PL3210991T3 - Postać krystaliczna lewoizowalerylospiramycyny II oraz preparaty, sposoby wytwarzania i ich zastosowanie - Google Patents

Postać krystaliczna lewoizowalerylospiramycyny II oraz preparaty, sposoby wytwarzania i ich zastosowanie

Info

Publication number
PL3210991T3
PL3210991T3 PL17166118T PL17166118T PL3210991T3 PL 3210991 T3 PL3210991 T3 PL 3210991T3 PL 17166118 T PL17166118 T PL 17166118T PL 17166118 T PL17166118 T PL 17166118T PL 3210991 T3 PL3210991 T3 PL 3210991T3
Authority
PL
Poland
Prior art keywords
levoisovalerylspiramycin
preparations
crystalline form
preparation methods
preparation
Prior art date
Application number
PL17166118T
Other languages
English (en)
Inventor
Yang Jiang
Xiaofeng Zhao
Original Assignee
Shenyang Fuyang Pharmaceutical Technology Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shenyang Fuyang Pharmaceutical Technology Co., Ltd. filed Critical Shenyang Fuyang Pharmaceutical Technology Co., Ltd.
Publication of PL3210991T3 publication Critical patent/PL3210991T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
PL17166118T 2010-05-25 2011-05-25 Postać krystaliczna lewoizowalerylospiramycyny II oraz preparaty, sposoby wytwarzania i ich zastosowanie PL3210991T3 (pl)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
CN201010182108 2010-05-25
CN201010182109 2010-05-25
CN201010182111 2010-05-25
PCT/CN2011/074644 WO2011147313A1 (zh) 2010-05-25 2011-05-25 左旋异戊酰螺旋霉素i、ii或iii，及其制剂、制备方法及应用
EP11786085.8A EP2578595B1 (en) 2010-05-25 2011-05-25 Crystalline levoisovalerylspiramycin i
EP17166118.4A EP3210991B1 (en) 2010-05-25 2011-05-25 Crystalline form of levoisovalerylspiramycin ii and preparations, preparation methods and uses thereof

Publications (1)

Publication Number Publication Date
PL3210991T3 true PL3210991T3 (pl) 2020-03-31

Family

ID=45003321

Family Applications (3)

Application Number Title Priority Date Filing Date
PL17166118T PL3210991T3 (pl) 2010-05-25 2011-05-25 Postać krystaliczna lewoizowalerylospiramycyny II oraz preparaty, sposoby wytwarzania i ich zastosowanie
PL17166117T PL3210990T3 (pl) 2010-05-25 2011-05-25 Lewoizowalerylospiramycyna III i jej preparaty, sposoby wytwarzania i zastosowania
PL11786085T PL2578595T3 (pl) 2010-05-25 2011-05-25 Krystaliczna lewoizowalerylospiramycyna I

Family Applications After (2)

Application Number Title Priority Date Filing Date
PL17166117T PL3210990T3 (pl) 2010-05-25 2011-05-25 Lewoizowalerylospiramycyna III i jej preparaty, sposoby wytwarzania i zastosowania
PL11786085T PL2578595T3 (pl) 2010-05-25 2011-05-25 Krystaliczna lewoizowalerylospiramycyna I

Country Status (16)

Country Link
US (1) US8778896B2 (pl)
EP (3) EP3210990B1 (pl)
JP (1) JP5945868B2 (pl)
KR (2) KR20130041829A (pl)
BR (1) BR112012029913B1 (pl)
CA (3) CA2915236C (pl)
DK (3) DK3210990T3 (pl)
ES (3) ES2633723T3 (pl)
MX (1) MX340626B (pl)
MY (1) MY164231A (pl)
PH (1) PH12012502323A1 (pl)
PL (3) PL3210991T3 (pl)
PT (1) PT3210990T (pl)
RU (3) RU2647237C1 (pl)
WO (1) WO2011147313A1 (pl)
ZA (3) ZA201209738B (pl)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2578596T3 (en) * 2010-05-25 2017-07-17 Shenyang Fuyang Pharmaceutical Tech Co Ltd LEVOCARRIMYCIN, PHARMACEUTICAL COMPOSITIONS, METHODS OF PRODUCTION AND APPLICATIONS THEREOF
CN105497053B (zh) * 2015-12-31 2018-02-13 沈阳福洋医药科技有限公司 可利霉素在抗结核分枝杆菌感染中的应用
AU2018298187A1 (en) * 2017-07-04 2020-02-06 Shenyang Fuyang Pharmaceutical Technology Co., Ltd. Use of isovalerylspiramycin I, II and/or III in preparation of drug for treating and/or preventing tumour, and drug
US11413302B2 (en) * 2018-01-19 2022-08-16 Shenyang Fuyang Pharmaceutical Technology Co., Ltd. Use of carrimycin or active ingredients thereof and use thereof
RU2768583C2 (ru) * 2018-01-19 2022-03-24 Шенянг Фуянг Фармасьютекал Технолоджи Ко., Лтд. Ингибитор мишени рапамицина в клетках млекопитающих, фармацевтическая композиция и их применение
CN110384710B (zh) * 2018-04-17 2023-01-10 沈阳福洋医药科技有限公司 一种用于预防和/或治疗疼痛的药物、组合产品及其应用
EP3782627A4 (en) * 2018-04-17 2021-07-07 Shanghai Tonglian Pharmaceutical Co., Ltd. MEDICINAL PRODUCT USED TO PREVENT AND / OR TREAT PAIN AND / OR FEVER, A COMBINATION PRODUCT, AND USE OF THEM
US20220211735A1 (en) * 2019-05-16 2022-07-07 Shenyang Fuyang Pharmaceutical Technology Co., Ltd. Medicament and combination product used for preventing, alleviating and/or treating fibrosis, and use thereof
CN112239483B (zh) * 2019-07-18 2023-10-27 沈阳福洋医药科技有限公司 一种化合物及药物组合物
US11351185B2 (en) 2020-03-11 2022-06-07 Asclea Corporation Use of isovalerylspiramycins as anti-cancer agents to inhibit metastasis

