PL3191470T3 - Modulatory Cot i sposoby ich zastosowania - Google Patents

Modulatory Cot i sposoby ich zastosowania

Info

Publication number
PL3191470T3
PL3191470T3 PL16738976T PL16738976T PL3191470T3 PL 3191470 T3 PL3191470 T3 PL 3191470T3 PL 16738976 T PL16738976 T PL 16738976T PL 16738976 T PL16738976 T PL 16738976T PL 3191470 T3 PL3191470 T3 PL 3191470T3
Authority
PL
Poland
Prior art keywords
methods
cot
modulators
cot modulators
Prior art date
Application number
PL16738976T
Other languages
English (en)
Inventor
Elizabeth M. Bacon
Gayatri BALAN
Chien-Hung Chou
Christopher T. Clark
Jeromy J. Cottell
Musong Kim
Thorsten A. Kirschberg
John O. Link
Gary Phillips
Scott D. Schroeder
Neil H. Squires
Kirk L. Stevens
James G. Taylor
William J. Watkins
Nathan E. Wright
Sheila M. Zipfel
Original Assignee
Gilead Sciences, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences, Inc. filed Critical Gilead Sciences, Inc.
Publication of PL3191470T3 publication Critical patent/PL3191470T3/pl

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    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C07D215/44—Nitrogen atoms attached in position 4 with aryl radicals attached to said nitrogen atoms
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
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    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Ophthalmology & Optometry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Nutrition Science (AREA)
  • Emergency Medicine (AREA)
  • Otolaryngology (AREA)
PL16738976T 2015-07-06 2016-06-30 Modulatory Cot i sposoby ich zastosowania PL3191470T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562189158P 2015-07-06 2015-07-06
US201562269060P 2015-12-17 2015-12-17
EP16738976.6A EP3191470B1 (en) 2015-07-06 2016-06-30 Cot modulators and methods of use thereof
PCT/US2016/040520 WO2017007689A1 (en) 2015-07-06 2016-06-30 Cot modulators and methods of use thereof

Publications (1)

Publication Number Publication Date
PL3191470T3 true PL3191470T3 (pl) 2019-08-30

Family

ID=56411943

Family Applications (3)

Application Number Title Priority Date Filing Date
PL21162393.9T PL3896064T3 (pl) 2015-07-06 2016-06-30 Pochodne 4,6-diamino-chinolino-3-karbonitrylu jako modulatory cot w leczeniu choroby leśniowskiego-crohna i wrzodziejącego zapalenia jelita grubego
PL16738976T PL3191470T3 (pl) 2015-07-06 2016-06-30 Modulatory Cot i sposoby ich zastosowania
PL18186568T PL3456717T3 (pl) 2015-07-06 2016-06-30 Pochodna 4,6-diaminochinolino-3-karbonitrylu jako modulator cot (cancer osaka thyroid) do leczenia choroby zapalnej

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PL21162393.9T PL3896064T3 (pl) 2015-07-06 2016-06-30 Pochodne 4,6-diamino-chinolino-3-karbonitrylu jako modulatory cot w leczeniu choroby leśniowskiego-crohna i wrzodziejącego zapalenia jelita grubego

Family Applications After (1)

Application Number Title Priority Date Filing Date
PL18186568T PL3456717T3 (pl) 2015-07-06 2016-06-30 Pochodna 4,6-diaminochinolino-3-karbonitrylu jako modulator cot (cancer osaka thyroid) do leczenia choroby zapalnej

Country Status (41)

Country Link
US (8) US20170008905A1 (pl)
EP (4) EP3191470B1 (pl)
JP (6) JP6430060B2 (pl)
KR (5) KR101974793B1 (pl)
CN (4) CN107922390B (pl)
AU (5) AU2016290820B2 (pl)
BR (1) BR102016015656B1 (pl)
CA (1) CA2971640C (pl)
CL (1) CL2017003356A1 (pl)
CO (1) CO2017013351A2 (pl)
CR (1) CR20170599A (pl)
CU (1) CU20170172A7 (pl)
CY (1) CY1121750T1 (pl)
DK (1) DK3191470T3 (pl)
DO (1) DOP2017000311A (pl)
EA (1) EA036788B1 (pl)
EC (1) ECSP17084635A (pl)
ES (3) ES2734713T3 (pl)
HR (1) HRP20190853T1 (pl)
HU (1) HUE043310T2 (pl)
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PT3456717T (pt) 2021-05-26
CU20170172A7 (es) 2018-06-05
EP3896064A1 (en) 2021-10-20
EP4613332A3 (en) 2025-12-10
IL256433B (en) 2019-06-30
CA2971640A1 (en) 2017-01-12
IL293770A (en) 2022-08-01
IL266995A (en) 2019-07-31
PL3456717T3 (pl) 2021-10-25
JP2018520161A (ja) 2018-07-26
MX2017004737A (es) 2017-06-19

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