PL192786B1 - Pochodna izochinolinokarboksyamidu, jej kompozycja farmaceutyczna i zastosowanie jako inhibitora proteazy HIV - Google Patents

Pochodna izochinolinokarboksyamidu, jej kompozycja farmaceutyczna i zastosowanie jako inhibitora proteazy HIV

Info

Publication number: PL192786B1
Authority: PL; Poland
Prior art keywords: compound; hiv; active ingredient; pharmaceutically acceptable; stereoisomeric purity
Prior art date: 1997-03-13

Application number

PL335672A

Other languages

English (en)

Polish (pl)

Other versions

PL335672A1 (en

Inventor

Kim F. Albizati

Siegfried Reich

Michael D. Varney

Kanyin E. Zhang

Takuo Kobayashi

Original Assignee

Agouron Pharma

Japan Tobacco Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-03-13

Filing date

1998-03-12

Publication date

2006-12-29

1998-03-12 Application filed by Agouron Pharma, Japan Tobacco Inc filed Critical Agouron Pharma

2000-05-08 Publication of PL335672A1 publication Critical patent/PL335672A1/xx

2006-12-29 Publication of PL192786B1 publication Critical patent/PL192786B1/pl

Links

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230000008685 targeting Effects 0.000 description 1
229940095064 tartrate Drugs 0.000 description 1
239000012085 test solution Substances 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
231100000419 toxicity Toxicity 0.000 description 1
230000001988 toxicity Effects 0.000 description 1
238000012546 transfer Methods 0.000 description 1
238000013519 translation Methods 0.000 description 1
229960005486 vaccine Drugs 0.000 description 1
230000008957 viral persistence Effects 0.000 description 1
210000000605 viral structure Anatomy 0.000 description 1
210000002845 virion Anatomy 0.000 description 1
239000003039 volatile agent Substances 0.000 description 1
238000005406 washing Methods 0.000 description 1
229940071104 xylenesulfonate Drugs 0.000 description 1
239000012138 yeast extract Substances 0.000 description 1
229960002555 zidovudine Drugs 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/14—Nitrogen atoms not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/22—Nitrogen atoms not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/14—Nitrogen atoms not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/36—Nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
- C07D335/02—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Virology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Molecular Biology (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Plural Heterocyclic Compounds (AREA)
Pyrrole Compounds (AREA)
Medicines Containing Plant Substances (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

PL335672A 1997-03-13 1998-03-12 Pochodna izochinolinokarboksyamidu, jej kompozycja farmaceutyczna i zastosowanie jako inhibitora proteazy HIV PL192786B1 (pl)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US81595197A	1997-03-13	1997-03-13

Publications (2)

Publication Number	Publication Date
PL335672A1 PL335672A1 (en)	2000-05-08
PL192786B1 true PL192786B1 (pl)	2006-12-29

Family

ID=25219265

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL335672A PL192786B1 (pl)	1997-03-13	1998-03-12	Pochodna izochinolinokarboksyamidu, jej kompozycja farmaceutyczna i zastosowanie jako inhibitora proteazy HIV

Country Status (35)

Country	Link
EP (1)	EP0970055A2 (is)
JP (1)	JP2001516350A (is)
KR (1)	KR100511089B1 (is)
CN (1)	CN1179948C (is)
AP (1)	AP1358A (is)
AR (1)	AR012556A1 (is)
AU (1)	AU743078B2 (is)
BG (1)	BG63540B1 (is)
BR (1)	BR9808867A (is)
CA (1)	CA2284163A1 (is)
CO (1)	CO4940496A1 (is)
CZ (1)	CZ296647B6 (is)
EA (1)	EA002378B1 (is)
EE (1)	EE04114B1 (is)
GE (1)	GEP20022764B (is)
HR (1)	HRP980112A2 (is)
HU (1)	HUP0001380A3 (is)
IL (2)	IL131870A0 (is)
IS (1)	IS5176A (is)
MX (1)	MXPA99008395A (is)
MY (1)	MY117535A (is)
NO (1)	NO315555B1 (is)
NZ (1)	NZ337706A (is)
OA (1)	OA11196A (is)
PA (1)	PA8448801A1 (is)
PE (1)	PE58799A1 (is)
PL (1)	PL192786B1 (is)
SA (1)	SA98181116B1 (is)
SK (1)	SK283636B6 (is)
SV (1)	SV1998000038A (is)
TR (1)	TR199902508T2 (is)
TW (1)	TW200517112A (is)
UA (1)	UA57772C2 (is)
WO (1)	WO1998040357A2 (is)
ZA (1)	ZA982047B (is)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5484926A (en) *	1993-10-07	1996-01-16	Agouron Pharmaceuticals, Inc.	HIV protease inhibitors

