PL1794165T5 - Sposób wytwarzania analgetyków opioidowych przez reduktywne alkilowanie - Google Patents

Sposób wytwarzania analgetyków opioidowych przez reduktywne alkilowanie

Info

Publication number
PL1794165T5
PL1794165T5 PL05782842T PL05782842T PL1794165T5 PL 1794165 T5 PL1794165 T5 PL 1794165T5 PL 05782842 T PL05782842 T PL 05782842T PL 05782842 T PL05782842 T PL 05782842T PL 1794165 T5 PL1794165 T5 PL 1794165T5
Authority
PL
Poland
Prior art keywords
reductive alkylation
preparation
opiate analgesics
protected
hydroxyl group
Prior art date
Application number
PL05782842T
Other languages
English (en)
Other versions
PL1794165T3 (pl
Inventor
Neil John Goodwin
Melville Mitchell
Neil Kenneth Thomson
George Scott Wilson
Maureen Joan Young
Original Assignee
Johnson Matthey Public Limited Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=33427785&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL1794165(T5) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Johnson Matthey Public Limited Company filed Critical Johnson Matthey Public Limited Company
Publication of PL1794165T3 publication Critical patent/PL1794165T3/pl
Publication of PL1794165T5 publication Critical patent/PL1794165T5/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/28—Morphinans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
PL05782842T 2004-09-30 2005-09-14 Sposób wytwarzania analgetyków opioidowych przez reduktywne alkilowanie PL1794165T5 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0421687.5A GB0421687D0 (en) 2004-09-30 2004-09-30 Preparation of opiate analgesics
EP05782842.8A EP1794165B2 (en) 2004-09-30 2005-09-14 Preparation of opiate analgesics by reductive alkylation
PCT/GB2005/003547 WO2006035195A1 (en) 2004-09-30 2005-09-14 Preparation of opiate analgesics by reductive alkylation

Publications (2)

Publication Number Publication Date
PL1794165T3 PL1794165T3 (pl) 2009-09-30
PL1794165T5 true PL1794165T5 (pl) 2020-11-16

Family

ID=33427785

Family Applications (1)

Application Number Title Priority Date Filing Date
PL05782842T PL1794165T5 (pl) 2004-09-30 2005-09-14 Sposób wytwarzania analgetyków opioidowych przez reduktywne alkilowanie

Country Status (13)

