PL1856251T3 - Metabolicznie zmodyfikowane komórki do wytwarzania resweratrolu lub jego oligomerycznej lub związanej z glikozydem pochodnej - Google Patents

Metabolicznie zmodyfikowane komórki do wytwarzania resweratrolu lub jego oligomerycznej lub związanej z glikozydem pochodnej

Info

Publication number
PL1856251T3
PL1856251T3 PL06708430T PL06708430T PL1856251T3 PL 1856251 T3 PL1856251 T3 PL 1856251T3 PL 06708430 T PL06708430 T PL 06708430T PL 06708430 T PL06708430 T PL 06708430T PL 1856251 T3 PL1856251 T3 PL 1856251T3
Authority
PL
Poland
Prior art keywords
glycoside
oligomeric
modified cells
metabolically modified
related derivative
Prior art date
Application number
PL06708430T
Other languages
English (en)
Inventor
Michael Katz
Hans Peter Smits
Jochen Förster
Jens Bredal Nielsen
Original Assignee
Evolva Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Evolva Sa filed Critical Evolva Sa
Publication of PL1856251T3 publication Critical patent/PL1856251T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/22—Preparation of oxygen-containing organic compounds containing a hydroxy group aromatic
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23B—PRESERVATION OF FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES; CHEMICAL RIPENING OF FRUIT OR VEGETABLES
    • A23B11/00—Preservation of milk or dairy products
    • A23B11/10—Preservation of milk or milk preparations
    • A23B11/18—Preservation of milk or milk preparations by addition of preservatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0036—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6)
    • C12N9/0038—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6) with a heme protein as acceptor (1.6.2)
    • C12N9/0042—NADPH-cytochrome P450 reductase (1.6.2.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0073—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with NADH or NADPH as one donor, and incorporation of one atom of oxygen 1.14.13
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12N9/1037—Naringenin-chalcone synthase (2.3.1.74), i.e. chalcone synthase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P23/00—Preparation of compounds containing a cyclohexene ring having an unsaturated side chain containing at least ten carbon atoms bound by conjugated double bonds, e.g. carotenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12Y203/01074—Naringenin-chalcone synthase (2.3.1.74), i.e. chalcone synthase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y106/00—Oxidoreductases acting on NADH or NADPH (1.6)
    • C12Y106/02—Oxidoreductases acting on NADH or NADPH (1.6) with a heme protein as acceptor (1.6.2)
    • C12Y106/02004—NADPH-hemoprotein reductase (1.6.2.4), i.e. NADP-cytochrome P450-reductase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • C12Y114/13—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with NADH or NADPH as one donor, and incorporation of one atom of oxygen (1.14.13)
    • C12Y114/13011—Trans-cinnamate 4-monooxygenase (1.14.13.11)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y403/00—Carbon-nitrogen lyases (4.3)
    • C12Y403/01—Ammonia-lyases (4.3.1)
    • C12Y403/01005—Phenylalanine ammonia-lyase (4.3.1.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y602/00—Ligases forming carbon-sulfur bonds (6.2)
    • C12Y602/01—Acid-Thiol Ligases (6.2.1)
    • C12Y602/01012—4-Coumarate-CoA ligase (6.2.1.12)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y604/00—Ligases forming carbon-carbon bonds (6.4)
    • C12Y604/01—Ligases forming carbon-carbon bonds (6.4.1)
    • C12Y604/01002—Acetyl-CoA carboxylase (6.4.1.2)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Enzymes And Modification Thereof (AREA)
PL06708430T 2005-02-22 2006-02-21 Metabolicznie zmodyfikowane komórki do wytwarzania resweratrolu lub jego oligomerycznej lub związanej z glikozydem pochodnej PL1856251T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0503657.9A GB0503657D0 (en) 2005-02-22 2005-02-22 Metabolically engineered cells for the production of resveratrol or an oligomeric or glycosidically-bound derivative thereof
EP06708430A EP1856251B1 (en) 2005-02-22 2006-02-21 Metabolically engineered cells for the production of resveratrol or an oligomeric or glycosidically-bound derivative thereof
PCT/EP2006/060154 WO2006089898A1 (en) 2005-02-22 2006-02-21 Metabolically engineered cells for the production of resveratrol or an oligomeric or glycosidically-bound derivative thereof

