PL1805163T3 - 1,1A,5,5A-tetrahydro-3-tiacyklopropa[A]pentaleny: pochodne tricyklicznego tiofenu jako agonistów receptorów S1P1/EDG1 - Google Patents
1,1A,5,5A-tetrahydro-3-tiacyklopropa[A]pentaleny: pochodne tricyklicznego tiofenu jako agonistów receptorów S1P1/EDG1Info
- Publication number
- PL1805163T3 PL1805163T3 PL05772622T PL05772622T PL1805163T3 PL 1805163 T3 PL1805163 T3 PL 1805163T3 PL 05772622 T PL05772622 T PL 05772622T PL 05772622 T PL05772622 T PL 05772622T PL 1805163 T3 PL1805163 T3 PL 1805163T3
- Authority
- PL
- Poland
- Prior art keywords
- pentalenes
- cyclopropa
- thia
- tetrahydro
- receptor agonists
- Prior art date
Links
- 101000693265 Homo sapiens Sphingosine 1-phosphate receptor 1 Proteins 0.000 title 1
- LORQSSYPABVWKU-UHFFFAOYSA-N S1C=C2C3CC3CC2=C1 Chemical class S1C=C2C3CC3CC2=C1 LORQSSYPABVWKU-UHFFFAOYSA-N 0.000 title 1
- 102100025750 Sphingosine 1-phosphate receptor 1 Human genes 0.000 title 1
- 239000000018 receptor agonist Substances 0.000 title 1
- 229940044601 receptor agonist Drugs 0.000 title 1
- 150000003577 thiophenes Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/78—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Transplantation (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP2004/008501 WO2006010379A1 (en) | 2004-07-29 | 2004-07-29 | Novel thiophene derivatives as immunosuppressive agents |
| PCT/EP2005/007892 WO2006010544A2 (en) | 2004-07-29 | 2005-07-20 | 1, 1a, 5, 5a-tetrahydro-3-thia-cyclopropa’a! pentalenes: tricyclic thiophene derivatives as s1p1/edg1 receptor agonists |
| EP05772622A EP1805163B1 (en) | 2004-07-29 | 2005-07-20 | 1,1a,5,5a-tetrahydro-3-thia-cyclopropa[a]pentalenes: tricyclic thiophene derivatives as s1p1/edg1 receptor agonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL1805163T3 true PL1805163T3 (pl) | 2009-04-30 |
Family
ID=34958296
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL05772622T PL1805163T3 (pl) | 2004-07-29 | 2005-07-20 | 1,1A,5,5A-tetrahydro-3-tiacyklopropa[A]pentaleny: pochodne tricyklicznego tiofenu jako agonistów receptorów S1P1/EDG1 |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US7750040B2 (pl) |
| EP (1) | EP1805163B1 (pl) |
| JP (1) | JP4807884B2 (pl) |
| KR (1) | KR20070046849A (pl) |
| CN (1) | CN1993346B (pl) |
| AR (1) | AR050273A1 (pl) |
| AT (1) | ATE409697T1 (pl) |
| AU (1) | AU2005266529A1 (pl) |
| BR (1) | BRPI0513841A (pl) |
| CA (1) | CA2574305A1 (pl) |
| DE (1) | DE602005010109D1 (pl) |
| DK (1) | DK1805163T3 (pl) |
| ES (1) | ES2313391T3 (pl) |
| IL (1) | IL180962A0 (pl) |
| MX (1) | MX2007000972A (pl) |
| NO (1) | NO20071095L (pl) |
| PL (1) | PL1805163T3 (pl) |
| PT (1) | PT1805163E (pl) |
| RU (1) | RU2386626C2 (pl) |
| SI (1) | SI1805163T1 (pl) |
| TW (1) | TW200616994A (pl) |
| WO (2) | WO2006010379A1 (pl) |
