PL2734538T5 - Sposób odwracalnego barwienia komórki docelowej - Google Patents
Sposób odwracalnego barwienia komórki docelowejInfo
- Publication number
- PL2734538T5 PL2734538T5 PL12747985.5T PL12747985T PL2734538T5 PL 2734538 T5 PL2734538 T5 PL 2734538T5 PL 12747985 T PL12747985 T PL 12747985T PL 2734538 T5 PL2734538 T5 PL 2734538T5
- Authority
- PL
- Poland
- Prior art keywords
- target cell
- reversible staining
- staining
- reversible
- target
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/557—Immunoassay; Biospecific binding assay; Materials therefor using kinetic measurement, i.e. time rate of progress of an antigen-antibody interaction
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
- G01N33/56972—White blood cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/22—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a Strep-tag
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2458/00—Labels used in chemical analysis of biological material
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Virology (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Developmental Biology & Embryology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Diabetes (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Transplantation (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161508943P | 2011-07-18 | 2011-07-18 | |
| PCT/EP2012/063969 WO2013011011A2 (en) | 2011-07-18 | 2012-07-17 | Method of reversibly staining a target cell |
| EP12747985.5A EP2734538B2 (en) | 2011-07-18 | 2012-07-17 | Method of reversibly staining a target cell |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL2734538T3 PL2734538T3 (pl) | 2018-10-31 |
| PL2734538T5 true PL2734538T5 (pl) | 2025-11-12 |
Family
ID=46682800
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL12747985.5T PL2734538T5 (pl) | 2011-07-18 | 2012-07-17 | Sposób odwracalnego barwienia komórki docelowej |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US9023604B2 (pl) |
| EP (2) | EP3418295B1 (pl) |
| JP (2) | JP6310388B2 (pl) |
| CN (2) | CN103797028B (pl) |
| ES (1) | ES2682750T5 (pl) |
| PL (1) | PL2734538T5 (pl) |
| PT (1) | PT2734538T (pl) |
| SI (1) | SI2734538T2 (pl) |
| TR (1) | TR201811128T4 (pl) |
| WO (1) | WO2013011011A2 (pl) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9023604B2 (en) * | 2011-07-18 | 2015-05-05 | Iba Gmbh | Method of reversibly staining a target cell |
| ES3011307T3 (en) | 2012-02-23 | 2025-04-07 | Juno Therapeutics Gmbh | Chromatographic isolation of cells and other complex biological materials |
| BR112015021866A2 (pt) | 2013-03-15 | 2017-08-29 | Bayer Healthcare Llc | Domínios de gla como agentes direcionadores |
| SI3132247T1 (sl) * | 2014-04-16 | 2021-12-31 | Juno Therapeutics Gmbh | Postopki, kompleti in naprava za povečanje populacije celic |
| CA2946312A1 (en) | 2014-04-23 | 2015-10-29 | Juno Therapeutics, Inc. | Methods for isolating, culturing, and genetically engineering immune cell populations for adoptive therapy |
| CN106062185A (zh) * | 2014-04-24 | 2016-10-26 | 美天旎生物技术有限公司 | 用于自动生成遗传修饰的t细胞的方法 |
| US11150239B2 (en) | 2014-04-30 | 2021-10-19 | Iba Lifesciences Gmbh | Method of isolating a target cell |
| EP3037820A1 (en) * | 2014-12-27 | 2016-06-29 | Miltenyi Biotec GmbH | Cell detection methods and reagents having a releasable labelling moiety |
| US11867696B2 (en) * | 2015-02-06 | 2024-01-09 | Cell Idx, Inc. | Antigen-coupled immunoreagents |
| WO2016166568A1 (en) | 2015-04-16 | 2016-10-20 | Juno Therapeutics Gmbh | Methods, kits and apparatus for expanding a population of cells |
