PL2734538T5 - Sposób odwracalnego barwienia komórki docelowej - Google Patents
Sposób odwracalnego barwienia komórki docelowejInfo
- Publication number
- PL2734538T5 PL2734538T5 PL12747985.5T PL12747985T PL2734538T5 PL 2734538 T5 PL2734538 T5 PL 2734538T5 PL 12747985 T PL12747985 T PL 12747985T PL 2734538 T5 PL2734538 T5 PL 2734538T5
- Authority
- PL
- Poland
- Prior art keywords
- target cell
- reversible staining
- staining
- reversible
- target
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/557—Immunoassay; Biospecific binding assay; Materials therefor using kinetic measurement, i.e. time rate of progress of an antigen-antibody interaction
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
- G01N33/56972—White blood cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/22—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a Strep-tag
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2458/00—Labels used in chemical analysis of biological material
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Developmental Biology & Embryology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Diabetes (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Transplantation (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161508943P | 2011-07-18 | 2011-07-18 | |
| PCT/EP2012/063969 WO2013011011A2 (en) | 2011-07-18 | 2012-07-17 | Method of reversibly staining a target cell |
| EP12747985.5A EP2734538B2 (en) | 2011-07-18 | 2012-07-17 | Method of reversibly staining a target cell |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL2734538T3 PL2734538T3 (pl) | 2018-10-31 |
| PL2734538T5 true PL2734538T5 (pl) | 2025-11-12 |
Family
ID=46682800
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL12747985.5T PL2734538T5 (pl) | 2011-07-18 | 2012-07-17 | Sposób odwracalnego barwienia komórki docelowej |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US9023604B2 (pl) |
| EP (2) | EP2734538B2 (pl) |
| JP (2) | JP6310388B2 (pl) |
| CN (2) | CN103797028B (pl) |
| ES (1) | ES2682750T5 (pl) |
| PL (1) | PL2734538T5 (pl) |
| PT (1) | PT2734538T (pl) |
| SI (1) | SI2734538T2 (pl) |
| TR (1) | TR201811128T4 (pl) |
| WO (1) | WO2013011011A2 (pl) |
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2682750T5 (en) * | 2011-07-18 | 2025-02-04 | Iba Lifesciences Gmbh | Method of reversibly staining a target cell |
| SG11201404991YA (en) | 2012-02-23 | 2014-09-26 | Stage Cell Therapeutics Gmbh | Chromatographic isolation of cells and other complex biological materials |
| PT3524618T (pt) | 2013-03-15 | 2023-06-06 | Gladiator Biosciences Inc | Domínios gla como agentes de marcação |
| RS62471B1 (sr) * | 2014-04-16 | 2021-11-30 | Juno Therapeutics Gmbh | Metode, kompleti i uređaji za proširenje populacije ćelija |
| IL292038B2 (en) | 2014-04-23 | 2024-12-01 | Juno Therapeutics Inc | Methods for enriching or producing immune cell populations for adoptive therapy |
| JP6661544B2 (ja) * | 2014-04-24 | 2020-03-11 | ミルテニイ バイオテック ゲゼルシャフト ミット ベシュレンクテル ハフツング | 遺伝子改変したt細胞の自動生成法 |
| CN106662584B (zh) * | 2014-04-30 | 2020-05-05 | Iba股份有限公司 | 分离靶细胞的方法 |
| EP3037820A1 (en) * | 2014-12-27 | 2016-06-29 | Miltenyi Biotec GmbH | Cell detection methods and reagents having a releasable labelling moiety |
| IL282614B2 (en) * | 2015-02-06 | 2024-02-01 | Cell Idx Inc | Antigen-conjugated immune reagents |
| WO2016166568A1 (en) | 2015-04-16 | 2016-10-20 | Juno Therapeutics Gmbh | Methods, kits and apparatus for expanding a population of cells |