| ZA (1) | ZA200700535B (pl) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4678139B2 (ja) * | 2004-05-10 | 2011-04-27 | トヨタ自動車株式会社 | 自動車の暖房制御システム |
| WO2006010379A1 (en) | 2004-07-29 | 2006-02-02 | Actelion Pharmaceuticals Ltd. | Novel thiophene derivatives as immunosuppressive agents |
| BRPI0514316A (pt) | 2004-08-13 | 2008-06-10 | Praecis Pharm Inc | métodos e composições para modulação de atividade de receptor de esfingosina-1-fosfato (s1p) |
| JP5047941B2 (ja) | 2005-03-23 | 2012-10-10 | アクテリオン ファーマシューティカルズ リミテッド | 免疫調節物質としての水素付加されたベンゾ（ｃ）チオフェン誘導体 |
| ES2370791T3 (es) * | 2005-03-23 | 2011-12-22 | Actelion Pharmaceuticals Ltd. | Nuevos derivados de tiofeno como agonistas del receptor de esfingosina-1-fosfato-1. |
| WO2006100633A1 (en) | 2005-03-23 | 2006-09-28 | Actelion Pharmaceuticals Ltd | NOVEL THIOPHENE DERIVATIVES AS SPHINGOSINE-l-PHOSPHATE-1 RECEPTOR AGONISTS |
| CA2612661A1 (en) | 2005-06-24 | 2006-12-28 | Actelion Pharmaceuticals Ltd. | Novel thiophene derivatives |
| AR057894A1 (es) * | 2005-11-23 | 2007-12-26 | Actelion Pharmaceuticals Ltd | Derivados de tiofeno |
| TWI404706B (zh) * | 2006-01-11 | 2013-08-11 | Actelion Pharmaceuticals Ltd | 新穎噻吩衍生物 |
| CN101370805B (zh) | 2006-01-24 | 2011-04-27 | 埃科特莱茵药品有限公司 | 吡啶衍生物 |
| AR061841A1 (es) | 2006-09-07 | 2008-09-24 | Actelion Pharmaceuticals Ltd | Derivados de tiofen-oxadiazoles, agonistas del receptor s1p1/edg1, composiciones farmaceuticas que los contienen y usos como agentes inmunomoduladores. |
| JP5253401B2 (ja) * | 2006-09-07 | 2013-07-31 | アクテリオン ファーマシューティカルズ リミテッド | 免疫調節薬としてのピリジン−４−イル誘導体 |
| CL2007002594A1 (es) * | 2006-09-08 | 2008-06-06 | Actelion Pharmaceuticals Ltd | Compuestos derivados de piridin-3-il, agentes inmunomoduladores; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto en el tratamiento de enfermedades asociadas con un sistema inmunologico activado. . |
| DE102007019677A1 (de) | 2006-11-06 | 2008-05-08 | Carl Zeiss Surgical Gmbh | Operationsmikroskop mit OCT-System und Operationsmikroskop-Beleuchtungsmodul mit OCT-System |
| DE102007019679B4 (de) | 2006-11-06 | 2025-04-30 | Carl Zeiss Meditec Ag | Operationsmikroskop mit OCT-System |
| DE102007019680A1 (de) | 2006-11-06 | 2008-05-08 | Carl Zeiss Surgical Gmbh | Ophthalmo-Operationsmikroskop mit OCT-System |
| DK2125797T3 (da) * | 2007-03-16 | 2014-02-10 | Actelion Pharmaceuticals Ltd | Aminopyridinderivater som s1p1/edg1-receptoragonister |
| WO2009011850A2 (en) * | 2007-07-16 | 2009-01-22 | Abbott Laboratories | Novel therapeutic compounds |
| BRPI0820868A2 (pt) * | 2007-12-10 | 2019-09-24 | Actelion Pharmaceuticals Ltd | composto de tiofeno fórmula(i), composição farmacêutica contendo o mesmo e uso deste para a prevenção ou tratamento de doenças ou disturbíos associados a um sistema imune ativado |
