PL2841428T3 - Inhibitory DNA-PK - Google Patents

Inhibitory DNA-PK

Info

Publication number
PL2841428T3
PL2841428T3 PL13719359T PL13719359T PL2841428T3 PL 2841428 T3 PL2841428 T3 PL 2841428T3 PL 13719359 T PL13719359 T PL 13719359T PL 13719359 T PL13719359 T PL 13719359T PL 2841428 T3 PL2841428 T3 PL 2841428T3
Authority
PL
Poland
Prior art keywords
inhibitors
dna
Prior art date
Application number
PL13719359T
Other languages
English (en)
Polish (pl)
Inventor
Paul S. Charifson
Kevin Michael Cottrell
Hongbo Deng
John P. Duffy
Huai Gao
Simon Giroux
Jeremy Green
Katrina Lee Jackson
John Patrick Maxwell
Mark A. Morris
Albert Charles Pierce
Nathan D. Waal
Joseph M. Kennedy
David J. Lauffer
Mark Willem Ledeboer
Pan Li
Jinwang Xu
Original Assignee
Vertex Pharmaceuticals Incorporated
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharmaceuticals Incorporated filed Critical Vertex Pharmaceuticals Incorporated
Publication of PL2841428T3 publication Critical patent/PL2841428T3/pl

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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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