PL1890996T3 - Krystaliczna forma tigecykliny w postaci stałej i sposoby jej wytarzania - Google Patents

Krystaliczna forma tigecykliny w postaci stałej i sposoby jej wytarzania

Info

Publication number: PL1890996T3
Authority: PL; Poland
Prior art keywords: tigecycline; methods; crystalline solid; solid forms; preparing same
Prior art date: 2005-05-27

Application number

PL06760544T

Other languages

English (en)

Inventor

Lalitha Krishnan

Subodh S Deshmukh

Anthony Hadfield

James W Huang

Mannching Sherry Ku

Original Assignee

Wyeth Llc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-05-27

Filing date

2006-05-25

Publication date

2013-08-30

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37026996&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL1890996(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2006-05-25 Application filed by Wyeth Llc filed Critical Wyeth Llc

2013-08-30 Publication of PL1890996T3 publication Critical patent/PL1890996T3/pl

Links

239000007787 solid Substances 0.000 title 1
FPZLLRFZJZRHSY-HJYUBDRYSA-N tigecycline Chemical compound C([C@H]1C2)C3=C(N(C)C)C=C(NC(=O)CNC(C)(C)C)C(O)=C3C(=O)C1=C(O)[C@@]1(O)[C@@H]2[C@H](N(C)C)C(O)=C(C(N)=O)C1=O FPZLLRFZJZRHSY-HJYUBDRYSA-N 0.000 title 1
229960004089 tigecycline Drugs 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/22—Separation; Purification; Stabilisation; Use of additives
- C07C231/24—Separation; Purification
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
- C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
- C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
- C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
- C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biomedical Technology (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Pathology (AREA)
Radiology & Medical Imaging (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Analysing Materials By The Use Of Radiation (AREA)
Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)

PL06760544T 2005-05-27 2006-05-25 Krystaliczna forma tigecykliny w postaci stałej i sposoby jej wytarzania PL1890996T3 (pl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US68495505P	2005-05-27	2005-05-27
PCT/US2006/020871 WO2006128150A2 (en)	2005-05-27	2006-05-25	Crystalline solid forms of tigecycline and methods of preparing same
EP06760544.4A EP1890996B1 (en)	2005-05-27	2006-05-25	Crystalline solid forms of tigecycline and methods of preparing same

Publications (1)

Publication Number	Publication Date
PL1890996T3 true PL1890996T3 (pl)	2013-08-30

Family

ID=37026996

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL06760544T PL1890996T3 (pl)	2005-05-27	2006-05-25	Krystaliczna forma tigecykliny w postaci stałej i sposoby jej wytarzania

Country Status (27)

