DK1756052T3 - Forbedret fremgangsmåde til at fremstille 3-hydroxy-4-hydroxymethyl-pyrrolidin-forbindelser - Google Patents

Forbedret fremgangsmåde til at fremstille 3-hydroxy-4-hydroxymethyl-pyrrolidin-forbindelser

Info

Publication number
DK1756052T3
DK1756052T3 DK05757531T DK05757531T DK1756052T3 DK 1756052 T3 DK1756052 T3 DK 1756052T3 DK 05757531 T DK05757531 T DK 05757531T DK 05757531 T DK05757531 T DK 05757531T DK 1756052 T3 DK1756052 T3 DK 1756052T3
Authority
DK
Denmark
Prior art keywords
hydroxy
preparing
hydroxymethyl
improved process
pyrrolidine compounds
Prior art date
Application number
DK05757531T
Other languages
English (en)
Inventor
Gary Brian Evans
Peter Charles Tyler
Dirk Henning Lenz
Jennifer Mary Mason
Keith Clinch
Original Assignee
Ind Res Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ind Res Ltd filed Critical Ind Res Ltd
Application granted granted Critical
Publication of DK1756052T3 publication Critical patent/DK1756052T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK05757531T 2004-06-04 2005-06-03 Forbedret fremgangsmåde til at fremstille 3-hydroxy-4-hydroxymethyl-pyrrolidin-forbindelser DK1756052T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NZ533360A NZ533360A (en) 2004-06-04 2004-06-04 Improved method for preparing 3-hydroxy-4-hydroxymethyl-pyrrolidine compounds
PCT/NZ2005/000114 WO2005118532A1 (en) 2004-06-04 2005-06-03 Improved method for preparing 3-hydroxy-4-hydroxymethyl-pyrrolidine compounds

Publications (1)

Publication Number Publication Date
DK1756052T3 true DK1756052T3 (da) 2009-03-09

Family

ID=35462865

Family Applications (1)

Application Number Title Priority Date Filing Date
DK05757531T DK1756052T3 (da) 2004-06-04 2005-06-03 Forbedret fremgangsmåde til at fremstille 3-hydroxy-4-hydroxymethyl-pyrrolidin-forbindelser

Country Status (19)

Country Link
US (1) US8183019B2 (da)
EP (1) EP1756052B1 (da)
JP (2) JP5219506B2 (da)
KR (1) KR101294732B1 (da)
CN (1) CN101018768B (da)
AT (1) ATE417036T1 (da)
AU (1) AU2005250308B2 (da)
CA (1) CA2568836C (da)
CY (1) CY1108866T1 (da)
DE (1) DE602005011609D1 (da)
DK (1) DK1756052T3 (da)
ES (1) ES2318504T3 (da)
IL (1) IL179749A (da)
MX (1) MXPA06014139A (da)
NZ (1) NZ533360A (da)
PL (1) PL1756052T3 (da)
PT (1) PT1756052E (da)
SI (1) SI1756052T1 (da)
WO (1) WO2005118532A1 (da)