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5334788A (en) * 1976-09-11 1978-03-31 Sanraku Inc Antibiotics spiramycin derivatives
CN1058295C (zh) 1997-06-03 2000-11-08 中国医学科学院医药生物技术研究所 一种利用基因工程技术制造生技霉素的方法
CN1169947C (zh) * 2002-11-19 2004-10-06 中国医学科学院医药生物技术研究所 必特螺旋霉素的基因工程菌株螺旋霉素链霉菌wsj-195
CN1237976C (zh) * 2003-12-23 2006-01-25 沈阳同联集团有限公司 必特螺旋霉素及其在抗感染性疾病中的应用
MX2007001669A (es) * 2004-08-12 2007-04-10 Glaxosmithkline Zagreb Uso de conjugados especificos celulares para el tratamiento de enfermedades inflamatorias del tracto gastrointestinal.
CN101054553A (zh) * 2007-04-09 2007-10-17 中国医学科学院医药生物技术研究所 异戊酰螺旋霉素i基因工程菌株的构建
CN101649325B (zh) * 2009-07-03 2011-09-07 中国医学科学院医药生物技术研究所 一种提高基因工程异戊酰螺旋霉素主组分含量的基因串连技术
CN101785779B (zh) 2010-03-09 2014-03-05 沈阳同联集团有限公司 异戊酰螺旋霉素ii的分离制备
CN101773510B (zh) * 2010-03-09 2013-06-05 沈阳同联集团有限公司 异戊酰螺旋霉素iii的分离制备
CN101785778A (zh) * 2010-03-09 2010-07-28 沈阳同联集团有限公司 异戊酰螺旋霉素i的分离制备及其应用
DK2578596T3 (en) * 2010-05-25 2017-07-17 Shenyang Fuyang Pharmaceutical Tech Co Ltd LEVOCARRIMYCIN, PHARMACEUTICAL COMPOSITIONS, METHODS OF PRODUCTION AND APPLICATIONS THEREOF

Also Published As

Publication number Publication date
RU2647236C1 (ru) 2018-03-14
CA2915222A1 (en) 2011-12-01
ES2754614T3 (es) 2020-04-20
PL3210990T3 (pl) 2020-10-05
KR20130041829A (ko) 2013-04-25
ZA201406382B (en) 2015-12-23
KR20160017124A (ko) 2016-02-15
MX2012013470A (es) 2013-03-18
EP2578595A1 (en) 2013-04-10
BR112012029913A8 (pt) 2018-01-09
RU2647237C1 (ru) 2018-03-14
PL2578595T3 (pl) 2017-10-31
EP3210991B1 (en) 2019-08-07
BR112012029913A2 (pt) 2017-11-28
DK2578595T3 (en) 2017-07-10
BR112012029913B1 (pt) 2021-02-02
MY164231A (en) 2017-11-30
US20130065848A1 (en) 2013-03-14
EP3210990B1 (en) 2020-01-01
RU2593498C2 (ru) 2016-08-10
ZA201406381B (en) 2016-08-31
WO2011147313A1 (zh) 2011-12-01
MX340626B (es) 2016-07-18
EP3210991A1 (en) 2017-08-30
ZA201209738B (en) 2015-04-29
CA2915236A1 (en) 2011-12-01
ES2633723T3 (es) 2017-09-25
JP5945868B2 (ja) 2016-07-13
US8778896B2 (en) 2014-07-15
PH12012502323A1 (en) 2023-03-10
CA2915222C (en) 2019-03-12
DK3210990T3 (da) 2020-03-23
EP3210990A1 (en) 2017-08-30
JP2013528166A (ja) 2013-07-08
EP2578595A4 (en) 2013-11-06
EP2578595B1 (en) 2017-04-19
CA2800021A1 (en) 2011-12-01
DK3210991T3 (da) 2019-11-11
CA2800021C (en) 2016-03-22
KR101706518B1 (ko) 2017-02-14
ES2781425T3 (es) 2020-09-02
CA2915236C (en) 2019-03-12
PT3210990T (pt) 2020-04-01
RU2012156420A (ru) 2014-06-27

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