| WO2009074969A2 (en) * | 2007-12-12 | 2009-06-18 | University Of Lausanne | Sphingosine-1-phosphate, analogs and antagonists for use as medicaments |
| CN101965345B (zh) * | 2008-03-06 | 2014-05-28 | 埃科特莱茵药品有限公司 | 吡啶化合物 |
| JP5435745B2 (ja) * | 2008-03-07 | 2014-03-05 | アクテリオン ファーマシューティカルズ リミテッド | 免疫調節剤としてのピリジン−２−イル誘導体 |
| CA2716448A1 (en) | 2008-03-17 | 2009-09-24 | Patrick Brossard | Dosing regimen for a selective s1p1 receptor agonist |
| EP2318415B1 (en) | 2008-07-15 | 2013-02-20 | Sanofi | Oxazolopyrimidines as edg-1 receptor agonists |
| CN104311472B9 (zh) | 2008-07-23 | 2020-03-17 | 艾尼纳制药公司 | 经取代的1,2,3,4-四氢环戊并[b]吲哚-3-基乙酸衍生物 |
| PL2342205T4 (pl) | 2008-08-27 | 2016-12-30 | Podstawione tricykliczne pochodne kwasowe jako antagoniści receptora S1P1 użyteczni w leczeniu zaburzeń autoimmunologicznych i zapalnych | |
| DE102009002514A1 (de) | 2009-04-21 | 2010-10-28 | Evonik Degussa Gmbh | Verfahren zur Herstellung von substituierten 1,4-Chinonmethiden |
| TWI410421B (zh) | 2009-07-16 | 2013-10-01 | Actelion Pharmaceuticals Ltd | 吡啶－４－基衍生物 |
| EP2470508A1 (en) * | 2009-08-28 | 2012-07-04 | Arena Pharmaceuticals, Inc. | Cannabinoid receptor modulators |
| EP2528894A1 (en) | 2010-01-27 | 2012-12-05 | Arena Pharmaceuticals, Inc. | Processes for the preparation of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid and salts thereof |
| CN105503882B (zh) | 2010-03-03 | 2019-07-05 | 艾尼纳制药公司 | 制备s1p1受体调节剂及其晶体形式的方法 |
| CA2818470C (en) | 2011-01-19 | 2019-03-05 | Actelion Pharmaceuticals Ltd | 2-methoxy-pyridin-4-yl derivatives |
| US9597340B2 (en) | 2011-02-25 | 2017-03-21 | Arena Pharmaceuticals, Inc. | Cannabinoid receptor modulators |
| HUE050733T2 (hu) | 2012-08-17 | 2021-01-28 | Actelion Pharmaceuticals Ltd | Eljárás (2Z,5Z)-5-(3-klór-4-((R)-2,3-dihidroxipropoxi)benzilidén)-2-(pro-pilimino)-3-(O-tolil)tiazolidin-4-on elõállítására és ezen eljárásban alkalmazott köztitermék |
| DE102013208091B4 (de) | 2013-05-02 | 2019-05-09 | Carl Zeiss Ag | Vorrichtung und Verfahren zum Vermessen einer Flächentopografie |
| DE102014222629A1 (de) | 2014-11-05 | 2016-05-12 | Carl Zeiss Meditec Ag | Untersuchen eines Objekts mit OCT-Abtastlichtstrahlen |
| DE202014011050U1 (de) | 2014-11-05 | 2017-07-26 | Carl Zeiss Meditec Ag | Vorrichtung für das Untersuchen eines Patientenauges |
| DE202014011051U1 (de) | 2014-11-05 | 2017-07-26 | Carl Zeiss Meditec Ag | Vorrichtung für das Untersuchen eines Patientenauges |
| CA3002540C (en) | 2015-01-06 | 2023-11-07 | Arena Pharmaceuticals, Inc. | Use of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid for treating conditions related to the s1p1 receptor |
| ES2770348T3 (es) | 2015-05-20 | 2020-07-01 | Idorsia Pharmaceuticals Ltd | Forma cristalina del compuesto (s)-3-{4-[5-(2-ciclopentil-6-metoxi-piridin-4-il)-[1,2,4]oxadiazol-3-il]-2-etil-6-metil-fenoxi}-propano-1,2-diol |
