PL329912A1 - Benzofurane carboxyamides and their therapeutic applications - Google Patents

Benzofurane carboxyamides and their therapeutic applications

Info

Publication number: PL329912A1
Authority: PL; Poland
Prior art keywords: alkyl; heteroaryl; heterocyclo; optionally substituted; heterocyclyl
Prior art date: 1996-05-20

Application number

PL97329912A

Other languages

English (en)

Inventor

Hazel Joan Dyke

Christopher Lowe

John Gary Montana

Hannah Jayne Kendall

Verity Margaret Sabin

Original Assignee

Darwin Discovery Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-05-20

Filing date

1997-05-20

Publication date

1999-04-26

1996-05-20 Priority claimed from GBGB9610515.0A external-priority patent/GB9610515D0/en

1996-12-05 Priority claimed from PCT/GB1996/003012 external-priority patent/WO1997020833A1/en

1997-04-22 Priority claimed from GBGB9708070.9A external-priority patent/GB9708070D0/en

1997-05-20 Application filed by Darwin Discovery Ltd filed Critical Darwin Discovery Ltd

1999-04-26 Publication of PL329912A1 publication Critical patent/PL329912A1/xx

Links

QQKOWGCGSWKHDK-UHFFFAOYSA-N 1-benzofuran;carbamic acid Chemical class NC(O)=O.C1=CC=C2OC=CC2=C1 QQKOWGCGSWKHDK-UHFFFAOYSA-N 0.000 title 1
230000001225 therapeutic effect Effects 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 5
125000003710 aryl alkyl group Chemical group 0.000 abstract 5
125000003118 aryl group Chemical group 0.000 abstract 5
125000001475 halogen functional group Chemical group 0.000 abstract 5
125000001072 heteroaryl group Chemical group 0.000 abstract 5
125000004446 heteroarylalkyl group Chemical group 0.000 abstract 5
125000000623 heterocyclic group Chemical group 0.000 abstract 5
125000000592 heterocycloalkyl group Chemical group 0.000 abstract 5
CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 abstract 3
125000003545 alkoxy group Chemical group 0.000 abstract 3
125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 abstract 3
-1 NR8R9 Chemical group 0.000 abstract 2
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
125000000753 cycloalkyl group Chemical group 0.000 abstract 2
QHKJIJXBJCOABP-UHFFFAOYSA-N 1-benzofuran-2-carboxamide Chemical compound C1=CC=C2OC(C(=O)N)=CC2=C1 QHKJIJXBJCOABP-UHFFFAOYSA-N 0.000 abstract 1
101100134925 Gallus gallus COR6 gene Proteins 0.000 abstract 1
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
125000004448 alkyl carbonyl group Chemical group 0.000 abstract 1
125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
125000002102 aryl alkyloxo group Chemical group 0.000 abstract 1
125000005129 aryl carbonyl group Chemical group 0.000 abstract 1
125000004391 aryl sulfonyl group Chemical group 0.000 abstract 1
125000004104 aryloxy group Chemical group 0.000 abstract 1
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
125000005114 heteroarylalkoxy group Chemical group 0.000 abstract 1
125000005223 heteroarylcarbonyl group Chemical group 0.000 abstract 1
125000005553 heteroaryloxy group Chemical group 0.000 abstract 1
125000004470 heterocyclooxy group Chemical group 0.000 abstract 1
125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000004001 thioalkyl group Chemical group 0.000 abstract 1
150000003556 thioamides Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/86—Benzo [b] furans; Hydrogenated benzo [b] furans with an oxygen atom directly attached in position 7
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pulmonology (AREA)
Biomedical Technology (AREA)
Rheumatology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Physical Education & Sports Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Oncology (AREA)
Psychiatry (AREA)
Immunology (AREA)
Vascular Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Hospice & Palliative Care (AREA)
Communicable Diseases (AREA)
Urology & Nephrology (AREA)
Pain & Pain Management (AREA)
Hematology (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Furan Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

PL97329912A 1996-05-20 1997-05-20 Benzofurane carboxyamides and their therapeutic applications PL329912A1 (en)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GBGB9610515.0A GB9610515D0 (en)	1996-05-20	1996-05-20	Novel compounds
PCT/GB1996/003012 WO1997020833A1 (en)	1995-12-05	1996-12-05	Benzofuran carboxamides and sulphonamides
GBGB9708070.9A GB9708070D0 (en)	1997-04-22	1997-04-22	Compounds
PCT/GB1997/001361 WO1997044337A1 (en)	1996-05-20	1997-05-20	Benzofuran carboxamides and their therapeutic use

Publications (1)

