PL2300452T3 - 5-[5-[2-(3,5-Bis(trifluorometylo)fenylo)-2-metylopropanoilometyloamino]-4-(4-fluoro-2-metylofenylo)]-2-pirydynylo-2-alkilo-prolinoamidy jako antagonisty receptora NK1 - Google Patents

5-[5-[2-(3,5-Bis(trifluorometylo)fenylo)-2-metylopropanoilometyloamino]-4-(4-fluoro-2-metylofenylo)]-2-pirydynylo-2-alkilo-prolinoamidy jako antagonisty receptora NK1

Info

Publication number: PL2300452T3
Authority: PL; Poland
Prior art keywords: methylpropanoylmethylamino; prolinamide; pyridinyl; methylphenyl; trifluoromethyl
Prior art date: 2008-05-14

Application number

PL09745725T

Other languages

English (en)

Inventor

Giuseppe Alvaro

Agostino Marasco

Original Assignee

Nerre Therapeutics Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-05-14

Filing date

2009-05-12

Publication date

2014-04-30

2009-05-12 Application filed by Nerre Therapeutics Ltd filed Critical Nerre Therapeutics Ltd

2014-04-30 Publication of PL2300452T3 publication Critical patent/PL2300452T3/pl

Links

102000002002 Neurokinin-1 Receptors Human genes 0.000 title 1
108010040718 Neurokinin-1 Receptors Proteins 0.000 title 1
239000002464 receptor antagonist Substances 0.000 title 1
229940044551 receptor antagonist Drugs 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
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- A61P1/10—Laxatives
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
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- A61P11/14—Antitussive agents
- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P25/22—Anxiolytics
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- A61P25/34—Tobacco-abuse
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- A61P25/36—Opioid-abuse
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A61P37/00—Drugs for immunological or allergic disorders
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Addiction (AREA)
Immunology (AREA)
Pulmonology (AREA)
Psychiatry (AREA)
Dermatology (AREA)
Urology & Nephrology (AREA)
Cardiology (AREA)
Hematology (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Diabetes (AREA)
Anesthesiology (AREA)
Hospice & Palliative Care (AREA)
Obesity (AREA)
Ophthalmology & Optometry (AREA)
Child & Adolescent Psychology (AREA)
Vascular Medicine (AREA)
Transplantation (AREA)
Rheumatology (AREA)
Otolaryngology (AREA)
Gynecology & Obstetrics (AREA)
Endocrinology (AREA)

PL09745725T 2008-05-14 2009-05-12 5-[5-[2-(3,5-Bis(trifluorometylo)fenylo)-2-metylopropanoilometyloamino]-4-(4-fluoro-2-metylofenylo)]-2-pirydynylo-2-alkilo-prolinoamidy jako antagonisty receptora NK1 PL2300452T3 (pl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GBGB0808747.0A GB0808747D0 (en)	2008-05-14	2008-05-14	Novel compounds
EP09745725.3A EP2300452B1 (en)	2008-05-14	2009-05-12	5-[5-[2-(3,5-bis(trifluoromethyl)phenyl)-2-methylpropanoylmethylamino]-4-(4-fluoro-2-methylphenyl)]-2-pyridinyl-2-alkyl-prolinamide as nk1 receptor antagonists
PCT/EP2009/055700 WO2009138393A1 (en)	2008-05-14	2009-05-12	5-[5-[2-(3,5-bis(trifluoromethyl)phenyl)-2-methylpropanoylmethylamino]-4-(4-fluoro-2-methylphenyl)]-2-pyridinyl-2-alkyl-prolinamide as nk1 receptor antagonists

Publications (1)

Publication Number	Publication Date
PL2300452T3 true PL2300452T3 (pl)	2014-04-30

Family

ID=39571329

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL09745725T PL2300452T3 (pl)	2008-05-14	2009-05-12	5-[5-[2-(3,5-Bis(trifluorometylo)fenylo)-2-metylopropanoilometyloamino]-4-(4-fluoro-2-metylofenylo)]-2-pirydynylo-2-alkilo-prolinoamidy jako antagonisty receptora NK1

Country Status (22)