Publications (1)

Publication Number Publication Date
PL1856251T3 true PL1856251T3 (pl) 2013-07-31

Family

ID=34401134

Family Applications (1)

Application Number Title Priority Date Filing Date
PL06708430T PL1856251T3 (pl) 2005-02-22 2006-02-21 Metabolicznie zmodyfikowane komórki do wytwarzania resweratrolu lub jego oligomerycznej lub związanej z glikozydem pochodnej

Country Status (13)

Country Link
US (4) US8895287B2 (pl)
EP (1) EP1856251B1 (pl)
JP (2) JP5288806B2 (pl)
CN (1) CN101160393B (pl)
AU (1) AU2006217963B2 (pl)
CA (1) CA2598414C (pl)
DK (1) DK1856251T3 (pl)
ES (1) ES2397282T3 (pl)
GB (1) GB0503657D0 (pl)
NZ (1) NZ561409A (pl)
PL (1) PL1856251T3 (pl)
WO (1) WO2006089898A1 (pl)
ZA (1) ZA200707942B (pl)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1765977A4 (en) * 2004-03-01 2008-10-08 Univ Minnesota Flavonoids
GB0503657D0 (en) * 2005-02-22 2005-03-30 Fluxome Sciences As Metabolically engineered cells for the production of resveratrol or an oligomeric or glycosidically-bound derivative thereof
US7772444B2 (en) 2005-05-19 2010-08-10 E. I. Du Pont De Nemours And Company Method for the production of resveratrol in a recombinant oleaginous microorganism
GB0614442D0 (en) * 2006-07-20 2006-08-30 Fluxome Sciences As Metabolically engineered cells for the production of pinosylvin
UA103457C2 (ru) * 2006-12-07 2013-10-25 Инбев С.А. Способ производства пива
GB0714671D0 (en) * 2007-07-27 2007-09-05 Fluxome Sciences As Microbial bioreaction process
US20090054497A1 (en) * 2007-08-21 2009-02-26 Nawaz Ahmad Methods for attaining enhanced sexual wellness using anhydrous compositions
GB0800674D0 (en) * 2008-01-15 2008-02-20 Fluxome Sciences As Production of consumable products
GB0806256D0 (en) * 2008-04-07 2008-05-14 Fluxome Sciences As Production of stilbenoids
GB0806592D0 (en) * 2008-04-11 2008-05-14 Fluxome Sciences As Conversion of stilbenoids
GB0806595D0 (en) * 2008-04-11 2008-05-14 Fluxome Sciences As Recovery of stilbenoids
FR2934160B1 (fr) * 2008-07-25 2012-12-07 Lvmh Rech Procede de preparation d'un extrait lipophile de vigne.
