PL3303619T3 - Metylacja promotora PD-L1 w chorobach nowotworowych - Google Patents

Metylacja promotora PD-L1 w chorobach nowotworowych

Info

Publication number
PL3303619T3
PL3303619T3 PL16728525T PL16728525T PL3303619T3 PL 3303619 T3 PL3303619 T3 PL 3303619T3 PL 16728525 T PL16728525 T PL 16728525T PL 16728525 T PL16728525 T PL 16728525T PL 3303619 T3 PL3303619 T3 PL 3303619T3
Authority
PL
Poland
Prior art keywords
cancer
promoter methylation
methylation
promoter
Prior art date
Application number
PL16728525T
Other languages
English (en)
Inventor
Edward KADEL
Marcin KOWANETZ
Kimberly Walter
Original Assignee
F. Hoffmann-La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F. Hoffmann-La Roche Ag filed Critical F. Hoffmann-La Roche Ag
Publication of PL3303619T3 publication Critical patent/PL3303619T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Hospice & Palliative Care (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PL16728525T 2015-05-29 2016-05-27 Metylacja promotora PD-L1 w chorobach nowotworowych PL3303619T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562168668P 2015-05-29 2015-05-29
PCT/US2016/034856 WO2016196381A1 (en) 2015-05-29 2016-05-27 Pd-l1 promoter methylation in cancer
EP16728525.3A EP3303619B1 (en) 2015-05-29 2016-05-27 Pd-l1 promoter methylation in cancer

Publications (1)

Publication Number Publication Date
PL3303619T3 true PL3303619T3 (pl) 2020-10-05

Family

ID=56118051

Family Applications (1)

Application Number Title Priority Date Filing Date
PL16728525T PL3303619T3 (pl) 2015-05-29 2016-05-27 Metylacja promotora PD-L1 w chorobach nowotworowych

Country Status (14)

Country Link
US (1) US11254987B2 (pl)
EP (2) EP3763827A1 (pl)
JP (2) JP6884111B2 (pl)
KR (1) KR20180013881A (pl)
CN (1) CN108064170B (pl)
AR (1) AR105618A1 (pl)
AU (1) AU2016271142A1 (pl)
CA (1) CA2984638A1 (pl)
ES (1) ES2810700T3 (pl)
HK (1) HK1255200A1 (pl)
IL (1) IL255375A0 (pl)
MX (1) MX388405B (pl)
PL (1) PL3303619T3 (pl)
WO (1) WO2016196381A1 (pl)

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KR20170135860A (ko) 2015-03-13 2017-12-08 싸이톰스 테라퓨틱스, 인크. 항-pdl1 항체, 활성화 가능한 항-pdl1 항체, 및 이들의 사용 방법
JP6903055B2 (ja) 2015-08-03 2021-07-14 イーエヌビー・セラピューティクス・インク Ｅｔｂｒ活性化に関連した癌を治療するための組成物及び方法
AU2017205089B2 (en) 2016-01-08 2023-10-05 F. Hoffmann-La Roche Ag Methods of treating CEA-positive cancers using PD-1 axis binding antagonists and anti-CEA/anti-CD3 bispecific antibodies
US11685955B2 (en) 2016-05-16 2023-06-27 Dimo Dietrich Method for predicting response of patients with malignant diseases to immunotherapy
DE102016005947B3 (de) * 2016-05-16 2017-06-08 Dimo Dietrich Verfahren zur Abschätzung der Prognose und zur Prädiktion des Ansprechens auf eine Immuntherapie von Patienten mit malignen Erkrankungen
WO2018039629A2 (en) 2016-08-25 2018-03-01 Northwestern University Micellar spherical nucleic acids from thermoresponsive, traceless templates
JP2020522486A (ja) 2017-06-01 2020-07-30 サイトメックス セラピューティクス インコーポレイテッド 活性化可能抗ｐｄｌ１抗体、およびその使用方法
CN110831972B (zh) * 2017-06-25 2023-05-12 西雅图免疫公司 抗pd-l1抗体及其制备和使用方法
MX2020007293A (es) 2018-01-12 2021-01-08 Enb Therapeutics Inc Compuestos desuterados, composiciones y metodos para tratar canceres asociados con la activacion etbr.
AU2019222644B2 (en) 2018-02-13 2021-04-01 Gilead Sciences, Inc. PD-1/PD-L1 inhibitors
SI3820572T1 (sl) 2018-07-13 2023-12-29 Gilead Sciences, Inc. Inhibitorji pd-1/pd-l1
CN109355381A (zh) * 2018-09-14 2019-02-19 深圳市太空科技南方研究院 用于预测pd1/l1抑制剂疗效的生物标记物和方法
CN111035758A (zh) * 2018-10-11 2020-04-21 江苏康缘药业股份有限公司 药物组合物及其应用、无菌容器和试剂盒
KR20210148077A (ko) * 2018-12-21 2021-12-07 에이전시 포 사이언스, 테크놀로지 앤드 리서치 면역 체크포인트 억제 요법으로부터의 수혜를 예측하는 방법
WO2021035172A1 (en) * 2019-08-21 2021-02-25 H. Lee Moffitt Cancer Center And Research Institute, Inc. Diagnostics and methods for prognosing response to immunotherapy based on the methylation status of immune synapse gene signature
CN112735513B (zh) * 2021-01-04 2021-11-19 江苏先声医疗器械有限公司 基于dna甲基化谱的肿瘤免疫检查点抑制剂治疗有效性评估模型的构建方法
WO2025007038A1 (en) * 2023-06-30 2025-01-02 Guardant Health, Inc. Methods for early detection of cancer

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US11254987B2 (en) 2022-02-22
CN108064170A (zh) 2018-05-22
EP3303619A1 (en) 2018-04-11
MX2017014735A (es) 2018-03-23
MX388405B (es) 2025-03-19
JP2018526323A (ja) 2018-09-13
CA2984638A1 (en) 2016-12-08
EP3763827A1 (en) 2021-01-13
US20180216196A1 (en) 2018-08-02
HK1255200A1 (zh) 2019-08-09
JP2021102621A (ja) 2021-07-15
EP3303619B1 (en) 2020-06-10
ES2810700T3 (es) 2021-03-09
AR105618A1 (es) 2017-10-25
KR20180013881A (ko) 2018-02-07
AU2016271142A1 (en) 2017-11-23
CN108064170B (zh) 2022-07-15
JP6884111B2 (ja) 2021-06-09
IL255375A0 (en) 2017-12-31

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