Country Link
US (2) US8119803B2 (pl)
EP (1) EP1794165B2 (pl)
CN (1) CN101027307B (pl)
AT (1) ATE428715T1 (pl)
AU (1) AU2005288728B2 (pl)
DE (1) DE602005013986D1 (pl)
DK (1) DK1794165T4 (pl)
ES (1) ES2322486T5 (pl)
GB (1) GB0421687D0 (pl)
PL (1) PL1794165T5 (pl)
PT (1) PT1794165E (pl)
WO (1) WO2006035195A1 (pl)
ZA (1) ZA200701784B (pl)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
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AU2007267362B2 (en) * 2006-05-25 2011-08-11 Alpharma (Bermuda) Investments Ltd Process useful in the preparation of morphinan antagonists
GB2471801B (en) * 2006-05-25 2011-02-16 Alpharma Process useful in the preparation of morphine antagonists
GB2444052A (en) * 2006-05-25 2008-05-28 Alpharma Aps Processes of preparing morphinan derivatives such as naltrexone and naloxone comprising O- and N-demethylation and reductive alkylation steps
GB2471800B (en) * 2006-05-25 2011-03-09 Alpharma Preparation of N-alkylated morphinans by reduction of an iminium group
KR100780932B1 (ko) * 2006-05-30 2007-11-30 엠텍비젼 주식회사 컬러 보간 방법 및 장치
ATE493416T1 (de) 2007-05-04 2011-01-15 Mallinckrodt Inc Verbessertes verfahren zur herstellung von 6- alpha-hydroxy-n-alkylierten opiaten
US8962841B2 (en) 2007-06-29 2015-02-24 Brock University Methods for one-pot N-demethylation/N-functionalization of morphine and tropane alkaloids
JP2010533719A (ja) * 2007-07-17 2010-10-28 マリンクロッド・インコーポレイテッド 還元的アミノ化によるｎ−アルキル化オピエートの調製
EP2112152A1 (en) 2008-04-22 2009-10-28 GPC Biotech AG Dihydropteridinones as Plk Inhibitors
CA2738628C (en) * 2008-09-30 2017-07-04 Mallinckrodt Inc. Processes for the selective amination of ketomorphinans
WO2010039220A1 (en) 2008-09-30 2010-04-08 Mallinckrodt Inc. Processes for the production of buprenorphine with reduced impurity formation
ES2529057T3 (es) * 2008-09-30 2015-02-16 Mallinckrodt Inc. Procedimientos para la hidrogenación de derivados de alcaloides opiáceos
JP5778042B2 (ja) * 2009-02-17 2015-09-16 マリンクロッド エルエルシー ノルモルフィナンの還元的アルキル化のためのプロセス
US8946419B2 (en) 2009-02-23 2015-02-03 Mallinckrodt Llc (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
US8471023B2 (en) 2009-06-11 2013-06-25 Mallinckrodt Llc Reductive amination of 6-keto normorphinans by catalytic hydrogen transfer
CA2764915C (en) * 2009-06-11 2017-07-11 Mallinckrodt Llc Preparation of 6-alpha-amino n-substituted morphinans by catalytic hydrogen transfer
GB0914338D0 (en) 2009-08-17 2009-09-30 Johnson Matthey Plc Improved process
ES2698408T3 (es) 2011-06-09 2019-02-04 SpecGx LLC Aminación reductora de 6-ceto morfinanos por transferencia de hidrógeno catalítico
KR20140063763A (ko) * 2011-09-08 2014-05-27 말린크로트 엘엘씨 중간체를 단리하지 않는 알칼로이드의 제조 방법
US9315514B2 (en) 2012-08-27 2016-04-19 Rhodes Technologies 1,3-dioxanomorphides and 1,3-dioxanocodides
ES2631197T3 (es) 2012-12-14 2017-08-29 Purdue Pharma Lp Análogos de piridonamorfinano y actividad biológica sobre los receptores opiodes
EP2931726B1 (en) 2012-12-14 2017-01-25 Purdue Pharma LP Spirocyclic morphinans and their use
US8937084B2 (en) 2012-12-14 2015-01-20 Purdue Pharma L.P. Nitrogen containing morphinan derivatives and the use thereof
EP2941430B1 (en) 2012-12-28 2017-04-26 Purdue Pharma LP 7,8-cyclicmorphinan analogs
CA2896202A1 (en) 2012-12-28 2014-07-03 Purdue Pharma L.P. Substituted morphinans and the use thereof
WO2014102591A1 (en) 2012-12-31 2014-07-03 Rhodes Technologies PROCESS FOR PREPARING 7β-SUBSTITUTED 6α,14α -ETHENOMORPHINANS AND 7β-SUBSTITUTED 6α,14α-ETHANOMORPHINANS
GB201313915D0 (en) 2013-08-02 2013-09-18 Johnson Matthey Plc Process
MX370344B (es) 2013-11-01 2019-12-10 SpecGx LLC Preparacion conveniente de morfinan-6-oles n-sustituidos a partir de morfinan-6-onas.
WO2015082932A1 (en) 2013-12-05 2015-06-11 The University Of Bath Novel opioid compounds and their uses
WO2015097546A1 (en) 2013-12-26 2015-07-02 Purdue Pharma L.P. Propellane-based compounds and their use as opioid receptor modulators
US9862726B2 (en) 2013-12-26 2018-01-09 Purdue Pharma L.P. Opioid receptor modulating oxabicyclo[2.2.2]octane morphinans
WO2015097547A1 (en) 2013-12-26 2015-07-02 Purdue Pharma L.P. 10-substituted morphinan hydantoins
EP3087078B1 (en) 2013-12-26 2019-05-15 Purdue Pharma LP 7-beta-alkyl analogs of orvinols
WO2015102682A1 (en) 2013-12-30 2015-07-09 Purdue Pharma L.P. Pyridone-sulfone morphinan analogs as opioid receptor ligands
MA41125A (fr) 2014-12-05 2017-10-10 Purdue Pharma Lp Dérivés de 6.7-cyclomorphinane et leur utilisation
CN110198945B (zh) 2016-12-23 2023-06-27 米尼奥尔克斯治疗有限公司 用于制备噻唑烷二酮化合物及其盐的方法
CA3091826A1 (en) 2018-02-23 2019-08-29 Rhodes Technologies Novel opioid compounds and uses thereof

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GB1136214A (en) 1965-06-15 1968-12-11 Reckitt & Sons Ltd Thebaine and oripavine derivatives
US3332950A (en) 1963-03-23 1967-07-25 Endo Lab 14-hydroxydihydronormorphinone derivatives
US3717643A (en) * 1967-05-04 1973-02-20 Sterling Drug Inc N-substituted-norapomorphines
DE2107989A1 (de) * 1971-02-19 1972-09-07 Boehringer Sohn Ingelheim N-(Furyl-methy])-morphinane, deren Säureadditionssalze sowie Verfahren zu deren Herstellung
US4082744A (en) * 1973-05-08 1978-04-04 Nihon Iyakuhin Kogyo Co., Ltd. 4-benzazonine derivatives and process for preparation thereof
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US5869669A (en) * 1996-07-26 1999-02-09 Penick Corporation Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates

Also Published As

Publication number Publication date
CN101027307B (zh) 2011-12-21
GB0421687D0 (en) 2004-11-03
ZA200701784B (en) 2008-11-26
US20080045715A1 (en) 2008-02-21
US8318937B2 (en) 2012-11-27
US20110144341A1 (en) 2011-06-16
ES2322486T5 (es) 2021-02-05
PL1794165T3 (pl) 2009-09-30
US20120046466A9 (en) 2012-02-23
DK1794165T4 (da) 2020-07-13
ES2322486T3 (es) 2009-06-22
US8119803B2 (en) 2012-02-21
AU2005288728A1 (en) 2006-04-06
PT1794165E (pt) 2009-05-06
CN101027307A (zh) 2007-08-29
WO2006035195A1 (en) 2006-04-06
EP1794165A1 (en) 2007-06-13
DK1794165T3 (da) 2010-03-08
DE602005013986D1 (de) 2009-05-28
EP1794165B2 (en) 2020-04-29
AU2005288728B2 (en) 2012-05-03
ATE428715T1 (de) 2009-05-15
EP1794165B1 (en) 2009-04-15

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