PL2915813T3 - Antybiotyki oksazolidynonowe - Google Patents

Antybiotyki oksazolidynonowe

Info

Publication number
PL2915813T3
PL2915813T3 PL15154086T PL15154086T PL2915813T3 PL 2915813 T3 PL2915813 T3 PL 2915813T3 PL 15154086 T PL15154086 T PL 15154086T PL 15154086 T PL15154086 T PL 15154086T PL 2915813 T3 PL2915813 T3 PL 2915813T3
Authority
PL
Poland
Prior art keywords
oxazolidinone antibiotics
oxazolidinone
antibiotics
Prior art date
Application number
PL15154086T
Other languages
English (en)
Inventor
Daniel Bur
Christian Hubschwerlen
Georg Rueedi
Jean-Philippe Surivet
Cornelia Zumbrunn
Original Assignee
Actelion Pharmaceuticals Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd. filed Critical Actelion Pharmaceuticals Ltd.
Publication of PL2915813T3 publication Critical patent/PL2915813T3/pl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
PL15154086T 2007-04-11 2008-04-11 Antybiotyki oksazolidynonowe PL2915813T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IB2007051290 2007-04-11
IB2007054587 2007-11-12
IB2007054768 2007-11-23
EP15154086.1A EP2915813B1 (en) 2007-04-11 2008-04-11 Oxazolidinone antibiotics

Publications (1)

Publication Number Publication Date
PL2915813T3 true PL2915813T3 (pl) 2017-07-31

Family

ID=39682545

Family Applications (3)

Application Number Title Priority Date Filing Date
PL15154086T PL2915813T3 (pl) 2007-04-11 2008-04-11 Antybiotyki oksazolidynonowe
PL15154003T PL2905283T3 (pl) 2007-04-11 2008-04-11 Pochodne oksazolidynonu
PL08737800T PL2144910T3 (pl) 2007-04-11 2008-04-11 Antybiotyki oksazolidynonowe

Family Applications After (2)

Application Number Title Priority Date Filing Date
PL15154003T PL2905283T3 (pl) 2007-04-11 2008-04-11 Pochodne oksazolidynonu
PL08737800T PL2144910T3 (pl) 2007-04-11 2008-04-11 Antybiotyki oksazolidynonowe

Country Status (16)

