PL2124565T3 - N-podstawione pochodne glicyny: inhibitory hydroksylaz - Google Patents

N-podstawione pochodne glicyny: inhibitory hydroksylaz

Info

Publication number
PL2124565T3
PL2124565T3 PL08727581T PL08727581T PL2124565T3 PL 2124565 T3 PL2124565 T3 PL 2124565T3 PL 08727581 T PL08727581 T PL 08727581T PL 08727581 T PL08727581 T PL 08727581T PL 2124565 T3 PL2124565 T3 PL 2124565T3
Authority
PL
Poland
Prior art keywords
hydroxylase inhibitors
substituted glycine
glycine derivatives
derivatives
hydroxylase
Prior art date
Application number
PL08727581T
Other languages
English (en)
Inventor
Antony N Shaw
Kevin J Duffy
William Henry Miller
Andrea K Myers
Michael N Zimmerman
Original Assignee
Glaxosmithkline Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39636631&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2124565(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Glaxosmithkline Llc filed Critical Glaxosmithkline Llc
Publication of PL2124565T3 publication Critical patent/PL2124565T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PL08727581T 2007-01-12 2008-01-11 N-podstawione pochodne glicyny: inhibitory hydroksylaz PL2124565T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US88471007P 2007-01-12 2007-01-12
PCT/US2008/050833 WO2008089052A2 (en) 2007-01-12 2008-01-11 N-substituted glycine derivatives: hydroxylase inhibitors
EP08727581.4A EP2124565B1 (en) 2007-01-12 2008-01-11 N-substituted glycine derivatives: hydroxylase inhibitors

Publications (1)

Publication Number Publication Date
PL2124565T3 true PL2124565T3 (pl) 2015-05-29

Family

ID=39636631

Family Applications (1)

Application Number Title Priority Date Filing Date
PL08727581T PL2124565T3 (pl) 2007-01-12 2008-01-11 N-podstawione pochodne glicyny: inhibitory hydroksylaz

Country Status (20)

Country Link
US (2) US7608621B2 (pl)
EP (2) EP2124565B1 (pl)
JP (1) JP5313925B2 (pl)
KR (1) KR101458655B1 (pl)
CN (1) CN101626685B (pl)
AR (1) AR064878A1 (pl)
AU (1) AU2008206441B2 (pl)
BR (1) BRPI0806566A2 (pl)
CA (1) CA2675252C (pl)
CL (1) CL2008000066A1 (pl)
DK (1) DK2124565T3 (pl)
EA (1) EA017112B1 (pl)
ES (2) ES2528745T3 (pl)
HR (1) HRP20150119T1 (pl)
MX (1) MX2009007548A (pl)
PL (1) PL2124565T3 (pl)
PT (1) PT2124565E (pl)
SI (1) SI2124565T1 (pl)
TW (1) TW200845991A (pl)
WO (1) WO2008089052A2 (pl)