DE102008042144A1 (de) 2008-09-17 2010-03-18 Evonik Degussa Gmbh Verfahren zur Herstellung von Silbenoiden
JP4681038B2 (ja) * 2008-11-26 2011-05-11 麒麟麦酒株式会社 麦酒味覚の発泡酒の製造方法
JP2011001300A (ja) * 2009-06-18 2011-01-06 Kao Corp 皮膚老化防止剤、表皮細胞分裂回数減少に対する抑制剤、及び表皮厚減少に対する抑制剤
CN102220350B (zh) * 2010-04-15 2012-09-19 上海科爱生物技术有限公司 利用昆虫系统表达白藜芦醇芪合酶和制备白藜芦醇的方法
GB201008826D0 (en) 2010-05-26 2010-07-14 Fluxome Sciences As Production of metabolites
DE102010023749A1 (de) 2010-06-14 2011-12-15 Evonik Degussa Gmbh Zelle und Verfahren zur Herstellung von Resveratrol
CN102605006B (zh) * 2012-02-17 2014-07-30 天津大学 一种白藜芦醇的生物生产方法
ITTO20120870A1 (it) * 2012-10-05 2014-04-06 Chemtex Italia Spa Organismo microbico resistente allo stress biochimico
EP3039132A2 (en) 2013-08-30 2016-07-06 Evolva SA A method for producing modified resveratrol
KR102350425B1 (ko) 2013-11-01 2022-01-11 코나겐 인크. 프테로스틸벤의 생합성 제조를 위한 o-메틸트랜스퍼라제의 사용 방법
CN103865803B (zh) * 2014-01-26 2016-01-27 玉林师范学院 β-葡萄糖苷酶高产菌及其在转化制备京尼平和白藜芦醇中的应用
CN104611354B (zh) * 2015-02-05 2017-09-05 北京农学院 融合蛋白Nt4CL5aPcSTS的相关生物材料及其应用
WO2016180956A1 (en) 2015-05-12 2016-11-17 Evolva Sa A method for producing resveratrol
ES2590221B1 (es) * 2015-05-18 2017-07-10 Universidad De Oviedo Ácido nucleico recombinante para su uso en la producción de polifenoles
JP6799010B2 (ja) * 2015-05-28 2020-12-09 エヴォルヴァ エスアー．Ｅｖｏｌｖａ Ｓａ． フェニルプロパノイドおよびフェニルプロパノイド誘導体の生合成
JP7034715B2 (ja) * 2015-06-05 2022-03-14 エヴォルヴァ エスアー． フェニルプロパノイドおよびジヒドロフェニルプロパノイド誘導体の生合成
CN105018359B (zh) * 2015-07-14 2018-03-27 厦门欧米克生物科技有限公司 一种酵母菌的用途及天然对香豆酸的生产方法
CN105505989A (zh) * 2016-01-15 2016-04-20 福建农林大学 启动子NtR12驱动AhRESS基因在本生烟草发状根产白藜芦醇的方法
CN105441478A (zh) * 2016-01-15 2016-03-30 福建农林大学 一种烟草根特异启动子NtR2驱动AhRESS基因产白藜芦醇的方法
CN105505983A (zh) * 2016-01-15 2016-04-20 福建农林大学 NtR2根启动子驱动AhRESS在本生烟草发状根产白藜芦醇方法
CN107574176A (zh) * 2016-07-05 2018-01-12 天津大学 一种改进的白藜芦醇生物生产方法
GB201701598D0 (en) 2017-01-31 2017-03-15 Evolva Sa Process and compostion
WO2018146643A1 (en) * 2017-02-13 2018-08-16 Evolva Sa Nature-identical supplements to improve the health and performance of animals
WO2018197385A1 (en) 2017-04-25 2018-11-01 Evolva Sa Nature-identical supplements to improve the productivity of animals
