PL195574B1 - Cząstki do podawania substancji czynnej do pęcherzyków płucnych, sposób wytwarzania tych cząstek i zastosowanie inhibitora wzrostu higroskopowego - Google Patents

Cząstki do podawania substancji czynnej do pęcherzyków płucnych, sposób wytwarzania tych cząstek i zastosowanie inhibitora wzrostu higroskopowego

Info

Publication number: PL195574B1
Authority: PL; Poland
Prior art keywords: particles; active ingredient; cyclodextrin; growth inhibitor; hygroscopic growth
Prior art date: 1998-09-14

Application number

PL99346768A

Other languages

English (en)

Polish (pl)

Other versions

PL346768A1 (en

Inventor

Andrew Clark

Mei-Chang Kuo

Cecily Lalor

Barry John Aldous

Original Assignee

Nektar Therapeutics

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-09-14

Filing date

1999-09-13

Publication date

2007-10-31

1999-09-13 Application filed by Nektar Therapeutics filed Critical Nektar Therapeutics

2002-02-25 Publication of PL346768A1 publication Critical patent/PL346768A1/xx

2007-10-31 Publication of PL195574B1 publication Critical patent/PL195574B1/pl

Links

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LCJVIYPJPCBWKS-NXPQJCNCSA-N thymosin Chemical compound SC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CO)C(=O)N[C@H](CO)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@H]([C@H](C)O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@H](CCC(O)=O)C(O)=O LCJVIYPJPCBWKS-NXPQJCNCSA-N 0.000 description 1
210000001519 tissue Anatomy 0.000 description 1
230000001988 toxicity Effects 0.000 description 1
231100000419 toxicity Toxicity 0.000 description 1
230000002110 toxicologic effect Effects 0.000 description 1
231100000759 toxicological effect Toxicity 0.000 description 1
210000003437 trachea Anatomy 0.000 description 1
239000003204 tranquilizing agent Substances 0.000 description 1
230000002936 tranquilizing effect Effects 0.000 description 1
230000001131 transforming effect Effects 0.000 description 1
229960005294 triamcinolone Drugs 0.000 description 1
GFNANZIMVAIWHM-OBYCQNJPSA-N triamcinolone Chemical compound O=C1C=C[C@]2(C)[C@@]3(F)[C@@H](O)C[C@](C)([C@@]([C@H](O)C4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 GFNANZIMVAIWHM-OBYCQNJPSA-N 0.000 description 1
LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
150000004043 trisaccharides Chemical class 0.000 description 1
HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 1
229940073585 tromethamine hydrochloride Drugs 0.000 description 1
239000002753 trypsin inhibitor Substances 0.000 description 1
239000011882 ultra-fine particle Substances 0.000 description 1
238000001291 vacuum drying Methods 0.000 description 1
239000013603 viral vector Substances 0.000 description 1
230000003612 virological effect Effects 0.000 description 1
229940088594 vitamin Drugs 0.000 description 1
235000013343 vitamin Nutrition 0.000 description 1
239000011782 vitamin Substances 0.000 description 1
229930003231 vitamin Natural products 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Pulmonology (AREA)
Epidemiology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Otolaryngology (AREA)
Inorganic Chemistry (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Solid-Sorbent Or Filter-Aiding Compositions (AREA)

PL99346768A 1998-09-14 1999-09-13 Cząstki do podawania substancji czynnej do pęcherzyków płucnych, sposób wytwarzania tych cząstek i zastosowanie inhibitora wzrostu higroskopowego PL195574B1 (pl)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US10016398P	1998-09-14	1998-09-14
PCT/US1999/021109 WO2000015262A1 (en)	1998-09-14	1999-09-13	Dry powder active agent pulmonary delivery

Publications (2)

Publication Number	Publication Date
PL346768A1 PL346768A1 (en)	2002-02-25
PL195574B1 true PL195574B1 (pl)	2007-10-31