Country	Link
US (4)	US8344005B2 (pl)
EP (1)	EP2300452B1 (pl)
JP (1)	JP5465716B2 (pl)
KR (1)	KR101567116B1 (pl)
CN (1)	CN102105458B (pl)
AR (1)	AR071721A1 (pl)
AU (1)	AU2009248102B8 (pl)
BR (1)	BRPI0911990B1 (pl)
CA (1)	CA2724219C (pl)
CL (1)	CL2009001146A1 (pl)
DK (1)	DK2300452T3 (pl)
EA (1)	EA019037B1 (pl)
ES (1)	ES2446866T3 (pl)
GB (1)	GB0808747D0 (pl)
IL (1)	IL209197A (pl)
MX (1)	MX2010012421A (pl)
PE (1)	PE20091847A1 (pl)
PL (1)	PL2300452T3 (pl)
TW (1)	TWI444376B (pl)
UY (1)	UY31824A (pl)
WO (1)	WO2009138393A1 (pl)
ZA (1)	ZA201007904B (pl)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8426450B1 (en) *	2011-11-29	2013-04-23	Helsinn Healthcare Sa	Substituted 4-phenyl pyridines having anti-emetic effect
CA2930008A1 (en)	2013-11-08	2015-05-14	Kissei Pharmaceutical Co., Ltd.	Carboxymethyl piperidine derivative
TWI649307B (zh) *	2014-05-07	2019-02-01	日商橘生藥品工業股份有限公司	Cyclohexylpyridine derivative
WO2016021562A1 (ja) *	2014-08-06	2016-02-11	キッセイ薬品工業株式会社	シアノチオフェン誘導体
WO2018197638A1 (en)	2017-04-27	2018-11-01	Nerre Therapeutics Limited	Novel use of (5r)-5-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-2-methyl-d-prolinamide
WO2021154631A1 (en) *	2020-01-30	2021-08-05	Javed Mohammad	Combination drug therapies for cns disorders
CA3177477A1 (en) *	2020-06-02	2021-12-09	Nerre Therapeutics Limited	Neurokinin (nk)-1 receptor antagonists for use in the treatment of pulmonary fibrosis conditions promoted by mechanical injury to the lungs
EP4175630A4 (en) *	2020-07-01	2024-12-11	Ecstasy LLC	POLYCYCLIC AMINES FOR MODULATION OF THE OPIOID RECEPTOR

Family Cites Families (14)

* Cited by examiner, † Cited by third party
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PT1035115E (pt)	1999-02-24	2005-01-31	Hoffmann La Roche	Derivados de 4-fenilpiridina e a sua utilizacao como antagonistas do receptor nk-1
TR200102490T2 (tr)	1999-02-24	2001-12-21	F.Hoffmann-La Roche Ag	Fenil ve piridinil türevleri
US6303790B1 (en)	1999-11-29	2001-10-16	Hoffman-La Roche Inc.	Process for the preparation of pyridine derivatives
MXPA03000366A (es)	2000-07-14	2003-05-27	Hoffmann La Roche	N-oxidos como profarmacos antagonistas del receptor nk1 de derivados de 4-fenil-piridina.
TWI287003B (en)	2000-07-24	2007-09-21	Hoffmann La Roche	4-phenyl-pyridine derivatives
TWI259180B (en)	2000-08-08	2006-08-01	Hoffmann La Roche	4-Phenyl-pyridine derivatives
CA2444395C (en)	2001-04-23	2010-12-21	F. Hoffmann-La Roche Ag	Use of nk-1 receptor antagonists against benign prostatic hyperplasia
US20030083345A1 (en) *	2001-07-10	2003-05-01	Torsten Hoffmann	Method of treatment and/or prevention of brain, spinal or nerve injury
US6849624B2 (en)	2001-07-31	2005-02-01	Hoffmann-La Roche Inc.	Aromatic and heteroaromatic substituted amides
RU2347777C2 (ru)	2003-07-03	2009-02-27	Ф.Хоффманн-Ля Рош Аг	Двойные агонисты nk1/nk3 для лечения шизофрении
CN1984891B (zh)	2004-07-06	2012-08-08	弗·哈夫曼-拉罗切有限公司	用作合成nk-1受体拮抗剂的中间体的甲酰胺吡啶衍生物的制备方法
US20060030600A1 (en)	2004-08-06	2006-02-09	Patrick Schnider	Dual NK1/NK3 receptor antagonists for the treatment of schizophrenia
EA013909B1 (ru) *	2005-09-09	2010-08-30	Смитклайн Бичам Корпорейшн	Пиридиновые производные и их применение для лечения психотических расстройств
EP1943216B1 (en) *	2005-10-10	2010-06-30	Glaxo Group Limited	Prolinamide derivatives as sodium channel modulators

