DK2049480T3 - 2-arylindolderivater som mPGES-1-hæmmere - Google Patents

2-arylindolderivater som mPGES-1-hæmmere

Info

Publication number
DK2049480T3
DK2049480T3 DK07786740.6T DK07786740T DK2049480T3 DK 2049480 T3 DK2049480 T3 DK 2049480T3 DK 07786740 T DK07786740 T DK 07786740T DK 2049480 T3 DK2049480 T3 DK 2049480T3
Authority
DK
Denmark
Prior art keywords
mpges
inhibitors
arylindole derivatives
arylindole
derivatives
Prior art date
Application number
DK07786740.6T
Other languages
English (en)
Inventor
Barbara Garofalo
Caterina Maugeri
Beatrice Garrone
Lorenzo Polenzani
Maria Alessandra Alisi
Nicola Cazzolla
Guido Furlotti
Rosella Ombrato
Isabella Coletta
Giorgina Mangano
Angelo Guglielmotti
Original Assignee
Acraf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acraf filed Critical Acraf
Application granted granted Critical
Publication of DK2049480T3 publication Critical patent/DK2049480T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK07786740.6T 2006-07-14 2007-06-14 2-arylindolderivater som mPGES-1-hæmmere DK2049480T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT001368A ITMI20061368A1 (it) 2006-07-14 2006-07-14 Composto 2-arilindolico sostituito in posizione 5, composizione farmaceutica che lo comprende nonche' composti intermedi e procedimento per prepararlo
PCT/EP2007/055901 WO2008006663A1 (en) 2006-07-14 2007-06-14 2-arylindole derivatives as npges-i inhibitors

Publications (1)

Publication Number Publication Date
DK2049480T3 true DK2049480T3 (da) 2014-01-20

Family

ID=37895798

Family Applications (1)

Application Number Title Priority Date Filing Date
DK07786740.6T DK2049480T3 (da) 2006-07-14 2007-06-14 2-arylindolderivater som mPGES-1-hæmmere

Country Status (21)

Country Link
US (1) US8017644B2 (da)
EP (1) EP2049480B1 (da)
JP (1) JP5302191B2 (da)
KR (2) KR20140091569A (da)
CN (1) CN101490000B (da)
AR (1) AR061973A1 (da)
AU (1) AU2007271865B2 (da)
BR (1) BRPI0712889A8 (da)
CA (1) CA2655750C (da)
DK (1) DK2049480T3 (da)
EA (1) EA015689B1 (da)
ES (1) ES2441594T3 (da)
GE (1) GEP20115166B (da)
IL (1) IL196000A (da)
IT (1) ITMI20061368A1 (da)
MX (1) MX2009000492A (da)
PL (1) PL2049480T3 (da)
PT (1) PT2049480E (da)
SI (1) SI2049480T1 (da)
UA (1) UA96759C2 (da)
WO (1) WO2008006663A1 (da)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2078711A1 (en) 2007-12-28 2009-07-15 AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.p.A. (Aza)indole derivative substituted in position 5, pharmaceutical composition comprising it, intermediate compounds and preparation process therefor
AU2010232729A1 (en) 2009-03-31 2011-10-20 Arqule, Inc. Substituted indolo-pyridinone compounds
WO2011077313A1 (en) 2009-12-22 2011-06-30 Pfizer Inc. Piperidinecarboxamides as mpges - 1 inhibitors
ES2561105T3 (es) * 2011-08-18 2016-02-24 Nippon Shinyaku Co., Ltd. Derivado heterocíclico como inhibidor de prostaglandina E sintasa microsómica (mPGES)
WO2013038308A1 (en) * 2011-09-15 2013-03-21 Glenmark Pharmaceuticals S.A. SUBSTITUTED BICYCLIC HETEROARYL COMPOUNDS AS mPGES-1 INHIBITORS
KR20160134865A (ko) * 2014-04-14 2016-11-23 샹하이 헨그루이 파마수티컬 컴퍼니 리미티드 아미드 유도체 및 이의 약제학적으로 허용되는 염, 이의 제조방법 및 이의 의학적 적용
US20170298081A1 (en) * 2014-08-08 2017-10-19 Kasuma Partners Inc. Condensed heterocyclic compound
CR20200464A (es) 2018-03-08 2021-04-14 Incyte Corp Compuestos diólicos de aminopirazina como inhibidores de pi3k-y
WO2020010003A1 (en) 2018-07-02 2020-01-09 Incyte Corporation AMINOPYRAZINE DERIVATIVES AS PI3K-γ INHIBITORS
CN114302874B (zh) 2019-08-26 2025-02-25 国际药品株式会社 吲哚甲酰胺衍生物和包含吲哚甲酰胺衍生物的药物组合物
EP4149459A4 (en) * 2020-05-12 2024-05-22 PMV Pharmaceuticals, Inc. METHODS AND COMPOUNDS FOR RESTORING MUTANT P53 FUNCTION

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003270426A1 (en) * 2002-09-12 2004-04-30 Avanir Pharmaceuticals PHENYL-INDOLE COMPOUNDS FOR MODULATING IgE AND INHIBITING CELLULAR PROLIFERATION
BRPI0407258A (pt) * 2003-02-07 2006-01-31 Ono Pharmaceutical Co Compostos de ácido carboxìlico
CA2536870C (en) * 2003-09-03 2009-10-27 Pfizer Inc. Phenyl or pyridyl amide compounds as prostaglandin e2 antagonists
ITTO20040125A1 (it) * 2004-03-01 2004-06-01 Rotta Research Lab Nuove amidine eterocicliche inibitrici la produzione di ossido d'azoto (no) ad attivita' antinfiammatoria ed analgesica
GB0410121D0 (en) * 2004-05-06 2004-06-09 Glaxo Group Ltd Compounds

Also Published As

Publication number Publication date
CN101490000B (zh) 2012-10-03
EP2049480A1 (en) 2009-04-22
EA200970124A1 (ru) 2009-06-30
AU2007271865A1 (en) 2008-01-17
ITMI20061368A1 (it) 2008-01-15
PL2049480T3 (pl) 2014-03-31
CA2655750C (en) 2014-09-09
US20090186922A1 (en) 2009-07-23
KR20090054962A (ko) 2009-06-01
AU2007271865B2 (en) 2013-02-21
WO2008006663A1 (en) 2008-01-17
KR101440015B1 (ko) 2014-09-12
IL196000A (en) 2013-10-31
IL196000A0 (en) 2009-09-01
MX2009000492A (es) 2009-01-27
BRPI0712889A8 (pt) 2018-01-02
JP2009543766A (ja) 2009-12-10
GEP20115166B (en) 2011-02-25
JP5302191B2 (ja) 2013-10-02
EP2049480B1 (en) 2013-10-30
HK1124068A1 (en) 2009-08-07
EA015689B1 (ru) 2011-10-31
SI2049480T1 (sl) 2014-02-28
BRPI0712889A2 (pt) 2012-10-09
PT2049480E (pt) 2013-12-16
UA96759C2 (en) 2011-12-12
US8017644B2 (en) 2011-09-13
ES2441594T3 (es) 2014-02-05
AR061973A1 (es) 2008-08-10
KR20140091569A (ko) 2014-07-21
CA2655750A1 (en) 2008-01-17
CN101490000A (zh) 2009-07-22

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