PL1756052T3 - Ulepszony sposób wytwarzania związków 3-hydroksy-4-hydroksymetylopirolidynowych - Google Patents

Ulepszony sposób wytwarzania związków 3-hydroksy-4-hydroksymetylopirolidynowych

Info

Publication number
PL1756052T3
PL1756052T3 PL05757531T PL05757531T PL1756052T3 PL 1756052 T3 PL1756052 T3 PL 1756052T3 PL 05757531 T PL05757531 T PL 05757531T PL 05757531 T PL05757531 T PL 05757531T PL 1756052 T3 PL1756052 T3 PL 1756052T3
Authority
PL
Poland
Prior art keywords
hydroxy
preparing
hydroxymethyl
improved method
pyrrolidine compounds
Prior art date
Application number
PL05757531T
Other languages
English (en)
Inventor
Dirk Henning Lenz
Jennifer Mary Mason
Keith Clinch
Gary Brian Evans
Peter Charles Tyler
Original Assignee
Industrial Res Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Industrial Res Limited filed Critical Industrial Res Limited
Publication of PL1756052T3 publication Critical patent/PL1756052T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PL05757531T 2004-06-04 2005-06-03 Ulepszony sposób wytwarzania związków 3-hydroksy-4-hydroksymetylopirolidynowych PL1756052T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
NZ533360A NZ533360A (en) 2004-06-04 2004-06-04 Improved method for preparing 3-hydroxy-4-hydroxymethyl-pyrrolidine compounds
PCT/NZ2005/000114 WO2005118532A1 (en) 2004-06-04 2005-06-03 Improved method for preparing 3-hydroxy-4-hydroxymethyl-pyrrolidine compounds
EP05757531A EP1756052B1 (en) 2004-06-04 2005-06-03 Improved method for preparing 3-hydroxy-4-hydroxymethyl-pyrrolidine compounds

Publications (1)

Publication Number Publication Date
PL1756052T3 true PL1756052T3 (pl) 2009-05-29

Family

ID=35462865

Family Applications (1)

Application Number Title Priority Date Filing Date
PL05757531T PL1756052T3 (pl) 2004-06-04 2005-06-03 Ulepszony sposób wytwarzania związków 3-hydroksy-4-hydroksymetylopirolidynowych

Country Status (19)

Country Link
US (1) US8183019B2 (pl)
EP (1) EP1756052B1 (pl)
JP (2) JP5219506B2 (pl)
KR (1) KR101294732B1 (pl)
CN (1) CN101018768B (pl)
AT (1) ATE417036T1 (pl)
AU (1) AU2005250308B2 (pl)
CA (1) CA2568836C (pl)
CY (1) CY1108866T1 (pl)
DE (1) DE602005011609D1 (pl)
DK (1) DK1756052T3 (pl)
ES (1) ES2318504T3 (pl)
IL (1) IL179749A (pl)
MX (1) MXPA06014139A (pl)
NZ (1) NZ533360A (pl)
PL (1) PL1756052T3 (pl)
PT (1) PT1756052E (pl)
SI (1) SI1756052T1 (pl)
WO (1) WO2005118532A1 (pl)