Country	Link
US (1)	US8372995B2 (pl)
EP (1)	EP1890996B1 (pl)
JP (2)	JP2008545717A (pl)
KR (1)	KR20080016890A (pl)
CN (1)	CN101248038B (pl)
AR (1)	AR057649A1 (pl)
AU (1)	AU2006251954A1 (pl)
BR (1)	BRPI0610653A2 (pl)
CA (1)	CA2609875C (pl)
CL (1)	CL2006001266A1 (pl)
CR (1)	CR9540A (pl)
DK (1)	DK1890996T3 (pl)
EC (1)	ECSP078055A (pl)
ES (1)	ES2415518T3 (pl)
GT (1)	GT200600227A (pl)
IL (1)	IL187359A (pl)
MX (1)	MX2007014735A (pl)
NO (1)	NO20076005L (pl)
PE (1)	PE20070024A1 (pl)
PL (1)	PL1890996T3 (pl)
PT (1)	PT1890996E (pl)
RU (1)	RU2478612C2 (pl)
SI (1)	SI1890996T1 (pl)
SV (1)	SV2008002542A (pl)
TW (1)	TWI421232B (pl)
WO (1)	WO2006128150A2 (pl)
ZA (1)	ZA200710151B (pl)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP2007713A2 (en) *	2006-04-17	2008-12-31	Teva Pharmaceutical Industries Ltd	Isolation of tetracycline derivatives
US8198470B2 (en) *	2006-04-24	2012-06-12	Teva Pharmaceutical Industries Ltd.	Crystalline form II of tigecycline and processes for preparation thereof
ES2622356T3 (es)	2006-04-24	2017-07-06	Teva Pharmaceutical Industries, Ltd.	Formas cristalinas de tigeciclina y procesos para su preparación
EP2086926A2 (en)	2006-11-29	2009-08-12	Teva Pharmaceutical Industries Ltd.	Crystalline forms of tigecycline and processes for preparation thereof
EP2084126A1 (en) *	2006-11-30	2009-08-05	Teva Pharmaceutical Industries Ltd.	Processes for preparation of 9-haloacetamidominocyclines
PT103661B (pt) *	2007-02-23	2010-09-07	Hovione Farmaciencia S A	Processo de preparação de minociclina base cristalina
EP2114865A1 (en) *	2007-03-01	2009-11-11	Teva Pharmaceutical Industries Ltd.	Processes for purification of tigecycline
AT13157U1 (de) *	2007-04-24	2013-07-15	Teva Pharma	Tigecyclin, kristalline Formen und Herstellungsverfahren dafür
EP2178827A1 (en)	2007-06-21	2010-04-28	Sandoz AG	Crystalline solid forms
WO2009062964A1 (en) *	2007-11-14	2009-05-22	Sandoz Ag	Novel solvate
WO2009062963A1 (en) *	2007-11-14	2009-05-22	Sandoz Ag	Crystalline forms of tigecycline hydrochloride
WO2009070799A1 (en) *	2007-11-29	2009-06-04	Teva Pharmaceutical Industries Ltd.	Processes for preparation of crystalline tigecycline form ii
WO2009092680A2 (en) *	2008-01-23	2009-07-30	Sandoz Ag	Antibiotic compounds
ITMI20080807A1 (it)	2008-05-05	2009-11-06	Antibioticos Spa	Procedimento per la preparazione di tigeciclina in forma amorfa
TW202332671A (zh) *	2008-05-19	2023-08-16	美商ＰｒｔｋＳｐｖ２公司	四環素化合物之甲苯磺酸鹽及同素異形體
CA2746585C (en)	2008-12-18	2017-08-29	Sandoz Ag	Crystalline form c of tigecycline dihydrochloride and methods for its preparation
PT104350A (pt)	2009-01-23	2010-07-23	Hovione Farmaci Ncia S A	Processo de isolamento de tigeciclina
CN102746183B (zh) *	2011-04-20	2014-12-17	胡梨芳	替加环素结晶水合物及其制备方法和用途
CN102295576A (zh) *	2011-06-29	2011-12-28	赵军旭	替加环素的晶型及其制备方法
CN102898325B (zh) *	2011-07-29	2015-07-08	江苏奥赛康药业股份有限公司	替加环素晶体及其制备方法
CN102924322B (zh) *	2012-11-05	2014-09-17	赵军旭	一种替加环素的新晶型及其制备方法
CN103833590A (zh) *	2012-11-26	2014-06-04	石药集团中奇制药技术（石家庄）有限公司	替加环素晶型及其制备方法
RU2764723C2 (ru) *	2016-06-22	2022-01-19	Кбп Байосайенсиз Ко., Лтд.	Кристаллические формы 9-аминометил-замещенного соединения тетрациклина и способ их получения
CA3196954A1 (en)	2020-11-03	2022-05-12	Josep Bassaganya-Riera	Crystalline forms of piperazine-1,4-diylbis((6-(1h-benzoi[d]imidazo-2-yl)pyridin-2yl)methanone) as lancl2 modulators
CN116917009A (zh)	2021-02-19	2023-10-20	美国迈胜医疗系统有限公司	用于粒子治疗系统的机架