| US10111841B2 (en) | 2015-06-19 | 2018-10-30 | University Of South Florida | Stabilization of alcohol intoxication-induced cardiovascular instability |
| JP6838744B2 (ja) | 2015-06-22 | 2021-03-03 | アリーナ ファーマシューティカルズ， インコーポレイテッド | Ｓ１Ｐ１レセプター関連障害における使用のための（Ｒ）−２−（７−（４−シクロペンチル−３−（トリフルオロメチル）ベンジルオキシ）−１，２，３，４−テトラヒドロシクロペンタ［ｂ］インドール−３−イル）酢酸（化合物１）の結晶性Ｌ−アルギニン塩 |
| KR20190113955A (ko) | 2017-02-16 | 2019-10-08 | 아레나 파마슈티칼스, 인크. | 장-외 증상을 갖는 염증성 장질환의 치료를 위한 화합물 및 방법 |
| CN110520124A (zh) | 2017-02-16 | 2019-11-29 | 艾尼纳制药公司 | 用于治疗原发性胆汁性胆管炎的化合物和方法 |
| US20200078358A1 (en) | 2017-05-08 | 2020-03-12 | Arena Pharmaceuticals, Inc. | Compounds and Methods for Treatment of Visceral Pain |
| CA3062444A1 (en) * | 2017-05-19 | 2018-11-22 | Etna-Tec, Ltd | Methods for making functionalized fluorinated monomers, fluorinated monomers, and compositions for making the same |
| JP7397011B2 (ja) | 2018-06-06 | 2023-12-12 | アリーナ ファーマシューティカルズ， インコーポレイテッド | Ｓ１ｐ１受容体に関連する状態を治療する方法 |
| EP3847158B1 (en) | 2018-09-06 | 2026-06-24 | Arena Pharmaceuticals, Inc. | Compounds useful in the treatment of autoimmune and inflammatory disorders |
| US11014897B1 (en) | 2018-10-16 | 2021-05-25 | Celgene Corporation | Solid forms comprising a thiazolidinone compound, compositions and methods of use thereof |
| US11014940B1 (en) | 2018-10-16 | 2021-05-25 | Celgene Corporation | Thiazolidinone and oxazolidinone compounds and formulations |
| US11013723B1 (en) | 2018-10-16 | 2021-05-25 | Celgene Corporation | Solid forms of a thiazolidinone compound, compositions and methods of use thereof |
| US11186556B1 (en) | 2018-10-16 | 2021-11-30 | Celgene Corporation | Salts of a thiazolidinone compound, solid forms, compositions and methods of use thereof |
| CN113072519A (zh) * | 2021-04-01 | 2021-07-06 | 福建海西新药创制有限公司 | 一种利用微反应装置连续生产非布司他的方法 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2599740B1 (fr) * | 1986-06-05 | 1988-08-12 | Rhone Poulenc Sante | Derives de benzo(b)thiophene de benzo(b)furannecarboxamides, leurs procedes de preparation et les medicaments les contenant |
| US4963557A (en) | 1987-09-28 | 1990-10-16 | Smithkline Beecham Corporation | Immunomodulatory azaspiranes |
| WO1991015583A1 (en) | 1990-04-05 | 1991-10-17 | The American National Red Cross | A protein family related to immediate-early protein expressed by human endothelial cells during differentiation |
| AU653957B2 (en) | 1990-09-20 | 1994-10-20 | Merrell Dow Pharmaceuticals Inc. | 1-aryl-3-pyridinyl-2-propene-1-ones |
| US6423508B1 (en) | 1998-03-09 | 2002-07-23 | Smithkline Beecham Corporation | Polynucleotide sequences of human EDG-1c |
| GB9808665D0 (en) | 1998-04-23 | 1998-06-24 | Merck Sharp & Dohme | Therapeutic compounds |
| ATE315559T1 (de) | 2001-08-01 | 2006-02-15 | Basell Polyolefine Gmbh | Verfahren zur herstellung von heterocyclischen pentalen derivaten |