| RU2761555C2 (ru) * | 2015-10-22 | 2021-12-09 | Джуно Терапьютикс Гмбх | Способы, наборы, средства и устройства для трансдукции |
| MA45489A (fr) | 2015-10-22 | 2018-08-29 | Juno Therapeutics Gmbh | Procédés de culture de cellules, kits et appareil associés |
| KR102908806B1 (ko) * | 2015-10-22 | 2026-01-07 | 주노 테라퓨틱스 게엠베하 | 세포의 배양 방법 및 이를 위한 키트와 장치 |
| WO2018001985A1 (en) | 2016-06-28 | 2018-01-04 | Technische Universitaet Muenchen | Combination of reversible and irreversible cell labeling for analizing receptor-ligand koff rate |
| US10294454B2 (en) | 2016-08-24 | 2019-05-21 | General Electric Company | Methods and kits for cell activation |
| EP3336545A1 (en) | 2016-12-13 | 2018-06-20 | Miltenyi Biotec GmbH | Reversible labeling of antigens in biological specimens |
| EP3336546B1 (en) | 2016-12-13 | 2020-07-01 | Miltenyi Biotec B.V. & Co. KG | Reversible cell labelling with conjugates having two releasable binding sites |
| JP7061125B2 (ja) | 2016-12-16 | 2022-04-27 | ダイアグノロジックス・エルエルシー | 浮力による分離方法およびシステム |
| EP3571221A2 (en) | 2017-01-20 | 2019-11-27 | Juno Therapeutics GmbH | Cell surface conjugates and related cell compositions and methods |
| AU2018260380B2 (en) | 2017-04-27 | 2025-02-13 | Juno Therapeutics Gmbh | Oligomeric particle reagents and methods of use thereof |
| EP4549554A3 (en) | 2017-07-29 | 2025-08-06 | Juno Therapeutics, Inc. | Reagents for expanding cells expressing recombinant receptors |
| KR102755437B1 (ko) | 2017-08-09 | 2025-01-20 | 주노 쎄러퓨티크스 인코퍼레이티드 | 유전자 조작된 세포 조성물 및 관련 조성물의 제조 방법 |
| JP2020533976A (ja) | 2017-09-05 | 2020-11-26 | グラディエーター バイオサイエンシーズ インコーポレイテッド | エキソソームを標的化する方法 |
| JP7357626B2 (ja) | 2017-11-01 | 2023-10-06 | ジュノー セラピューティクス インコーポレイテッド | 操作された細胞の治療用組成物を生成するためのプロセス |
| CN119193493A (zh) | 2017-12-08 | 2024-12-27 | 朱诺治疗学股份有限公司 | 生产工程化t细胞组合物的过程 |
| CN116148467B (zh) * | 2017-12-12 | 2026-05-26 | 清华大学 | 检测翻译后修饰蛋白质与其配体间相互作用的成套试剂 |
| BR112021002390A2 (pt) | 2018-08-09 | 2021-05-11 | Juno Therapeutics Inc | processos para gerar células modificadas e suas composições |
| US20210246189A1 (en) | 2018-09-03 | 2021-08-12 | Technische Universitaet Muenchen | A double peptide tag combining reversibility and flexible functionalization |
| JP7504891B2 (ja) | 2018-09-11 | 2024-06-24 | ジュノー セラピューティクス インコーポレイテッド | 操作された細胞組成物のマススペクトロメトリー分析のための方法 |
| WO2020089343A1 (en) | 2018-10-31 | 2020-05-07 | Juno Therapeutics Gmbh | Methods for selection and stimulation of cells and apparatus for same |
| US20210393691A1 (en) | 2018-11-06 | 2021-12-23 | Juno Therapeutics, Inc. | Process for producing genetically engineered t cells |
| WO2020216439A1 (en) | 2019-04-23 | 2020-10-29 | Miltenyi Biotec B.V. & Co. KG | Reversible cell detection with conjugates having a linker for increased fluorescent brightness and an enzymatically releasable fluorescent moiety |
| CN113966394A (zh) | 2019-05-28 | 2022-01-21 | 美天施生物科技有限两合公司 | 产生遗传修饰的t细胞的方法 |
| US20220228101A1 (en) | 2019-06-07 | 2022-07-21 | Juno Therapeutics, Inc. | Automated t cell culture |
| CN114600172A (zh) | 2019-08-30 | 2022-06-07 | 朱诺治疗学股份有限公司 | 用于将细胞分类的机器学习方法 |
| WO2021047804A1 (en) | 2019-09-11 | 2021-03-18 | Miltenyi Biotec B.V. & Co. KG | In vitro method for transduction of t cells in the presence of malignant cells |
| MX2022005145A (es) | 2019-10-30 | 2022-06-29 | Juno Therapeutics Gmbh | Dispositivos de estimulación y/o selección celular y método de uso. |
| US20230090117A1 (en) | 2020-01-28 | 2023-03-23 | Juno Therapeutics, Inc. | Methods for t cell transduction |
| JP2023519099A (ja) | 2020-02-12 | 2023-05-10 | ジュノー セラピューティクス インコーポレイテッド | Bcma指向性キメラ抗原受容体t細胞組成物ならびにその方法および使用 |
