PL2399910T3 - Pochodne triazyny jako antagoniści receptora p2x3 i/albo p2x2/3 i kompozycja farmaceutyczna zawierająca je - Google Patents

Pochodne triazyny jako antagoniści receptora p2x3 i/albo p2x2/3 i kompozycja farmaceutyczna zawierająca je

Info

Publication number
PL2399910T3
PL2399910T3 PL10741243T PL10741243T PL2399910T3 PL 2399910 T3 PL2399910 T3 PL 2399910T3 PL 10741243 T PL10741243 T PL 10741243T PL 10741243 T PL10741243 T PL 10741243T PL 2399910 T3 PL2399910 T3 PL 2399910T3
Authority
PL
Poland
Prior art keywords
pharmaceutical composition
composition containing
receptor antagonists
triazine derivatives
triazine
Prior art date
Application number
PL10741243T
Other languages
English (en)
Inventor
Hiroyuki Kai
Takayuki Kameyama
Tsuyoshi Hasegawa
Miho Oohara
Yukio Tada
Takeshi Endoh
Original Assignee
Shionogi & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi & Co filed Critical Shionogi & Co
Publication of PL2399910T3 publication Critical patent/PL2399910T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40—Nitrogen atoms
    • C07D251/42—One nitrogen atom
    • C07D251/46—One nitrogen atom with oxygen or sulfur atoms attached to the two other ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/14—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom
    • C07D251/16—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to only one ring carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40—Nitrogen atoms
    • C07D251/42—One nitrogen atom
    • C07D251/44—One nitrogen atom with halogen atoms attached to the two other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40—Nitrogen atoms
    • C07D251/48—Two nitrogen atoms
    • C07D251/52—Two nitrogen atoms with an oxygen or sulfur atom attached to the third ring carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
PL10741243T 2009-02-13 2010-02-10 Pochodne triazyny jako antagoniści receptora p2x3 i/albo p2x2/3 i kompozycja farmaceutyczna zawierająca je PL2399910T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2009031520 2009-02-13
JP2009266903 2009-11-25
PCT/JP2010/051920 WO2010092966A1 (ja) 2009-02-13 2010-02-10 新規トリアジン誘導体およびそれを含有する医薬組成物
EP10741243.9A EP2399910B1 (en) 2009-02-13 2010-02-10 Triazine derivatives as p2x3 and/or p2x2/3 receptor antagonists and pharmaceutical composition containing them

Publications (1)

Publication Number Publication Date
PL2399910T3 true PL2399910T3 (pl) 2014-09-30

Family

ID=42561808

Family Applications (1)

Application Number Title Priority Date Filing Date
PL10741243T PL2399910T3 (pl) 2009-02-13 2010-02-10 Pochodne triazyny jako antagoniści receptora p2x3 i/albo p2x2/3 i kompozycja farmaceutyczna zawierająca je

Country Status (16)

