PL1697380T3 - Sposób wytwarzania 7-etylo-10-hydroksykamptotecyny - Google Patents

Sposób wytwarzania 7-etylo-10-hydroksykamptotecyny

Info

Publication number: PL1697380T3
Authority: PL; Poland
Prior art keywords: ethyl; hydroxycamptothecin; manufacturing; iodosobenzene; formula
Prior art date: 2003-12-16

Application number

PL04820383T

Other languages

English (en)

Inventor

Petr Dobrovolny

Original Assignee

Pliva Lachema As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-12-16

Filing date

2004-12-14

Publication date

2007-10-31

2004-12-14 Application filed by Pliva Lachema As filed Critical Pliva Lachema As

2007-10-31 Publication of PL1697380T3 publication Critical patent/PL1697380T3/pl

Links

FJHBVJOVLFPMQE-QFIPXVFZSA-N 7-Ethyl-10-Hydroxy-Camptothecin Chemical compound C1=C(O)C=C2C(CC)=C(CN3C(C4=C([C@@](C(=O)OC4)(O)CC)C=C33)=O)C3=NC2=C1 FJHBVJOVLFPMQE-QFIPXVFZSA-N 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title abstract 2
JYJVVHFRSFVEJM-UHFFFAOYSA-N iodosobenzene Chemical compound O=IC1=CC=CC=C1 JYJVVHFRSFVEJM-UHFFFAOYSA-N 0.000 abstract 2
JQWHASGSAFIOCM-UHFFFAOYSA-M sodium periodate Chemical compound [Na+].[O-]I(=O)(=O)=O JQWHASGSAFIOCM-UHFFFAOYSA-M 0.000 abstract 2
MLIWQXBKMZNZNF-KUHOPJCQSA-N (2e)-2,6-bis[(4-azidophenyl)methylidene]-4-methylcyclohexan-1-one Chemical compound O=C1\C(=C\C=2C=CC(=CC=2)N=[N+]=[N-])CC(C)CC1=CC1=CC=C(N=[N+]=[N-])C=C1 MLIWQXBKMZNZNF-KUHOPJCQSA-N 0.000 abstract 1
125000001931 aliphatic group Chemical group 0.000 abstract 1
ROOXNKNUYICQNP-UHFFFAOYSA-N ammonium persulfate Chemical compound [NH4+].[NH4+].[O-]S(=O)(=O)OOS([O-])(=O)=O ROOXNKNUYICQNP-UHFFFAOYSA-N 0.000 abstract 1
239000012935 ammoniumperoxodisulfate Substances 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
239000007800 oxidant agent Substances 0.000 abstract 1
USHAGKDGDHPEEY-UHFFFAOYSA-L potassium persulfate Chemical compound [K+].[K+].[O-]S(=O)(=O)OOS([O-])(=O)=O USHAGKDGDHPEEY-UHFFFAOYSA-L 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

PL04820383T 2003-12-16 2004-12-14 Sposób wytwarzania 7-etylo-10-hydroksykamptotecyny PL1697380T3 (pl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
CZ20033442A CZ299593B6 (cs)	2003-12-16	2003-12-16	Zpusob výroby 7-ethyl-10-hydroxykamptothecinu
EP04820383A EP1697380B1 (en)	2003-12-16	2004-12-14	The method of manufacturing of 7-ethyl-10-hydroxycamptothecin
PCT/CZ2004/000085 WO2005058910A1 (en)	2003-12-16	2004-12-14	The method of manufacturing of 7-ethyl-10-hydroxycamptothecin

Publications (1)

Publication Number	Publication Date
PL1697380T3 true PL1697380T3 (pl)	2007-10-31

Family

ID=34683186

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL04820383T PL1697380T3 (pl)	2003-12-16	2004-12-14	Sposób wytwarzania 7-etylo-10-hydroksykamptotecyny

Country Status (10)

