PL1858861T3 - Hamujące HIV 2-(4-cyjanofenylo)-6-hydroksyloaminopirymidyny - Google Patents
Hamujące HIV 2-(4-cyjanofenylo)-6-hydroksyloaminopirymidynyInfo
- Publication number
- PL1858861T3 PL1858861T3 PL06708609T PL06708609T PL1858861T3 PL 1858861 T3 PL1858861 T3 PL 1858861T3 PL 06708609 T PL06708609 T PL 06708609T PL 06708609 T PL06708609 T PL 06708609T PL 1858861 T3 PL1858861 T3 PL 1858861T3
- Authority
- PL
- Poland
- Prior art keywords
- hydroxylaminopyrimidines
- cyanophenyl
- compounds
- hiv inhibiting
- hiv
- Prior art date
Links
- MMXJEHSOCRNQTF-UHFFFAOYSA-N 4-[4-(hydroxyamino)pyrimidin-2-yl]benzonitrile Chemical class ONC1=CC=NC(C=2C=CC(=CC=2)C#N)=N1 MMXJEHSOCRNQTF-UHFFFAOYSA-N 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000010076 replication Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- AIDS & HIV (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05101707 | 2005-03-04 | ||
| PCT/EP2006/060407 WO2006094930A1 (en) | 2005-03-04 | 2006-03-02 | Hiv inhibiting 2-(4-cyanophenyl)-6-hydroxylaminopyrimidines |
| EP06708609A EP1858861B1 (en) | 2005-03-04 | 2006-03-02 | Hiv inhibiting 2-(4-cyanophenyl)-6-hydroxylaminopyrimidines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL1858861T3 true PL1858861T3 (pl) | 2010-12-31 |
Family
ID=34938904
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL06708609T PL1858861T3 (pl) | 2005-03-04 | 2006-03-02 | Hamujące HIV 2-(4-cyjanofenylo)-6-hydroksyloaminopirymidyny |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US20080214588A1 (sr) |
| EP (1) | EP1858861B1 (sr) |
| JP (1) | JP5118978B2 (sr) |
| CN (1) | CN101133038B (sr) |
| AT (1) | ATE473212T1 (sr) |
| AU (1) | AU2006222057B2 (sr) |
| BR (1) | BRPI0609291B1 (sr) |
| CY (1) | CY1111102T1 (sr) |
| DE (1) | DE602006015291D1 (sr) |
| DK (1) | DK1858861T3 (sr) |
| ES (1) | ES2347815T3 (sr) |
| HR (1) | HRP20100504T1 (sr) |
| ME (1) | ME01229B (sr) |
| MX (1) | MX2007010744A (sr) |
| PL (1) | PL1858861T3 (sr) |
| PT (1) | PT1858861E (sr) |
| RS (1) | RS51435B (sr) |
| RU (1) | RU2401261C2 (sr) |
| SI (1) | SI1858861T1 (sr) |
| WO (1) | WO2006094930A1 (sr) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2533258T3 (es) * | 2005-02-18 | 2015-04-08 | Janssen Sciences Ireland Uc | Derivados de óxido de 2-(4-cianofenilamino)pirimidina que inhiben el VIH |
| MX2009005881A (es) | 2006-12-13 | 2009-06-12 | Hoffmann La Roche | Derivados de 2-(piperidin-4-il)-4-fenoxi o fenilamino-pirimidina como inhibidores de la transcriptasa inversa no nucleosida. |
| EP2342186B1 (en) * | 2009-06-22 | 2014-09-17 | Emcure Pharmaceuticals Limited | Process for synthesis of etravirine |
| US8153790B2 (en) | 2009-07-27 | 2012-04-10 | Krizmanic Irena | Process for the preparation and purification of etravirine and intermediates thereof |
| CN101993419B (zh) * | 2009-08-20 | 2013-01-16 | 浙江九洲药业股份有限公司 | 一种4-［（5-溴-4，6-二氯-2-嘧啶基）氨基］苯甲腈的制备方法 |
| GR1007010B (el) | 2009-10-08 | 2010-10-07 | Χημικα Και Βιοφαρμακευτικα Εργαστηρια Πατρων Αε (Cbl-Patras), | Ινσουλινοειδη πεπτιδια |
| WO2011135578A1 (en) | 2010-04-28 | 2011-11-03 | Chetan Balar | Composition comprising chitin and tinosporin for use in the treatment of viral diseases |
| US20130123498A1 (en) | 2011-10-19 | 2013-05-16 | Maja Sepelj MAJER | Process for the preparation of etravirine and intermediates in the synthesis thereof |
| PE20242348A1 (es) | 2020-02-19 | 2024-12-16 | Pharmasyntez | Agentes antivirales para el tratamiento y la prevencion de la infeccion por vih |