1998
- 1998-03-04 HR HR08/815,951A patent/HRP980112A2/hr not_active Application Discontinuation
- 1998-03-11 ZA ZA982047A patent/ZA982047B/xx unknown
- 1998-03-12 BR BR9808867-0A patent/BR9808867A/pt not_active Application Discontinuation
- 1998-03-12 EE EEP199900416A patent/EE04114B1/xx not_active IP Right Cessation
- 1998-03-12 NZ NZ337706A patent/NZ337706A/en unknown
- 1998-03-12 AP APAP/P/1999/001648A patent/AP1358A/en active
- 1998-03-12 EA EA199900823A patent/EA002378B1/ru unknown
- 1998-03-12 TW TW094100045A patent/TW200517112A/zh unknown
- 1998-03-12 MX MXPA99008395A patent/MXPA99008395A/es not_active IP Right Cessation
- 1998-03-12 CZ CZ0319199A patent/CZ296647B6/cs not_active IP Right Cessation
- 1998-03-12 JP JP53974598A patent/JP2001516350A/ja not_active Ceased
- 1998-03-12 GE GEAP19984984A patent/GEP20022764B/en unknown
- 1998-03-12 EP EP98910300A patent/EP0970055A2/en not_active Withdrawn
- 1998-03-12 CN CNB988045389A patent/CN1179948C/zh not_active Expired - Fee Related
- 1998-03-12 TR TR1999/02508T patent/TR199902508T2/xx unknown
- 1998-03-12 PL PL335672A patent/PL192786B1/pl not_active IP Right Cessation
- 1998-03-12 IL IL13187098A patent/IL131870A0/xx active IP Right Grant
- 1998-03-12 HU HU0001380A patent/HUP0001380A3/hu unknown
- 1998-03-12 MY MYPI98001071A patent/MY117535A/en unknown
- 1998-03-12 CA CA002284163A patent/CA2284163A1/en not_active Abandoned
- 1998-03-12 WO PCT/US1998/004735 patent/WO1998040357A2/en not_active Ceased
- 1998-03-12 AU AU64575/98A patent/AU743078B2/en not_active Ceased
- 1998-03-12 SK SK1222-99A patent/SK283636B6/sk not_active IP Right Cessation
- 1998-03-12 AR ARP980101104A patent/AR012556A1/es active IP Right Grant
- 1998-03-12 PE PE1998000171A patent/PE58799A1/es not_active Application Discontinuation
- 1998-03-12 KR KR10-1999-7008331A patent/KR100511089B1/ko not_active Expired - Fee Related
- 1998-03-13 CO CO98014251A patent/CO4940496A1/es unknown
- 1998-03-13 PA PA19988448801A patent/PA8448801A1/es unknown
- 1998-03-13 SV SV1998000038A patent/SV1998000038A/es not_active Application Discontinuation
- 1998-04-21 SA SA98181116A patent/SA98181116B1/ar unknown
- 1998-12-03 UA UA99095049A patent/UA57772C2/uk unknown
1999
- 1999-09-10 IL IL131870A patent/IL131870A/en not_active IP Right Cessation
- 1999-09-10 IS IS5176A patent/IS5176A/is unknown
- 1999-09-10 NO NO19994415A patent/NO315555B1/no not_active IP Right Cessation
- 1999-09-13 OA OA9900207A patent/OA11196A/en unknown
- 1999-09-13 BG BG103727A patent/BG63540B1/bg unknown