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2168254T3 (es)	1991-10-04	2002-06-16	American Cyanamid Co	Nuevas 7-sustituidas-9-(amino sustituido)-6-desmetil-6-desoxitetraciclinas.
SG47520A1 (en)	1992-08-13	1998-04-17	American Cyanamid Co	New method for the production of 9-amino-6-demethyl-6-deoxytetracycline
US5420272A (en)	1992-08-13	1995-05-30	American Cyanamid Company	7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
US5284963A (en)	1992-08-13	1994-02-08	American Cyanamid Company	Method of producing 7-(substituted)-9-[(substituted glycyl)-amidol]-6-demethyl-6-deoxytetra-cyclines
US5328902A (en)	1992-08-13	1994-07-12	American Cyanamid Co.	7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
US5675030A (en) *	1994-11-16	1997-10-07	American Cyanamid Company	Method for selective extracting a 7-(hydrogen or substituted amino)-9- (substituted glycyl) amido!-6-demethyl-6-deoxytetracycline compound
NZ519984A (en) *	2000-01-07	2004-03-26	Transform Pharmaceuticals Inc	High-throughput formation, identification, and analysis of diverse solid-forms
CN102512429A (zh) *	2005-03-14	2012-06-27	惠氏公司	替加环素组合物及制备方法
AR057033A1 (es) *	2005-05-27	2007-11-14	Wyeth Corp	Tigeciclina y metodos para preparar 9-nitrominociclina
AR057034A1 (es) *	2005-05-27	2007-11-14	Wyeth Corp	Metodos para purificar tigeciclina
AR057032A1 (es) *	2005-05-27	2007-11-14	Wyeth Corp	Tigeciclina y metodos de preparacion
AR057324A1 (es) *	2005-05-27	2007-11-28	Wyeth Corp	Tigeciclina y metodos para preparar 9-aminominociclina

2006
- 2006-05-24 AR ARP060102152A patent/AR057649A1/es unknown
- 2006-05-25 GT GT200600227A patent/GT200600227A/es unknown
- 2006-05-25 CN CN200680027182.5A patent/CN101248038B/zh not_active Expired - Fee Related
- 2006-05-25 JP JP2008513821A patent/JP2008545717A/ja not_active Withdrawn
- 2006-05-25 RU RU2007143160/04A patent/RU2478612C2/ru active
- 2006-05-25 KR KR1020077030562A patent/KR20080016890A/ko not_active Abandoned
- 2006-05-25 US US11/440,032 patent/US8372995B2/en active Active
- 2006-05-25 BR BRPI0610653-6A patent/BRPI0610653A2/pt not_active Application Discontinuation
- 2006-05-25 ES ES06760544T patent/ES2415518T3/es active Active
- 2006-05-25 DK DK06760544.4T patent/DK1890996T3/da active
- 2006-05-25 PE PE2006000551A patent/PE20070024A1/es not_active Application Discontinuation
- 2006-05-25 SV SV2006002542A patent/SV2008002542A/es unknown
- 2006-05-25 SI SI200631580T patent/SI1890996T1/sl unknown
- 2006-05-25 MX MX2007014735A patent/MX2007014735A/es active IP Right Grant
- 2006-05-25 CL CL200601266A patent/CL2006001266A1/es unknown
- 2006-05-25 PL PL06760544T patent/PL1890996T3/pl unknown
- 2006-05-25 WO PCT/US2006/020871 patent/WO2006128150A2/en not_active Ceased
- 2006-05-25 EP EP06760544.4A patent/EP1890996B1/en not_active Revoked
- 2006-05-25 TW TW095118573A patent/TWI421232B/zh not_active IP Right Cessation
- 2006-05-25 CA CA2609875A patent/CA2609875C/en active Active
- 2006-05-25 PT PT67605444T patent/PT1890996E/pt unknown
- 2006-05-25 AU AU2006251954A patent/AU2006251954A1/en not_active Abandoned
2007
- 2007-11-14 IL IL187359A patent/IL187359A/en active IP Right Grant
- 2007-11-22 CR CR9540A patent/CR9540A/es not_active Application Discontinuation
- 2007-11-23 NO NO20076005A patent/NO20076005L/no not_active Application Discontinuation
- 2007-11-26 ZA ZA200710151A patent/ZA200710151B/xx unknown
- 2007-12-26 EC EC2007008055A patent/ECSP078055A/es unknown
2013
- 2013-02-15 JP JP2013028239A patent/JP2013100354A/ja active Pending

