PL2943227T3 - Triazynowe radiofarmaceutyki i środki do obrazowania radiologicznego - Google Patents

Triazynowe radiofarmaceutyki i środki do obrazowania radiologicznego

Info

Publication number
PL2943227T3
PL2943227T3 PL14738117T PL14738117T PL2943227T3 PL 2943227 T3 PL2943227 T3 PL 2943227T3 PL 14738117 T PL14738117 T PL 14738117T PL 14738117 T PL14738117 T PL 14738117T PL 2943227 T3 PL2943227 T3 PL 2943227T3
Authority
PL
Poland
Prior art keywords
triazine based
based radiopharmaceuticals
radioimaging agents
radioimaging
agents
Prior art date
Application number
PL14738117T
Other languages
English (en)
Inventor
John W Babich
Craig Zimmerman
John Joyal
Genliang Lu
Original Assignee
Molecular Insight Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Molecular Insight Pharmaceuticals, Inc. filed Critical Molecular Insight Pharmaceuticals, Inc.
Publication of PL2943227T3 publication Critical patent/PL2943227T3/pl

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/0497Organic compounds conjugates with a carrier being an organic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/48Diagnostic techniques
    • A61B6/481Diagnostic techniques involving the use of contrast agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/50Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/08Drugs for disorders of the urinary system of the prostate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/10Drugs for disorders of the urinary system of the bladder
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/003Compounds containing elements of Groups 3 or 13 of the Periodic Table without C-Metal linkages

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medical Informatics (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Biophysics (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Pathology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dentistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Reproductive Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PL14738117T 2013-01-14 2014-01-10 Triazynowe radiofarmaceutyki i środki do obrazowania radiologicznego PL2943227T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201361752350P 2013-01-14 2013-01-14
US201361785788P 2013-03-14 2013-03-14
PCT/US2014/011047 WO2014110372A1 (en) 2013-01-14 2014-01-10 Triazine based radiopharmaceuticals and radioimaging agents
EP14738117.2A EP2943227B8 (en) 2013-01-14 2014-01-10 Triazine based radiopharmaceuticals and radioimaging agents

Publications (1)

Publication Number Publication Date
PL2943227T3 true PL2943227T3 (pl) 2018-02-28

Family

ID=51167394

Family Applications (2)

Application Number Title Priority Date Filing Date
PL17187271T PL3300746T3 (pl) 2013-01-14 2014-01-10 Oparte na triazynie radiofarmaceutyki i środki radioobrazujące
PL14738117T PL2943227T3 (pl) 2013-01-14 2014-01-10 Triazynowe radiofarmaceutyki i środki do obrazowania radiologicznego

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PL17187271T PL3300746T3 (pl) 2013-01-14 2014-01-10 Oparte na triazynie radiofarmaceutyki i środki radioobrazujące

Country Status (14)