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US5985848A (en) 1997-10-14 1999-11-16 Albert Einstein College Of Medicine Of Yeshiva University Inhibitors of nucleoside metabolism
CA2696826C (en) 1999-04-08 2013-01-08 Industrial Research Limited Process for preparing inhibitors of nucleoside metabolism
ES2363766T3 (es) * 2002-08-21 2011-08-16 Albert Einstein College Of Medicine Of Yeshiva University Inhibidores de nucleosidasas y fosforilasas de nucleosidos.
NZ523970A (en) * 2003-02-04 2005-02-25 Ind Res Ltd Process for preparing inhibitors of nucleoside phoshorylases and nucleosidases
CN1329374C (zh) * 2004-06-09 2007-08-01 上海靶点药物有限公司 作为ccr5拮抗剂的化合物
CA2615549A1 (en) * 2005-07-27 2007-02-08 Albert Einstein College Of Medicine Of Yeshiva University Transition state structure of 5'-methylthioadenosine/s-adenosylhomocysteine nucleosidases
NZ544187A (en) * 2005-12-15 2008-07-31 Ind Res Ltd Deazapurine analogs of 1'-aza-l-nucleosides
WO2007097643A1 (en) 2006-02-22 2007-08-30 Industrial Research Limited Analogues of coformycin and their use for treating protozoan parasite infections
EP1991231A4 (en) * 2006-02-24 2010-01-06 Ind Res Ltd METHOD FOR THE TREATMENT OF DISEASES WITH NUCLEOSIDE PHOSPHORUSLASES AND NUCLEOSIDASES INHIBITORS
US8916571B2 (en) 2006-02-24 2014-12-23 Albert Einstein College Of Medicine Of Yeshiva University Methods of treating cancer using inhibitors of 5′-methylthioadenosine phosphorylase
CN101094080B (zh) * 2006-06-22 2012-06-20 华为技术有限公司 一种即按即通系统中的计费方法
CN101528749B (zh) * 2006-09-07 2013-07-31 工业研究有限公司 核苷磷酸化酶和水解酶的无环胺抑制剂
AU2007293773B2 (en) * 2006-09-07 2013-01-31 Albert Einstein College Of Medicine, Inc. Acyclic amine inhibitors of 5'-methylthioadenosine phosphorylase and nucleosidase
ES2385759T3 (es) * 2006-12-22 2012-07-31 Industrial Research Limited Análogos azetidina de inhibidores de nucleosidasa y fosforilasa
EP2250143B1 (en) * 2008-01-25 2016-04-20 XenoPort, Inc. Method for the enzymatic kinetic resolution of acyloxyalkyl thiocarbonates used for the synthesis of acyloxyalkyl carbamates
US20110190265A1 (en) * 2008-09-22 2011-08-04 Schramm Vern L Methods and compositions for treating bacterial infections by inhibiting quorum sensing
US9493465B2 (en) 2009-07-17 2016-11-15 Victoria Link Limited 3-hydroxypyrrolidine inhibitors of 5′-methylthioadenosine phosphorylase and nucleosidase
WO2012074912A1 (en) 2010-11-29 2012-06-07 Albert Einstein College Of Medicine Of Yeshiva University Methods, assays and compounds for treating bacterial infections by inhibiting methylthioinosine phosphorylase
JP6063571B2 (ja) 2012-08-07 2017-01-18 アルバート アインシュタイン カレッジ オブ メディシン，インコーポレイティド ヘリコバクター・ピロリ感染の治療
EP2920179A4 (en) 2012-11-12 2016-03-30 Victoria Link Ltd SALT AND POLYMORPHIC FORMS OF (3R, 4S) -L - ((4-AMINO-5H-PYRROLO [3,2-D] PYRIMIDIN-7-YL) METHYL) -4 (METHYLTHIOMETHYL) PYRODIN-3-OL (MTDIA)
HK1232071A1 (zh) 2014-02-12 2018-01-05 Albert Einstein College Of Medicine, Inc. 使用mtan抑制剂治疗h.pylori感染
CN104529814A (zh) * 2014-12-15 2015-04-22 上海同昌生物医药科技有限公司 一种合成n-苄基羟胺盐酸盐的方法
CN111793017B (zh) * 2019-04-04 2024-01-16 广东东阳光药业股份有限公司 一种内酰胺化合物的制备方法
CN120136758A (zh) * 2025-03-14 2025-06-13 宏济堂制药(商河)有限公司 一种氯马斯汀中间体的合成方法
CN121736008B (zh) * 2026-02-28 2026-05-01 苏州大学 一种催化合成1-芳甲基-4-芳甲基-3-羟基吡咯-2(5h)-酮及其衍生物的方法

