PL2089511T3 - Rozrost in vitro komórek pochodzących z tkanki pępowinowej wykorzystujących mikronośniki - Google Patents

Rozrost in vitro komórek pochodzących z tkanki pępowinowej wykorzystujących mikronośniki

Info

Publication number
PL2089511T3
PL2089511T3 PL07867434T PL07867434T PL2089511T3 PL 2089511 T3 PL2089511 T3 PL 2089511T3 PL 07867434 T PL07867434 T PL 07867434T PL 07867434 T PL07867434 T PL 07867434T PL 2089511 T3 PL2089511 T3 PL 2089511T3
Authority
PL
Poland
Prior art keywords
microcarriers
postpartum
derived cells
vitro expansion
vitro
Prior art date
Application number
PL07867434T
Other languages
English (en)
Inventor
Alexander M Harmon
Klaudyne L S Hong
Anthony J Kihm
Anna Gosiewska
Original Assignee
Depuy Synthes Products Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Depuy Synthes Products Llc filed Critical Depuy Synthes Products Llc
Publication of PL2089511T3 publication Critical patent/PL2089511T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0607—Non-embryonic pluripotent stem cells, e.g. MASC
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/16—Particles; Beads; Granular material; Encapsulation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0605—Cells from extra-embryonic tissues, e.g. placenta, amnion, yolk sac, Wharton's jelly
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2531/00—Microcarriers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/52—Fibronectin; Laminin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/54—Collagen; Gelatin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Developmental Biology & Embryology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Immunology (AREA)
  • Sustainable Development (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
PL07867434T 2006-11-13 2007-11-13 Rozrost in vitro komórek pochodzących z tkanki pępowinowej wykorzystujących mikronośniki PL2089511T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US86555806P 2006-11-13 2006-11-13
PCT/US2007/023846 WO2008060541A2 (en) 2006-11-13 2007-11-13 In vitro expansion of postpartum-derived cells using microcarriers
EP07867434.8A EP2089511B1 (en) 2006-11-13 2007-11-13 In vitro expansion of postpartum-derived cells using microcarriers

Publications (1)

Publication Number Publication Date
PL2089511T3 true PL2089511T3 (pl) 2015-02-27

Family

ID=39402235

Family Applications (1)

Application Number Title Priority Date Filing Date
PL07867434T PL2089511T3 (pl) 2006-11-13 2007-11-13 Rozrost in vitro komórek pochodzących z tkanki pępowinowej wykorzystujących mikronośniki

Country Status (9)

Country Link
US (1) US9102915B2 (pl)
EP (1) EP2089511B1 (pl)
JP (2) JP5670053B2 (pl)
CN (1) CN101611139B (pl)
AU (1) AU2007319820B2 (pl)
CA (1) CA2669589C (pl)
ES (1) ES2524443T3 (pl)
PL (1) PL2089511T3 (pl)
WO (1) WO2008060541A2 (pl)