2008
- 2008-05-14 GB GBGB0808747.0A patent/GB0808747D0/en not_active Ceased
2009
- 2009-05-12 AU AU2009248102A patent/AU2009248102B8/en not_active Ceased
- 2009-05-12 CA CA2724219A patent/CA2724219C/en active Active
- 2009-05-12 US US12/991,515 patent/US8344005B2/en not_active Expired - Fee Related
- 2009-05-12 CN CN2009801275140A patent/CN102105458B/zh active Active
- 2009-05-12 UY UY0001031824A patent/UY31824A/es not_active Application Discontinuation
- 2009-05-12 KR KR1020107027927A patent/KR101567116B1/ko not_active Expired - Fee Related
- 2009-05-12 WO PCT/EP2009/055700 patent/WO2009138393A1/en not_active Ceased
- 2009-05-12 JP JP2011508893A patent/JP5465716B2/ja not_active Expired - Fee Related
- 2009-05-12 CL CL2009001146A patent/CL2009001146A1/es unknown
- 2009-05-12 TW TW098115612A patent/TWI444376B/zh not_active IP Right Cessation
- 2009-05-12 EP EP09745725.3A patent/EP2300452B1/en active Active
- 2009-05-12 PE PE2009000650A patent/PE20091847A1/es not_active Application Discontinuation
- 2009-05-12 PL PL09745725T patent/PL2300452T3/pl unknown
- 2009-05-12 EA EA201071299A patent/EA019037B1/ru not_active IP Right Cessation
- 2009-05-12 MX MX2010012421A patent/MX2010012421A/es active IP Right Grant
- 2009-05-12 ES ES09745725.3T patent/ES2446866T3/es active Active
- 2009-05-12 US US12/464,171 patent/US20090286836A1/en not_active Abandoned
- 2009-05-12 BR BRPI0911990-6A patent/BRPI0911990B1/pt not_active IP Right Cessation
- 2009-05-12 DK DK09745725.3T patent/DK2300452T3/da active
- 2009-05-12 AR ARP090101713A patent/AR071721A1/es not_active Application Discontinuation
2010
- 2010-11-04 ZA ZA2010/07904A patent/ZA201007904B/en unknown
- 2010-11-08 IL IL209197A patent/IL209197A/en active IP Right Grant
2012
- 2012-11-20 US US13/681,925 patent/US8822504B2/en active Active
2014
- 2014-05-16 US US14/280,280 patent/US9006271B2/en active Active

Also Published As

Publication number	Publication date
US20090286836A1 (en)	2009-11-19
CA2724219A1 (en)	2009-11-19
ZA201007904B (en)	2011-11-30
AU2009248102B2 (en)	2012-06-28
EA201071299A1 (ru)	2011-06-30
EA019037B1 (ru)	2013-12-30
AR071721A1 (es)	2010-07-07
US20110060015A1 (en)	2011-03-10
JP2011520834A (ja)	2011-07-21
CA2724219C (en)	2016-04-05
US20130143931A1 (en)	2013-06-06
CN102105458A (zh)	2011-06-22
WO2009138393A1 (en)	2009-11-19
US9006271B2 (en)	2015-04-14
AU2009248102A1 (en)	2009-11-19
EP2300452B1 (en)	2013-11-20
GB0808747D0 (en)	2008-06-18
AU2009248102B8 (en)	2012-07-26
CL2009001146A1 (es)	2010-09-24
MX2010012421A (es)	2011-03-25
KR101567116B1 (ko)	2015-11-06
IL209197A (en)	2014-09-30
KR20110017384A (ko)	2011-02-21
PE20091847A1 (es)	2010-01-09
EP2300452A1 (en)	2011-03-30
US8344005B2 (en)	2013-01-01
ES2446866T3 (es)	2014-03-10
DK2300452T3 (da)	2014-02-17
BRPI0911990A2 (pt)	2020-08-18
BRPI0911990B1 (pt)	2021-07-13
US20140249188A1 (en)	2014-09-04
IL209197A0 (en)	2011-01-31
US8822504B2 (en)	2014-09-02
UY31824A (es)	2009-11-10
TWI444376B (zh)	2014-07-11
CN102105458B (zh)	2013-06-12
TW201006813A (en)	2010-02-16
JP5465716B2 (ja)	2014-04-09

Publication	Publication Date	Title
IL209197A0 (en)	2011-01-31	5-[5-[2-(3,5-bis(trifluoromethyl)phenyl)-2-methylpropanoylmethylamino]-4-(4-fluoro-2-methylphenyl)]-2-pyridinyl-2-alkyl-prolinamide as nk1 receptor antagonists
IL195511A0 (en)	2009-09-01	1-[2-(2,4-dimethylphenylsulfanyl)-phenyl]
EP2349262A4 (en)	2012-08-29	2,5-DISUBSTITUTED PHENYL CARBOXYLIC ACID AMOID-OREXINE RECEPTOR ANTAGONISTS
EP2349270A4 (en)	2012-04-25	2,5-DISUBSTITUTED PIPERIDINOREXINE RECEPTOR ANTAGONISTS
BRPI0914772A2 (pt)	2015-10-20	compostos heterocíclicos 1,2-dissubstituídos
ATE509928T1 (de)	2011-06-15	8-azabicycloä3.2.1üoktan-verbindungen als mu- opioid-rezeptorantagonisten
EP2348856A4 (en)	2012-06-27	2,4-DISUBSTITUTED PYRROLIDINOREXINE RECEPTOR ANTAGONISTS
IL200543A0 (en)	2010-04-29	Ppar active compounds
IL200548A0 (en)	2010-05-17	Ppar active compounds
EP2349269A4 (en)	2012-04-25	2,5-DISUBSTITUTED PIPERIDINOREXINE RECEPTOR ANTAGONISTS
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