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JP3504026B2 (ja) 1995-06-16 2004-03-08 株式会社トクヤマ ピロリジン誘導体の製造方法
AU1739097A (en) 1996-02-23 1997-09-10 Albert Einstein College Of Medicine Of Yeshiva University Enzyme detection/assay method and substrates
US5985848A (en) 1997-10-14 1999-11-16 Albert Einstein College Of Medicine Of Yeshiva University Inhibitors of nucleoside metabolism
US6239163B1 (en) 1999-03-15 2001-05-29 Novo Nordisk A/S Salt of (2R,3R,4R)-3,4-dihydroxy-2-hydroxymethylpyrrolidine
JP2002539195A (ja) 1999-03-15 2002-11-19 ノボ ノルディスク アクティーゼルスカブ （２ｒ，３ｒ，４ｒ）−３，４−ジヒドロキシ−２−ヒドロキシメチルピロリジンの新規塩
CA2696826C (en) 1999-04-08 2013-01-08 Industrial Research Limited Process for preparing inhibitors of nucleoside metabolism
US6448799B1 (en) * 1999-09-30 2002-09-10 Hitachi Electronics Engineering Co., Ltd. Timing adjustment method and apparatus for semiconductor IC tester
AU2001284564A1 (en) 2000-08-29 2002-03-13 Albert Einstein College Of Medicine Of Yeshiva University Nucleoside metabolism inhibitors
US6458799B1 (en) 2000-08-31 2002-10-01 Biocryst Pharmaceuticals, Inc. Deazaguanine analog, preparation thereof and use thereof
JP4468701B2 (ja) 2002-03-18 2010-05-26 杏林製薬株式会社 耐性菌に有効な１０−（３−シクロプロピルアミノメチル−１−ピロリジニル）ピリドベンズオキサジンカルボン酸誘導体
US7098334B2 (en) 2002-03-25 2006-08-29 Industrial Research Limited 4-amino-5H-pyrrolo[3,2-d]pyrimidine inhibitors of nucleoside phosphorylases and nucleosidases
ES2363766T3 (es) 2002-08-21 2011-08-16 Albert Einstein College Of Medicine Of Yeshiva University Inhibidores de nucleosidasas y fosforilasas de nucleosidos.
NZ523970A (en) 2003-02-04 2005-02-25 Ind Res Ltd Process for preparing inhibitors of nucleoside phoshorylases and nucleosidases
US20060216775A1 (en) 2003-06-17 2006-09-28 The Regents Of The University Of Califoenia Compositions and methods for analysis and manipulation of enzymes in biosynthetic proteomes
CA2538169A1 (en) * 2003-09-09 2005-03-17 Albert Einstein College Of Medicine Of Yeshiva University Transition state analog inhibitors of ricin a-chain
CN1329374C (zh) 2004-06-09 2007-08-01 上海靶点药物有限公司 作为ccr5拮抗剂的化合物
JP2008508287A (ja) 2004-07-27 2008-03-21 バイオクリスト・フアーマシユーテイカルズ・インコーポレイテツド ５’−メチルチオアデノシンホスホリラーゼ及び５’メチルチオアデノシン／ｓ−アデノシルホモシステインヌクレオシダーゼの阻害剤
NZ540160A (en) 2005-05-20 2008-03-28 Einstein Coll Med Inhibitors of nucleoside phosphorylases
CA2615549A1 (en) 2005-07-27 2007-02-08 Albert Einstein College Of Medicine Of Yeshiva University Transition state structure of 5'-methylthioadenosine/s-adenosylhomocysteine nucleosidases
NZ544187A (en) 2005-12-15 2008-07-31 Ind Res Ltd Deazapurine analogs of 1'-aza-l-nucleosides
US8916571B2 (en) 2006-02-24 2014-12-23 Albert Einstein College Of Medicine Of Yeshiva University Methods of treating cancer using inhibitors of 5′-methylthioadenosine phosphorylase
EP1991231A4 (en) 2006-02-24 2010-01-06 Ind Res Ltd METHOD FOR THE TREATMENT OF DISEASES WITH NUCLEOSIDE PHOSPHORUSLASES AND NUCLEOSIDASES INHIBITORS
AR060216A1 (es) * 2006-03-29 2008-06-04 Medichem Sa Procesos para preparar ezetimibe y compuestos intermediarios utiles para su preparacion
CN101528749B (zh) 2006-09-07 2013-07-31 工业研究有限公司 核苷磷酸化酶和水解酶的无环胺抑制剂
AU2007293773B2 (en) 2006-09-07 2013-01-31 Albert Einstein College Of Medicine, Inc. Acyclic amine inhibitors of 5'-methylthioadenosine phosphorylase and nucleosidase
EP2066671A1 (en) 2006-09-26 2009-06-10 Albert Einstein College Of Medicine Of Yeshiva University Transition state structure of human 5'-methylthioadenosine phosphorylase
ES2385759T3 (es) 2006-12-22 2012-07-31 Industrial Research Limited Análogos azetidina de inhibidores de nucleosidasa y fosforilasa
WO2009082247A1 (en) 2007-12-21 2009-07-02 Industrial Research Limited Process for preparing immucillins having a methylene link
US20110190265A1 (en) 2008-09-22 2011-08-04 Schramm Vern L Methods and compositions for treating bacterial infections by inhibiting quorum sensing
US9493465B2 (en) 2009-07-17 2016-11-15 Victoria Link Limited 3-hydroxypyrrolidine inhibitors of 5′-methylthioadenosine phosphorylase and nucleosidase

Also Published As

Publication number Publication date
JP2012211136A (ja) 2012-11-01
US8183019B2 (en) 2012-05-22
AU2005250308B2 (en) 2012-04-26
EP1756052B1 (en) 2008-12-10
JP2008501682A (ja) 2008-01-24
CA2568836C (en) 2013-04-16
DK1756052T3 (da) 2009-03-09
KR20070050037A (ko) 2007-05-14
AU2005250308A1 (en) 2005-12-15
ATE417036T1 (de) 2008-12-15
WO2005118532A1 (en) 2005-12-15
MXPA06014139A (es) 2007-05-09
JP5219506B2 (ja) 2013-06-26
CA2568836A1 (en) 2005-12-15
PT1756052E (pt) 2009-02-11
SI1756052T1 (sl) 2009-04-30
EP1756052A1 (en) 2007-02-28
US20080280334A1 (en) 2008-11-13
CN101018768B (zh) 2012-11-21
CY1108866T1 (el) 2014-07-02
DE602005011609D1 (de) 2009-01-22
IL179749A (en) 2011-07-31
HK1106518A1 (en) 2008-03-14
EP1756052A4 (en) 2007-08-22
NZ533360A (en) 2007-02-23
KR101294732B1 (ko) 2013-08-12
CN101018768A (zh) 2007-08-15
IL179749A0 (en) 2007-05-15
ES2318504T3 (es) 2009-05-01

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