| CN117343017A (zh) * | 2023-09-28 | 2024-01-05 | 四川大学 | 含联芳基结构的卤代二芳基嘧啶类化合物及其制备方法和用途 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3459731A (en) * | 1966-12-16 | 1969-08-05 | Corn Products Co | Cyclodextrin polyethers and their production |
| UA56992C2 (uk) * | 1995-05-08 | 2003-06-16 | Фармація Енд Апджон Компані | <font face="Symbol">a</font>-ПІРИМІДИНТІОАЛКІЛЗАМІЩЕНІ ТА <font face="Symbol">a</font>-ПІРИМІДИНОКСОАЛКІЛЗАМІЩЕНІ СПОЛУКИ |
| BR9611562A (pt) | 1995-11-23 | 1999-03-02 | Janssen Pharmaceutica Nv | Misturas sólidas de ciclodextrinas preparadas via extrusão sob fusão |
| SK287270B6 (sk) * | 1998-11-10 | 2010-05-07 | Janssen Pharmaceutica N. V. | Derivát pyrimidínu |
| TR200200763T2 (tr) * | 1999-09-24 | 2003-09-22 | Janssen Pharmaceutica N.V. | Antiviral bileşimler |
| AU782948B2 (en) * | 2000-05-08 | 2005-09-15 | Janssen Pharmaceutica N.V. | Prodrugs of HIV replication inhibiting pyrimidines |
-
2006
- 2006-03-02 ME MEP-2010-147A patent/ME01229B/me unknown
- 2006-03-02 HR HR20100504T patent/HRP20100504T1/hr unknown
- 2006-03-02 AT AT06708609T patent/ATE473212T1/de active
- 2006-03-02 DE DE602006015291T patent/DE602006015291D1/de not_active Expired - Lifetime
- 2006-03-02 JP JP2007557513A patent/JP5118978B2/ja not_active Expired - Lifetime
- 2006-03-02 CN CN2006800069458A patent/CN101133038B/zh not_active Expired - Fee Related
- 2006-03-02 MX MX2007010744A patent/MX2007010744A/es active IP Right Grant
- 2006-03-02 AU AU2006222057A patent/AU2006222057B2/en not_active Ceased
- 2006-03-02 RU RU2007136782/04A patent/RU2401261C2/ru active
- 2006-03-02 RS RSP-2010/0412A patent/RS51435B/sr unknown
- 2006-03-02 PL PL06708609T patent/PL1858861T3/pl unknown
- 2006-03-02 BR BRPI0609291-8A patent/BRPI0609291B1/pt not_active IP Right Cessation
- 2006-03-02 WO PCT/EP2006/060407 patent/WO2006094930A1/en not_active Ceased
- 2006-03-02 SI SI200630779T patent/SI1858861T1/sl unknown
- 2006-03-02 ES ES06708609T patent/ES2347815T3/es not_active Expired - Lifetime
- 2006-03-02 US US11/814,982 patent/US20080214588A1/en not_active Abandoned
- 2006-03-02 PT PT06708609T patent/PT1858861E/pt unknown
- 2006-03-02 DK DK06708609.0T patent/DK1858861T3/da active
- 2006-03-02 EP EP06708609A patent/EP1858861B1/en not_active Expired - Lifetime
-
2010
- 2010-01-20 US US12/690,673 patent/US8119801B2/en active Active
- 2010-10-06 CY CY20101100890T patent/CY1111102T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1858861B1 (en) | 2010-07-07 |
| RU2007136782A (ru) | 2009-04-10 |
| US20100121060A1 (en) | 2010-05-13 |
| DK1858861T3 (da) | 2010-11-08 |
| RS51435B (sr) | 2011-04-30 |
| SI1858861T1 (sl) | 2010-10-29 |
| JP2008531658A (ja) | 2008-08-14 |
| DE602006015291D1 (de) | 2010-08-19 |
| ES2347815T3 (es) | 2010-11-04 |
| US20080214588A1 (en) | 2008-09-04 |
| BRPI0609291B1 (pt) | 2022-02-08 |
| WO2006094930A1 (en) | 2006-09-14 |
| ME01229B (me) | 2013-06-20 |
| CY1111102T1 (el) | 2015-06-11 |
| PT1858861E (pt) | 2010-09-16 |
| CN101133038A (zh) | 2008-02-27 |
| AU2006222057B2 (en) | 2012-10-04 |
| EP1858861A1 (en) | 2007-11-28 |
| ATE473212T1 (de) | 2010-07-15 |
| RU2401261C2 (ru) | 2010-10-10 |
| BRPI0609291A2 (pt) | 2010-03-09 |
| CN101133038B (zh) | 2012-06-27 |
| HRP20100504T1 (hr) | 2010-10-31 |
| JP5118978B2 (ja) | 2013-01-16 |
| MX2007010744A (es) | 2007-09-12 |
| US8119801B2 (en) | 2012-02-21 |
| AU2006222057A1 (en) | 2006-09-14 |
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