Families Citing this family (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003008535A2 (en) * 2001-07-20 2003-01-30 Technion Research And Development Foundation Ltd. Methods of generating human cardiac cells and tissues and uses thereof
US8790637B2 (en) 2003-06-27 2014-07-29 DePuy Synthes Products, LLC Repair and regeneration of ocular tissue using postpartum-derived cells
US9572840B2 (en) 2003-06-27 2017-02-21 DePuy Synthes Products, Inc. Regeneration and repair of neural tissue using postpartum-derived cells
US8491883B2 (en) 2003-06-27 2013-07-23 Advanced Technologies And Regenerative Medicine, Llc Treatment of amyotrophic lateral sclerosis using umbilical derived cells
AU2005322060B2 (en) 2003-06-27 2011-11-17 Ethicon Incorporated Postpartum cells derived from umbilical cord tissue, and methods of making and using the same
US9592258B2 (en) 2003-06-27 2017-03-14 DePuy Synthes Products, Inc. Treatment of neurological injury by administration of human umbilical cord tissue-derived cells
US8518390B2 (en) 2003-06-27 2013-08-27 Advanced Technologies And Regenerative Medicine, Llc Treatment of stroke and other acute neural degenerative disorders via intranasal administration of umbilical cord-derived cells
ES2564044T3 (es) 2003-06-27 2016-03-17 DePuy Synthes Products, Inc. Células posparto derivadas de tejido del cordón umbilical y métodos de preparación y uso de las mismas
US7875272B2 (en) 2003-06-27 2011-01-25 Ethicon, Incorporated Treatment of stroke and other acute neuraldegenerative disorders using postpartum derived cells
WO2006071802A2 (en) 2004-12-23 2006-07-06 Ethicon Incorporated Treatment of stroke and other acute neural degenerative disorders using postpartum derived cells
CA2624925C (en) 2005-10-13 2014-09-30 Anthrogenesis Corporation Immunomodulation using placental stem cells
CN101374946B (zh) 2005-12-16 2017-07-18 伊西康公司 用于在组织相容性不匹配的移植中抑制有害的免疫反应的组合物和方法
AU2006327073B2 (en) * 2005-12-19 2012-08-30 Ethicon, Inc. In vitro expansion of postpartum derived cells in roller bottles
US9125906B2 (en) 2005-12-28 2015-09-08 DePuy Synthes Products, Inc. Treatment of peripheral vascular disease using umbilical cord tissue-derived cells
ES2708933T3 (es) 2005-12-29 2019-04-12 Celularity Inc Poblaciones de células madre placentarias
ES2432395T3 (es) 2006-10-12 2013-12-03 Ethicon, Inc. Células derivadas de riñon y metodo de uso en la reparación y regeneración tisular
ES2524443T3 (es) 2006-11-13 2014-12-09 DePuy Synthes Products, LLC Expansión in vitro de células postparto usando microportadores
KR101569168B1 (ko) 2007-02-12 2015-11-13 안트로제네시스 코포레이션 태반 줄기세포를 이용한 염증 질환의 치료
JP5350364B2 (ja) * 2007-04-28 2013-11-27 ヒョンジン ヤン， 粉末状の足場を用いた細胞間の信号調節による細胞培養方法
CA2700617C (en) 2007-09-28 2018-11-06 Celgene Cellular Therapeutics Tumor suppression using human placental perfusate and human placenta-derived intermediate natural killer cells
PT103843B (pt) * 2007-10-04 2008-08-12 Medinfar Produtos Farmaceutico Método de isolamento de células precursoras a partir do cordão umbilical humano
US8034329B2 (en) 2007-10-05 2011-10-11 Advanced Technologies And Regenerative Medicine, Llc Repair and regeneration of renal tissue using human umbilical cord tissue-derived cells
US8236538B2 (en) 2007-12-20 2012-08-07 Advanced Technologies And Regenerative Medicine, Llc Methods for sterilizing materials containing biologically active agents
US20090233334A1 (en) * 2008-03-11 2009-09-17 Excellgene Sa Cell cultivation and production of recombinant proteins by means of an orbital shake bioreactor system with disposable bags at the 1,500 liter scale
US20120219531A1 (en) * 2008-03-17 2012-08-30 Agency For Science, Technology And Research Microcarriers for Stem Cell Culture
US8691569B2 (en) * 2008-03-17 2014-04-08 Agency For Science, Technology And Research Microcarriers for stem cell culture
SG188918A1 (pl) 2008-03-17 2013-04-30 Agency Science Tech & Res
US9458431B2 (en) 2008-03-17 2016-10-04 Agency For Science, Technology And Research Microcarriers for stem cell culture