Country	Link
US (2)	US7544801B2 (pl)
EP (1)	EP1697380B1 (pl)
JP (1)	JP4856549B2 (pl)
AT (1)	ATE362478T1 (pl)
CZ (1)	CZ299593B6 (pl)
DE (1)	DE602004006533T2 (pl)
ES (1)	ES2285573T3 (pl)
HR (1)	HRP20070308T3 (pl)
PL (1)	PL1697380T3 (pl)
WO (1)	WO2005058910A1 (pl)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7151179B2 (en)	2003-05-12	2006-12-19	Scinopharm Taiwan, Ltd.	Process for the preparation of 7-alkyl-10-hydroxy-20(S)-camptothecin
CZ299329B6 (cs)	2003-08-26	2008-06-18	Pliva-Lachema A.S.	Zpusob výroby 7-ethyl-10-[ 4-(1-piperidino)-1-piperidino]karbonyloxykamptothecinu
CZ299593B6 (cs)	2003-12-16	2008-09-10	Pliva-Lachema A. S.	Zpusob výroby 7-ethyl-10-hydroxykamptothecinu
US7608740B2 (en)	2005-08-03	2009-10-27	Avra Laboratories Pvt. Ltd	Method of synthesizing key intermediates for the production of camptothecin derivatives
EP2881396A1 (en)	2013-12-03	2015-06-10	Synbias Pharma AG	Method for the synthesis of irinotecan

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3894029A (en)	1971-08-26	1975-07-08	Basf Ag	Production of camptothecin and camptothecin-like compounds
JPS5198300A (en)	1975-02-20	1976-08-30		Kanputoteshin oyobi sonoruijitaino seizoho
US4399282A (en)	1979-07-10	1983-08-16	Kabushiki Kaisha Yakult Honsha	Camptothecin derivatives
JPS5682843A (en)	1979-12-08	1981-07-06	Nippon Oil Co Ltd	Wax emulsion
US4383431A (en)	1980-11-03	1983-05-17	The Perkin-Elmer Corporation	Auto-zero system for pressure transducers
US4399276A (en)	1981-01-09	1983-08-16	Kabushiki Kaisha Yakult Honsha	7-Substituted camptothecin derivatives
US4473692A (en) *	1981-09-04	1984-09-25	Kabushiki Kaisha Yakult Honsha	Camptothecin derivatives and process for preparing same
JPS5839685A (ja)	1981-09-04	1983-03-08	Yakult Honsha Co Ltd	新規なカンプトテシン誘導体及びその製造法
JPS58154582A (ja)	1982-03-10	1983-09-14	Yakult Honsha Co Ltd	新規なカンプトテシン誘導体およびその製造法
JPS595188A (ja) *	1982-06-30	1984-01-12	Yakult Honsha Co Ltd	１０−ヒドロキシカンプトテシンの製造法
JPS6019790A (ja)	1983-07-14	1985-01-31	Yakult Honsha Co Ltd	新規なカンプトテシン誘導体
FR2560442B1 (fr)	1984-02-24	1987-08-07	Thomson Csf	Dispositif de commutation et de limitation a ligne a fente, fonctionnant en hyperfrequences
FR2560315B1 (fr)	1984-02-29	1990-05-18	Dba	Dispositif de rattrapage automatique de jeu pour embrayage
CA1332413C (en)	1987-06-25	1994-10-11	Kabushiki Kaisha Yakult Honsha	Camptothecin derivatives and process for preparing same
JPH0615547B2 (ja)	1988-01-20	1994-03-02	株式会社ヤクルト本社	新規なカンプトテシン誘導体
JP2848958B2 (ja) *	1990-09-28	1999-01-20	スミスクライン・ビーチャム・コーポレイション	水溶性カンプトテシン類似体、方法および手段
GB9402934D0 (en)	1994-02-16	1994-04-06	Erba Carlo Spa	Camptothecin derivatives and process for their preparation
US5491237A (en)	1994-05-03	1996-02-13	Glaxo Wellcome Inc.	Intermediates in pharmaceutical camptothecin preparation
JPH0873461A (ja)	1994-09-06	1996-03-19	Yakult Honsha Co Ltd	新規なカンプトテシン誘導体、その製造法および抗腫瘍剤
TW438775B (en)	1995-04-07	2001-06-07	Pharmacia & Upjohn Co Llc	Novel intermediates and process for the manufacture of camptothecin derivatives (CPT-11) and related compounds
JP4094710B2 (ja)	1997-11-06	2008-06-04	株式会社ヤクルト本社	新規なカンプトテシン誘導体
AU4564200A (en)	1999-04-29	2000-11-17	Aventis Pharma S.A.	Method for treating cancer using camptothecin derivatives and 5-fluorouracil
AR027687A1 (es)	2000-03-22	2003-04-09	Yakult Honsha Kk	Procedimiento para preparar camptotecina
TWI245768B (en)	2001-02-21	2005-12-21	Yakult Honsha Kk	Process for synthesizing camptothecin related compound(s)
AU2003207369A1 (en) *	2002-02-18	2003-09-04	Dr. Reddy's Laboratories Limited	A process for the preparation of 10-hydroxy-9-n,n-dimethylaminomethyl-5-(2'-fluoroethoxy)-20(s)-camptothecin hydrochloride
US7151179B2 (en)	2003-05-12	2006-12-19	Scinopharm Taiwan, Ltd.	Process for the preparation of 7-alkyl-10-hydroxy-20(S)-camptothecin
CZ299329B6 (cs)	2003-08-26	2008-06-18	Pliva-Lachema A.S.	Zpusob výroby 7-ethyl-10-[ 4-(1-piperidino)-1-piperidino]karbonyloxykamptothecinu
CZ299593B6 (cs)	2003-12-16	2008-09-10	Pliva-Lachema A. S.	Zpusob výroby 7-ethyl-10-hydroxykamptothecinu
US20050272757A1 (en)	2004-06-04	2005-12-08	Phytogen Life Sciences Inc.	Process to prepare camptothecin derivatives and novel intermediate and compounds thereof