Country Link
US (5) US9447121B2 (pl)
EP (4) EP3300746B1 (pl)
JP (2) JP6468602B2 (pl)
KR (1) KR102187940B1 (pl)
CN (1) CN105025933B (pl)
AU (1) AU2014205304B2 (pl)
BR (1) BR112015016585B1 (pl)
CA (1) CA2897437C (pl)
ES (2) ES2648096T3 (pl)
HU (2) HUE044552T2 (pl)
MX (1) MX378439B (pl)
PL (2) PL3300746T3 (pl)
SG (1) SG11201505477TA (pl)
WO (1) WO2014110372A1 (pl)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2897437C (en) * 2013-01-14 2021-12-14 Molecular Insight Pharmaceuticals, Inc. Triazine based radiopharmaceuticals and radioimaging agents
GEP20237497B (en) 2013-10-18 2023-04-10 Deutsches Krebsforsch Labeled inhibitors of prostate specific membrane antigen (psma), their use as imaging agents and pharmaceutical agents for the treatment of prostate cancer
JP6749249B2 (ja) * 2014-05-06 2020-09-02 ザ ジョンズ ホプキンズ ユニヴァーシティー Psmaを標的としたイメージング及び放射線治療のための金属/放射性金属標識psma阻害剤
US9956305B2 (en) 2014-09-08 2018-05-01 Molecular Insight Pharmaceuticals, Inc. Organ protection in PSMA-targeted radionuclide therapy of prostate cancer
EP3101012A1 (en) 2015-06-04 2016-12-07 Bayer Pharma Aktiengesellschaft New gadolinium chelate compounds for use in magnetic resonance imaging
US10688200B2 (en) * 2015-12-31 2020-06-23 Five Eleven Pharma Inc. Urea-based prostate specific membrane antigen (PSMA) inhibitors for imaging and therapy
PT3925952T (pt) 2016-03-22 2023-12-13 Univ Johns Hopkins Agentes alvo de alta afinidade direcionados ao antigénio de membrana específica da próstata para endo radioterapia de cancro da próstata
ES3041039T3 (en) * 2016-10-27 2025-11-06 Progenics Pharm Inc Network for medical image analysis, decision support system, and related graphical user interface (gui) applications
ES2814555T3 (es) 2016-11-28 2021-03-29 Bayer Pharma AG Compuestos de quelato de gadolinio con alta relaxividad para usar en la obtención de imágenes por resonancia magnética
US11478558B2 (en) 2017-05-30 2022-10-25 The Johns Hopkins University Prostate-specific membrane antigen targeted high-affinity agents for endoradiotherapy of prostate cancer
ES2912392T3 (es) 2017-06-19 2022-05-25 Futurechem Co Ltd Compuesto marcado con 18F para el diagnóstico del cáncer de próstata y uso del mismo
WO2018236115A1 (ko) * 2017-06-19 2018-12-27 (주)퓨쳐켐 전립선암 진단을 위한 18f-표지된 화합물 및 그의 용도
EA202092333A1 (ru) 2018-03-30 2021-01-21 Фьючеркем Ко., Лтд. Псма-таргетные радиофармацевтические средства для диагностики и лечения рака простаты
EP3883613A1 (en) 2018-11-23 2021-09-29 Bayer Aktiengesellschaft Formulation of contrast media and process of preparation thereof
JP7729609B2 (ja) * 2019-04-26 2025-08-26 ファイブ イレブン ファーマ インコーポレイテッド 診断および放射性核種治療剤としての前立腺特異的膜抗原(psma)阻害剤
WO2023092184A1 (en) * 2021-11-24 2023-06-01 Clarity Pharmaceuticals Ltd Compounds and compositions thereof for the treatment of cancer
CN116199736B (zh) * 2023-03-01 2025-03-18 西南医科大学附属医院 一种DOTA-Te-PSMA化合物及其应用