Publication Number	Publication Date
PL329912A1 true PL329912A1 (en)	1999-04-26

Family

ID=26309366

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL97329912A PL329912A1 (en)	1996-05-20	1997-05-20	Benzofurane carboxyamides and their therapeutic applications

Country Status (19)

Country	Link
US (2)	US5972936A (2)
EP (1)	EP0901482B1 (2)
JP (1)	JP2000510848A (2)
CN (1)	CN1219171A (2)
AT (1)	ATE239004T1 (2)
BR (1)	BR9709113A (2)
CA (1)	CA2252537A1 (2)
CZ (1)	CZ371998A3 (2)
DE (1)	DE69721526T2 (2)
ES (1)	ES2193376T3 (2)
HU (1)	HUP0100042A3 (2)
IL (1)	IL126558A (2)
NO (1)	NO985375D0 (2)
NZ (1)	NZ332340A (2)
PL (1)	PL329912A1 (2)
RU (1)	RU2162467C2 (2)
SK (1)	SK282676B6 (2)
TR (1)	TR199802386T2 (2)
WO (1)	WO1997044337A1 (2)

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DE10238257B4 (de) *	2002-08-21	2007-04-19	Johannes-Gutenberg-Universität Mainz	Sorbicillacton A und Sorbicillacton-A-Derivate, Verfahren zu ihrer Herstellung und sie enthaltende Arzneimittel
US20050215626A1 (en) *	2003-09-25	2005-09-29	Wyeth	Substituted benzofuran oximes
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ES2251866B1 (es) *	2004-06-18	2007-06-16	Laboratorios Almirall S.A.	Nuevos derivados de piridazin-3(2h)-ona.
ES2251867B1 (es) *	2004-06-21	2007-06-16	Laboratorios Almirall S.A.	Nuevos derivados de piridazin-3(2h)-ona.
EP1849465A4 (en) *	2005-02-18	2008-12-24	Takeda Pharmaceutical	AGENS TO CONTROL THE FUNCTION OF THE GPR34 RECEPTOR
EP1928437A2 (en)	2005-08-26	2008-06-11	Braincells, Inc.	Neurogenesis by muscarinic receptor modulation
EP2258358A3 (en)	2005-08-26	2011-09-07	Braincells, Inc.	Neurogenesis with acetylcholinesterase inhibitor
EP1940389A2 (en)	2005-10-21	2008-07-09	Braincells, Inc.	Modulation of neurogenesis by pde inhibition
US20070112017A1 (en)	2005-10-31	2007-05-17	Braincells, Inc.	Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en)	2006-03-08	2010-08-26	Braincells, Inc.	Modulation of neurogenesis by nootropic agents
US7842713B2 (en) *	2006-04-20	2010-11-30	Pfizer Inc	Fused phenyl amido heterocyclic compounds
AU2007249399A1 (en)	2006-05-09	2007-11-22	Braincells, Inc.	Neurogenesis by modulating angiotensin
MX2008014450A (es)	2006-05-18	2009-03-09	Mannkind Corp	Inhibidores de cinasa intracelular.
US20100184806A1 (en)	2006-09-19	2010-07-22	Braincells, Inc.	Modulation of neurogenesis by ppar agents
CN100434426C (zh) *	2006-10-10	2008-11-19	中国科学院昆明植物研究所	盐肤木内酯a,其制备方法和其在制药中的应用
CA2676933C (en)	2007-02-28	2015-09-29	Leo Pharma A/S	Novel phosphodiesterase inhibitors
UA98639C2 (en) *	2007-02-28	2012-06-11	Лео Фарма А/С	Phosphodiesterase inhibitors
ES2320954B1 (es) *	2007-03-02	2010-03-16	Laboratorio Almirall S.A.	Nuevo procedimiento de preparacion de 3-metil-4-fenilisoxazolo (3,4-d)iridazin-7(6h)-ona.
KR100752613B1 (ko) *	2007-05-02	2007-08-29	우석대학교 산학협력단	신규 벤조푸란 유도체를 포함하는 부정맥 예방용 식품
AR067354A1 (es)	2007-06-29	2009-10-07	Sunesis Pharmaceuticals Inc	Compuestos utiles como inhibidores de la raf quinasa
KR101258331B1 (ko)	2008-09-11	2013-04-26	화이자 인코포레이티드	헤테로아릴 아미드 유도체 및 글루코키나제 활성화제로서의 그의 용도
WO2010099217A1 (en)	2009-02-25	2010-09-02	Braincells, Inc.	Modulation of neurogenesis using d-cycloserine combinations
MY151246A (en) *	2009-03-11	2014-04-30	Pfizer	Benzofuranyl derivatives
SI3070091T1 (sl) *	2010-06-24	2019-08-30	Leo Pharma A/S	Derivati benzodioksola kot zaviralci fosfodiesteraze
CN102010405B (zh) *	2010-11-08	2012-07-25	湖南大学	4-(苯并呋喃-5-基)-2-苄亚氨基噻唑及其作为抗肿瘤药物的应用