US20120028352A1 (en) * 2008-03-17 2012-02-02 Agency For Science, Technology And Research Microcarriers for Stem Cell Culture
US8828720B2 (en) * 2008-03-17 2014-09-09 Agency For Science, Technology And Research Microcarriers for stem cell culture
DK2330889T3 (en) 2008-08-20 2017-01-30 Anthrogenesis Corp Improved cell composition and process for making the same
JP5950577B2 (ja) 2008-08-20 2016-07-13 アンスロジェネシス コーポレーション 単離胎盤細胞を使用した脳卒中の治療
HRP20130812T1 (en) 2008-08-22 2013-09-30 Anthrogenesis Corporation Methods and compositions for treatment of bone defects with placental cell populations
CN102282252B (zh) 2008-11-19 2017-07-04 人类起源公司 羊膜来源的贴壁细胞
US20100151575A1 (en) * 2008-12-15 2010-06-17 Colter David C Method of Making Conditioned Media from Kidney Derived Cells
US10179900B2 (en) 2008-12-19 2019-01-15 DePuy Synthes Products, Inc. Conditioned media and methods of making a conditioned media
BRPI0923068B1 (pt) 2008-12-19 2021-05-25 Advanced Technologies And Regenerative Medicine, Llc Uso de células derivadas de tecido de cordão umbilical para tratar um paciente tendo uma doença, distúrbio ou injúria pulmonar
CN102498204B (zh) 2009-03-26 2015-02-04 德普伊新特斯产品有限责任公司 人脐带组织细胞作为用于阿尔茨海默病的疗法
US20100247495A1 (en) * 2009-03-30 2010-09-30 Tom Ichim Treatment of Muscular Dystrophy
WO2011016829A1 (en) * 2009-08-06 2011-02-10 Albert Einstein College Of Medicine Of Yeshiva University Cell therapy for treatment of liver failure
US8278101B2 (en) * 2009-12-07 2012-10-02 Synthecon, Inc. Stem cell bioprocessing and cell expansion
ES2646750T3 (es) 2010-01-26 2017-12-15 Anthrogenesis Corporation Tratamiento de cánceres relacionados con hueso utilizando células madre placentarias
IL250234B2 (en) 2010-04-07 2023-10-01 Anthrogenesis Llc Angiogenesis using placental stem cells
MX2012011543A (es) 2010-04-08 2013-05-06 Anthrogenesis Corp Tratamiento de sarcoidosis empleando celulas madre placentarias.
EP3443991A1 (en) * 2010-05-25 2019-02-20 Cook Biotech Incorporated Methods, substrates, and systems useful for cell seeding of medical grafts
CN102146356A (zh) * 2010-06-24 2011-08-10 辽宁成大生物股份有限公司 一种再生微载体的方法
KR20180099915A (ko) 2010-07-13 2018-09-05 안트로제네시스 코포레이션 천연 킬러 세포의 생성 방법
EP2606115A4 (en) * 2010-08-16 2017-07-19 Kiyatec Inc. Bioreactor system
AU2011352036A1 (en) 2010-12-31 2013-07-18 Anthrogenesis Corporation Enhancement of placental stem cell potency using modulatory RNA molecules
JP2012165719A (ja) * 2011-02-16 2012-09-06 National Institute Of Advanced Industrial Science & Technology 擬微小重力環境下での三次元癌組織モデルの構築方法
CN104220081A (zh) 2011-06-01 2014-12-17 人类起源公司 利用胎盘干细胞治疗疼痛
US20140170748A1 (en) * 2012-12-14 2014-06-19 DePuy Synthes Products, LLC Nutrient Enriched Media for hUTC Growth
AU2014215458A1 (en) 2013-02-05 2015-08-13 Anthrogenesis Corporation Natural killer cells from placenta
CN108663344A (zh) * 2013-02-19 2018-10-16 艾博特健康公司 分析生物流体样品的方法
JP2016526387A (ja) * 2013-06-24 2016-09-05 アントフロゲネシス コーポレーション 細胞培養のための細胞外マトリクス組成物ビーズ
JP6913094B2 (ja) * 2015-12-22 2021-08-04 コーニング インコーポレイテッド 細胞分離器具およびそれを使用する方法
RU2748057C2 (ru) 2016-01-14 2021-05-19 Депуи Синтез Продактс, Инк. Композиция и способы криоконсервации клеток hutc
JP6855508B2 (ja) 2016-05-31 2021-04-07 コーニング インコーポレイテッド インペラぐらつきの低減された細胞培養のための容器およびスピナーフラスコ
WO2018075940A1 (en) * 2016-10-21 2018-04-26 Georgia Tech Research Corporation Methods and systems for t cell expansion
EP3608398A4 (en) 2017-04-06 2020-12-09 Nikkiso Co., Ltd. CELL CULTURE PROCESS, PROCESS FOR MANUFACTURING A CELL SUPPORT COMPOSITE, CULTIVATED CELLS AND CELL SUPPORT COMPOSITE
WO2019181920A1 (ja) * 2018-03-22 2019-09-26 日機装株式会社 細胞の培養方法、細胞支持複合体の製造方法、培養細胞および細胞支持複合体
JP7588591B2 (ja) * 2019-01-31 2024-11-22 北京華龕生物科技有限公司 幹細胞の大規模調製のための三次元培養方法
CN111424011A (zh) * 2020-04-17 2020-07-17 深圳市旷逸生物科技有限公司 一种能够维持脐带间充质干细胞细胞形态的三维培养方法
CN114761533A (zh) * 2020-09-15 2022-07-15 株式会社Lg化学 细胞培养用微载体和用于制备其的方法
WO2024253069A1 (ja) * 2023-06-06 2024-12-12 東ソー株式会社 温度応答性マイクロキャリア