Family Cites Families (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2800457A (en) 1953-06-30 1957-07-23 Ncr Co Oil-containing microscopic capsules and method of making them
US2730456A (en) 1953-06-30 1956-01-10 Ncr Co Manifold record material
US2730457A (en) 1953-06-30 1956-01-10 Ncr Co Pressure responsive record materials
US3527789A (en) 1967-10-06 1970-09-08 Shell Oil Co Production of poly(lower)alkyl alkenepolycarboxylates
US3625214A (en) 1970-05-18 1971-12-07 Alza Corp Drug-delivery device
JPS5220203B2 (pl) 1973-03-05 1977-06-02
US4272398A (en) 1978-08-17 1981-06-09 The United States Of America As Represented By The Secretary Of Agriculture Microencapsulation process
US4906474A (en) 1983-03-22 1990-03-06 Massachusetts Institute Of Technology Bioerodible polyanhydrides for controlled drug delivery
JPS6131056A (ja) 1984-07-25 1986-02-13 K Baiorojikaru Sci Lab:Kk ホイッピングクリームの製造方法
US4885363A (en) 1987-04-24 1989-12-05 E. R. Squibb & Sons, Inc. 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
JP2876058B2 (ja) 1986-08-18 1999-03-31 エミスフィア・テクノロジーズ・インコーポレイテッド 薬物送達システム
JP2608550B2 (ja) 1986-10-17 1997-05-07 株式会社 片山化学工業研究所 軟水ボイラの防食処理方法
US4888136A (en) 1988-05-02 1989-12-19 Witco Corporation New flame retardant compositions of matter and cellulosic products containing same
TW353663B (en) 1991-04-06 1999-03-01 Hoechst Ag Process for the preparation of phosphorus-containing L-amino acids, their derivatives and intermediates for this process
JP3051497B2 (ja) 1991-05-17 2000-06-12 株式会社第一ラジオアイソトープ研究所 スルファニルアミド誘導体のテクネチウム錯体をもちいる放射性診断剤
US6359120B1 (en) 1991-10-29 2002-03-19 Bracco International B.V. Rhenium and technetium complexes containing a hypoxia-localizing moiety
IL103353A (en) 1991-10-29 1999-01-26 Bracco Int Bv Ligand metal complexes thereof diagnostic composition and processes for their preparation
IT1270260B (it) 1994-06-21 1997-04-29 Zambon Spa Derivati dell'acido fosfonico ad attivita' inibitrice delle metallopeptidasi
US6011021A (en) 1996-06-17 2000-01-04 Guilford Pharmaceuticals Inc. Methods of cancer treatment using naaladase inhibitors
JP2856098B2 (ja) 1995-04-11 1999-02-10 日本製紙株式会社 感熱記録シート
US5514505A (en) * 1995-05-15 1996-05-07 Xerox Corporation Method for obtaining improved image contrast in migration imaging members
US5795877A (en) 1996-12-31 1998-08-18 Guilford Pharmaceuticals Inc. Inhibitors of NAALADase enzyme activity
US6025344A (en) 1996-06-17 2000-02-15 Guilford Pharmaceuticals Inc. Certain dioic acid derivatives useful as NAALADase inhibitors
US5824662A (en) 1996-09-27 1998-10-20 Guilford Pharmaceuticals Inc. Treatment of global and focal ischemia using naaladase inhibitors
US6046180A (en) 1996-06-17 2000-04-04 Guilford Pharmaceuticals Inc. NAALADase inhibitors
US5672592A (en) 1996-06-17 1997-09-30 Guilford Pharmaceuticals Inc. Certain phosphonomethyl-pentanedioic acid derivatives thereof
US5902817A (en) 1997-04-09 1999-05-11 Guilford Pharmaceuticals Inc. Certain sulfoxide and sulfone derivatives
US6071965A (en) 1996-06-17 2000-06-06 Guilford Pharmaceuticals Inc. Phosphinic alkanoic acid derivatives
CN1230889A (zh) 1996-09-27 1999-10-06 吉尔福特药业有限公司 NAALADase组合物和治疗谷氨酸异常及在动物中产生神经元活性的方法
US5962521A (en) 1997-04-04 1999-10-05 Guilford Pharmaceuticals Inc. Hydroxamic acid derivatives
ZA983930B (en) 1997-05-14 1999-11-08 Lilly Co Eli Excitatory amino acid receptor modulators.
DK1064273T3 (da) 1998-03-19 2003-03-31 Upjohn Co 1,3,4-Thiadiazoler, som er nyttige til behandling af CMV-infektioner
DE60020962T2 (de) 1999-04-28 2006-05-24 Georgetown University Liganden für metabotropische Glutamat-Rezeptoren
US6528499B1 (en) 2000-04-27 2003-03-04 Georgetown University Ligands for metabotropic glutamate receptors and inhibitors of NAALADase
US6228888B1 (en) 1999-07-01 2001-05-08 Guilford Pharmaceuticals Inc. Methods for treating anxiety, anxiety disorders and memory impairment using naaladase inhibitors
US20040157818A1 (en) 2001-05-24 2004-08-12 Mikiro Yanaka Cxcr4-antagonistic drugs composed of nitrogen-containing compound
DE10135355C1 (de) 2001-07-20 2003-04-17 Schering Ag Konjugate makrocyclischer Metallkomplexe mit Biomolekülen und deren Verwendung zur Herstellung von Mitteln für die NMR- und Radiodiagnostik sowie die Radiotherapie
US20030100594A1 (en) 2001-08-10 2003-05-29 Pharmacia Corporation Carbonic anhydrase inhibitor
WO2003053932A1 (en) 2001-12-21 2003-07-03 Tohru Koike Zinc complexes capable of scavenging substances bearing anionic substituents
PT1472541E (pt) 2002-01-10 2009-12-21 Univ Johns Hopkins Agentes de imagiologia e métodos de imagiologia de naaladase de psma
ES2559764T3 (es) 2002-03-11 2016-02-15 Molecular Insight Pharmaceuticals, Inc. Complejos de tecnecio-dipiridina, y métodos de uso de los mismos
US7176227B2 (en) 2002-09-11 2007-02-13 Kureha Corporation Amine compounds and use thereof