WO2013106547A1 (en)	2012-01-10	2013-07-18	President And Fellows Of Harvard College	Beta-cell replication promoting compounds and methods of their use
EP3242661B1 (en)	2015-01-05	2019-08-21	The U.S.A. as represented by the Secretary, Department of Health and Human Services	Myc g-quadruplex stabilizing small molecules and their use
JPWO2020246418A1 (2) *	2019-06-04	2020-12-10
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1997
- 1997-05-20 CN CN97194736A patent/CN1219171A/zh active Pending
- 1997-05-20 HU HU0100042A patent/HUP0100042A3/hu unknown
- 1997-05-20 TR TR1998/02386T patent/TR199802386T2/xx unknown
- 1997-05-20 AT AT97923193T patent/ATE239004T1/de not_active IP Right Cessation
- 1997-05-20 JP JP09541240A patent/JP2000510848A/ja not_active Ceased
- 1997-05-20 ES ES97923193T patent/ES2193376T3/es not_active Expired - Lifetime
- 1997-05-20 RU RU98123097/04A patent/RU2162467C2/ru not_active IP Right Cessation
- 1997-05-20 EP EP97923193A patent/EP0901482B1/en not_active Expired - Lifetime
- 1997-05-20 SK SK1604-98A patent/SK282676B6/sk unknown
- 1997-05-20 US US08/859,510 patent/US5972936A/en not_active Expired - Fee Related
- 1997-05-20 IL IL12655897A patent/IL126558A/en not_active IP Right Cessation
- 1997-05-20 DE DE69721526T patent/DE69721526T2/de not_active Expired - Fee Related
- 1997-05-20 WO PCT/GB1997/001361 patent/WO1997044337A1/en not_active Ceased
- 1997-05-20 CA CA002252537A patent/CA2252537A1/en not_active Abandoned
- 1997-05-20 US US08/859,509 patent/US5925636A/en not_active Expired - Fee Related
- 1997-05-20 CZ CZ983719A patent/CZ371998A3/cs unknown
- 1997-05-20 BR BR9709113A patent/BR9709113A/pt active Search and Examination
- 1997-05-20 NZ NZ332340A patent/NZ332340A/xx unknown
- 1997-05-20 PL PL97329912A patent/PL329912A1/xx unknown
1998
- 1998-11-19 NO NO985375A patent/NO985375D0/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
HUP0100042A3 (en)	2003-01-28
SK160498A3 (en)	1999-06-11
RU2162467C2 (ru)	2001-01-27
BR9709113A (pt)	1999-08-03
EP0901482A1 (en)	1999-03-17
US5972936A (en)	1999-10-26
DE69721526T2 (de)	2004-04-08
TR199802386T2 (xx)	1999-02-22
JP2000510848A (ja)	2000-08-22
ES2193376T3 (es)	2003-11-01
ATE239004T1 (de)	2003-05-15
EP0901482B1 (en)	2003-05-02
DE69721526D1 (de)	2003-06-05
NZ332340A (en)	2000-04-28
US5925636A (en)	1999-07-20
CN1219171A (zh)	1999-06-09
WO1997044337A1 (en)	1997-11-27
IL126558A0 (en)	1999-08-17
HUP0100042A2 (hu)	2002-01-28
CA2252537A1 (en)	1997-11-27
IL126558A (en)	2002-07-25
NO985375L (no)	1998-11-19
SK282676B6 (sk)	2002-11-06
CZ371998A3 (cs)	1999-03-17
NO985375D0 (no)	1998-11-19

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YU83602A (sh)	2006-05-25	Derivati fenilglicina
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IL178362A0 (en)	2007-07-04	Benzylidene-??-dicarbonyl compounds as novel uv-absorbers
HRP20010776B1 (en)	2006-02-28	Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds
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AU2001258445A1 (en)	2001-11-12	A process for controlling microbial growth
ATE273498T1 (de)	2004-08-15	Verfahren zum regeln der fördergeschwindigkeit eines rostkühlers
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DE69503745D1 (de)	1998-09-03	3-Alkoxybenzylpiperidin-Derivate as melatonergisches Mittel
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AR014626A1 (es)	2001-03-28	Piridino arilpiperazinas sustituidas utiles en el tratamiento de hiperplasia prostatica benigna, una composicion farmaceutica que las comprende y el uso de las mismas para la fabricacion de un medicamento.