PL2049480T3 - Pochodne 2-aryloindolu jako inhibitory mPGES-1 - Google Patents

Pochodne 2-aryloindolu jako inhibitory mPGES-1

Info

Publication number
PL2049480T3
PL2049480T3 PL07786740T PL07786740T PL2049480T3 PL 2049480 T3 PL2049480 T3 PL 2049480T3 PL 07786740 T PL07786740 T PL 07786740T PL 07786740 T PL07786740 T PL 07786740T PL 2049480 T3 PL2049480 T3 PL 2049480T3
Authority
PL
Poland
Prior art keywords
mpges
inhibitors
arylindole derivatives
arylindole
derivatives
Prior art date
Application number
PL07786740T
Other languages
English (en)
Inventor
Maria Alessandra Alisi
Nicola Cazzolla
Barbara Garofalo
Guido Furlotti
Caterina Maugeri
Rosella Ombrato
Isabella Coletta
Lorenzo Polenzani
Giorgina Mangano
Beatrice Garrone
Angelo Guglielmotti
Original Assignee
Acraf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acraf filed Critical Acraf
Publication of PL2049480T3 publication Critical patent/PL2049480T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PL07786740T 2006-07-14 2007-06-14 Pochodne 2-aryloindolu jako inhibitory mPGES-1 PL2049480T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT001368A ITMI20061368A1 (it) 2006-07-14 2006-07-14 Composto 2-arilindolico sostituito in posizione 5, composizione farmaceutica che lo comprende nonche' composti intermedi e procedimento per prepararlo
PCT/EP2007/055901 WO2008006663A1 (en) 2006-07-14 2007-06-14 2-arylindole derivatives as npges-i inhibitors
EP07786740.6A EP2049480B1 (en) 2006-07-14 2007-06-14 2-ARYLINDOLE DERIVATIVES AS mPGES-1 INHIBITORS

Publications (1)

Publication Number Publication Date
PL2049480T3 true PL2049480T3 (pl) 2014-03-31

Family

ID=37895798

Family Applications (1)

Application Number Title Priority Date Filing Date
PL07786740T PL2049480T3 (pl) 2006-07-14 2007-06-14 Pochodne 2-aryloindolu jako inhibitory mPGES-1

Country Status (21)

Country Link
US (1) US8017644B2 (pl)
EP (1) EP2049480B1 (pl)
JP (1) JP5302191B2 (pl)
KR (2) KR20140091569A (pl)
CN (1) CN101490000B (pl)
AR (1) AR061973A1 (pl)
AU (1) AU2007271865B2 (pl)
BR (1) BRPI0712889A8 (pl)
CA (1) CA2655750C (pl)
DK (1) DK2049480T3 (pl)
EA (1) EA015689B1 (pl)
ES (1) ES2441594T3 (pl)
GE (1) GEP20115166B (pl)
IL (1) IL196000A (pl)
IT (1) ITMI20061368A1 (pl)
MX (1) MX2009000492A (pl)
PL (1) PL2049480T3 (pl)
PT (1) PT2049480E (pl)
SI (1) SI2049480T1 (pl)
UA (1) UA96759C2 (pl)
WO (1) WO2008006663A1 (pl)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2078711A1 (en) 2007-12-28 2009-07-15 AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.p.A. (Aza)indole derivative substituted in position 5, pharmaceutical composition comprising it, intermediate compounds and preparation process therefor
US8410144B2 (en) 2009-03-31 2013-04-02 Arqule, Inc. Substituted indolo-pyridinone compounds
WO2011077313A1 (en) 2009-12-22 2011-06-30 Pfizer Inc. Piperidinecarboxamides as mpges - 1 inhibitors
SI2746265T1 (sl) 2011-08-18 2016-03-31 Nippon Shinyaku Co., Ltd. Heterociklični derivat kot zaviralec mikrosomske prostaglandin-e sintaze (mpges)
WO2013038308A1 (en) * 2011-09-15 2013-03-21 Glenmark Pharmaceuticals S.A. SUBSTITUTED BICYCLIC HETEROARYL COMPOUNDS AS mPGES-1 INHIBITORS
MX368504B (es) * 2014-04-14 2019-10-04 Shanghai hengrui pharmaceutical co ltd Derivados de amidas y sales farmaceuticamente aceptables de los mismos, método de preparación de los mismos y aplicación médica de los mismos.
WO2016021706A1 (ja) * 2014-08-08 2016-02-11 カズマパートナーズ株式会社 縮合複素環化合物
MD3762368T2 (ro) 2018-03-08 2022-07-31 Incyte Corp Compuși diol aminopirazină ca inhibitori ai PI3K-Y
US11046658B2 (en) 2018-07-02 2021-06-29 Incyte Corporation Aminopyrazine derivatives as PI3K-γ inhibitors
WO2021040393A1 (ko) 2019-08-26 2021-03-04 국제약품 주식회사 인돌 카복사미드 유도체 및 그를 포함하는 약제학적 조성물
US11807644B2 (en) 2020-05-12 2023-11-07 Pmv Pharmaceuticals, Inc. Methods and compounds for restoring mutant p53 function

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004024655A2 (en) * 2002-09-12 2004-03-25 Avanir Pharmaceuticals Phenyl-indole compounds for modulating ige and inhibiting cellular proliferation
NZ541603A (en) * 2003-02-07 2008-03-28 Ono Pharmaceutical Co Carbonyl phenyl propanoic acid derivative compounds
RS20060143A (sr) * 2003-09-03 2008-06-05 Pfizer Inc., Jedinjenja fenil ili piridil amida kao antagonisti prostaglandina e2
ITTO20040125A1 (it) * 2004-03-01 2004-06-01 Rotta Research Lab Nuove amidine eterocicliche inibitrici la produzione di ossido d'azoto (no) ad attivita' antinfiammatoria ed analgesica
GB0410121D0 (en) * 2004-05-06 2004-06-09 Glaxo Group Ltd Compounds

Also Published As

Publication number Publication date
US8017644B2 (en) 2011-09-13
EP2049480B1 (en) 2013-10-30
UA96759C2 (en) 2011-12-12
ITMI20061368A1 (it) 2008-01-15
CN101490000B (zh) 2012-10-03
SI2049480T1 (sl) 2014-02-28
IL196000A (en) 2013-10-31
AU2007271865A1 (en) 2008-01-17
KR20090054962A (ko) 2009-06-01
CN101490000A (zh) 2009-07-22
EP2049480A1 (en) 2009-04-22
WO2008006663A1 (en) 2008-01-17
HK1124068A1 (en) 2009-08-07
JP5302191B2 (ja) 2013-10-02
GEP20115166B (en) 2011-02-25
CA2655750A1 (en) 2008-01-17
US20090186922A1 (en) 2009-07-23
KR101440015B1 (ko) 2014-09-12
BRPI0712889A2 (pt) 2012-10-09
PT2049480E (pt) 2013-12-16
DK2049480T3 (da) 2014-01-20
CA2655750C (en) 2014-09-09
AR061973A1 (es) 2008-08-10
JP2009543766A (ja) 2009-12-10
MX2009000492A (es) 2009-01-27
AU2007271865B2 (en) 2013-02-21
EA015689B1 (ru) 2011-10-31
EA200970124A1 (ru) 2009-06-30
KR20140091569A (ko) 2014-07-21
ES2441594T3 (es) 2014-02-05
IL196000A0 (en) 2009-09-01
BRPI0712889A8 (pt) 2018-01-02

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