| CA3169672A1 (en) | 2020-02-12 | 2021-08-19 | Juno Therapeutics, Inc. | Cd19-directed chimeric antigen receptor t cell compositions and methods and uses thereof |
| KR20230022868A (ko) | 2020-05-13 | 2023-02-16 | 주노 쎄러퓨티크스 인코퍼레이티드 | 재조합 수용체를 발현하는 공여자-배치 세포의 제조 방법 |
| CN115867807B (zh) | 2020-06-24 | 2025-10-31 | 旭化成生命科学股份有限公司 | 含蛋白质的溶液的评价方法 |
| WO2022043023A1 (en) | 2020-08-27 | 2022-03-03 | Miltenyi Biotec B.V. & Co. KG | Releasable reagents for cell separation |
| CN112285083B (zh) * | 2020-10-28 | 2022-01-07 | 上海睿钰生物科技有限公司 | 一种细胞杀伤效力的评价方法 |
| CN117916256A (zh) | 2021-05-06 | 2024-04-19 | 朱诺治疗学有限公司 | 用于刺激和转导t细胞的方法 |
| WO2023147510A1 (en) | 2022-01-28 | 2023-08-03 | Juno Therapeutics, Inc. | Chromatography arrays and related methods and kits |
| EP4227423A1 (en) | 2022-02-09 | 2023-08-16 | Technische Universität München | Means and methods for identifying high affinity t-cells |
| CN119095950A (zh) | 2022-04-28 | 2024-12-06 | 生物细胞再生有限公司 | 用于分离靶细胞的方法 |
| US20250297282A1 (en) | 2022-05-05 | 2025-09-25 | Juno Therapeutics Gmbh | Viral-binding protein and related reagents, articles, and methods of use |
| WO2023230581A1 (en) | 2022-05-25 | 2023-11-30 | Celgene Corporation | Methods of manufacturing t cell therapies |
| WO2024100604A1 (en) | 2022-11-09 | 2024-05-16 | Juno Therapeutics Gmbh | Methods for manufacturing engineered immune cells |
| CN121100267A (zh) | 2022-12-09 | 2025-12-09 | 朱诺治疗学股份有限公司 | 使用全息成像预测细胞表型的机器学习方法 |
| US20260232729A1 (en) | 2023-02-03 | 2026-08-13 | C3S2 Gmbh | Methods for non-viral manufacturing of engineered immune cells |
| WO2024182516A1 (en) | 2023-02-28 | 2024-09-06 | Juno Therapeutics, Inc. | Cell therapy for treating systemic autoimmune diseases |
| KR20260081300A (ko) | 2023-08-25 | 2026-06-02 | 주노 쎄러퓨티크스 인코퍼레이티드 | Dna-의존성 단백질 키나제의 가교된 사이클-기반 억제제 및 조성물 및 유전자 편집에서의 용도 |
| WO2025049254A1 (en) | 2023-08-25 | 2025-03-06 | Juno Therapeutics, Inc. | Pyrazolopyridine based inhibitors of dna-dependent protein kinase and compositions and application in gene editing |
| KR20260081299A (ko) | 2023-08-25 | 2026-06-02 | 주노 쎄러퓨티크스 인코퍼레이티드 | Dna-의존성 단백질 키나제의 5,6-코어 실라사이클 기반 억제제 및 조성물 및 유전자 편집에서의 용도 |
| WO2025049250A1 (en) | 2023-08-25 | 2025-03-06 | Juno Therapeutics, Inc. | 6,6-core silacycle based inhibitors of dna-dependent protein kinase and compositions and application in gene editing |
| KR20260096851A (ko) | 2023-10-18 | 2026-06-24 | 티큐 테라퓨틱스 게엠베하 | 세포 치료제 제조 방법 및 관련 키트와 장치 |
| US20250241912A1 (en) | 2024-01-25 | 2025-07-31 | Juno Therapeutics, Inc. | Use of bridged cycle-based inhibitors of dna-dependent protein kinase in combination of dna polymerase theta inhibitor and compositions and application in gene editing |
| WO2025179188A1 (en) | 2024-02-22 | 2025-08-28 | Juno Therapeutics, Inc. | Pyrazole-based inhibitors of dna-dependent protein kinase and compositions and applications in gene editing |
| EP4725578A1 (en) | 2024-10-08 | 2026-04-15 | TQ Therapeutics GmbH | Column designs for affinity chromatography |
| WO2026151682A1 (en) | 2025-01-07 | 2026-07-16 | Juno Therapeutics, Inc. | Dna polymerase theta inhibitors, compositions thereof, compositions further comprising a dna dependent protein kinase, and uses of both in gene editing |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4851341A (en) | 1986-12-19 | 1989-07-25 | Immunex Corporation | Immunoaffinity purification system |
| DE4237113B4 (de) | 1992-11-03 | 2006-10-12 | "Iba Gmbh" | Peptide und deren Fusionsproteine, Expressionsvektor und Verfahren zur Herstellung eines Fusionsproteins |