SI2594265T1 (sl) 2002-11-26 2016-03-31 Institute Of Virology Slovak Academy Of Sciences CA-IX specifični inhibitorji
US7833734B2 (en) 2002-11-26 2010-11-16 Institute Of Virology Of The Slovak Academy Of Sciences CA IX-specific inhibitors
US7291631B2 (en) 2003-04-11 2007-11-06 Genzyme Corporation CXCR4 chemokine receptor binding compounds
US7682601B2 (en) 2003-04-15 2010-03-23 Mallinckrodt Inc. Bifunctional tridentate pyrazolyl containing ligands for re and tc tricarbonyl complexes
WO2005056520A1 (en) 2003-12-12 2005-06-23 Oy Juvantia Pharma Ltd Somatostatin receptor subtype 1 (sstr1) active compounds and their use in therapy
CA2555963A1 (en) 2004-02-12 2005-09-01 Molecular Insight Pharmaceuticals Technetium-and rhenium-bis(heteroaryl) complexes, and methods of use thereof
GB0421308D0 (en) 2004-09-24 2004-10-27 Amersham Plc Enzyme inhibitor imaging agents
WO2008059489A2 (en) 2006-11-13 2008-05-22 Spectrum Dynamics Llc Radioimaging applications of and novel formulations of teboroxime
WO2006080993A1 (en) 2004-12-08 2006-08-03 Purdue Research Foundation Novel cationic metal complex radiopharmaceuticals
US20060155021A1 (en) 2005-01-13 2006-07-13 Lenges Christian P Coating compositions containing rheology control agents
US7741510B2 (en) 2005-01-13 2010-06-22 E. I. Du Pont De Nemours And Company Rheology control agents
WO2006093991A1 (en) 2005-03-02 2006-09-08 The Cleveland Clinic Foundation Compounds which bind psma and uses thereof
ATE527542T1 (de) 2005-04-27 2011-10-15 Siemens Medical Solutions Verfahren zur herstellung von abbildungssonden unter verwendung von click chemie
US8871720B2 (en) 2005-07-07 2014-10-28 Seattle Genetics, Inc. Monomethylvaline compounds having phenylalanine carboxy modifications at the C-terminus
FR2890657B1 (fr) 2005-09-15 2007-11-09 Commissariat Energie Atomique Procede d'obtention de complexes de lanthanides hautement luminescents.
US8926945B2 (en) 2005-10-07 2015-01-06 Guerbet Compounds comprising a biological target recognizing part, coupled to a signal part capable of complexing gallium
WO2007058322A1 (ja) 2005-11-18 2007-05-24 Ono Pharmaceutical Co., Ltd. 塩基性基を含有する化合物およびその用途
US20090044345A1 (en) 2006-02-06 2009-02-19 Gunther Schlingloff Use of Metal Complex Compounds as Oxidation Catalysts
US8618122B2 (en) 2006-05-16 2013-12-31 Ono Pharmaceutical Co., Ltd. Compound having acidic group which may be protected, and use thereof
MX2009000144A (es) 2006-06-20 2009-01-23 Ishihara Sangyo Kaisha Agente de control de plaga que contiene derivado de piridil-metanamina novedoso o su sal.
JP5245827B2 (ja) 2006-07-31 2013-07-24 小野薬品工業株式会社 スピロ結合した環状基を含有する化合物およびその用途
BRPI0716368A2 (pt) 2006-08-29 2013-10-01 Molecular Insight Pharm Inc porÇÕes de radioimageamento acopladas a porÇÕes de ligaÇço Á peptidase para imageamento de tecidos e àrgços que expressam peptidases
US20080193381A1 (en) * 2006-11-08 2008-08-14 Molecular Insight Pharmaceuticals, Inc. Heterodimers of glutamic acid
WO2008124703A2 (en) 2007-04-05 2008-10-16 Siemens Medical Solutions Usa, Inc. Development of molecular imaging probes for carbonic anhydrase-ix using click chemistry
WO2009076434A1 (en) 2007-12-12 2009-06-18 Molecular Insight Pharmaceuticals, Inc. Inhibitors of integrin vla-4
BRPI0906797A2 (pt) 2008-01-09 2015-07-14 Molecular Insight Pharm Inc Inibidores de anidrase carbônica ix
TW201006830A (en) * 2008-06-11 2010-02-16 Astrazeneca Ab Chemical compounds
JP2012503670A (ja) 2008-09-25 2012-02-09 モレキュラ インサイト ファーマシューティカルズ インコーポレイテッド 選択的セプラーゼ阻害剤
US8211402B2 (en) 2008-12-05 2012-07-03 Molecular Insight Pharmaceuticals, Inc. CA-IX specific radiopharmaceuticals for the treatment and imaging of cancer
EP2706057B1 (en) 2008-12-05 2016-04-20 Molecular Insight Pharmaceuticals, Inc. Bis(imidazolyl)compounds and radionuclide complexes
EP2373621A2 (en) 2008-12-05 2011-10-12 Molecular Insight Pharmaceuticals, Inc. Technetium-and rhenium-bis(heteroaryl)complexes and methods of use thereof
ES2712732T3 (es) 2009-02-17 2019-05-14 Cornell Res Foundation Inc Métodos y kits para el diagnóstico de cáncer y la predicción de valor terapéutico
HRP20221195T1 (hr) * 2009-03-19 2022-12-09 The Johns Hopkins University Spojevi koji ciljaju psma i njihova uporaba
GB201002508D0 (en) * 2010-02-12 2010-03-31 Algeta As Product
WO2012074840A2 (en) * 2010-11-22 2012-06-07 The General Hospital Corporation Compositions and methods for in vivo imaging
EP2648766B1 (en) 2010-12-06 2018-04-18 Molecular Insight Pharmaceuticals, Inc. Psma-targeted dendrimers
EP3505192A1 (en) 2011-08-05 2019-07-03 Molecular Insight Pharmaceuticals, Inc. Radiolabeled prostate specific membrane antigen inhibitors
WO2013166110A1 (en) 2012-05-02 2013-11-07 Yale University Tlr-agonist-conjugated antibody recruiting molecules (tlr_arms)
CA2897437C (en) 2013-01-14 2021-12-14 Molecular Insight Pharmaceuticals, Inc. Triazine based radiopharmaceuticals and radioimaging agents