Country Link
US (1) US8217029B2 (pl)
EP (3) EP2915813B1 (pl)
JP (1) JP5427770B2 (pl)
KR (1) KR101495269B1 (pl)
CN (3) CN101679415B (pl)
AR (1) AR066013A1 (pl)
AU (1) AU2008238904B2 (pl)
BR (1) BRPI0809977A8 (pl)
CA (3) CA2679071C (pl)
CL (1) CL2008001002A1 (pl)
ES (3) ES2618492T3 (pl)
MX (3) MX351590B (pl)
PL (3) PL2915813T3 (pl)
RU (1) RU2470022C2 (pl)
TW (1) TWI411434B (pl)
WO (1) WO2008126034A2 (pl)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2245028T3 (pl) * 2007-12-18 2012-07-31 Actelion Pharmaceuticals Ltd Pochodne 5-aminocyklilometyloksazolidyn-2-onu
ES2411930T3 (es) 2008-02-20 2013-07-09 Actelion Pharmaceuticals Ltd. Compuestos antibióticos azatricíclicos
KR101592046B1 (ko) 2008-02-22 2016-02-05 액테리온 파마슈티칼 리미티드 옥사졸리디논 유도체
CN102105467A (zh) 2008-08-04 2011-06-22 埃科特莱茵药品有限公司 三环烷氨基甲基噁唑烷酮衍生物
DK2344495T3 (en) 2008-10-07 2015-02-02 Actelion Pharmaceuticals Ltd TRICYCLIC OXAZOLIDINON ANTIBIOTIC COMPOUNDS
ES2395491T3 (es) * 2008-10-10 2013-02-13 Actelion Pharmaceuticals Ltd. 2-Benzotiofenil y 2-naftil-oxazolidinonas y sus análogos azaisósteros como agentes antibacterianos
FR2945533B1 (fr) * 2009-05-12 2011-05-27 Sanofi Aventis Derives de cyclopenta°c!pyrrolyl-alkylcarbamates d'heterocycles a 5 chainons, leur preparation et leur application en therapeutique
EP2388260A1 (de) * 2010-05-21 2011-11-23 Archimica GmbH Herstellungsverfahren für einen Inhibitor eines Blutgerinnungsfaktors
EP2674430A4 (en) 2011-02-07 2014-07-02 Daiichi Sankyo Co Ltd AMINO-GROUP-PYRROLIDINONE DERIVATIVES
RU2014108919A (ru) 2011-08-11 2015-09-20 Актелион Фармасьютиклз Лтд Хиназолин-2,4-дионовые производные
SG11201401710PA (en) * 2011-11-08 2014-09-26 Actelion Pharmaceuticals Ltd 2-oxo-oxazolidin-3,5-diyl antibiotic derivatives
DE102012006884A1 (de) 2012-04-04 2013-10-10 Merck Patent Gmbh Cyclische Amide als MetAP-2 Inhibitoren
CN104364239B (zh) 2012-06-13 2017-08-25 霍夫曼-拉罗奇有限公司 二氮杂螺环烷烃和氮杂螺环烷烃
EA201590053A1 (ru) 2012-06-20 2015-08-31 Новартис Аг Модуляторы пути системы комплемента и их применение
WO2014024056A1 (en) 2012-08-06 2014-02-13 Daiichi Sankyo Company, Limited Pyrrolidine derivatives with antibacterial properties
MX368615B (es) 2012-09-25 2019-10-09 Hoffmann La Roche Derivados bicíclicos como inhibidores de la autotaxina (atx) que son inhibidores de la producción de ácido lisofosfatídico (lpa) y el uso de los mismos.
CN103012389A (zh) * 2013-01-24 2013-04-03 中国药科大学 一种利伐沙班中间体的制备方法
AR095079A1 (es) 2013-03-12 2015-09-16 Hoffmann La Roche Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo
DK3074400T3 (en) 2013-11-26 2018-01-15 Hoffmann La Roche Octahydro-cyclobuta [1,2-c; 3,4-c '] dipyrrole derivatives as autotaxin inhibitors
EA032357B1 (ru) 2014-03-26 2019-05-31 Ф. Хоффманн-Ля Рош Аг Конденсированные [1,4]диазепиновые соединения в качестве ингибиторов продукции аутотаксина (atx) и лизофосфатидиловой кислоты (lpa)
CA2937616A1 (en) 2014-03-26 2015-10-01 F. Hoffmann-La Roche Ag Bicyclic compounds as autotaxin (atx) and lysophosphatidic acid (lpa) production inhibitors
AR102256A1 (es) 2014-10-15 2017-02-15 Actelion Pharmaceuticals Ltd Derivados biaromáticos básicos antibacterianos con sustitución de aminoalcoxi
MA41168A (fr) 2014-12-17 2017-10-24 Acraf Nouveaux composés antibactériens
MA41898A (fr) 2015-04-10 2018-02-13 Hoffmann La Roche Dérivés de quinazolinone bicyclique
CA2992889A1 (en) 2015-09-04 2017-03-09 F. Hoffmann-La Roche Ag Phenoxymethyl derivatives
AU2016328436B2 (en) 2015-09-24 2020-05-14 F. Hoffmann-La Roche Ag New bicyclic compounds as dual ATX/CA inhibitors
JP6876685B2 (ja) 2015-09-24 2021-05-26 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft Atx阻害剤としての二環式化合物
BR112017026682A2 (pt) 2015-09-24 2018-08-14 Hoffmann La Roche novos compostos bicíclicos como inibidores de dupla ação de atx/ca
WO2017050732A1 (en) 2015-09-24 2017-03-30 F. Hoffmann-La Roche Ag Bicyclic compounds as atx inhibitors
BR112018011541B1 (pt) 2015-12-10 2022-02-15 Bracco Imaging Spa Compostos de agentes de contraste, complexo quelado e composição farmacêutica compreendendo o referido complexo quelado
HRP20210061T1 (hr) 2015-12-10 2021-03-05 Bracco Imaging S.P.A Dimerna kontrastna sredstva
PT3889145T (pt) 2015-12-17 2024-04-02 Merck Patent Gmbh 8-ciano-5-piperidino-quinolinas como antagonistas de tlr7/8 e suas utilizações para tratamento de distúrbios imunitários
GB201602235D0 (en) * 2016-02-08 2016-03-23 Redx Pharma Plc Antibacterial compounds
SG11201806166WA (en) * 2016-02-08 2018-08-30 Redx Pharma Plc Heterocyclic compounds, in particular 2-oxo-4,4,5,5,6,6,7,7-octahydrobenzoxazole derivatives, and their use as antibacterial compounds
WO2017137743A1 (en) * 2016-02-08 2017-08-17 Redx Pharma Plc Antibacterial compounds
US11007283B2 (en) 2016-04-13 2021-05-18 Bracco Imaging S.P.A. Contrast agents
EP4198031A1 (en) 2016-08-08 2023-06-21 Merck Patent GmbH Tlr7/8 antagonists and uses thereof
EP3551614B1 (en) 2016-12-12 2021-08-25 Bracco Imaging SpA Dimeric contrast agents
TW201833120A (zh) 2017-02-17 2018-09-16 瑞士商愛杜西亞製藥有限公司 芳基噁唑啶酮抗生素化合物
JP7090099B2 (ja) 2017-03-16 2022-06-23 エフ.ホフマン-ラ ロシュ アーゲー Atxインヒビターとしての新規二環式化合物
RU2019132254A (ru) 2017-03-16 2021-04-16 Ф. Хоффманн-Ля Рош Аг Гетероциклические соединения, пригодные в качестве дуальных ингибиторов atx/ca
ES2965044T3 (es) * 2017-07-18 2024-04-10 Merck Patent Gmbh Antagonistas de TLR7/8 y sus usos
CN111527093B (zh) * 2017-11-29 2023-06-09 巴格沃克斯研究有限公司 抗菌杂环化合物及其合成
CN109265389B (zh) * 2018-08-31 2020-08-18 南京富润凯德生物医药有限公司 2-(氨基甲基)-1-氧杂-7-氮杂螺[3.5]壬烷衍生物、中间体及其制备方法