| AU2016341529B2 (en) * | 2015-10-22 | 2023-03-30 | Juno Therapeutics Gmbh | Methods for culturing cells and kits and apparatus for same |
| MX2018004875A (es) | 2015-10-22 | 2018-08-01 | Juno Therapeutics Gmbh | Metodos para cultivar celulas y kits y aparatos para ello. |
| EP3365453A2 (en) | 2015-10-22 | 2018-08-29 | Juno Therapeutics GmbH | Methods, kits, agents and apparatuses for transduction |
| EP3488011A1 (en) | 2016-06-28 | 2019-05-29 | Technische Universität München | Combination of reversible and irreversible cell labeling for analizing receptor-ligand koff rate |
| US10294454B2 (en) | 2016-08-24 | 2019-05-21 | General Electric Company | Methods and kits for cell activation |
| EP3336545A1 (en) * | 2016-12-13 | 2018-06-20 | Miltenyi Biotec GmbH | Reversible labeling of antigens in biological specimens |
| EP3336546B1 (en) | 2016-12-13 | 2020-07-01 | Miltenyi Biotec B.V. & Co. KG | Reversible cell labelling with conjugates having two releasable binding sites |
| CN110072993B (zh) | 2016-12-16 | 2023-07-07 | 大集有限责任公司 | 由浮力实现的分离方法和系统 |
| CA3050085A1 (en) | 2017-01-20 | 2018-07-26 | Juno Therapeutics Gmbh | Cell surface conjugates and related cell compositions and methods |
| JP7339160B2 (ja) | 2017-04-27 | 2023-09-05 | ジュノ セラピューティクス ゲーエムベーハー | オリゴマー粒子試薬およびその使用方法 |
| SG11202000606TA (en) | 2017-07-29 | 2020-02-27 | Juno Therapeutics Inc | Reagents for expanding cells expressing recombinant receptors |
| KR20250016455A (ko) | 2017-08-09 | 2025-02-03 | 주노 쎄러퓨티크스 인코퍼레이티드 | 유전자 조작된 세포 조성물 및 관련 조성물의 제조 방법 |
| EP3679129A1 (en) * | 2017-09-05 | 2020-07-15 | GLAdiator Biosciences, Inc. | A method of intracellular delivery |
| US12258580B2 (en) | 2017-11-01 | 2025-03-25 | Juno Therapeutics, Inc. | Process for generating therapeutic compositions of engineered cells |
| CN119193493A (zh) | 2017-12-08 | 2024-12-27 | 朱诺治疗学股份有限公司 | 生产工程化t细胞组合物的过程 |
| CN116148467A (zh) * | 2017-12-12 | 2023-05-23 | 清华大学 | 检测翻译后修饰蛋白质与其配体间相互作用的成套试剂 |
| US12516099B2 (en) | 2018-08-09 | 2026-01-06 | Juno Therapeutics, Inc. | Processes for generating engineered cells and compositions thereof |
| US20210246189A1 (en) | 2018-09-03 | 2021-08-12 | Technische Universitaet Muenchen | A double peptide tag combining reversibility and flexible functionalization |
| SG11202102108QA (en) | 2018-09-11 | 2021-04-29 | Juno Therapeutics Inc | Methods for mass spectrometry analysis of engineered cell compositions |
| SG11202104355SA (en) | 2018-10-31 | 2021-05-28 | Juno Therapeutics Gmbh | Methods for selection and stimulation of cells and apparatus for same |
| ES2968737T3 (es) | 2018-11-06 | 2024-05-13 | Juno Therapeutics Inc | Proceso para producir células T manipuladas genéticamente |
| CN113677995A (zh) | 2019-04-23 | 2021-11-19 | 美天施生物科技有限两合公司 | 使用具有用于增加荧光亮度的接头和酶促可释放荧光部分的缀合物的可逆细胞检测 |
| CA3142108A1 (en) | 2019-05-28 | 2020-12-03 | Miltenyi Biotec B.V. & Co. KG | Method for generation of genetically modified t cells |
| CN114207136A (zh) | 2019-06-07 | 2022-03-18 | 朱诺治疗学股份有限公司 | 自动化t细胞培养 |
| KR20220073738A (ko) | 2019-08-30 | 2022-06-03 | 주노 쎄러퓨티크스 인코퍼레이티드 | 세포 분류를 위한 기계 학습 방법 |
| WO2021047804A1 (en) | 2019-09-11 | 2021-03-18 | Miltenyi Biotec B.V. & Co. KG | In vitro method for transduction of t cells in the presence of malignant cells |
| KR20220101641A (ko) | 2019-10-30 | 2022-07-19 | 주노 테라퓨틱스 게엠베하 | 세포 선택 및/또는 자극 장치 및 사용 방법 |
| JP2023512209A (ja) | 2020-01-28 | 2023-03-24 | ジュノー セラピューティクス インコーポレイテッド | T細胞形質導入のための方法 |
| IL295381B1 (en) | 2020-02-12 | 2026-04-01 | Juno Therapeutics Inc | BCMA-directed chimeric T-cell antigen receptor compounds and methods and uses thereof |