Also Published As

Publication number	Publication date
MXPA99008395A (es)	2003-08-12
BR9808867A (pt)	2000-07-11
CN1253548A (zh)	2000-05-17
CO4940496A1 (es)	2000-07-24
EP0970055A2 (en)	2000-01-12
SA98181116B1 (ar)	2006-10-04
NO315555B1 (no)	2003-09-22
TW200517112A (en)	2005-06-01
AP1358A (en)	2004-12-03
GEP20022764B (en)	2002-08-26
AU743078B2 (en)	2002-01-17
CN1179948C (zh)	2004-12-15
EA199900823A1 (ru)	2000-04-24
EE04114B1 (et)	2003-08-15
WO1998040357A2 (en)	1998-09-17
PL335672A1 (en)	2000-05-08
BG63540B1 (bg)	2002-04-30
CZ319199A3 (cs)	2000-06-14
PA8448801A1 (es)	2000-05-24
ZA982047B (en)	1998-09-28
IL131870A (en)	2006-04-10
UA57772C2 (uk)	2003-07-15
KR20000076236A (ko)	2000-12-26
OA11196A (en)	2003-05-21
TR199902508T2 (xx)	2000-02-21
NO994415L (no)	1999-11-10
EE9900416A (et)	2000-04-17
NO994415D0 (no)	1999-09-10
CA2284163A1 (en)	1998-09-17
SV1998000038A (es)	1999-02-15
MY117535A (en)	2004-07-31
BG103727A (bg)	2000-04-28
CZ296647B6 (cs)	2006-05-17
HRP980112A2 (en)	1998-12-31
PE58799A1 (es)	1999-07-12
IL131870A0 (en)	2001-03-19
KR100511089B1 (ko)	2005-08-31
IS5176A (is)	1999-09-10
WO1998040357A3 (en)	1998-11-26
SK122299A3 (en)	2000-05-16
NZ337706A (en)	2001-04-27
SK283636B6 (sk)	2003-11-04
HUP0001380A3 (en)	2001-12-28
AP9901648A0 (en)	1999-09-30
JP2001516350A (ja)	2001-09-25
HUP0001380A2 (hu)	2000-09-28
EA002378B1 (ru)	2002-04-25
AR012556A1 (es)	2000-11-08
AU6457598A (en)	1998-09-29

Legal Events

Date	Code	Title	Description
2011-05-31	LAPS	Decisions on the lapse of the protection rights	Effective date: 20100312

Publication	Publication Date	Title
US5296604A (en)	1994-03-22	Proline derivatives and compositions for their use as inhibitors of HIV protease
AU700417B2 (en)	1999-01-07	Protease inhibitors
JP5250732B2 (ja)	2013-07-31	Ｈｉｖアスパルチルプロテアーゼ阻害剤としての芳香族誘導体
US6448254B1 (en)	2002-09-10	Substituted amides, their production and their use
US5719287A (en)	1998-02-17	Intermediates for inhibitors of HIV protease and method of preparation thereof
US20110269834A1 (en)	2011-11-03	Compounds and methods for treating respiratory diseases
JPH06234789A (ja)	1994-08-23	Ａｉｄｓの処置のために有用なｈｉｖ−プロテアーゼ阻害剤
PL185647B1 (pl)	2003-06-30	Nowy inhibitor proteazy HIV i kompozycja farmaceutyczna
JP6408008B2 (ja)	2018-10-17	ジペプチジルペプチダーゼｉインヒビターとしてのペプチジルニトリル化合物
JPH07179417A (ja)	1995-07-18	Ａｉｄｓの処置のために有用なｈｉｖ−プロテアーゼ阻害剤
JPH06256277A (ja)	1994-09-13	Ａｉｄｓの処置のために有用なｈｉｖ−プロテアーゼ阻害剤
EP0575097B1 (en)	2000-11-02	2,3-Bis-carboxamidomethyl substituted oxiranes as inhibitors of HIV protease and their use for the treatment of AIDS
US5508407A (en)	1996-04-16	Retroviral protease inhibitors
JPH09509657A (ja)	1997-09-30	中間体および製造のための方法
JPH06234716A (ja)	1994-08-23	Ａｉｄｓの処置に有用なｈｉｖ−プロテアーゼ阻害剤
US7179835B2 (en)	2007-02-20	2-(3-sulfonylamino-2-oxopyrrolidin-1-yl)propanamides as factor xa inhibitors
AP1358A (en)	2004-12-03	1-Aryl-2-Hydroxy-3-Isoquinoline Carboxamide HIV Protease Inhibitors, Their Preparation and Use.
KR0138603B1 (ko)	1998-05-15	인간 면역결핍 바이러스(hiv)프로테아제 억제 화합물, 이의 제조방법 및 이를 포함하는 조성물(human hiv protease inhibitor, process for the preparation thereof and composition containing same)
KR100441635B1 (ko)	2006-01-12	경구투여가가능한선택적트롬빈억제제
MXPA00009755A (en)	2001-07-09	New substituted amides, their production and their use
KR19980077253A (ko)	1998-11-16	선택적 트롬빈 억제제
HK1035893A (en)	2001-12-14	New substituted amides, their production and their use