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US7588924B2 (en) 2006-03-07 2009-09-15 Procter & Gamble Company Crystal of hypoxia inducible factor 1 alpha prolyl hydroxylase
BRPI0713350B1 (pt) 2006-06-26 2022-04-12 Akebia Therapeutics Inc Composto, e, composição
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ES2444574T3 (es) * 2006-09-19 2014-02-25 Incyte Corporation N-hidroxiamidinoheterociclos como moduladores de la indolamina 2,3-dioxigenasa
EP2252619B1 (en) 2008-01-11 2013-10-09 Fibrogen, Inc. Isothiazole-pyridine derivatives as modulators of hif (hypoxia inducible factor) activity
US8324405B2 (en) 2008-02-05 2012-12-04 Fibrogen, Inc. Chromene derivatives and use thereof as HIF hydroxylase activity inhibitors
EP2294066B9 (en) 2008-04-28 2015-03-11 Janssen Pharmaceutica, N.V. Benzoimidazoles as prolyl hydroxylase inhibitors
PL2315756T3 (pl) 2008-07-08 2015-02-27 Incyte Holdings Corp 1,2,5-oksadiazole jako inhibitory 2,3-dioksygenazy indoloaminy
EP2334682B1 (en) 2008-08-20 2017-10-04 Fibrogen, Inc. Pyrrolo [ 1, 2 -b] pyridazine derivatives and their use as hif modulators
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WO2010055884A1 (ja) * 2008-11-13 2010-05-20 日本農薬株式会社 ピラジン誘導体類の製造方法及びその中間体類
WO2010056767A1 (en) 2008-11-14 2010-05-20 Fibrogen, Inc. Thiochromene derivatives as hip hydroxylase inhibitors
DE102009004061A1 (de) * 2009-01-08 2010-07-15 Merck Patent Gmbh Pyridazinonderivate
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EP3698794A1 (en) 2009-11-06 2020-08-26 Aerpio Therapeutics, Inc. Compositions and methods for treating colitis
WO2011115687A2 (en) * 2010-03-19 2011-09-22 Northwestern University Alkylated sp-b peptoid compounds and related lung surfactant compositions
CN103608346B (zh) 2011-02-02 2016-06-15 菲布罗根有限公司 作为缺氧诱导因子(hif)羟化酶抑制剂的萘啶衍生物
GB201102659D0 (en) 2011-02-15 2011-03-30 Isis Innovation Assay
NO2686520T3 (pl) 2011-06-06 2018-03-17
EP2717870B1 (en) 2011-06-06 2017-09-27 Akebia Therapeutics Inc. Composition for stabilizing hypoxia inducible factor-2 alpha useful for treating cancer
GB201113101D0 (en) 2011-07-28 2011-09-14 Isis Innovation Assay
US9273034B2 (en) 2011-10-25 2016-03-01 Janssen Pharmaceutica Nv Meglumine salt formulations of 1-(5,6-dichloro-1H-benzo[D]imidazol-2-yl)-1H-pyrazole-4-carboxylic acid
MX360858B (es) 2012-07-30 2018-11-20 Taisho Pharmaceutical Co Ltd Compuesto heterocíclico que contiene nitrógeno parcialmente saturado.
SG10201910773VA (en) 2013-06-13 2020-01-30 Akebia Therapeutics Inc Compositions and methods for treating anemia
DK3066085T3 (da) 2013-11-08 2020-06-02 Incyte Holdings Corp Fremgangsmåde til syntesen af en indolamin-2,3-dioxygenaseinhibitor
AR099354A1 (es) 2013-11-15 2016-07-20 Akebia Therapeutics Inc Formas sólidas de ácido {[5-(3-clorofenil)-3-hidroxipiridin-2-carbonil]amino}acético, composiciones, y sus usos
JP6506390B2 (ja) 2014-09-02 2019-04-24 サンシャイン・レイク・ファーマ・カンパニー・リミテッドＳｕｎｓｈｉｎｅ Ｌａｋｅ Ｐｈａｒｍａ Ｃｏ．，Ｌｔｄ． キノリノン系化合物及びその薬物への使用
AU2016209126A1 (en) 2015-01-23 2017-08-10 Akebia Therapeutics, Inc. Solid forms of 2-(5-(3-fluorophenyl)-3-hydroxypicolinamido)acetic acid, compositions, and uses thereof
US11324734B2 (en) 2015-04-01 2022-05-10 Akebia Therapeutics, Inc. Compositions and methods for treating anemia
CN105130888A (zh) * 2015-10-09 2015-12-09 中国药科大学 炔基吡啶类脯氨酰羟化酶抑制剂、其制备方法和医药用途
MX391259B (es) 2015-10-14 2025-03-21 X Therma Inc Composiciones y métodos para reducir la formación de cristales de hielo.
EP3790863A1 (en) 2018-05-09 2021-03-17 Akebia Therapeutics Inc. Process for preparing 2-[[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino]acetic acid
US11524939B2 (en) 2019-11-13 2022-12-13 Akebia Therapeutics, Inc. Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino} acetic acid
WO2021127273A1 (en) * 2019-12-20 2021-06-24 Gb004, Inc. 1 -((6-oxo-1,6-dihydropyridazin-4-yl)methyl)piperazine and 1 -((6-oxo-1,6-dihydropyrimidin-4-yl)methyl)piperazine derivatives as prolyl hydroxylase, hif-1 alpha and pgk modulators for use in treating inflammatory diseases, cancer or infections
WO2022179967A1 (en) 2021-02-23 2022-09-01 Glaxosmithkline Intellectual Property (No.2) Limited Vadadustat for treating covid-19 in a hospitalized subject

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Also Published As

Publication number Publication date
SI2124565T1 (sl) 2015-04-30
EP2124565A4 (en) 2011-06-29
MX2009007548A (es) 2009-07-22
EA017112B1 (ru) 2012-09-28
CA2675252A1 (en) 2008-07-24
TW200845991A (en) 2008-12-01
EA200970680A1 (ru) 2010-02-26
WO2008089052A3 (en) 2008-09-18
CN101626685B (zh) 2013-03-13
AR064878A1 (es) 2009-04-29
AU2008206441A1 (en) 2008-07-24
CN101626685A (zh) 2010-01-13
US7608621B2 (en) 2009-10-27
ES2614355T3 (es) 2017-05-30
BRPI0806566A2 (pt) 2014-05-06
WO2008089052A2 (en) 2008-07-24
US20080214549A1 (en) 2008-09-04
ES2528745T3 (es) 2015-02-12
EP2889289A1 (en) 2015-07-01
KR101458655B1 (ko) 2014-11-05
CA2675252C (en) 2015-05-26
AU2008206441B2 (en) 2014-06-19
EP2124565B1 (en) 2015-01-07
CL2008000066A1 (es) 2008-08-01
USRE44613E1 (en) 2013-11-26
EP2889289B1 (en) 2016-12-21
HRP20150119T1 (hr) 2015-05-08
PT2124565E (pt) 2015-03-26
KR20090101376A (ko) 2009-09-25
DK2124565T3 (en) 2015-02-09
EP2124565A2 (en) 2009-12-02
JP5313925B2 (ja) 2013-10-09
JP2010515756A (ja) 2010-05-13

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