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US7553839B2 (en) 2002-08-21 2009-06-30 Industrial Research Limited 5h-pyrrolo[3,2-D] pyrimidine inhibitors of nucleoside phosphorylases and nucleosidases
NZ523970A (en) 2003-02-04 2005-02-25 Ind Res Ltd Process for preparing inhibitors of nucleoside phoshorylases and nucleosidases
CN1329374C (zh) * 2004-06-09 2007-08-01 上海靶点药物有限公司 作为ccr5拮抗剂的化合物
WO2007016291A2 (en) * 2005-07-27 2007-02-08 Albert Einstein College Of Medicine Of Yeshiva University Transition state structure of 5'-methylthioadenosine/s-adenosylhomocysteine nucleosidases
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WO2007097643A1 (en) 2006-02-22 2007-08-30 Industrial Research Limited Analogues of coformycin and their use for treating protozoan parasite infections
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CN101094080B (zh) * 2006-06-22 2012-06-20 华为技术有限公司 一种即按即通系统中的计费方法
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US8383636B2 (en) 2006-09-07 2013-02-26 Industrial Research Limited Acyclic amine inhibitors of 5-methytioadenosine phosphorylase and nucleosidase
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WO2010033236A2 (en) * 2008-09-22 2010-03-25 Albert Einstein College Of Medicine Of Yeshiva University Methods and compositions for treating bacterial infections by inhibiting quorum sensing
JP5861243B2 (ja) 2009-07-17 2016-02-16 アルバート アインシュタイン カレッジ オブ メディシン オブ イエシバ ユニバーシティ ５’−メチルチオアデノシンホスホリラーゼ及びヌクレオシダーゼの３−ヒドロキシピロリジン阻害剤
US9290501B2 (en) 2010-11-29 2016-03-22 Albert Einstein College Of Medicine, Inc. Methods, assays and compounds for treating bacterial infections by inhibiting methylthioinosine phosphorylase
JP6063571B2 (ja) 2012-08-07 2017-01-18 アルバート アインシュタイン カレッジ オブ メディシン，インコーポレイティド ヘリコバクター・ピロリ感染の治療
WO2014073989A1 (en) 2012-11-12 2014-05-15 Callaghan Innovation Research Limited Salt and polymorphic forms of (3r,4s)-l-((4-amino-5h-pyrrolo[3,2-d]pyrimidin-7-yl)methyl)-4(methylthiomethyl)pyrodin-3-ol(mtdia)
EP3104707B1 (en) 2014-02-12 2020-07-15 Albert Einstein College of Medicine, Inc. Treatment of h. pylori infections using mtan inhibitors
CN104529814A (zh) * 2014-12-15 2015-04-22 上海同昌生物医药科技有限公司 一种合成n-苄基羟胺盐酸盐的方法
CN111793017B (zh) * 2019-04-04 2024-01-16 广东东阳光药业股份有限公司 一种内酰胺化合物的制备方法
CN120136758A (zh) * 2025-03-14 2025-06-13 宏济堂制药(商河)有限公司 一种氯马斯汀中间体的合成方法
CN121736008B (zh) * 2026-02-28 2026-05-01 苏州大学 一种催化合成1-芳甲基-4-芳甲基-3-羟基吡咯-2(5h)-酮及其衍生物的方法