Country Link
US (2) US9150546B2 (pl)
EP (1) EP2399910B1 (pl)
JP (1) JP5692747B2 (pl)
KR (1) KR101422901B1 (pl)
CN (1) CN102395571B (pl)
AU (1) AU2010214356B2 (pl)
BR (1) BRPI1013642A2 (pl)
CA (1) CA2752269C (pl)
ES (1) ES2474490T3 (pl)
MX (1) MX2011008362A (pl)
PL (1) PL2399910T3 (pl)
PT (1) PT2399910E (pl)
RU (1) RU2551845C2 (pl)
SG (1) SG173647A1 (pl)
TW (1) TWI457328B (pl)
WO (1) WO2010092966A1 (pl)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102395571B (zh) 2009-02-13 2015-12-16 盐野义制药株式会社 三嗪衍生物及含有该三嗪衍生物的药物组合物
EP2585069A1 (en) * 2010-06-28 2013-05-01 Janssen Pharmaceutica, N.V. Prokineticin 1 receptor antagonists for the treatment of pain
US9212130B2 (en) 2010-08-10 2015-12-15 Shionogi & Co., Ltd. Heterocyclic derivative and pharmaceutical composition comprising the same
PL2604595T3 (pl) 2010-08-10 2016-09-30 Pochodna triazyny i związek farmaceutyczny, który ją zawiera i wykazuje aktywność przeciwbólową
TW201331188A (zh) * 2011-12-15 2013-08-01 Shionogi & Co 經取代之三□衍生物及含有其之醫藥組成物
US9550763B2 (en) 2012-02-09 2017-01-24 Shionogi & Co., Ltd. Heterocyclic ring and carbocyclic derivative
TWI597271B (zh) * 2012-03-30 2017-09-01 日產化學工業股份有限公司 三嗪酮化合物及ｔ型鈣通道抑制劑
TWI637949B (zh) 2013-06-14 2018-10-11 塩野義製藥股份有限公司 胺基三衍生物及含有其等之醫藥組合物
WO2015050212A1 (ja) * 2013-10-02 2015-04-09 日産化学工業株式会社 Ｔ型カルシウムチャネル阻害剤
US9988373B2 (en) 2013-12-26 2018-06-05 Shionogi & Co., Ltd. Nitrogen-containing six-membered cyclic derivatives and pharmaceutical composition comprising the same
WO2016084922A1 (ja) * 2014-11-28 2016-06-02 塩野義製薬株式会社 １，２，４－トリアジン誘導体およびその医薬組成物
EP3287443B1 (en) 2015-04-24 2021-10-27 Shionogi & Co., Ltd 6-membered heterocyclic derivative and pharmaceutical composition comprising same
JP6705111B2 (ja) * 2016-02-25 2020-06-03 国立大学法人金沢大学 トリアジノン化合物
WO2018074390A1 (ja) 2016-10-17 2018-04-26 塩野義製薬株式会社 二環性含窒素複素環誘導体およびそれらを含有する医薬組成物
EP3554504B1 (en) 2016-12-15 2022-10-26 Afferent Pharmaceuticals Inc. Substituted pyrazole-pyrimidines, variants thereof, and uses thereof
MX2021014116A (es) 2019-05-31 2021-12-10 Chiesi Farm Spa Derivados de piridopirimidinas como inhibidores del purinoreceptor 3 de p2x (p2x3).
US12312327B2 (en) 2019-09-19 2025-05-27 Shionogi & Co., Ltd. Crystal of 1,3,5-triazine derivative or solvate thereof and method for producing same
TW202203929A (zh) 2020-04-03 2022-02-01 日商塩野義製藥股份有限公司 疼痛治療用醫藥
CN116323598B (zh) * 2020-11-20 2024-11-15 江苏恒瑞医药股份有限公司 三嗪二酮类衍生物、其制备方法及其在医药上的应用
DK4122926T3 (da) 2021-04-14 2025-06-30 Shionogi & Co Triazinderivater med virusreplikationsinhiberende aktivitet og farmaceutisk sammensætning, der omfatter disse
CN117425643A (zh) * 2021-06-04 2024-01-19 上海海雁医药科技有限公司 三嗪基甲基环烷基羧酸衍生物及其药物组合物和用途
CA3233206A1 (en) 2021-09-28 2023-04-06 Yuki Tachibana Pharmaceutical composition containing triazine derivative
TW202320793A (zh) 2021-09-28 2023-06-01 日商塩野義製藥股份有限公司 含有三嗪衍生物之醫藥組合物
CN116514734A (zh) * 2021-11-24 2023-08-01 盐野义制药株式会社 三嗪衍生物的制造方法和含有三嗪衍生物的口服给与的制剂
EP4289432A4 (en) * 2021-11-24 2025-01-15 Shionogi & Co., Ltd PREPARATION FOR ORAL ADMINISTRATION CONTAINING TRIAZINE DERIVATIVES
JP7261529B1 (ja) 2021-11-24 2023-04-20 塩野義製薬株式会社 ウイルス増殖阻害作用を有するトリアジン誘導体の製造方法
US20250025459A1 (en) * 2021-11-26 2025-01-23 Shionogi & Co., Ltd. Covid-19 treatment medicine characterized by combining 3cl protease inhibitor and covid-19 treatment drug
WO2023054732A2 (ja) 2022-01-19 2023-04-06 塩野義製薬株式会社 新型コロナウイルス感染症治療用医薬
WO2023184482A1 (zh) * 2022-04-01 2023-10-05 湖南南新制药股份有限公司 氨基三嗪酮化合物及其制备方法和药物用途
CN119698410A (zh) * 2022-05-27 2025-03-25 广州国家实验室 3c样蛋白酶抑制剂
CN116514783A (zh) 2022-11-21 2023-08-01 歌礼生物科技（杭州）有限公司 三嗪衍生物
WO2024114665A1 (zh) * 2022-11-30 2024-06-06 上海海雁医药科技有限公司 取代的三嗪-2,4-二酮类衍生物中间体及其制备方法
WO2024114663A1 (zh) * 2022-11-30 2024-06-06 上海海雁医药科技有限公司 三嗪基甲基环烷基羧酸衍生物的晶型及其应用