WO2018210880A1 (en) 2017-05-15 2018-11-22 Evolva Sa Stilbenes for pre-harvest treatment and crop protection
WO2018210872A1 (en) 2017-05-15 2018-11-22 Evolva Sa Stilbenes for post-harvest treatment and food preservation and/or shelf life extension
JP7444370B2 (ja) * 2017-08-04 2024-03-06 株式会社明治 乳酸菌の培養方法
SG11202004412RA (en) * 2017-11-20 2020-06-29 Axxence Holding B V Production of a flavour compound in a host cell
AU2019207737B2 (en) 2018-01-10 2023-07-13 Brightseed, Inc. Method for modulating metabolism
KR102187682B1 (ko) * 2018-06-08 2020-12-07 한국과학기술원 타입 iii 폴리케타이드 합성 효소 기반 신규 말로닐-코에이 바이오센서 및 그 용도
CN109609421A (zh) * 2018-09-17 2019-04-12 中国药科大学 一种提高白藜芦醇累积量的生物方法
CN109750078A (zh) * 2019-01-16 2019-05-14 南京师范大学 一种复合菌剂生物转化花生废弃物高效合成白藜芦醇联产木犀草素的方法及应用
MX2022004794A (es) * 2019-10-25 2022-07-11 Brightseed Inc Celula recombinante, extracto, producto consumible y metodo para la produccion de metabolito vegetal bioactivo.
JP2023501483A (ja) 2019-11-11 2023-01-18 ブライトシード・インコーポレイテッド 抽出物、消費可能な製品及び抽出物における生物活性代謝産物を濃縮するための方法
CN110819660A (zh) * 2019-11-25 2020-02-21 陈江 一种酶催化法合成反式-4-香豆酸的方法
FR3110598B1 (fr) * 2020-05-20 2025-05-02 Abolis Biotechnologies Methode de biosynthese de phenylpropanoïdes
CN112359051B (zh) * 2020-11-10 2023-07-18 杭州鑫旺途科技有限公司 一种来源于三叶青的苯丙氨酸解氨酶基因ThPAL及其应用
KR20240069742A (ko) 2021-09-20 2024-05-20 단스타 퍼멘트 에이쥐 레스베라트롤의 제형 및 용도
CN113930349B (zh) * 2021-10-08 2024-05-07 河北维达康生物科技有限公司 一种以l-酪氨酸为底物生物合成白藜芦醇的工程菌、构建及应用
CN114395497B (zh) * 2021-12-24 2024-01-02 河北维达康生物科技有限公司 一种以葡萄糖为底物微生物合成白皮杉醇的工程菌、构建及其应用
WO2023244843A1 (en) * 2022-06-16 2023-12-21 Amyris, Inc. HIGH pH METHODS AND COMPOSITIONS FOR CULTURING GENETICALLY MODIFIED HOST CELLS
CN115109793B (zh) * 2022-06-24 2024-03-26 浙江工业大学 一种从头合成络缌的重组大肠杆菌及其构建方法和应用
CN116875474B (zh) * 2023-06-12 2026-03-31 河北维达康生物科技股份有限公司 一种利用对香豆酸合成白藜芦醇工程菌、构建及应用
CN117625698B (zh) * 2023-11-28 2026-01-06 湖南鸿健生物科技有限公司 一种利用解脂亚洛酵母菌株发酵生产白藜芦醇的工艺
CN119639835B (zh) * 2025-02-20 2025-11-14 广州中妆美业化妆品有限公司 一种祁门山茶籽发酵油的制备方法
CN121160814B (zh) * 2025-09-16 2026-04-21 安徽斛生记生物科技有限公司 一种霍山石斛多糖高效酶解及寡糖检测方法

