DK1805163T3 - 1,1A,5,5A-tetrahydro-3-thia-cyclopropa[A]pentalener: Tricykliske thiophenderivater som S1P1/Edg1-receptoragonister - Google Patents

1,1A,5,5A-tetrahydro-3-thia-cyclopropa[A]pentalener: Tricykliske thiophenderivater som S1P1/Edg1-receptoragonister

Info

Publication number
DK1805163T3
DK1805163T3 DK05772622T DK05772622T DK1805163T3 DK 1805163 T3 DK1805163 T3 DK 1805163T3 DK 05772622 T DK05772622 T DK 05772622T DK 05772622 T DK05772622 T DK 05772622T DK 1805163 T3 DK1805163 T3 DK 1805163T3
Authority
DK
Denmark
Prior art keywords
pentalenes
cyclopropa
thia
tetrahydro
receptor agonists
Prior art date
Application number
DK05772622T
Other languages
English (en)
Inventor
Martin Bolli
Daniel Bur
Martine Clozel
Walter Fischli
David Lehmann
Boris Mathys
Claus Mueller
Oliver Nayler
Michael Scherz
Thomas Weller
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Application granted granted Critical
Publication of DK1805163T3 publication Critical patent/DK1805163T3/da

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/78Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/14Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Transplantation (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DK05772622T 2004-07-29 2005-07-20 1,1A,5,5A-tetrahydro-3-thia-cyclopropa[A]pentalener: Tricykliske thiophenderivater som S1P1/Edg1-receptoragonister DK1805163T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/EP2004/008501 WO2006010379A1 (en) 2004-07-29 2004-07-29 Novel thiophene derivatives as immunosuppressive agents
PCT/EP2005/007892 WO2006010544A2 (en) 2004-07-29 2005-07-20 1, 1a, 5, 5a-tetrahydro-3-thia-cyclopropa’a! pentalenes: tricyclic thiophene derivatives as s1p1/edg1 receptor agonists

Publications (1)

Publication Number Publication Date
DK1805163T3 true DK1805163T3 (da) 2008-12-15

Family

ID=34958296

Family Applications (1)

Application Number Title Priority Date Filing Date
DK05772622T DK1805163T3 (da) 2004-07-29 2005-07-20 1,1A,5,5A-tetrahydro-3-thia-cyclopropa[A]pentalener: Tricykliske thiophenderivater som S1P1/Edg1-receptoragonister

Country Status (23)

Country Link
US (1) US7750040B2 (da)
EP (1) EP1805163B1 (da)
JP (1) JP4807884B2 (da)
KR (1) KR20070046849A (da)
CN (1) CN1993346B (da)
AR (1) AR050273A1 (da)
AT (1) ATE409697T1 (da)
AU (1) AU2005266529A1 (da)
BR (1) BRPI0513841A (da)
CA (1) CA2574305A1 (da)
DE (1) DE602005010109D1 (da)
DK (1) DK1805163T3 (da)
ES (1) ES2313391T3 (da)
IL (1) IL180962A0 (da)
MX (1) MX2007000972A (da)
NO (1) NO20071095L (da)
PL (1) PL1805163T3 (da)
PT (1) PT1805163E (da)
RU (1) RU2386626C2 (da)
SI (1) SI1805163T1 (da)
TW (1) TW200616994A (da)
WO (2) WO2006010379A1 (da)
ZA (1) ZA200700535B (da)

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Also Published As

Publication number Publication date
ES2313391T3 (es) 2009-03-01
KR20070046849A (ko) 2007-05-03
AU2005266529A1 (en) 2006-02-02
CN1993346B (zh) 2011-04-27
JP2008508210A (ja) 2008-03-21
EP1805163A2 (en) 2007-07-11
RU2386626C2 (ru) 2010-04-20
PT1805163E (pt) 2008-12-05
AR050273A1 (es) 2006-10-11
TW200616994A (en) 2006-06-01
WO2006010544A2 (en) 2006-02-02
RU2007107164A (ru) 2008-09-10
ATE409697T1 (de) 2008-10-15
US7750040B2 (en) 2010-07-06
EP1805163B1 (en) 2008-10-01
US20080064740A1 (en) 2008-03-13
NO20071095L (no) 2007-02-27
IL180962A0 (en) 2007-07-04
CN1993346A (zh) 2007-07-04
MX2007000972A (es) 2007-04-10
WO2006010379A1 (en) 2006-02-02
SI1805163T1 (sl) 2009-02-28
BRPI0513841A (pt) 2008-05-20
ZA200700535B (en) 2008-10-29
DE602005010109D1 (de) 2008-11-13
PL1805163T3 (pl) 2009-04-30
WO2006010544A3 (en) 2006-03-30
CA2574305A1 (en) 2006-02-02
JP4807884B2 (ja) 2011-11-02

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