Family Cites Families (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3598815A (en) 1968-10-25 1971-08-10 Goodrich Co B F Bis-(hydroxyphenylalkylene) alkyl isocyanurates
JPS5132324A (en) 1974-09-12 1976-03-18 Fuji Photo Film Co Ltd Netsugenzokankozairyo
CH622536A5 (pl) 1976-07-08 1981-04-15 Ciba Geigy Ag
US4158724A (en) 1976-10-18 1979-06-19 Ciba-Geigy Corporation Tris-tetrazoles as chemical blowing agents
CH623840A5 (pl) 1976-10-18 1981-06-30 Ciba Geigy Ag
GB1599518A (en) * 1977-02-21 1981-10-07 Ici Ltd 1,3,5-triazine-2,6-diones and pharmaceutical compositions thereof
DE2962124D1 (en) * 1978-05-26 1982-03-25 Ici Plc Analgesic 6-acylaminotetrahydro-1,3,5-triazine-2,4-dione derivatives, pharmaceutical compositions thereof, and process for their manufacture
JPS57144269A (en) * 1981-03-03 1982-09-06 Taiho Yakuhin Kogyo Kk Triazine derivative and its preparation
EP0110828B1 (de) 1982-11-26 1988-01-20 Ciba-Geigy Ag Farbphotographisches Aufzeichnungsmaterial
JPS62156110A (ja) 1985-12-27 1987-07-11 Res Inst For Prod Dev 測鎖にイソシアヌレ−ト構造を含む吸着能力を有する重合体
EP0401707B1 (en) 1989-06-05 1994-09-21 Daiichi Pharmaceutical Co., Ltd. Heterocyclic triazin or triazolo compounds having serotonin 2-receptor antagonistic activity
RU2057754C1 (ru) * 1989-06-05 1996-04-10 Дайити Фармасьютикал Ко., Лтд. Гетероциклические соединения или их кислотно-аддитивные соли
DE4141721A1 (de) * 1991-12-18 1993-06-24 Bayer Ag Substituierte heterocyclyltriazindione
JP3542482B2 (ja) 1997-12-25 2004-07-14 日研化学株式会社 ３−アニリノ−２−シクロアルケノン誘導体
JP4478854B2 (ja) 1998-04-15 2010-06-09 財団法人相模中央化学研究所 ２−アニリノピリミジノン誘導体及び製造中間体、それらの製造方法並びにそれらを有効成分として含有する農薬
JP2995293B1 (ja) 1998-08-25 1999-12-27 工業技術院長 １，６‐ジ置換‐１，３，５‐トリアジン‐２，４（１ｈ，３ｈ）‐ジオン化合物の製造方法
US6177437B1 (en) 1998-09-04 2001-01-23 University Of Massachusetts Medical Center Inhibitors of Herpes Simplex virus uracil-DNA glycosylase
GB9828511D0 (en) 1998-12-24 1999-02-17 Zeneca Ltd Chemical compounds
ATE274500T1 (de) 1999-03-04 2004-09-15 Korea Res Inst Chem Tech Anivirale 2,4-pyrimidindion-derivate und ein verfahren zu ihrer herstellung
WO2001055093A1 (en) 2000-01-25 2001-08-02 Japan Tobacco Inc. N-arylhydrazide compounds and use thereof as drugs
US20020049320A1 (en) * 2000-04-27 2002-04-25 American Cyanamid Company 6-amino-2,4-dioxo-3,4-dihydro-1,3,5-triazine derivatives and methods for the solid phase synthesis thereof
EP1392643B1 (en) 2001-05-18 2005-09-14 Abbott Laboratories Trisubstituted-n- (1s)-1,2,3,4-tetrahydro-1-naphthalenyl] benzamides which inhibit p2x3 and p2x2/3 containing receptors
WO2004054617A1 (ja) 2002-12-13 2004-07-01 Kyowa Hakko Kogyo Co., Ltd. 中枢疾患の予防および／または治療剤
US20070161637A1 (en) * 2003-07-22 2007-07-12 Neurogen Corporation Substituted pyridin-2-ylamine analogues
ES2391636T3 (es) 2004-03-05 2012-11-28 F. Hoffmann-La Roche Ag Diaminopirimidinas como antagonistas de P2X3 y P2X2/3
EP1773405A4 (en) 2004-07-22 2011-10-05 Duska Scient Co METHOD FOR DIAGNOSIS, MONITORING AND TREATMENT OF LUNG DISEASES
CA2590110C (en) 2004-12-30 2014-06-03 Exelixis, Inc. Kinase modulators and method of use
JP2008534499A (ja) * 2005-03-24 2008-08-28 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ プロキネチシン２受容体アンタゴニストとしてのピリミジンジオン誘導体
CN101326168A (zh) * 2005-03-24 2008-12-17 詹森药业有限公司 激肽原1受体拮抗剂