Also Published As

Publication number Publication date
US9447121B2 (en) 2016-09-20
US20140255306A1 (en) 2014-09-11
JP6468602B2 (ja) 2019-02-13
US11712485B2 (en) 2023-08-01
CA2897437C (en) 2021-12-14
EP2943227B8 (en) 2017-11-22
MX2015008993A (es) 2016-04-04
BR112015016585B1 (pt) 2021-02-02
EP2943227A1 (en) 2015-11-18
ES2738474T3 (es) 2020-01-23
HUE035739T2 (en) 2018-05-28
US20210338850A1 (en) 2021-11-04
AU2014205304A1 (en) 2015-08-13
HK1212908A1 (zh) 2016-06-24
JP2019073532A (ja) 2019-05-16
US20160346410A1 (en) 2016-12-01
EP3300746B1 (en) 2019-05-15
US10086096B2 (en) 2018-10-02
EP3545978B1 (en) 2021-09-08
EP2943227A4 (en) 2016-05-25
MX378439B (es) 2025-03-11
US20190134237A1 (en) 2019-05-09
SG11201505477TA (en) 2015-08-28
EP3300746A1 (en) 2018-04-04
AU2014205304B2 (en) 2018-03-29
BR112015016585A2 (pt) 2017-08-22
KR20150115797A (ko) 2015-10-14
US20170296683A1 (en) 2017-10-19
EP3939972A1 (en) 2022-01-19
EP3545978A1 (en) 2019-10-02
EP2943227B1 (en) 2017-09-20
CN105025933B (zh) 2019-03-26
ES2648096T3 (es) 2017-12-28
WO2014110372A1 (en) 2014-07-17
CN105025933A (zh) 2015-11-04
PL3300746T3 (pl) 2019-11-29
JP6707677B2 (ja) 2020-06-10
HUE044552T2 (hu) 2019-11-28
JP2016511231A (ja) 2016-04-14
US10201624B2 (en) 2019-02-12
KR102187940B1 (ko) 2020-12-07
US10898598B2 (en) 2021-01-26
CA2897437A1 (en) 2014-07-17

Similar Documents

Publication Publication Date Title
SG11201505477TA (en) Triazine based radiopharmaceuticals and radioimaging agents
IL274355B (en) Aza-pyridone compounds and their uses
GB201323008D0 (en) Compounds and uses thereof
IL244434B (en) Pyridazinone compounds and their uses
GB201305277D0 (en) Novel combination and use
HUE044890T2 (hu) Tetrazolinon vegyület és annak felhasználása
GB2513227B (en) Backpack
IL243361B (en) Radioactively labeled material
GB201322456D0 (en) Radiotracer compositions and methods
GB201321056D0 (en) Debug circuitry
GB201307233D0 (en) Compounds and uses thereof
GB201311107D0 (en) Bioorthogonal methods and compounds
EP2974713A4 (en) CERAMIDES FOR FUNCTIONAL ACTIVATION
ZA201602676B (en) Parent radionuclide container
LT2958454T (lt) Magnetoterapijos juosta
GB201314936D0 (en) Radiolabelling method
GB201309180D0 (en) Compounds and Their Uses
GB201314610D0 (en) Compounds and their uses
GB201306248D0 (en) Compounds and their uses
GB201305297D0 (en) Novel agents and uses thereof
GB201309248D0 (en) Compounds and combinations
AU353456S (en) Hammock
PH32013001091S1 (en) Toothbrush and portions thereof
PH32013001020S1 (en) Toothbrush and portions thereof
GB201313405D0 (en) Hammock