Family

ID=22278404

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL99346768A PL195574B1 (pl)	1998-09-14	1999-09-13	Cząstki do podawania substancji czynnej do pęcherzyków płucnych, sposób wytwarzania tych cząstek i zastosowanie inhibitora wzrostu higroskopowego

Country Status (44)

Country	Link
EP (1)	EP1117442A1 (uk)
JP (1)	JP2002524535A (uk)
KR (1)	KR20010075063A (uk)
CN (1)	CN1317977A (uk)
AP (1)	AP1374A (uk)
AR (1)	AR022090A1 (uk)
AU (1)	AU753014B2 (uk)
BG (1)	BG105430A (uk)
BR (1)	BR9913722A (uk)
CA (1)	CA2343920A1 (uk)
CO (1)	CO5130023A1 (uk)
CZ (1)	CZ2001829A3 (uk)
DZ (1)	DZ2892A1 (uk)
EA (1)	EA003476B1 (uk)
EE (1)	EE200100151A (uk)
GE (1)	GEP20043257B (uk)
GT (1)	GT199900156A (uk)
HK (1)	HK1042231A1 (uk)
HN (1)	HN1999000159A (uk)
HR (1)	HRP20010189A2 (uk)
HU (1)	HUP0103837A3 (uk)
ID (1)	ID28845A (uk)
IL (2)	IL141562A0 (uk)
IS (1)	IS5878A (uk)
LT (1)	LT4897B (uk)
LV (1)	LV12658B (uk)
MA (1)	MA25590A1 (uk)
MY (1)	MY129282A (uk)
NO (1)	NO20011251L (uk)
NZ (1)	NZ510168A (uk)
OA (1)	OA11781A (uk)
PA (1)	PA8481901A1 (uk)
PE (1)	PE20001061A1 (uk)
PL (1)	PL195574B1 (uk)
SA (1)	SA99200718B1 (uk)
SK (1)	SK3442001A3 (uk)
TN (1)	TNSN99173A1 (uk)
TR (1)	TR200101182T2 (uk)
TW (1)	TWI226248B (uk)
UA (1)	UA76085C2 (uk)
UY (1)	UY25711A1 (uk)
WO (1)	WO2000015262A1 (uk)
YU (1)	YU24201A (uk)
ZA (1)	ZA200101995B (uk)