Also Published As

Publication number	Publication date
AR057649A1 (es)	2007-12-12
EP1890996A2 (en)	2008-02-27
NO20076005L (no)	2008-02-22
JP2008545717A (ja)	2008-12-18
WO2006128150A3 (en)	2007-03-08
SV2008002542A (es)	2008-02-22
ES2415518T3 (es)	2013-07-25
TWI421232B (zh)	2014-01-01
HK1113786A1 (en)	2008-10-17
CR9540A (es)	2008-02-21
RU2007143160A (ru)	2009-07-10
CN101248038B (zh)	2014-03-05
IL187359A0 (en)	2008-04-13
GT200600227A (es)	2007-01-12
IL187359A (en)	2013-04-30
AU2006251954A1 (en)	2006-11-30
EP1890996B1 (en)	2013-04-24
DK1890996T3 (da)	2013-05-13
TW200720232A (en)	2007-06-01
RU2478612C2 (ru)	2013-04-10
MX2007014735A (es)	2008-02-15
CA2609875A1 (en)	2006-11-30
BRPI0610653A2 (pt)	2010-07-13
CL2006001266A1 (es)	2008-05-16
CN101248038A (zh)	2008-08-20
PE20070024A1 (es)	2007-02-06
KR20080016890A (ko)	2008-02-22
US20070123497A1 (en)	2007-05-31
JP2013100354A (ja)	2013-05-23
CA2609875C (en)	2014-01-07
ECSP078055A (es)	2008-01-23
WO2006128150A2 (en)	2006-11-30
ZA200710151B (en)	2010-05-26
SI1890996T1 (sl)	2013-06-28
PT1890996E (pt)	2013-06-24
US8372995B2 (en)	2013-02-12

Publication	Publication Date	Title
IL187359A0 (en)	2008-04-13	Crystalline solid forms of tigecycline and methods of preparing same
IL187539A0 (en)	2008-03-20	Tigecycline and methods of preparing 9-nitrominocycline
IL187358A0 (en)	2008-04-13	Tigecycline and methods of preparing 9-aminominocycline
ZA200710153B (en)	2009-08-26	Tigecycline and methods of preparation
ZA200707831B (en)	2011-02-23	Tigecycline compositions and methods of preparation
ZA200710163B (en)	2008-12-31	Methods of preparing 3-cyano-quinolines and intermediates made thereby
IL187361A0 (en)	2008-04-13	Methods of purifying tigecycline
ZA200710148B (en)	2008-09-25	Methods of synthesizing substituted 3-cyanoquinolines and inermediates thereof
IL185757A0 (en)	2008-01-06	Methods of decreasing calcifcation
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EP1964538A4 (en)	2013-04-10	PROCESS FOR THE PREPARATION OF PHARMACEUTICAL SUBSTANCES
ZA200802775B (en)	2009-06-24	9-aminocarbonylsubstituted derivatives of glycylcyclines
EP1862078A4 (en)	2008-03-26	CHOCOLATE AND METHOD OF MANUFACTURING THE SAME
IL186277A0 (en)	2008-01-20	Dnt-maleate and methods of preparation thereof
ZA200709015B (en)	2008-12-31	Crystalline solid and amorphous forms of (-)-halofenate
HK1112615A (en)	2008-09-12	Tigecycline and methods of preparing 9-aminominocycline
HK1112894A (en)	2008-09-19	Tigecycline and methods of preparing 9-nitrominocycline