BRPI0518152A - pirazolbenzodiazepinas dissubstituìdas úteis como inibidores para cdk2 e angiogênese e para o tratamento de cánceres de mama, cólon, pulmão e próstata - Google Patents

pirazolbenzodiazepinas dissubstituìdas úteis como inibidores para cdk2 e angiogênese e para o tratamento de cánceres de mama, cólon, pulmão e próstata

Info

Publication number
BRPI0518152A
BRPI0518152A BRPI0518152-6A BRPI0518152A BRPI0518152A BR PI0518152 A BRPI0518152 A BR PI0518152A BR PI0518152 A BRPI0518152 A BR PI0518152A BR PI0518152 A BRPI0518152 A BR PI0518152A
Authority
BR
Brazil
Prior art keywords
colon
cdk2
breast
angiogenesis
lung
Prior art date
Application number
BRPI0518152-6A
Other languages
English (en)
Inventor
Jin-Jun Liu
Kin-Chun Luk
Giacomo Pizzolato
Yi Ren
Kshitij Chhabilbhai Thakkar
Peter Michael Wovkulich
Zhuming Zhang
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35311946&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0518152(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BRPI0518152A publication Critical patent/BRPI0518152A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PIRAZOLBENZODIAZEPINAS DISSUBSTITUìDAS úTEIS COMO INIBIDORES PARA CDK2 E ANGIOGéNESE E PARA O TRATAMENTO DE CáNCERES DE MAMA, CóLON, PULMãO E PRóS-TATA. A presente invenção provê compostos da fórmula (I) onde R˜, R, R e R¬ 4¬ são descritos aqui. A invenção também provê síntese para preparação de tais compostos e composições farmacêuticas contendoos. A invenção provê ainda métodos para inibição de cinases, em particular CDK2, para inibição de angiogênese e para tratamento de cânceres, em particular cânceres de mama, cólon, próstata e pulmão.
BRPI0518152-6A 2004-10-13 2005-10-04 pirazolbenzodiazepinas dissubstituìdas úteis como inibidores para cdk2 e angiogênese e para o tratamento de cánceres de mama, cólon, pulmão e próstata BRPI0518152A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US61817404P 2004-10-13 2004-10-13
PCT/EP2005/010653 WO2006040036A1 (en) 2004-10-13 2005-10-04 Disubstituted pyrazolobenzodiazepines useful as inhibitors for cdk2 and angiogesis, and for the treatment of breast, colon, lung and prostate cancer

Publications (1)

Publication Number Publication Date
BRPI0518152A true BRPI0518152A (pt) 2008-11-04

Family

ID=35311946

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0518152-6A BRPI0518152A (pt) 2004-10-13 2005-10-04 pirazolbenzodiazepinas dissubstituìdas úteis como inibidores para cdk2 e angiogênese e para o tratamento de cánceres de mama, cólon, pulmão e próstata

Country Status (25)

Country Link
US (1) US7524840B2 (pt)
EP (1) EP1802625B1 (pt)
JP (1) JP2008515939A (pt)
KR (1) KR100858262B1 (pt)
CN (2) CN101039946B (pt)
AR (1) AR051326A1 (pt)
AT (1) ATE398619T1 (pt)
AU (1) AU2005293818A1 (pt)
BR (1) BRPI0518152A (pt)
CA (1) CA2582985A1 (pt)
DE (1) DE602005007623D1 (pt)
DK (1) DK1802625T3 (pt)
ES (1) ES2308551T3 (pt)
HR (1) HRP20080429T3 (pt)
IL (1) IL182423A0 (pt)
MX (1) MX2007004464A (pt)
NO (1) NO20071794L (pt)
NZ (1) NZ554353A (pt)
PL (1) PL1802625T3 (pt)
PT (1) PT1802625E (pt)
RU (1) RU2394826C2 (pt)
SI (1) SI1802625T1 (pt)
TW (1) TWI309652B (pt)
WO (1) WO2006040036A1 (pt)
ZA (1) ZA200702973B (pt)