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CA2465675C (en)	2001-11-20	2008-06-10	Advanced Inhalation Research, Inc.	Improved particulate compositions for pulmonary delivery
US7759506B2 (en)	2002-02-25	2010-07-20	Diffusion Pharmaceuticals Llc	Bipolar trans carotenoid salts and their uses
EA200401111A1 (ru)	2002-02-25	2005-02-24	Диффьюжн Фармасьютикалз Ллс	Биполярные соли транс-каротиноидов и их применение
AU2003232081B2 (en) *	2002-07-03	2009-02-05	Brandeis University	Central airway administration for systemic delivery of therapeutics
WO2004060352A1 (en) *	2002-12-19	2004-07-22	Pharmacia Corporation	Non-hygroscopic formulation comprising a hydroscopic drug
DE10338403A1 (de) *	2003-08-18	2005-03-17	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Pulverformulierung, enthaltend den CGRP-Antagonisten 1-[N2-[3,5-Dibrom-N-[[4-(3,4-dihydro-2(1H)-oxochinazolin-3-yl]-1-piperidinyl]carbonyl]-D-tyrosyl]-L-lysyl]-4-(4-pyrindinyl)-piperazin, Verfahren zu dessen Herstellung sowie dessen Verwendung als Inhalativum
GB0327723D0 (en) *	2003-09-15	2003-12-31	Vectura Ltd	Pharmaceutical compositions
US20070020299A1 (en)	2003-12-31	2007-01-25	Pipkin James D	Inhalant formulation containing sulfoalkyl ether cyclodextrin and corticosteroid
PL2708225T3 (pl) *	2004-04-23	2019-07-31	Cydex Pharmaceuticals, Inc.	Formulacja DPI zawierająca eter sulfoalkilowy cyklodekstryny
UA95903C2 (uk) *	2005-02-24	2011-09-26	Дифьюжен Фармасьютикалз Ллк	Транс-каротиноїди, їх синтез, лікарська форма та застосування
RU2007137121A (ru) *	2005-03-09	2009-04-20	Оно Фармасьютикал Ко., Лтд. (Jp)	Частица и препарат, содержащий указанную частицу
DK1945228T4 (da)	2005-10-26	2015-01-12	Cydex Pharmaceuticals Inc	Sulfoalkyl-ether-cyclodextrin-sammensætninger og fremgangsmåder til fremstilling deraf
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US20080035143A1 (en) *	2006-08-14	2008-02-14	Sievers Robert E	Human-powered dry powder inhaler and dry powder inhaler compositions
JP5315056B2 (ja) *	2006-10-25	2013-10-16	大日本住友製薬株式会社	固結抑制粒状製剤
EP1925295A1 (de) *	2006-11-22	2008-05-28	Boehringer Ingelheim Pharma GmbH & Co. KG	Stabile Pulverformulierung enthaltend ein Anticholinergikum
CN101687757A (zh)	2007-04-13	2010-03-31	扩散药品有限公司	双极性反式类胡萝卜素作为预治疗及其在周围血管疾病的治疗中的应用
US12370352B2 (en)	2007-06-28	2025-07-29	Cydex Pharmaceuticals, Inc.	Nasal and ophthalmic delivery of aqueous corticosteroid solutions
JP2011502125A (ja)	2007-10-31	2011-01-20	ディフュージョン・ファーマシューティカルズ・エルエルシー	小分子拡散を促進する新しい種類の治療法
DK2432502T3 (en)	2009-05-20	2018-03-12	Aeras	STABLE, SPRAY DRIED, IMMUNOGENE, VIRUS COMPOSITIONS
KR101875843B1 (ko)	2009-06-22	2018-07-06	디퓨젼 파마슈티컬즈 엘엘씨	확산 촉진 화합물 및 그 화합물 단독 또는 혈전 용해제와 합쳐진 화합물의 용도
KR101891357B1 (ko)	2010-06-02	2018-08-24	디퓨젼 파마슈티컬즈 엘엘씨	양극성 트랜스 카로티노이드의 경구용 제형
NZ630040A (en)	2012-05-03	2016-10-28	Janssen Sciences Ireland Uc	Polyinosinic-polycytidylic acid (poly (i:c)) formulations for the treatment of upper respiratory tract infections
BR112015010601B1 (pt) *	2012-11-09	2022-07-19	Civitas Therapeutics, Inc.	Composição farmacêutica e uso da composição
WO2015042352A1 (en) *	2013-09-20	2015-03-26	Virginia Commonwealth University	Delivery of particles using hygroscopic excipients
WO2016067252A1 (en)	2014-10-31	2016-05-06	Glaxosmithkline Intellectual Property Development Limited	Powder formulation
US11185523B2 (en)	2016-03-24	2021-11-30	Diffusion Pharmaceuticals Llc	Use of bipolar trans carotenoids with chemotherapy and radiotherapy for treatment of cancer
US20220378727A1 (en) *	2021-05-14	2022-12-01	The University Of Hong Kong	Dry powder formulations of tamibarotene for pulmonary and intranasal delivery