| DE19641876B4 (de) | 1996-10-10 | 2011-09-29 | Iba Gmbh | Streptavidinmuteine |
| US5985658A (en) | 1997-11-14 | 1999-11-16 | Health Research Incorporated | Calmodulin-based cell separation technique |
| EP1227321A1 (en) | 2000-12-28 | 2002-07-31 | Institut für Bioanalytik GmbH | Reversible MHC multimer staining for functional purification of antigen-specific T cells |
| DE10113776B4 (de) | 2001-03-21 | 2012-08-09 | "Iba Gmbh" | Isoliertes streptavidinbindendes, kompetitiv eluierbares Peptid, dieses umfassendes Fusionspeptid, dafür codierende Nukleinsäure, Expressionsvektor, Verfahren zur Herstellung eines rekombinanten Fusionsproteins und Verfahren zum Nachweis und/oder zur Gewinnung des Fusionsproteins |
| KR100911951B1 (ko) * | 2001-08-23 | 2009-08-13 | 젠맵 에이/에스 | 인터루킨 15 (il-15)에 대하여 특이적인 인간 항체 |
| FR2841905B1 (fr) | 2002-07-05 | 2004-09-03 | Centre Nat Rech Scient | Fragments fab mutants de l'anticorps anti-cd4 chimere 13b8.2 et leurs applications |
| JP4517081B2 (ja) * | 2005-12-22 | 2010-08-04 | 独立行政法人産業技術総合研究所 | 免疫センサ用デバイス |
| US8372950B2 (en) * | 2006-11-02 | 2013-02-12 | Kagoshima University | IgG binding peptide |
| CN101587043B (zh) * | 2008-05-20 | 2013-10-02 | 北京莱尔生物医药科技有限公司 | 从生物体液样本中富集与检测稀有细胞的整合方法 |
| US9273136B2 (en) | 2008-08-04 | 2016-03-01 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Fully human anti-human NKG2D monoclonal antibodies |
| ES2682750T5 (en) * | 2011-07-18 | 2025-02-04 | Iba Lifesciences Gmbh | Method of reversibly staining a target cell |
-
2012
- 2012-07-17 ES ES12747985T patent/ES2682750T5/es active Active
- 2012-07-17 JP JP2014520636A patent/JP6310388B2/ja active Active
- 2012-07-17 CN CN201280045377.8A patent/CN103797028B/zh active Active
- 2012-07-17 EP EP12747985.5A patent/EP2734538B2/en active Active
- 2012-07-17 PL PL12747985.5T patent/PL2734538T5/pl unknown
- 2012-07-17 EP EP18168713.8A patent/EP3418295B1/en active Active
- 2012-07-17 CN CN201710565030.0A patent/CN107843730B/zh active Active
- 2012-07-17 WO PCT/EP2012/063969 patent/WO2013011011A2/en not_active Ceased
- 2012-07-17 US US14/234,463 patent/US9023604B2/en active Active
- 2012-07-17 PT PT127479855T patent/PT2734538T/pt unknown
- 2012-07-17 TR TR2018/11128T patent/TR201811128T4/tr unknown
- 2012-07-17 SI SI201231352T patent/SI2734538T2/sl unknown
-
2015
- 2015-04-24 US US14/696,284 patent/US9188589B2/en active Active
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2018
- 2018-03-16 JP JP2018048668A patent/JP6770989B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP2018119982A (ja) | 2018-08-02 |
| US20140295458A1 (en) | 2014-10-02 |
| US20150301046A1 (en) | 2015-10-22 |
| JP6310388B2 (ja) | 2018-04-11 |
| WO2013011011A3 (en) | 2013-05-02 |
| EP2734538B2 (en) | 2024-07-03 |
| PT2734538T (pt) | 2018-08-02 |
| WO2013011011A2 (en) | 2013-01-24 |
| PL2734538T3 (pl) | 2018-10-31 |
| EP3418295B1 (en) | 2020-09-02 |
| JP2014529361A (ja) | 2014-11-06 |
| CN103797028A (zh) | 2014-05-14 |
| US9023604B2 (en) | 2015-05-05 |
| ES2682750T5 (en) | 2025-02-04 |
| CN107843730A (zh) | 2018-03-27 |
| JP6770989B2 (ja) | 2020-10-21 |
| SI2734538T1 (sl) | 2018-09-28 |
| CN103797028B (zh) | 2017-08-25 |
| ES2682750T3 (es) | 2018-09-21 |
| EP2734538A2 (en) | 2014-05-28 |
| SI2734538T2 (sl) | 2024-10-30 |
| TR201811128T4 (tr) | 2018-08-27 |
| EP2734538B1 (en) | 2018-05-02 |
| HK1258907A1 (en) | 2019-11-22 |
| US9188589B2 (en) | 2015-11-17 |
| EP3418295A1 (en) | 2018-12-26 |
| CN107843730B (zh) | 2021-08-20 |
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