2003
- 2003-12-16 CZ CZ20033442A patent/CZ299593B6/cs not_active IP Right Cessation
2004
- 2004-12-14 AT AT04820383T patent/ATE362478T1/de active
- 2004-12-14 JP JP2006544199A patent/JP4856549B2/ja not_active Expired - Fee Related
- 2004-12-14 WO PCT/CZ2004/000085 patent/WO2005058910A1/en not_active Ceased
- 2004-12-14 US US10/582,650 patent/US7544801B2/en not_active Expired - Fee Related
- 2004-12-14 EP EP04820383A patent/EP1697380B1/en not_active Expired - Lifetime
- 2004-12-14 PL PL04820383T patent/PL1697380T3/pl unknown
- 2004-12-14 ES ES04820383T patent/ES2285573T3/es not_active Expired - Lifetime
- 2004-12-14 HR HR20070308T patent/HRP20070308T3/xx unknown
- 2004-12-14 DE DE602004006533T patent/DE602004006533T2/de not_active Expired - Lifetime
2009
- 2009-05-07 US US12/437,478 patent/US8039626B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
WO2005058910B1 (en)	2007-02-22
CZ20033442A3 (cs)	2005-08-17
US7544801B2 (en)	2009-06-09
ES2285573T3 (es)	2007-11-16
JP2007517778A (ja)	2007-07-05
DE602004006533D1 (de)	2007-06-28
ATE362478T1 (de)	2007-06-15
HRP20070308T3 (en)	2007-09-30
JP4856549B2 (ja)	2012-01-18
US20070123552A1 (en)	2007-05-31
EP1697380B1 (en)	2007-05-16
EP1697380A1 (en)	2006-09-06
DE602004006533T2 (de)	2008-01-31
CZ299593B6 (cs)	2008-09-10
US20090306387A1 (en)	2009-12-10
US8039626B2 (en)	2011-10-18
WO2005058910A1 (en)	2005-06-30

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