| US20040058894A1 (en) * | 2002-01-18 | 2004-03-25 | Doherty George A. | Selective S1P1/Edg1 receptor agonists |
| ATE448193T1 (de) | 2002-01-18 | 2009-11-15 | Merck & Co Inc | ßN-(BENZYL)AMINOALKYL CARBOXYLATE, PHOSPHINATE, PHOSPHONATE UND TETRAZOLE ALS EDG REZEPTORAGONISTENß |
| EP1549640A4 (en) | 2002-06-17 | 2008-08-06 | Merck & Co Inc | 1 - ((5-ARYL-1,2,4-OXADIAZOL-3-YL) BENZYL) AZETIDINE-3-CARBOXYLATE AND 1 - ((5-ARYL-1,2,4-OXADIAZOL-3-YL) BENZYL) PYRROLIDIN-3-CARBOXYLATE AS EDG RECEPTOR AGONISTS |
| DE10231370B4 (de) * | 2002-07-11 | 2006-04-06 | Sanofi-Aventis Deutschland Gmbh | Thiophenglycosidderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zur Herstellung dieser Arzneimittel |
| AU2003259296A1 (en) * | 2002-07-30 | 2004-02-16 | University Of Virginia Patent Foundation | Compounds active in spinigosine 1-phosphate signaling |
| AU2003279915A1 (en) | 2002-10-15 | 2004-05-04 | Merck And Co., Inc. | Process for making azetidine-3-carboxylic acid |
| CA2524867A1 (en) | 2003-05-15 | 2004-12-02 | Merck & Co., Inc. | 3-(2-amino-1-azacyclyl)-5-aryl-1,2,4-oxadiazoles as s1p receptor agonists |
| WO2005014525A2 (en) | 2003-08-12 | 2005-02-17 | Mitsubishi Pharma Corporation | Bi-aryl compound having immunosuppressive activity |
| WO2005032465A2 (en) | 2003-10-01 | 2005-04-14 | Merck & Co., Inc. | 3,5-aryl, heteroaryl or cycloalkyl substituted-1,2,4-oxadiazoles as s1p receptor agonists |
| US7605171B2 (en) | 2003-12-17 | 2009-10-20 | Merck & Co., Inc. | (3,4-disubstituted)propanoic carboxylates as S1P (Edg) receptor agonists |
| WO2006010379A1 (en) | 2004-07-29 | 2006-02-02 | Actelion Pharmaceuticals Ltd. | Novel thiophene derivatives as immunosuppressive agents |
| JP5047941B2 (ja) | 2005-03-23 | 2012-10-10 | アクテリオン ファーマシューティカルズ リミテッド | 免疫調節物質としての水素付加されたベンゾ（ｃ）チオフェン誘導体 |
| WO2006100633A1 (en) * | 2005-03-23 | 2006-09-28 | Actelion Pharmaceuticals Ltd | NOVEL THIOPHENE DERIVATIVES AS SPHINGOSINE-l-PHOSPHATE-1 RECEPTOR AGONISTS |
| ES2370791T3 (es) * | 2005-03-23 | 2011-12-22 | Actelion Pharmaceuticals Ltd. | Nuevos derivados de tiofeno como agonistas del receptor de esfingosina-1-fosfato-1. |
| US20080306124A1 (en) | 2005-06-08 | 2008-12-11 | Rainer Albert | Polycyclic Oxadiazoles or I Soxazoles and Their Use as Sip Receptor Ligands |
| CA2612661A1 (en) | 2005-06-24 | 2006-12-28 | Actelion Pharmaceuticals Ltd. | Novel thiophene derivatives |
| AR057894A1 (es) * | 2005-11-23 | 2007-12-26 | Actelion Pharmaceuticals Ltd | Derivados de tiofeno |
| GB0601744D0 (en) | 2006-01-27 | 2006-03-08 | Novartis Ag | Organic compounds |
| US20080005421A1 (en) * | 2006-05-19 | 2008-01-03 | Chi-Tung Chang | Switching Device of Input and Output Interfaces of Computer Systems |
| RU2009127095A (ru) | 2006-12-15 | 2011-01-20 | Эбботт Лэборетриз (Us) | Новые оксадиазольные соединения |