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1999
- 1999-09-09 MA MA25762A patent/MA25590A1/fr unknown
- 1999-09-13 OA OA1200100063A patent/OA11781A/en unknown
- 1999-09-13 WO PCT/US1999/021109 patent/WO2000015262A1/en not_active Ceased
- 1999-09-13 EA EA200100300A patent/EA003476B1/ru active IP Right Revival
- 1999-09-13 IL IL14156299A patent/IL141562A0/xx not_active IP Right Cessation
- 1999-09-13 AP APAP/P/2001/002093A patent/AP1374A/en active
- 1999-09-13 ID IDW20010582A patent/ID28845A/id unknown
- 1999-09-13 CZ CZ2001829A patent/CZ2001829A3/cs unknown
- 1999-09-13 EP EP99969035A patent/EP1117442A1/en not_active Withdrawn
- 1999-09-13 TW TW088115876A patent/TWI226248B/zh not_active IP Right Cessation
- 1999-09-13 BR BR9913722-4A patent/BR9913722A/pt not_active IP Right Cessation
- 1999-09-13 PL PL99346768A patent/PL195574B1/pl not_active IP Right Cessation
- 1999-09-13 EE EEP200100151A patent/EE200100151A/xx unknown
- 1999-09-13 AU AU60397/99A patent/AU753014B2/en not_active Ceased
- 1999-09-13 HN HN1999000159A patent/HN1999000159A/es unknown
- 1999-09-13 PE PE1999000925A patent/PE20001061A1/es not_active Application Discontinuation
- 1999-09-13 HR HR20010189A patent/HRP20010189A2/hr not_active Application Discontinuation
- 1999-09-13 JP JP2000569846A patent/JP2002524535A/ja not_active Withdrawn
- 1999-09-13 NZ NZ510168A patent/NZ510168A/en unknown
- 1999-09-13 MY MYPI99003947A patent/MY129282A/en unknown
- 1999-09-13 GE GEAP19995857A patent/GEP20043257B/en unknown
- 1999-09-13 SK SK344-2001A patent/SK3442001A3/sk unknown
- 1999-09-13 UA UA2001031707A patent/UA76085C2/uk unknown
- 1999-09-13 ZA ZA200101995A patent/ZA200101995B/en unknown
- 1999-09-13 TR TR2001/01182T patent/TR200101182T2/xx unknown
- 1999-09-13 KR KR1020017003208A patent/KR20010075063A/ko not_active Ceased
- 1999-09-13 YU YU24201A patent/YU24201A/sh unknown
- 1999-09-13 AR ARP990104587A patent/AR022090A1/es unknown
- 1999-09-13 CN CN99810871A patent/CN1317977A/zh active Pending
- 1999-09-13 CA CA002343920A patent/CA2343920A1/en not_active Abandoned
- 1999-09-13 DZ DZ990192A patent/DZ2892A1/xx active
- 1999-09-13 HK HK02101738.3A patent/HK1042231A1/zh unknown
- 1999-09-13 HU HU0103837A patent/HUP0103837A3/hu unknown
- 1999-09-14 PA PA19998481901A patent/PA8481901A1/es unknown
- 1999-09-14 CO CO99058265A patent/CO5130023A1/es unknown
- 1999-09-14 UY UY25711A patent/UY25711A1/es not_active Application Discontinuation
- 1999-09-14 TN TNTNSN99173A patent/TNSN99173A1/fr unknown
- 1999-09-14 GT GT199900156A patent/GT199900156A/es unknown
- 1999-10-31 SA SA99200718A patent/SA99200718B1/ar unknown
2001
- 2001-02-21 IL IL141562A patent/IL141562A/en unknown
- 2001-03-05 IS IS5878A patent/IS5878A/is unknown
- 2001-03-13 NO NO20011251A patent/NO20011251L/no not_active Application Discontinuation
- 2001-03-14 LT LT2001021A patent/LT4897B/lt not_active IP Right Cessation
- 2001-03-14 LV LV010041A patent/LV12658B/xx unknown
- 2001-04-10 BG BG105430A patent/BG105430A/xx unknown

