PL3069735T3 - ADC duokarmycyny do zastosowania w leczeniu raka pęcherza - Google Patents

ADC duokarmycyny do zastosowania w leczeniu raka pęcherza

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Publication number
PL3069735T3
PL3069735T3 PL16160637T PL16160637T PL3069735T3 PL 3069735 T3 PL3069735 T3 PL 3069735T3 PL 16160637 T PL16160637 T PL 16160637T PL 16160637 T PL16160637 T PL 16160637T PL 3069735 T3 PL3069735 T3 PL 3069735T3
Authority
PL
Poland
Prior art keywords
treatment
bladder cancer
duocarmycin
adcs
duocarmycin adcs
Prior art date
Application number
PL16160637T
Other languages
English (en)
Inventor
Willem DOKTER
Peter Johannes GOEDINGS
Gijsbertus Franciscus Maria Verheijden
Patrick Henry Beusker
Original Assignee
Synthon Biopharmaceuticals B.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthon Biopharmaceuticals B.V. filed Critical Synthon Biopharmaceuticals B.V.
Publication of PL3069735T3 publication Critical patent/PL3069735T3/pl

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    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61K47/6889Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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