| WO2008091967A1 (en) | 2007-01-26 | 2008-07-31 | Smithkline Beecham Corporation | Chemical compounds |
-
2004
- 2004-07-29 WO PCT/EP2004/008501 patent/WO2006010379A1/en not_active Ceased
-
2005
- 2005-07-20 CN CN2005800255902A patent/CN1993346B/zh not_active Expired - Fee Related
- 2005-07-20 DK DK05772622T patent/DK1805163T3/da active
- 2005-07-20 JP JP2007522982A patent/JP4807884B2/ja not_active Expired - Fee Related
- 2005-07-20 PL PL05772622T patent/PL1805163T3/pl unknown
- 2005-07-20 AT AT05772622T patent/ATE409697T1/de not_active IP Right Cessation
- 2005-07-20 MX MX2007000972A patent/MX2007000972A/es active IP Right Grant
- 2005-07-20 BR BRPI0513841-8A patent/BRPI0513841A/pt not_active IP Right Cessation
- 2005-07-20 SI SI200530472T patent/SI1805163T1/sl unknown
- 2005-07-20 EP EP05772622A patent/EP1805163B1/en not_active Expired - Lifetime
- 2005-07-20 ES ES05772622T patent/ES2313391T3/es not_active Expired - Lifetime
- 2005-07-20 RU RU2007107164/04A patent/RU2386626C2/ru not_active IP Right Cessation
- 2005-07-20 AU AU2005266529A patent/AU2005266529A1/en not_active Abandoned
- 2005-07-20 WO PCT/EP2005/007892 patent/WO2006010544A2/en not_active Ceased
- 2005-07-20 CA CA002574305A patent/CA2574305A1/en not_active Abandoned
- 2005-07-20 PT PT05772622T patent/PT1805163E/pt unknown
- 2005-07-20 DE DE602005010109T patent/DE602005010109D1/de not_active Expired - Lifetime
- 2005-07-20 US US11/572,801 patent/US7750040B2/en not_active Expired - Fee Related
- 2005-07-20 KR KR1020077003174A patent/KR20070046849A/ko not_active Withdrawn
- 2005-07-28 TW TW094125581A patent/TW200616994A/zh unknown
- 2005-07-28 AR ARP050103142A patent/AR050273A1/es not_active Application Discontinuation
-
2007
- 2007-01-18 ZA ZA200700535A patent/ZA200700535B/en unknown
- 2007-01-25 IL IL180962A patent/IL180962A0/en unknown
- 2007-02-27 NO NO20071095A patent/NO20071095L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| JP4807884B2 (ja) | 2011-11-02 |
| DE602005010109D1 (de) | 2008-11-13 |
| TW200616994A (en) | 2006-06-01 |
| AR050273A1 (es) | 2006-10-11 |
| JP2008508210A (ja) | 2008-03-21 |
| EP1805163A2 (en) | 2007-07-11 |
| PT1805163E (pt) | 2008-12-05 |
| CN1993346B (zh) | 2011-04-27 |
| RU2007107164A (ru) | 2008-09-10 |
| WO2006010544A2 (en) | 2006-02-02 |
| ES2313391T3 (es) | 2009-03-01 |
| KR20070046849A (ko) | 2007-05-03 |
| ATE409697T1 (de) | 2008-10-15 |
| NO20071095L (no) | 2007-02-27 |
| WO2006010379A1 (en) | 2006-02-02 |
| ZA200700535B (en) | 2008-10-29 |
| MX2007000972A (es) | 2007-04-10 |
| CN1993346A (zh) | 2007-07-04 |
| DK1805163T3 (da) | 2008-12-15 |
| BRPI0513841A (pt) | 2008-05-20 |
| US7750040B2 (en) | 2010-07-06 |
| RU2386626C2 (ru) | 2010-04-20 |
| SI1805163T1 (sl) | 2009-02-28 |
| AU2005266529A1 (en) | 2006-02-02 |