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1220832B (de) 1964-09-22 1966-07-14 Siemens Ag Ziehduese zum Ziehen von Halbleiterkristallen aus einer Schmelze
US3665061A (en) 1969-07-16 1972-05-23 United States Banknote Corp Process for producing collagen sponges
US4216144A (en) 1977-10-20 1980-08-05 Ashmead H H Soluble iron proteinates
JPS6040439B2 (ja) 1978-03-29 1985-09-11 大正製薬株式会社 ヒドロコルチゾン誘導体
US4487865A (en) 1983-12-15 1984-12-11 Biomatrix, Inc. Polymeric articles modified with hyaluronate
US5266476A (en) 1985-06-18 1993-11-30 Yeda Research & Development Co., Ltd. Fibrous matrix for in vitro cell cultivation
US5266480A (en) 1986-04-18 1993-11-30 Advanced Tissue Sciences, Inc. Three-dimensional skin culture system
US4963489A (en) 1987-04-14 1990-10-16 Marrow-Tech, Inc. Three-dimensional cell and tissue culture system
US4925677A (en) 1988-08-31 1990-05-15 Theratech, Inc. Biodegradable hydrogel matrices for the controlled release of pharmacologically active agents
US5284766A (en) 1989-02-10 1994-02-08 Kao Corporation Bed material for cell culture
NL9100038A (nl) 1991-01-11 1992-08-03 Stamicarbon Enzym-gekatalyseerde bereiding van optisch aktieve carbonzuren.
DE4406073A1 (de) 1994-02-24 1995-08-31 Univ Ludwigs Albert Verfahren zur Herstellung von humanen, klonogenen Fibroblasten, Verfahren zur Gentransfizierung von Fibroblasten und so erhaltene Fibroblasten
US5919702A (en) 1996-10-23 1999-07-06 Advanced Tissue Science, Inc. Production of cartilage tissue using cells isolated from Wharton's jelly
WO1998052560A1 (en) 1997-05-21 1998-11-26 Sloan-Kettering Institute For Cancer Research Method for increasing the concentration of ascorbic acid in brain tissues of a subject
US7560280B2 (en) * 2000-11-03 2009-07-14 Kourion Therapeutics Gmbh Human cord blood derived unrestricted somatic stem cells (USSC)
EP2336299A1 (en) 2001-02-14 2011-06-22 Anthrogenesis Corporation Post-partum mammalian placenta, its use and placental stem cells therefrom
WO2002081723A1 (fr) * 2001-04-02 2002-10-17 Keio University Methode de production d'une chaine d'oligosaccharide
EP1575524A4 (en) 2002-02-08 2008-11-05 Univ South Florida PROLIFERED CELL LINES AND ITS USE
ES2287447T3 (es) 2002-02-19 2007-12-16 Medipost, Co., Ltd. Metodos de aislamiento y expansion del cultivo de celulas troncales/madre mesenquimatosas a partir de sangre del cordon umbilical, y metodo de diferenciacion de celulas troncales/madre mesenquimatosas derivadas de sangre del cordon umbilical en diversos tejidos mesenquimatosos.
JP2003259862A (ja) 2002-03-12 2003-09-16 Fuji Photo Film Co Ltd 細胞培養担体
AU2003265094A1 (en) 2002-08-26 2004-03-11 Neuronova Ab Method for culturing stem cells
GB0222846D0 (en) 2002-10-03 2002-11-06 Choo Yen Cell culture