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3723797A1 (de) * 1987-07-18 1989-01-26 Merck Patent Gmbh Oxazolidinone
KR950014567B1 (ko) 1991-08-01 1995-12-08 주식회사대웅제약 신규한 퀴놀론 카르복실산 유도체
DE19707628A1 (de) * 1997-02-26 1998-08-27 Merck Patent Gmbh Oxazolidinone
ES2219302T3 (es) 1999-01-07 2004-12-01 Wyeth Derivados de arilpiperazinil-ciclohexilindol para el tratamiento de la depresion.
EP1305308B1 (en) 2000-07-26 2006-12-20 Smithkline Beecham Plc Aminopiperidine quinolines and their azaisosteric analogues with antibacterial activity
GB0031086D0 (en) * 2000-12-20 2001-01-31 Smithkline Beecham Plc Medicaments
GB0112834D0 (en) 2001-05-25 2001-07-18 Smithkline Beecham Plc Medicaments
GB0112836D0 (en) * 2001-05-25 2001-07-18 Smithkline Beecham Plc Medicaments
AR040336A1 (es) 2002-06-26 2005-03-30 Glaxo Group Ltd Compuesto de piperidina, uso del mismo para la fabricacion de un medicamento, composicion farmaceutica que lo comprende y procedimiento para preparar dicho compuesto
DE10247233A1 (de) * 2002-10-10 2004-06-17 Morphochem AG Aktiengesellschaft für kombinatorische Chemie Neue Verbindungen, die Topoisomerase IV inhibieren
WO2004050036A2 (en) * 2002-12-04 2004-06-17 Glaxo Group Limited Quinolines and nitrogenated derivatives thereof and their use as antibacterial agents
DE10316081A1 (de) * 2003-04-08 2004-10-21 Morphochem AG Aktiengesellschaft für kombinatorische Chemie Neue Verbindungen mit antibakterieller Aktivität
US7160888B2 (en) 2003-08-22 2007-01-09 Warner Lambert Company Llc [1,8]naphthyridin-2-ones and related compounds for the treatment of schizophrenia
FR2872164B1 (fr) * 2004-06-29 2006-11-17 Aventis Pharma Sa Derives de quinoleines-4-substituees, leur procede et intermediaires de preparation et les compositions pharmaceutiques qui les contiennent
BRPI0514381A (pt) * 2004-07-30 2008-06-10 Palumed Sa compostos hìbridos de aminoquinolina-antibiótico, composições farmacêuticas, método de preparação e uso destes
JP4887297B2 (ja) 2004-09-24 2012-02-29 アクテリオン ファーマシューティカルズ リミテッド 新規二環式抗生物質
US7511035B2 (en) * 2005-01-25 2009-03-31 Glaxo Group Limited Antibacterial agents
AR054608A1 (es) 2005-08-08 2007-06-27 Actelion Pharmaceuticals Ltd Derivados de oxazolidinona enlazados a quinolonas como antibacterianos
ES2340531T3 (es) 2005-10-21 2010-06-04 Glaxo Group Limited Compuestos triciclos peri-condensados utiles como agentes antibacterianos.
US8067457B2 (en) 2005-11-01 2011-11-29 Millennium Pharmaceuticals, Inc. Compounds useful as antagonists of CCR2
ATE465163T1 (de) 2005-12-22 2010-05-15 Glaxo Group Ltd Heterocyclische verbindungen, ihre herstellung und ihre verwendung als antibakterielle mittel
EP2001478B1 (en) 2006-03-23 2010-06-02 Actelion Pharmaceuticals Ltd. Cyclohexyl or piperidinyl carboxamide antibiotic derivatives
WO2007118130A2 (en) 2006-04-06 2007-10-18 Glaxo Group Limited Antibacterial agents
GB0613208D0 (en) 2006-07-03 2006-08-09 Glaxo Group Ltd Compounds