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4865973A (en) 1985-09-13 1989-09-12 Queen's University At Kingston Process for extractive fermentation
US5689046A (en) 1987-09-30 1997-11-18 Bayer Aktiengesellschaft Stilbene synthase gene
DE3733017A1 (de) 1987-09-30 1989-04-13 Bayer Ag Stilbensynthase-gen
DE4107396A1 (de) 1990-06-29 1992-01-02 Bayer Ag Stilbensynthase-gene aus weinrebe
DE4130986A1 (de) 1991-09-18 1993-03-25 Bayer Ag Pinosylvinsynthase-gene
US6284523B1 (en) 1997-09-19 2001-09-04 Andrew J. Daugulis Process for biodegradation of a xenobiotic
EP1181383B1 (de) 1999-05-28 2004-10-20 Inotech Ag Verfahren und vorrichtung zur in-situ extraktion
JP4244086B2 (ja) 1999-06-30 2009-03-25 メルシャン株式会社 ポリフェノールの濃縮・回収方法およびポリフェノール高含有酵母。
US6521748B2 (en) 1999-08-06 2003-02-18 E. I. Du Pont De Nemours And Company Polynucleotide encoding a mutant Rhodotorula glutinis tyrosine ammonia lyase polypeptide
US6368837B1 (en) 1999-08-06 2002-04-09 E. I. Du Pont Nemours And Company Bioproduction of para-hydroxycinnamic acid
US20060263864A1 (en) 1999-10-20 2006-11-23 Robert Busby Methods for improving secondary metabolite production of fungi
CN1116264C (zh) 2000-07-20 2003-07-30 北京孚曼生物技术有限公司 白藜芦醇和白藜芦醇甙分离方法及其应用
US20040078846A1 (en) 2002-01-25 2004-04-22 Desouza Mervyn L. Carotenoid biosynthesis
US20050003474A1 (en) 2001-01-26 2005-01-06 Desouza Mervyn L. Carotenoid biosynthesis
US6951751B2 (en) 2002-05-23 2005-10-04 E. I. Du Pont De Nemours And Company DNA and amino acid sequences of a tyrosine-inducible tyrosine ammonia lyase enzyme from the yeast Trichosporon cutaneum
US7067302B2 (en) 2002-07-23 2006-06-27 E. I. Du Pont De Nemours And Company DNA and amino acid sequence of a tyrosine ammonia lyase enzyme from the bacterium Rhodobacter sphaeroides
AU2002953170A0 (en) 2002-12-04 2002-12-19 Lang Technologies Pty Ltd Juice recovery process
US7157256B2 (en) 2003-04-14 2007-01-02 E. I. Du Pont De Nemours And Company Method for producing para-hydroxystyrene and other multifunctional aromatic compounds using two-phase extractive fermentation
US20040234671A1 (en) 2003-05-20 2004-11-25 Ector Betty J. Houston Method and system for processing muscadine grape pomace
KR20040105110A (ko) 2003-06-05 2004-12-14 피재호 피노실빈을 포함하는 항미생물제용 조성물 및 상기화합물의 합성방법
EP1510586A1 (en) 2003-08-26 2005-03-02 Poalis A/S A method of producing a low molecular weight organic compound in a cell
ZA200408194B (en) 2003-07-11 2005-08-02 Univ Stellenbosch Recombinant yeast cells increasing the synthesis of resveratrol during fermentation.
AU2003903909A0 (en) 2003-07-25 2003-08-07 Albright & Wilson (Australia) Limited Production methods
JP4537024B2 (ja) 2003-08-06 2010-09-01 株式会社琉球バイオリソース開発 炎症疾患予防・治療剤
EP1765977A4 (en) 2004-03-01 2008-10-08 Univ Minnesota Flavonoids
CA2568689A1 (en) 2004-06-04 2005-12-15 Fluxome Sciences A/S Metabolically engineered cells for the production of polyunsaturated fatty acids
US7550286B2 (en) 2004-11-04 2009-06-23 E. I. Du Pont De Nemours And Company Docosahexaenoic acid producing strains of Yarrowia lipolytica
GB0503657D0 (en) 2005-02-22 2005-03-30 Fluxome Sciences As Metabolically engineered cells for the production of resveratrol or an oligomeric or glycosidically-bound derivative thereof
DE102005018256B3 (de) 2005-04-20 2006-08-31 Dechema Gesellschaft Für Chemische Technik Und Biotechnologie E.V. Verfahren zur fermentativen Herstellung von Duft- und/oder Aromastoffen
WO2006111163A1 (en) 2005-04-21 2006-10-26 Novozymes A/S Plant extraction process
WO2006124999A2 (en) 2005-05-19 2006-11-23 E. I. Du Pont De Nemours And Company Method for the production of resveratrol in a recombinant bacterial host cell
US7772444B2 (en) 2005-05-19 2010-08-10 E. I. Du Pont De Nemours And Company Method for the production of resveratrol in a recombinant oleaginous microorganism
GB0519231D0 (en) 2005-09-21 2005-10-26 Univ York Regioselective glycosylation
GB0614442D0 (en) 2006-07-20 2006-08-30 Fluxome Sciences As Metabolically engineered cells for the production of pinosylvin
GB0714671D0 (en) 2007-07-27 2007-09-05 Fluxome Sciences As Microbial bioreaction process
GB0806256D0 (en) 2008-04-07 2008-05-14 Fluxome Sciences As Production of stilbenoids
GB0806595D0 (en) 2008-04-11 2008-05-14 Fluxome Sciences As Recovery of stilbenoids
GB0806592D0 (en) 2008-04-11 2008-05-14 Fluxome Sciences As Conversion of stilbenoids
US9181539B2 (en) 2010-05-07 2015-11-10 Massachusetts Institute Of Technology Strains for the production of flavonoids from glucose
GB201008826D0 (en) 2010-05-26 2010-07-14 Fluxome Sciences As Production of metabolites