US7875272B2 (en) 2003-06-27 2011-01-25 Ethicon, Incorporated Treatment of stroke and other acute neuraldegenerative disorders using postpartum derived cells
US9572840B2 (en) 2003-06-27 2017-02-21 DePuy Synthes Products, Inc. Regeneration and repair of neural tissue using postpartum-derived cells
AU2005322060B2 (en) 2003-06-27 2011-11-17 Ethicon Incorporated Postpartum cells derived from umbilical cord tissue, and methods of making and using the same
ES2564044T3 (es) 2003-06-27 2016-03-17 DePuy Synthes Products, Inc. Células posparto derivadas de tejido del cordón umbilical y métodos de preparación y uso de las mismas
US8790637B2 (en) 2003-06-27 2014-07-29 DePuy Synthes Products, LLC Repair and regeneration of ocular tissue using postpartum-derived cells
AU2004260106C1 (en) * 2003-07-17 2010-12-09 Global Cell Solutions, Llc. Automated cell culture system and process
JP4575654B2 (ja) * 2003-09-05 2010-11-04 エスエス製薬株式会社 溶解性と流動性を改善した医薬組成物
DE102004043256B4 (de) * 2004-09-07 2013-09-19 Rheinische Friedrich-Wilhelms-Universität Bonn Skalierbarer Prozess zur Kultivierung undifferenzierter Stammzellen in Suspension
WO2006050050A2 (en) 2004-10-29 2006-05-11 Centocor, Inc. Chemically defined media compositions
WO2006083394A2 (en) 2004-12-21 2006-08-10 Ethicon, Inc. Postpartum cells derived from placental tissue, and methods of making, culturing, and using the same
WO2006071802A2 (en) 2004-12-23 2006-07-06 Ethicon Incorporated Treatment of stroke and other acute neural degenerative disorders using postpartum derived cells
US20060182724A1 (en) 2005-02-15 2006-08-17 Riordan Neil H Method for expansion of stem cells
ES2387402T3 (es) * 2005-03-31 2012-09-21 Stemnion, Inc. Composiciones celulares derivadas del amnios, procedimientos de fabricación y usos de las mismas
CN101374946B (zh) 2005-12-16 2017-07-18 伊西康公司 用于在组织相容性不匹配的移植中抑制有害的免疫反应的组合物和方法
AU2006327073B2 (en) 2005-12-19 2012-08-30 Ethicon, Inc. In vitro expansion of postpartum derived cells in roller bottles
PL2548951T3 (pl) 2006-03-23 2016-08-31 Pluristem Ltd Sposoby ekspansji komórek oraz zastosowania w terapii komórek i pożywek kondycjonowanych wytworzonych w ten sposób
PL2046946T3 (pl) 2006-06-26 2017-04-28 Lifescan, Inc. Hodowla pluripotencjalnych komórek macierzystych
ES2524443T3 (es) 2006-11-13 2014-12-09 DePuy Synthes Products, LLC Expansión in vitro de células postparto usando microportadores
PT2379087E (pt) 2008-12-19 2014-12-02 Depuy Synthes Products Llc Células derivadas do tecido do cordão umbilical para o tratamento da dor neuropática e espasticidade
US10179900B2 (en) 2008-12-19 2019-01-15 DePuy Synthes Products, Inc. Conditioned media and methods of making a conditioned media
WO2010071863A1 (en) 2008-12-19 2010-06-24 Ethicon, Incorporated Regeneration and repair of neural tissue following injury
CN102498204B (zh) 2009-03-26 2015-02-04 德普伊新特斯产品有限责任公司 人脐带组织细胞作为用于阿尔茨海默病的疗法