| IL295384B1 (en) | 2020-02-12 | 2026-04-01 | Juno Therapeutics Inc | T-cell preparations with chimeric antigen receptor directed against CD19 and methods and uses thereof |
| CN115835873A (zh) | 2020-05-13 | 2023-03-21 | 朱诺治疗学股份有限公司 | 用于产生表达重组受体的供体分批细胞的方法 |
| WO2021261451A1 (ja) | 2020-06-24 | 2021-12-30 | 旭化成メディカル株式会社 | タンパク質含有溶液の評価方法 |
| EP4204809A1 (en) | 2020-08-27 | 2023-07-05 | Miltenyi Biotec B.V. & Co. KG | Releasable reagents for cell separation |
| CN112285083B (zh) * | 2020-10-28 | 2022-01-07 | 上海睿钰生物科技有限公司 | 一种细胞杀伤效力的评价方法 |
| JP2024517863A (ja) | 2021-05-06 | 2024-04-23 | ジュノ・セラピューティクス・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 細胞を刺激し、形質導入する方法 |
| WO2023147510A1 (en) | 2022-01-28 | 2023-08-03 | Juno Therapeutics, Inc. | Chromatography arrays and related methods and kits |
| EP4227423A1 (en) | 2022-02-09 | 2023-08-16 | Technische Universität München | Means and methods for identifying high affinity t-cells |
| CN119095950A (zh) | 2022-04-28 | 2024-12-06 | 生物细胞再生有限公司 | 用于分离靶细胞的方法 |
| US20250297282A1 (en) | 2022-05-05 | 2025-09-25 | Juno Therapeutics Gmbh | Viral-binding protein and related reagents, articles, and methods of use |
| EP4532695A1 (en) | 2022-05-25 | 2025-04-09 | Celgene Corporation | Methods of manufacturing t cell therapies |
| WO2024100604A1 (en) | 2022-11-09 | 2024-05-16 | Juno Therapeutics Gmbh | Methods for manufacturing engineered immune cells |
| WO2024124132A1 (en) | 2022-12-09 | 2024-06-13 | Juno Therapeutics, Inc. | Machine learning methods for predicting cell phenotype using holographic imaging |
| JP2026504491A (ja) | 2023-02-03 | 2026-02-05 | ツェー3エス2 ゲーエムベーハー | 操作された免疫細胞の非ウイルス的製造のための方法 |
| CN121127253A (zh) | 2023-02-28 | 2025-12-12 | 朱诺治疗学股份有限公司 | 治疗系统性自身免疫性疾病的细胞疗法 |
| WO2025049247A1 (en) | 2023-08-25 | 2025-03-06 | Juno Therapeutics, Inc. | 5,6-core silacycle based inhibitors of dna-dependent protein kinase and compositions and application in gene editing |
| WO2025049250A1 (en) | 2023-08-25 | 2025-03-06 | Juno Therapeutics, Inc. | 6,6-core silacycle based inhibitors of dna-dependent protein kinase and compositions and application in gene editing |
| WO2025049253A1 (en) | 2023-08-25 | 2025-03-06 | Juno Therapeutics, Inc. | Bridged cycle‑based inhibitors of dna‑dependent protein kinase and compositions and application in gene editing |
| WO2025049254A1 (en) | 2023-08-25 | 2025-03-06 | Juno Therapeutics, Inc. | Pyrazolopyridine based inhibitors of dna-dependent protein kinase and compositions and application in gene editing |
| WO2025083196A1 (en) | 2023-10-18 | 2025-04-24 | Tq Therapeutics Gmbh | A method of manufacturing a cellular therapy product and respective kits and devices |
| US20250241912A1 (en) | 2024-01-25 | 2025-07-31 | Juno Therapeutics, Inc. | Use of bridged cycle-based inhibitors of dna-dependent protein kinase in combination of dna polymerase theta inhibitor and compositions and application in gene editing |
| WO2025179188A1 (en) | 2024-02-22 | 2025-08-28 | Juno Therapeutics, Inc. | Pyrazole-based inhibitors of dna-dependent protein kinase and compositions and applications in gene editing |
| EP4725578A1 (en) | 2024-10-08 | 2026-04-15 | TQ Therapeutics GmbH | Column designs for affinity chromatography |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4851341A (en) | 1986-12-19 | 1989-07-25 | Immunex Corporation | Immunoaffinity purification system |
| DE4237113B4 (de) | 1992-11-03 | 2006-10-12 | "Iba Gmbh" | Peptide und deren Fusionsproteine, Expressionsvektor und Verfahren zur Herstellung eines Fusionsproteins |