Also Published As

Publication number Publication date
EP2905283B1 (en) 2016-12-14
ES2622961T3 (es) 2017-07-10
JP5427770B2 (ja) 2014-02-26
WO2008126034A2 (en) 2008-10-23
WO2008126034A3 (en) 2008-12-31
RU2470022C2 (ru) 2012-12-20
CA2876878C (en) 2017-07-11
AU2008238904B2 (en) 2013-11-28
CL2008001002A1 (es) 2008-10-17
MX351590B (es) 2017-10-20
PL2144910T3 (pl) 2016-04-29
US8217029B2 (en) 2012-07-10
BRPI0809977A8 (pt) 2017-12-26
JP2010523646A (ja) 2010-07-15
CN102746296A (zh) 2012-10-24
CN102746297A (zh) 2012-10-24
CN101679415B (zh) 2013-07-31
EP2144910A2 (en) 2010-01-20
CN101679415A (zh) 2010-03-24
EP2144910B1 (en) 2015-10-28
CN102746296B (zh) 2015-10-28
ES2618492T3 (es) 2017-06-21
MX2009010642A (es) 2009-10-22
AR066013A1 (es) 2009-07-15
EP2905283A1 (en) 2015-08-12
EP2915813A1 (en) 2015-09-09
KR101495269B1 (ko) 2015-02-26
PL2905283T3 (pl) 2017-06-30
TW200848031A (en) 2008-12-16
AU2008238904A1 (en) 2008-10-23
CA2876878A1 (en) 2008-10-23
MX351589B (es) 2017-10-20
US20110039823A1 (en) 2011-02-17
TWI411434B (zh) 2013-10-11
RU2009141311A (ru) 2011-05-20
CA2679071A1 (en) 2008-10-23
CN102746297B (zh) 2015-08-26
CA2679071C (en) 2016-06-07
BRPI0809977A2 (pt) 2014-10-07
EP2915813B1 (en) 2017-02-01
ES2557172T3 (es) 2016-01-22
CA2876879C (en) 2017-11-28
KR20090130086A (ko) 2009-12-17
CA2876879A1 (en) 2008-10-23

Similar Documents

Publication Publication Date Title
PL2905283T3 (pl) Pochodne oksazolidynonu
PL2146987T3 (pl) Pochodne oksazolidynonu jako antybiotyki
PL2254887T3 (pl) Pochodne oksazolidynonu
AP2010005314A0 (en) Nanodispersian
EP2352801A4 (en) ELECTROACTIVE MATERIALS
EP2352802A4 (en) ELECTROACTIVE MATERIALS
IL205301A0 (en) Carbacephem ?? - lactam antibiotics
EP2201180A4 (en) CLAMP
GB0814752D0 (en) Axial compliance
GB0917784D0 (en) Drive arrangement
EP2069339A4 (en) SUBSTITUTED PIPERIDINOPHENYLOXAZOLIDINONE
GB0608974D0 (en) Drive arrangement
GB0715132D0 (en) Tissue-adhesive materials
GB0713587D0 (en) Insulaitng materials
GB0617222D0 (en) Antibiotics
EP2134587A4 (en) INTERMEDIATE TRACTION BAR ARRANGEMENT
GB0705849D0 (en) Jellyloss
GB2450151B (en) Kiln
AU3642P (en) TAS100 Dianella tasmanica
AU3606P (en) Jaywick xTriticosecale
AU3613P (en) LS005A01 Leucospermum cuneiforme
AU3595P (en) Goldust Strobilanthes anisophyllus
AU3952P (en) FLOCHRDEF Chrysocephalum apiculatum
AU3646P (en) TAS300 Dianella tasmanica
GB0800695D0 (en) Drive arrangement