Also Published As

Publication number Publication date
CN101611139A (zh) 2009-12-23
JP2014236755A (ja) 2014-12-18
JP5670053B2 (ja) 2015-02-18
EP2089511B1 (en) 2014-09-17
US20080166328A1 (en) 2008-07-10
CA2669589C (en) 2016-01-12
ES2524443T3 (es) 2014-12-09
US9102915B2 (en) 2015-08-11
JP2010508851A (ja) 2010-03-25
AU2007319820A1 (en) 2008-05-22
CN101611139B (zh) 2012-07-04
EP2089511A2 (en) 2009-08-19
WO2008060541A2 (en) 2008-05-22
CA2669589A1 (en) 2008-05-22
AU2007319820B2 (en) 2013-09-05
WO2008060541A3 (en) 2008-08-28

Similar Documents

Publication Publication Date Title
IL276146A (en) Laboratory methods for increasing the vitality of the cells of the immune system
IL194438A (en) Diarrhylthiohydantoin Compounds, Pharmaceuticals Containing Them, Syntheses Methods and In Vitro Methods for Contacting them with Mammalian Cells
IL221384A0 (en) Improving il-15 and il-15r-alpha for expression in mammalian cells
SG10201405107YA (en) Compositions and methods useful for culturing differentiable cells
ZA200906061B (en) Use of copper and glutamate in cell culture for production of polypeptides
GB0605450D0 (en) Cell co-culture
EP2064324A4 (en) SUBSTRATES FOR CELL CULTURE AND MANUFACTURING METHOD THEREFOR
IL241906B (en) Methods for the production and uses of pluripotent cell populations and differentiated cell populations
EP2089507A4 (en) DEVICES AND METHODS PARTICULARLY EFFECTIVE IN CELL CULTURE
PL2046946T3 (pl) Hodowla pluripotencjalnych komórek macierzystych
PL3323883T3 (pl) Zdefiniowane powierzchnie do hodowli komórkowej i sposoby użycia
SG10201510384UA (en) Cell culture improvements
PL3524316T3 (pl) Urządzenia elektroporujące do elektroporowania komórek u ssaków
IL194894A0 (en) Substrate for the growth of cultured cells in three dimensions
PL2132562T3 (pl) Sposób oceniania komórek i hodowli komórkowych
GB0613756D0 (en) Cell culture medium
IL191868A (en) Extracellular method to cause planned cell death in a target cell
GB0622394D0 (en) Differentiation of pluripotent cells
GB0600972D0 (en) Enrichment of cells
EP2019860A4 (en) PROTEIN PRODUCTION USING EUKARYOTIC CELL LINES
IL220165B (en) A method for 3D co-culture of podocytes and endothelial cells and an in vitro system suitable for co-culture
ZA200902007B (en) In vivo transformation of pancreatic acinar cells into insulin-producing cells
IL194524A0 (en) Three dimensional cell culture
IL196803A0 (en) Differential labeling of cells
GB0606671D0 (en) Cell Culture