| DE19641876B4 (de) | 1996-10-10 | 2011-09-29 | Iba Gmbh | Streptavidinmuteine |
| US5985658A (en) * | 1997-11-14 | 1999-11-16 | Health Research Incorporated | Calmodulin-based cell separation technique |
| EP1227321A1 (en) * | 2000-12-28 | 2002-07-31 | Institut für Bioanalytik GmbH | Reversible MHC multimer staining for functional purification of antigen-specific T cells |
| DE10113776B4 (de) | 2001-03-21 | 2012-08-09 | "Iba Gmbh" | Isoliertes streptavidinbindendes, kompetitiv eluierbares Peptid, dieses umfassendes Fusionspeptid, dafür codierende Nukleinsäure, Expressionsvektor, Verfahren zur Herstellung eines rekombinanten Fusionsproteins und Verfahren zum Nachweis und/oder zur Gewinnung des Fusionsproteins |
| RS51829B (sr) * | 2001-08-23 | 2012-02-29 | Genmab A/S. | Ljudska antitela specifična za interleukin 15 (il-15) |
| FR2841905B1 (fr) | 2002-07-05 | 2004-09-03 | Centre Nat Rech Scient | Fragments fab mutants de l'anticorps anti-cd4 chimere 13b8.2 et leurs applications |
| JP4517081B2 (ja) * | 2005-12-22 | 2010-08-04 | 独立行政法人産業技術総合研究所 | 免疫センサ用デバイス |
| WO2008054030A1 (fr) * | 2006-11-02 | 2008-05-08 | Kagoshima University | Peptide liant l'igg |
| CN101587043B (zh) * | 2008-05-20 | 2013-10-02 | 北京莱尔生物医药科技有限公司 | 从生物体液样本中富集与检测稀有细胞的整合方法 |
| WO2010017103A2 (en) | 2008-08-04 | 2010-02-11 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Servic | Fully human anti-human nkg2d monoclonal antibodies |
| US9023604B2 (en) * | 2011-07-18 | 2015-05-05 | Iba Gmbh | Method of reversibly staining a target cell |
-
2012
- 2012-07-17 US US14/234,463 patent/US9023604B2/en active Active
- 2012-07-17 SI SI201231352T patent/SI2734538T2/sl unknown
- 2012-07-17 JP JP2014520636A patent/JP6310388B2/ja active Active
- 2012-07-17 PT PT127479855T patent/PT2734538T/pt unknown
- 2012-07-17 EP EP18168713.8A patent/EP3418295B1/en active Active
- 2012-07-17 WO PCT/EP2012/063969 patent/WO2013011011A2/en not_active Ceased
- 2012-07-17 PL PL12747985.5T patent/PL2734538T5/pl unknown
- 2012-07-17 TR TR2018/11128T patent/TR201811128T4/tr unknown
- 2012-07-17 EP EP12747985.5A patent/EP2734538B2/en active Active
- 2012-07-17 ES ES12747985T patent/ES2682750T5/es active Active
- 2012-07-17 CN CN201280045377.8A patent/CN103797028B/zh active Active
- 2012-07-17 CN CN201710565030.0A patent/CN107843730B/zh active Active
-
2015
- 2015-04-24 US US14/696,284 patent/US9188589B2/en active Active
-
2018
- 2018-03-16 JP JP2018048668A patent/JP6770989B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN103797028A (zh) | 2014-05-14 |
| JP2018119982A (ja) | 2018-08-02 |
| EP3418295A1 (en) | 2018-12-26 |
| EP2734538B2 (en) | 2024-07-03 |
| WO2013011011A3 (en) | 2013-05-02 |
| HK1258907A1 (en) | 2019-11-22 |
| EP3418295B1 (en) | 2020-09-02 |
| JP2014529361A (ja) | 2014-11-06 |
| US20150301046A1 (en) | 2015-10-22 |
| WO2013011011A2 (en) | 2013-01-24 |
| PL2734538T3 (pl) | 2018-10-31 |
| JP6310388B2 (ja) | 2018-04-11 |
| EP2734538B1 (en) | 2018-05-02 |
| PT2734538T (pt) | 2018-08-02 |
| SI2734538T1 (sl) | 2018-09-28 |
| US20140295458A1 (en) | 2014-10-02 |
| SI2734538T2 (sl) | 2024-10-30 |
| CN107843730A (zh) | 2018-03-27 |
| JP6770989B2 (ja) | 2020-10-21 |
| US9023604B2 (en) | 2015-05-05 |
| CN107843730B (zh) | 2021-08-20 |
| TR201811128T4 (tr) | 2018-08-27 |
| CN103797028B (zh) | 2017-08-25 |
| ES2682750T3 (es) | 2018-09-21 |
| EP2734538A2 (en) | 2014-05-28 |
| US9188589B2 (en) | 2015-11-17 |
| ES2682750T5 (en) | 2025-02-04 |
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