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JP3504026B2 (ja) 1995-06-16 2004-03-08 株式会社トクヤマ ピロリジン誘導体の製造方法
US6379911B2 (en) 1996-02-23 2002-04-30 Albert Einstein College Of Medicine Of Yeshiva University Enzyme detection/assay method and substrates
US5985848A (en) 1997-10-14 1999-11-16 Albert Einstein College Of Medicine Of Yeshiva University Inhibitors of nucleoside metabolism
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PT1165564E (pt) 1999-04-08 2009-04-16 Einstein Coll Med Processo para a preparação de inibidores do metabolismo de nucleósidos
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US7098334B2 (en) 2002-03-25 2006-08-29 Industrial Research Limited 4-amino-5H-pyrrolo[3,2-d]pyrimidine inhibitors of nucleoside phosphorylases and nucleosidases
US7553839B2 (en) 2002-08-21 2009-06-30 Industrial Research Limited 5h-pyrrolo[3,2-D] pyrimidine inhibitors of nucleoside phosphorylases and nucleosidases
NZ523970A (en) 2003-02-04 2005-02-25 Ind Res Ltd Process for preparing inhibitors of nucleoside phoshorylases and nucleosidases
WO2005003307A2 (en) 2003-06-17 2005-01-13 The Regents Of The University Of California Compositions and methods for analysis and manipulation of enzymes in biosynthetic proteomes
CA2538169A1 (en) * 2003-09-09 2005-03-17 Albert Einstein College Of Medicine Of Yeshiva University Transition state analog inhibitors of ricin a-chain
CN1329374C (zh) 2004-06-09 2007-08-01 上海靶点药物有限公司 作为ccr5拮抗剂的化合物
WO2006014913A2 (en) 2004-07-27 2006-02-09 Biocryst Pharmaceuticals, Inc. Inhibitors of 5'-methylthioadenosine phosphorylase and 5'methylthioadenosine/s-adenosylhomocysteine nucleosidase
NZ540160A (en) 2005-05-20 2008-03-28 Einstein Coll Med Inhibitors of nucleoside phosphorylases
WO2007016291A2 (en) 2005-07-27 2007-02-08 Albert Einstein College Of Medicine Of Yeshiva University Transition state structure of 5'-methylthioadenosine/s-adenosylhomocysteine nucleosidases
NZ544187A (en) 2005-12-15 2008-07-31 Ind Res Ltd Deazapurine analogs of 1'-aza-l-nucleosides
WO2007097647A1 (en) 2006-02-24 2007-08-30 Albert Einstein College Of Medicine Of Yeshiva University Methods of treating cancer
JP2009528996A (ja) 2006-02-24 2009-08-13 インダストリアル リサーチ リミテッド ヌクレオシドホスホリラーゼ及びヌクレオシダーゼの阻害剤を用いて疾患を処置する方法
AR060216A1 (es) * 2006-03-29 2008-06-04 Medichem Sa Procesos para preparar ezetimibe y compuestos intermediarios utiles para su preparacion
ES2362805T3 (es) 2006-09-07 2011-07-13 Industrial Research Limited Inhibidores aminoacíclicos de nucleósido fosforilasas e hidrolasas.
US8383636B2 (en) 2006-09-07 2013-02-26 Industrial Research Limited Acyclic amine inhibitors of 5-methytioadenosine phosphorylase and nucleosidase
EP2066671A1 (en) 2006-09-26 2009-06-10 Albert Einstein College Of Medicine Of Yeshiva University Transition state structure of human 5'-methylthioadenosine phosphorylase
DK2114925T3 (da) 2006-12-22 2012-05-29 Ind Res Ltd Azetidin-analoger af nucleosidase- og phosphorylase-inhibitorer
WO2009082247A1 (en) 2007-12-21 2009-07-02 Industrial Research Limited Process for preparing immucillins having a methylene link
WO2010033236A2 (en) 2008-09-22 2010-03-25 Albert Einstein College Of Medicine Of Yeshiva University Methods and compositions for treating bacterial infections by inhibiting quorum sensing
JP5861243B2 (ja) 2009-07-17 2016-02-16 アルバート アインシュタイン カレッジ オブ メディシン オブ イエシバ ユニバーシティ ５’−メチルチオアデノシンホスホリラーゼ及びヌクレオシダーゼの３−ヒドロキシピロリジン阻害剤

Also Published As

Publication number Publication date
ATE417036T1 (de) 2008-12-15
PL1756052T3 (pl) 2009-05-29
CN101018768A (zh) 2007-08-15
IL179749A0 (en) 2007-05-15
US20080280334A1 (en) 2008-11-13
KR101294732B1 (ko) 2013-08-12
JP5219506B2 (ja) 2013-06-26
KR20070050037A (ko) 2007-05-14
CN101018768B (zh) 2012-11-21
AU2005250308A1 (en) 2005-12-15
IL179749A (en) 2011-07-31
US8183019B2 (en) 2012-05-22
DE602005011609D1 (de) 2009-01-22
EP1756052A1 (en) 2007-02-28
ES2318504T3 (es) 2009-05-01
EP1756052B1 (en) 2008-12-10
PT1756052E (pt) 2009-02-11
SI1756052T1 (sl) 2009-04-30
EP1756052A4 (en) 2007-08-22
CY1108866T1 (el) 2014-07-02
JP2008501682A (ja) 2008-01-24
NZ533360A (en) 2007-02-23
AU2005250308B2 (en) 2012-04-26
HK1106518A1 (en) 2008-03-14
CA2568836C (en) 2013-04-16
WO2005118532A1 (en) 2005-12-15
MXPA06014139A (es) 2007-05-09
JP2012211136A (ja) 2012-11-01
CA2568836A1 (en) 2005-12-15

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