Also Published As

Publication number	Publication date
SK3442001A3 (en)	2001-11-06
HUP0103837A3 (en)	2002-11-28
MA25590A1 (fr)	2002-12-31
KR20010075063A (ko)	2001-08-09
EE200100151A (et)	2002-06-17
NO20011251L (no)	2001-04-17
LV12658A (lv)	2001-05-20
IL141562A0 (en)	2002-03-10
HK1042231A1 (zh)	2002-08-09
LT4897B (lt)	2002-02-25
BG105430A (en)	2001-12-29
EA200100300A1 (ru)	2001-10-22
PL346768A1 (en)	2002-02-25
HUP0103837A2 (hu)	2002-05-29
UA76085C2 (en)	2006-07-17
LV12658B (lv)	2001-09-20
AR022090A1 (es)	2002-09-04
SA99200718B1 (ar)	2006-11-04
ID28845A (id)	2001-07-05
IL141562A (en)	2007-07-24
CZ2001829A3 (cs)	2001-09-12
GEP20043257B (en)	2004-06-25
TWI226248B (en)	2005-01-11
OA11781A (en)	2005-07-26
LT2001021A (en)	2001-11-26
DZ2892A1 (fr)	2003-12-15
AP2001002093A0 (en)	2001-03-31
WO2000015262A1 (en)	2000-03-23
CN1317977A (zh)	2001-10-17
PE20001061A1 (es)	2000-10-08
AU6039799A (en)	2000-04-03
NO20011251D0 (no)	2001-03-13
EP1117442A1 (en)	2001-07-25
CO5130023A1 (es)	2002-02-27
UY25711A1 (es)	1999-11-17
HRP20010189A2 (en)	2005-04-30
ZA200101995B (en)	2002-03-11
GT199900156A (es)	2001-03-07
CA2343920A1 (en)	2000-03-23
PA8481901A1 (es)	2002-04-25
YU24201A (sh)	2003-08-29
HN1999000159A (es)	1999-11-11
AP1374A (en)	2005-02-28
BR9913722A (pt)	2001-05-29
AU753014B2 (en)	2002-10-03
JP2002524535A (ja)	2002-08-06
IS5878A (is)	2001-03-05
TNSN99173A1 (fr)	2005-11-10
NZ510168A (en)	2003-09-26
MY129282A (en)	2007-03-30
EA003476B1 (ru)	2003-06-26
TR200101182T2 (tr)	2001-09-21

Legal Events

Date	Code	Title	Description
2008-11-28	LAPS	Decisions on the lapse of the protection rights	Effective date: 20070913

Publication	Publication Date	Title
PL195574B1 (pl)	2007-10-31	Cząstki do podawania substancji czynnej do pęcherzyków płucnych, sposób wytwarzania tych cząstek i zastosowanie inhibitora wzrostu higroskopowego
US20220152145A1 (en)	2022-05-19	Method and formulation for inhalation
RU2275900C2 (ru)	2006-05-10	Способ высокоэффективной доставки аэрозоля с большой терапевтической массой
ES2213180T3 (es)	2004-08-16	Polvos y su uso en inhaladores de polvo seco.
US7625865B2 (en)	2009-12-01	Insulin highly respirable microparticles
EP1487411B1 (en)	2019-01-02	Inhalable sustained therapeutic formulations
AU2003218308B2 (en)	2006-07-20	hGH (human growth hormone) formulations for pulmonary administration
NZ530123A (en)	2007-01-26	Particles comprising DPPC, insulin, sodium citrate and optionally an amino acid in a composition for inhalation that has rapid release properties
SK7772001A3 (en)	2001-12-03	Particles of amino acid, process for their preparation, powder containing same, process for the preparation of such powder, an inhalator containing such powder, and their use
US7754242B2 (en)	2010-07-13	Inhalable sustained therapeutic formulations
MXPA01002649A (en)	2001-12-04	Dry powder active agent pulmonary delivery
Batycky et al.	2002	The development of large porous particles for inhalation drug delivery
HK1051139B (en)	2007-06-29	Highly efficient delivery of a large therapeutic mass aerosol
HK1098078A (en)	2007-07-13	Highly efficient delivery of a large therapeutic mass aerosol