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EP3070090B1 (en) 2007-06-13 2018-12-12 Incyte Holdings Corporation Use of salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h- pyrazol-1-yl)-3- cyclopentylpropanenitrile
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EP3643312A1 (en) 2009-05-22 2020-04-29 Incyte Holdings Corporation 3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]octane- or heptane-nitrile as jak inhibitors
AR076794A1 (es) 2009-05-22 2011-07-06 Incyte Corp Derivados de n-(hetero)aril-pirrolidina de pirazol-4-il-pirrolo [2,3-d]pirimidinas y pirrol-3-il-pirrolo [2,3-d ]pirimidinas como inhibidores de la quinasa janus y composiciones farmaceuticas que los contienen
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JP2011201794A (ja) * 2010-03-24 2011-10-13 Fujifilm Corp ５−アミノピラゾール誘導体及びその塩の製造方法
SG10201503983QA (en) 2010-05-21 2015-06-29 Incyte Corp Topical Formulation for a JAK Inhibitor
US9034884B2 (en) 2010-11-19 2015-05-19 Incyte Corporation Heterocyclic-substituted pyrrolopyridines and pyrrolopyrimidines as JAK inhibitors
CN103415515B (zh) 2010-11-19 2015-08-26 因塞特公司 作为jak抑制剂的环丁基取代的吡咯并吡啶和吡咯并嘧啶衍生物
PE20140832A1 (es) 2011-06-20 2014-07-14 Incyte Corp Derivados de azetidinil fenil, piridil o pirazinil carboxamida como inhibidores de jak
TW201313721A (zh) 2011-08-18 2013-04-01 Incyte Corp 作為ｊａｋ抑制劑之環己基氮雜環丁烷衍生物
UA111854C2 (uk) 2011-09-07 2016-06-24 Інсайт Холдінгс Корпорейшн Способи і проміжні сполуки для отримання інгібіторів jak
CN102603743B (zh) * 2012-02-24 2014-05-28 南京天易生物科技有限公司 抗肿瘤的氮杂苯并[f]薁衍生物其制备方法及其用途
TW201406761A (zh) 2012-05-18 2014-02-16 Incyte Corp 做爲ｊａｋ抑制劑之哌啶基環丁基取代之吡咯并吡啶及吡咯并嘧啶衍生物
CN103626761B (zh) * 2012-08-24 2015-07-29 上海医药工业研究院 苯并吡啶氮杂卓类化合物及其作为抗肿瘤药物的应用
PL2919766T3 (pl) 2012-11-15 2021-10-04 Incyte Holdings Corporation Postacie dawkowania ruksolitynibu o przedłużonym uwalnianiu
CN105189509B (zh) 2013-03-06 2017-12-19 因赛特公司 用于制备jak抑制剂的方法及中间体
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WO2015184305A1 (en) 2014-05-30 2015-12-03 Incyte Corporation TREATMENT OF CHRONIC NEUTROPHILIC LEUKEMIA (CNL) AND ATYPICAL CHRONIC MYELOID LEUKEMIA (aCML) BY INHIBITORS OF JAK1
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CN106928040A (zh) * 2015-12-31 2017-07-07 上海医药工业研究院 Sglt2抑制剂中间体的制备方法
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JP6594571B2 (ja) * 2016-12-13 2019-10-23 南京薬捷安康生物科技有限公司 マルチキナーゼ阻害剤化合物、並びにその結晶形及びその使用
CN109020980B (zh) * 2017-06-09 2020-11-20 华东师范大学 一类抗肿瘤作用的吡唑并嘧啶二氮*衍生物
WO2019113487A1 (en) 2017-12-08 2019-06-13 Incyte Corporation Low dose combination therapy for treatment of myeloproliferative neoplasms
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Also Published As

Publication number Publication date
MX2007004464A (es) 2007-05-07
DE602005007623D1 (de) 2008-07-31
RU2394826C2 (ru) 2010-07-20
WO2006040036A1 (en) 2006-04-20
EP1802625A1 (en) 2007-07-04
CN101039946B (zh) 2010-12-08
AU2005293818A1 (en) 2006-04-20
NZ554353A (en) 2010-01-29
PL1802625T3 (pl) 2008-12-31
EP1802625B1 (en) 2008-06-18
JP2008515939A (ja) 2008-05-15
RU2007117770A (ru) 2008-11-20
IL182423A0 (en) 2007-07-24
KR20070054243A (ko) 2007-05-28
SI1802625T1 (sl) 2008-10-31
ZA200702973B (en) 2009-09-30
US7524840B2 (en) 2009-04-28
CN101039946A (zh) 2007-09-19
US20060079511A1 (en) 2006-04-13
CA2582985A1 (en) 2006-04-20
PT1802625E (pt) 2008-08-06
CN101899049A (zh) 2010-12-01
AR051326A1 (es) 2007-01-03
KR100858262B1 (ko) 2008-09-11
TW200628469A (en) 2006-08-16
ATE398619T1 (de) 2008-07-15
TWI309652B (en) 2009-05-11
ES2308551T3 (es) 2008-12-01
DK1802625T3 (da) 2008-09-01
NO20071794L (no) 2007-07-10
HK1108284A1 (en) 2008-05-02
HRP20080429T3 (en) 2008-09-30

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Legal Events

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AO NAO RECOLHIMENTO DA 7A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2208 DE 30/04/2013.