Also Published As

Publication number Publication date
US20090035839A1 (en) 2009-02-05
JP5571762B2 (ja) 2014-08-13
US8895287B2 (en) 2014-11-25
CA2598414A1 (en) 2006-08-31
JP2013078337A (ja) 2013-05-02
CN101160393A (zh) 2008-04-09
ZA200707942B (en) 2009-02-25
US9040269B2 (en) 2015-05-26
US20150152444A1 (en) 2015-06-04
DK1856251T3 (da) 2013-02-04
WO2006089898A1 (en) 2006-08-31
EP1856251A1 (en) 2007-11-21
ES2397282T3 (es) 2013-03-06
NZ561409A (en) 2011-06-30
EP1856251B1 (en) 2012-10-10
CN101160393B (zh) 2012-07-18
AU2006217963A1 (en) 2006-08-31
JP2008530994A (ja) 2008-08-14
AU2006217963B2 (en) 2011-04-21
US9834793B2 (en) 2017-12-05
US20150361455A1 (en) 2015-12-17
US9404129B2 (en) 2016-08-02
CA2598414C (en) 2013-10-22
GB0503657D0 (en) 2005-03-30
US20080286844A1 (en) 2008-11-20
JP5288806B2 (ja) 2013-09-11

Similar Documents

Publication Publication Date Title
PL1856251T3 (pl) Metabolicznie zmodyfikowane komórki do wytwarzania resweratrolu lub jego oligomerycznej lub związanej z glikozydem pochodnej
FR22C1008I2 (fr) Composition immunogène
HRP20150012T1 (xx) 39-dezmetoksi derivati rapamicina
NO20055686D0 (no) Sammensetning
DE502006002383D1 (de) Turbinenrad
DE602006010581D1 (de) 4-phenyl-6-substituierte pyrimidin-2-carbonitrilderivate
ATE485294T1 (de) Azaindol-2-carboxamid-derivate
ATE527255T1 (de) Aryl-isoxazol-4-yl-imidazol-derivate
DE602006002443D1 (de) Reissverschluss
EP1917697A4 (en) DOUBLE ANTENNA ARTICULATION
DK1971588T3 (da) Tiglien-3-onderivater
DE602006001436D1 (de) Zerkleinerungsmaschine
DE602006014973D1 (de) Neuartige cercosporamidderivate
EP1942012A4 (en) COVER FIXING DEVICE
ATE541837T1 (de) Oxaphenanthren-derivate
ES1061105Y (es) Prenda convertible
DK1897776T3 (da) Bogie
FI20075703A7 (fi) Avoauto
DE602006019209D1 (de) Fluoroalkylpyrrolidin-derivate
NO20052873D0 (no) Materhylse
ES1060567Y (es) Escalon convertible
ATE471314T1 (de) Neuartige cercosporamidderivate
ES1065693Y (es) Pendiente 3 en 1
UA11010S (uk) Блузка
ATE545680T1 (de) Härtbare zusammensetzung