WO2006102112A2 (en) 2005-03-24 2006-09-28 Janssen Pharmaceutica N.V. Prokineticin 1 receptor
US8507415B2 (en) 2005-05-03 2013-08-13 Southwest Research Institute Lubricant oils and greases containing nanoparticle additives
WO2006119504A2 (en) 2005-05-04 2006-11-09 Renovis, Inc. Fused heterocyclic compounds, and compositions and uses thereof
ATE537169T1 (de) 2005-08-15 2011-12-15 Hoffmann La Roche Piperidin- und piperazinderivate als p2x3- antagonisten
ES2612890T3 (es) 2005-09-01 2017-05-19 F. Hoffmann-La Roche Ag Diaminopirimidinas como moduladores de P2X3 y P2X2/3
JP4850912B2 (ja) 2005-09-01 2012-01-11 エフ．ホフマン−ラ ロシュ アーゲー Ｐ２ｘ３およびｐ３ｘ２／３モジュレーターとしてのジアミノピリミジン
WO2007025901A1 (en) 2005-09-01 2007-03-08 F. Hoffmann-La Roche Ag Diaminopyrimidines as p2x3 and p2x2/3 modulators
KR101012926B1 (ko) 2005-09-01 2011-02-09 에프. 호프만-라 로슈 아게 Ｐ2ｘ3 및 ｐ2ｘ2/3 조정자로서의 다이아미노피리미딘
CA2635845A1 (en) * 2005-12-29 2007-07-12 Janssen Pharmaceutica N.V. Prokineticin 2 receptor antagonists
EP1973886B1 (en) 2005-12-29 2013-02-27 Janssen Pharmaceutica N.V. Prokineticin 1 receptor antagonists
EP2043651A2 (en) 2006-07-05 2009-04-08 Exelixis, Inc. Methods of using igf1r and abl kinase modulators
SG174016A1 (en) 2006-07-24 2011-09-29 Korea Res Inst Chem Tech Hiv reverse transcriptase inhibitors
TW200845994A (en) 2007-01-12 2008-12-01 Smithkline Beecham Corp N-substituted glycine derivatives: prolyl hydroxylase inhibitors
PE20090695A1 (es) 2007-04-13 2009-06-27 Schering Corp Derivados de pirimidindiona como agonistas del receptor de acido nicotinico
US20090099195A1 (en) 2007-05-08 2009-04-16 Astrazeneca Ab Therapeutic Compounds 570
JP2009007258A (ja) 2007-06-26 2009-01-15 Kowa Pharmaceutical Co Ltd Ｐａｉ−１産生抑制作用を有する３−アニリノ−２−シクロアルケノン誘導体
JP2011502154A (ja) * 2007-10-30 2011-01-20 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ アミノヘテロアリールを含むプロキネチシン１受容体拮抗物質連邦政府支援研究又は開発に関する陳述下に記述される本発明の研究及び開発は、連邦政府の支援によるものではない。
KR20100124262A (ko) 2008-02-13 2010-11-26 에자이 알앤드디 매니지먼트 가부시키가이샤 비시클로아민 유도체
JP5608655B2 (ja) 2008-09-18 2014-10-15 エヴォテック アーゲー Ｐ２ｘ３受容体活性のモジュレーター
US8598209B2 (en) 2008-10-31 2013-12-03 Merck Sharp & Dohme Corp. P2X3, receptor antagonists for treatment of pain
CN102395571B (zh) 2009-02-13 2015-12-16 盐野义制药株式会社 三嗪衍生物及含有该三嗪衍生物的药物组合物
SG177308A1 (en) 2009-06-22 2012-02-28 Hoffmann La Roche Novel biphenyl and phenyl-pyridine amides
KR20120047996A (ko) 2009-08-05 2012-05-14 이 아이 듀폰 디 네모아 앤드 캄파니 메소이온성 살충제
CA2806572C (en) 2010-07-30 2018-10-30 Expression Pathology, Inc. C-src selected reaction monitoring assay
US9212130B2 (en) 2010-08-10 2015-12-15 Shionogi & Co., Ltd. Heterocyclic derivative and pharmaceutical composition comprising the same
PL2604595T3 (pl) 2010-08-10 2016-09-30 Pochodna triazyny i związek farmaceutyczny, który ją zawiera i wykazuje aktywność przeciwbólową
EP3628665B1 (en) 2011-04-01 2022-11-02 University of Utah Research Foundation Substituted n-phenylpyrimidin-2-amine analogs as inhibitors of the axl kinase
TW201331188A (zh) 2011-12-15 2013-08-01 Shionogi & Co 經取代之三□衍生物及含有其之醫藥組成物
US9550763B2 (en) 2012-02-09 2017-01-24 Shionogi & Co., Ltd. Heterocyclic ring and carbocyclic derivative
TWI637949B (zh) 2013-06-14 2018-10-11 塩野義製藥股份有限公司 胺基三衍生物及含有其等之醫藥組合物