| US20080064740A1 (en) | 2008-03-13 |
| EP1805163B1 (en) | 2008-10-01 |
| CA2574305A1 (en) | 2006-02-02 |
| WO2006010544A3 (en) | 2006-03-30 |
| IL180962A0 (en) | 2007-07-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| SI1805163T1 (sl) | 1.1a,5,5a-tetrahidro-3-tia-ciklopropa(a)pentaleni: tricikliäśni tiofenski derivati kot agonisti receptorja s1p1/edg1 | |
| IL192657A0 (en) | Novel thiophene derivatives as s1p1/edg1 receptor agonists | |
| IL197395A0 (en) | Thiophene derivatives as s1p1/edg1 receptor agonists | |
| DK1720836T3 (da) | 6-substituerede 2,3,4,5-tetrahydro-1h-benzo [d]azepiner som 5-ht2c-receptoragonister | |
| IL186150A0 (en) | Novel thiophene derivatives as sphingosine-1-1phosphate-1 receptor agonists | |
| ZA200709086B (en) | Novel thiophene derivatives as sphingosine-1-phosphate-1 receptor agonists | |
| ZA200906736B (en) | New 3-([1,2,4] Triazolo [4,3-A]Pyridin-7-YL) Benzamide derivatives | |
| ZA200800785B (en) | Novel benzo [D] [1,3]-dioxol derivatives | |
| ZA201001151B (en) | 1',3'-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2h-1'h-[1,4']bipyridinyl-2'-ones | |
| IL177799A0 (en) | Substituted thiophene derivatives as anti-cancer agents | |
| IL182090A0 (en) | 2,6-substituted-4-monosubstitutedamino-pyrimidine as prostaglandin d2 receptor antagonists | |
| EP1863810A4 (en) | NEW TETRAHYDRO-1H-PYRIDO [4,3-B] INDOLDERIVATE AS CB1 'RECEPTOR LIGANDS | |
| IL186354A0 (en) | INTERMEDIATE COMPOUNDS FOR THE PREPARATION OF TRANS -5-CHLORO-2-METHYL-2,3,3a,12b-TETRAHYDRO-1H -DIBENZ[2,3:6,7] OXEPINO [4,5-c] PYRROLE | |
| AU2006287202A8 (en) | 6-arylalkylamino- 2,3,4,5-tetrahydro-1H-benzo[d]azepines as 5-HT2c receptor agonists | |
| IL189667A0 (en) | 4-amino-thieno[3,2-c]pyridine-7-carboxylic acid derivatives | |
| EP2062895A4 (en) | SUBSTITUTED AZEPINE [4,3-B] INDOLE, PHARMACOLOGICAL COMPOSITION AND METHOD FOR THE PRODUCTION THEREOF AND THEIR USE | |
| PT1161152E (pt) | Composicao nutricional destinada a maturacao gastrointestinal especifica, em mamiferos prematuros | |
| AP2006003840A0 (en) | Indole-2-carboxamidine derivatives as NMDA receptor antagonists | |
| IL179278A0 (en) | Substituted azepine derivatives as serotonin receptor modulators | |
| IL189181A0 (en) | Novel 4-amino-thieno[3,2-c]pyridine-7- | |
| PT1838683E (pt) | Um processo para a preparação de derivados de [1,4,5]-oxadiazepina | |
| IL197149A0 (en) | 4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4] diazepine derivatives | |
| ZA200610587B (en) | 1-Heterocyclyl-1,5-dihydro-pyrido[3,2-b]indol-2-ones | |
| ZA200502316B (en) | 4-Oxo-4,6,7,8-tetrahydrop-pyrrolofÄ1,2-aÜpyrazine-6-carbox-amide compounds, a process for their preparation and pharmaceutical compositions containingthem. | |
| HK1100558A (en) | 6-substituted 2,3,4,5-tetrahydro-1h-benzo [d]azepines as 5-ht2c receptor agonists |