29 CN CN2004800287913A patent/CN1863798B/zh not_active Expired - Fee Related
- 2004-09-29 MX MXPA06003618A patent/MXPA06003618A/es active IP Right Grant
- 2004-09-29 EP EP04789522A patent/EP1668002B1/en not_active Expired - Lifetime
- 2004-09-29 ES ES04789522T patent/ES2334795T3/es not_active Expired - Lifetime
- 2004-09-29 CA CA002540214A patent/CA2540214A1/en not_active Abandoned
- 2004-09-29 AU AU2004278030A patent/AU2004278030C1/en not_active Ceased
- 2004-09-29 AT AT04789522T patent/ATE448222T1/de active
- 2004-09-29 US US10/956,004 patent/US7109332B2/en not_active Expired - Fee Related
- 2004-09-29 KR KR1020067008644A patent/KR20060113700A/ko not_active Ceased
- 2004-09-29 PT PT04789522T patent/PT1668002E/pt unknown
- 2004-09-29 JP JP2006534290A patent/JP2007507551A/ja active Pending
- 2004-09-29 DE DE602004024093T patent/DE602004024093D1/de not_active Expired - Lifetime
- 2004-09-29 WO PCT/US2004/032921 patent/WO2005032488A2/en not_active Ceased
2006
- 2006-03-21 IL IL174446A patent/IL174446A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
WO2005032488A2 (en)	2005-04-14
WO2005032488A3 (en)	2005-05-12
IL174446A (en)	2012-02-29
MXPA06003618A (es)	2006-08-11
DE602004024093D1 (de)	2009-12-24
CN1863798B (zh)	2011-08-31
EP1668002A2 (en)	2006-06-14
KR20060113700A (ko)	2006-11-02
US7109332B2 (en)	2006-09-19
PT1668002E (pt)	2009-11-25
AU2004278030B2 (en)	2010-07-01
AU2004278030C1 (en)	2010-12-02
CN1863798A (zh)	2006-11-15
HK1093973A1 (en)	2007-03-16
ATE448222T1 (de)	2009-11-15
ES2334795T3 (es)	2010-03-16
JP2007507551A (ja)	2007-03-29
EP1668002A4 (en)	2006-12-20
US20050107357A1 (en)	2005-05-19
EP1668002B1 (en)	2009-11-11
AU2004278030A1 (en)	2005-04-14
CA2540214A1 (en)	2005-04-14
IL174446A0 (en)	2006-08-01

Publication	Publication Date	Title
EP1668002A4 (en)	2006-12-20	2,4-dioxo-3-CHINAZOLINYLARYLSULFONYLHARNSTOFFE
BG104248A (en)	2001-08-31	Benzamidoxim derivatives, intermediate products and methods for preparing and using them as fungicides
MXPA04004457A (es)	2005-06-08	Novedosos derivados de 1,2,4-tiadiazolio como moduladores del receptor de melanocortina.
GR3034398T3 (en)	2000-12-29	2-[1',2',4'-triazol-3'-yloxymethylene]-anilides and their use as pest-control agents
WO2004014913A3 (en)	2004-07-29	Derivatives of 2-trifluormethyl-6-aminopurine as phosphodiesterase 4 inhibitors
DE50204803D1 (en)	2005-12-08	4-alkylsubstituierte thienyloxy-pyrididne als herbizide
IL157179A0 (en)	2004-02-08	Fused heterocyclic compounds
WO2003084938A3 (en)	2004-02-05	Pyrimidone derivatives useful for the treatment of inflammatin and immunological diseases
NZ511311A (en)	2002-10-25	Pyrimidinylbenzimidazole and triazinylbenzimidazole derivatives useful as agricultural, horticultural bactericides
WO2001017972A3 (de)	2001-09-27	Neue herbizide
WO2007071632A3 (en)	2007-08-30	2-pyridin-2-yl-quinazoline derivatives as potassium channel modulating agents for the treatment of respiratory diseases
WO2004004730A3 (en)	2004-04-29	2-aminopyrazine derivatives as inhibitors of cyclin dependent kinases for the treatment of proliferative disorders
MY146599A (en)	2012-08-30	New azetidine compounds
AU2003249484A1 (en)	2004-02-09	Novel bio-active molecules
IL160874A0 (en)	2004-08-31	4-imidazolin-2-one derivatives
HRP20050082A2 (en)	2005-06-30	6-amino-1h-indazole and 4-aminobenzofuran compounds as phosphodiesterase 4 inhibitors
MXPA04003278A (es)	2004-07-23	Derivados de 5-metoxi-8-aril-?1,2,4?triazolo?1,5-a?piridina como antagonistas del receptor de adenosina.
HRP20070286T3 (en)	2007-08-31	Substituted diketopiperazines and their use as oxytocyn antagonists
PT1628968E (pt)	2011-07-01	Compostos de 4-imidazolin-2-ona
MXPA02003952A (es)	2004-09-06	Derivados de imidazol como inhibidores de la fosfodieterasa vii.
EA200400470A1 (ru)	2004-08-26	Замещенные производные алкиламинопиридазинона, способ их получения и содержащие их фармацевтические композиции
ATE238300T1 (de)	2003-05-15	(3,4-dihydro-2h-benzo(1,4)oxazinyl-methyl)-3-(1 - indol-3-yl)-alkylamine
MY139258A (en)	2009-09-30	Carbamoyl-type benzofuran derivatives
GB0106419D0 (en)	2001-05-02	Novel compounds
DK1756066T3 (da)	2008-12-15	Tetrasubstituerede imidazolderivater som canabinoid-CB1-receptormodulatorer med höj CB1/CB2-receptorundertypeselektivitet