Also Published As

Publication number Publication date
EP2399910A1 (en) 2011-12-28
CN102395571A (zh) 2012-03-28
KR20110103470A (ko) 2011-09-20
TWI457328B (zh) 2014-10-21
US9150546B2 (en) 2015-10-06
EP2399910B1 (en) 2014-04-02
CA2752269A1 (en) 2010-08-19
RU2551845C2 (ru) 2015-05-27
CA2752269C (en) 2016-08-30
US20160185736A1 (en) 2016-06-30
US9688643B2 (en) 2017-06-27
TW201033183A (en) 2010-09-16
PT2399910E (pt) 2014-05-02
JPWO2010092966A1 (ja) 2012-08-16
JP5692747B2 (ja) 2015-04-01
AU2010214356B2 (en) 2014-10-30
US20110319414A1 (en) 2011-12-29
CN102395571B (zh) 2015-12-16
MX2011008362A (es) 2011-08-24
EP2399910A4 (en) 2012-10-17
ES2474490T3 (es) 2014-07-09
AU2010214356A1 (en) 2011-08-18
BRPI1013642A2 (pt) 2016-04-19
RU2011137531A (ru) 2013-03-20
WO2010092966A1 (ja) 2010-08-19
SG173647A1 (en) 2011-10-28
KR101422901B1 (ko) 2014-07-23

Similar Documents

Publication Publication Date Title
PT2399910E (pt) Novo derivado de triazina e composição farmacéutica que contém o mesmo
IL205608A0 (en) Triazole -substituted arylamide derivatives and their use as p2x3 and/or p2x2/3purinergic receptor antagonists
ZA201207259B (en) 4-aminopyrimidine derivatives and their as as adenosine 121 receptor antagonists
GB0805477D0 (en) Pyrimidines triazines and their use as pharmaceutical agents
ZA201100513B (en) Cyclohexyl amide derivatives and their use as crf-1 receptor antagonists
IL238702A (en) Tetraazole Arilamide History and their Use as Antagonists for P2x3 and / or P2x2 / 3 Porinergic Receptors
EP2129654A4 (en) NEW ANTAGONISTS OF THE GLUCAGON RECEPTOR
IL214208A (en) Preserved heterotromatic bicycles, containing pharmaceutical preparations and their use in preventing the jak process
IL214425A (en) Converted metastatic heterocyclic compounds, their pharmaceutical preparations and their uses
IL202665A0 (en) Piperidine derivatives useful as orexin receptor antagonists
IL214236A0 (en) Heterocyclic compounds, pharmaceutical compositions containing them, and their use as inhibitors of the glycine transporter 1
IL196601A0 (en) Pyrimidine derivatives and pharmaceutical compositions containing the same
IL205665A0 (en) Heteroaryl derivatives as orexin receptor antagonists
PL2079688T3 (pl) Antagoniści receptora glukagonu, kompozycje zawierające takie związki oraz ich zastosowanie farmaceutyczne
ZA200709147B (en) Pyrimidindione derivatives as prokineticin 2 receptor antagonists
ZA201108158B (en) 6-(3-aza-bicyclo[3.1.0]hex-3-yl)-2-phenyl-pyrimidines as adp receptor antagonists
IL216361A0 (en) Anti-cancer compound and pharmaceutical composition containing the same
SI2966175T1 (sl) Farmacevtski sestavki vsebujoči korteksolon-17-alfa-propionat
IL217500A0 (en) Tetrazole derivatives, their preparartion and pharmaceutical compositions containing them
IL195972A0 (en) Cinnamoyl-piperazine derivatives and their use as par-i antagonists
IL192308A0 (en) Oxazoloisoquinoline derivatives as thrombin receptor antagonists
IL198334A0 (en) 2-phenyl-6-aminocarbonyl-pyrimidine derivatives and their use as p2y12 receptor antagonists
IL216827A0 (en) Benzyl substituted triazine derivatives, compositions comprising the same and uses thereof
IL205949A0 (en) 3-carboxypropyl-aminotetralin derivatives and related compounds as mu opioid receptor antagonists
ZA201006766B (en) Pharmaceutical composition 271