PL3375782T3 - Bloker kanału sodowego - Google Patents

Bloker kanału sodowego

Info

Publication number
PL3375782T3
PL3375782T3 PL16864614.9T PL16864614T PL3375782T3 PL 3375782 T3 PL3375782 T3 PL 3375782T3 PL 16864614 T PL16864614 T PL 16864614T PL 3375782 T3 PL3375782 T3 PL 3375782T3
Authority
PL
Poland
Prior art keywords
sodium channel
channel blocker
blocker
sodium
channel
Prior art date
Application number
PL16864614.9T
Other languages
English (en)
Inventor
Hyung-Geun Lee
Il-Hwan Kim
Myunggi JUNG
Hyo Shin Kim
Chun Ho Lee
Sun Ah Jun
Ji Sung Yoon
Sung-Young Kim
Original Assignee
iN Therapeutics Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by iN Therapeutics Co., Ltd. filed Critical iN Therapeutics Co., Ltd.
Publication of PL3375782T3 publication Critical patent/PL3375782T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/50—Nitrogen atoms bound to hetero atoms
    • C07D277/52—Nitrogen atoms bound to hetero atoms to sulfur atoms, e.g. sulfonamides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
PL16864614.9T 2015-11-13 2016-11-11 Bloker kanału sodowego PL3375782T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20150159637 2015-11-13
PCT/KR2016/013029 WO2017082688A1 (ko) 2015-11-13 2016-11-11 소디움 채널 차단제

Publications (1)

Publication Number Publication Date
PL3375782T3 true PL3375782T3 (pl) 2021-02-22

Family

ID=58695815

Family Applications (1)

Application Number Title Priority Date Filing Date
PL16864614.9T PL3375782T3 (pl) 2015-11-13 2016-11-11 Bloker kanału sodowego

Country Status (29)

Country Link
US (1) US10227338B2 (pl)
EP (1) EP3375782B1 (pl)
JP (1) JP6559894B2 (pl)
KR (1) KR102245930B1 (pl)
CN (1) CN108349963B (pl)
AU (1) AU2016351526B2 (pl)
BR (1) BR112018009754B1 (pl)
CA (1) CA3003119C (pl)
CL (1) CL2018001281A1 (pl)
CO (1) CO2018005064A2 (pl)
EC (1) ECSP18038014A (pl)
ES (1) ES2821962T3 (pl)
HR (1) HRP20201695T1 (pl)
HU (1) HUE052569T2 (pl)
MA (1) MA43231B1 (pl)
MX (1) MX376469B (pl)
MY (1) MY194015A (pl)
NZ (1) NZ742069A (pl)
PE (1) PE20181301A1 (pl)
PH (1) PH12018500999A1 (pl)
PL (1) PL3375782T3 (pl)
PT (1) PT3375782T (pl)
RS (1) RS60927B1 (pl)
RU (1) RU2705578C1 (pl)
SA (1) SA518391540B1 (pl)
SG (1) SG11201803867TA (pl)
SI (1) SI3375782T1 (pl)
TN (1) TN2018000157A1 (pl)
WO (1) WO2017082688A1 (pl)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112019007763A2 (pt) * 2016-10-17 2019-07-02 Genentech Inc composto de fórmula, composição farmacêutica, métodos para tratar uma doença ou condição, para tratar dores, para diminuir o fluxo de íons e para tratar prurido, uso de um composto e invenção
TW202003490A (zh) * 2018-05-22 2020-01-16 瑞士商赫孚孟拉羅股份公司 治療性化合物及其使用方法
CN110885319B (zh) * 2018-09-10 2022-08-12 成都康弘药业集团股份有限公司 作为钠通道阻滞剂的磺酰胺类化合物及其用途
CN112759559B (zh) * 2019-11-06 2022-08-12 成都康弘药业集团股份有限公司 作为钠通道阻滞剂的磺酰胺类化合物及其用途

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5591761A (en) * 1993-05-20 1997-01-07 Texas Biotechnology Corporation Thiophenyl-, furyl-and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin
US5464853A (en) 1993-05-20 1995-11-07 Immunopharmaceutics, Inc. N-(5-isoxazolyl)biphenylsulfonamides, N-(3-isoxazolyl)biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin
JP3555620B2 (ja) * 2001-03-12 2004-08-18 小野薬品工業株式会社 N−フェニル−アリールスルフォンアミド化合物、その化合物を有効成分として含有する薬剤、その化合物の合成中間体およびその製造方法
JP2006290791A (ja) 2005-04-11 2006-10-26 Astellas Pharma Inc アゾール置換スルホニルベンゼン誘導体
EP1901747A2 (en) * 2005-05-25 2008-03-26 Ingenium Pharmaceuticals AG Pyrimidine-based cdk inhibitors for treating pain
EP2032539A4 (en) 2006-06-09 2011-03-16 Merck Sharp & Dohme BENZAZEPINONE AS SODIUM CHANNEL BLOCKER
EP2139852A1 (en) * 2006-12-19 2010-01-06 Pharmos Corporation Sulfonamide derivatives with therapeutic indications
SA08290245B1 (ar) 2007-04-23 2012-02-12 استرازينيكا ايه بي مشتقات كربو كساميد جديدة من -n (8-اريل رباعي هيدرو نفثالين غير متجانس- 2- يل) أو -n (5-اريل كرومان غير متجانس -3-يل) لعلاج الألم
JP2008290791A (ja) * 2007-05-22 2008-12-04 Funai Electric Co Ltd 画像形成装置
JP5460589B2 (ja) * 2007-07-13 2014-04-02 アイカジェン, インコーポレイテッド ナトリウムチャネル阻害物質
CA2747419C (en) * 2009-01-12 2014-07-08 Icagen, Inc. Sulfonamide derivatives
JP2013532184A (ja) * 2010-07-12 2013-08-15 ファイザー・リミテッド 電位開口型ナトリウムチャネル阻害剤として有用なn−スルホニルベンズアミド誘導体
MX2014005304A (es) * 2011-10-31 2015-03-20 Xenon Pharmaceuticals Inc Biaril eter sulfonamidas y su uso como agentes terapeuticos.
WO2013086229A1 (en) 2011-12-07 2013-06-13 Amgen Inc. Bicyclic aryl and heteroaryl sodium channel inhibitors
ES2593533T3 (es) 2011-12-15 2016-12-09 Pfizer Limited Derivados de sulfonamida
WO2013093688A1 (en) 2011-12-19 2013-06-27 Pfizer Limited Sulfonamide derivatives and use thereof as vgsc inhibitors
CA2874621A1 (en) 2012-05-22 2013-11-28 Genentech, Inc. N-substituted benzamides and their use in the treatment of pain
US9376429B2 (en) * 2012-10-15 2016-06-28 Daewoong Pharmaceutical Co., Ltd. Sodium channel blockers, preparation method thereof and use thereof
US20170145003A1 (en) * 2014-02-27 2017-05-25 Mark G. DeGiacomo Heterocyclic inhibitors of the sodium channel

Also Published As

Publication number Publication date
CO2018005064A2 (es) 2018-06-20
WO2017082688A1 (ko) 2017-05-18
ES2821962T3 (es) 2021-04-28
EP3375782A1 (en) 2018-09-19
TN2018000157A1 (en) 2019-10-04
CL2018001281A1 (es) 2018-08-31
PT3375782T (pt) 2020-08-05
JP2018533606A (ja) 2018-11-15
CA3003119C (en) 2019-10-22
ECSP18038014A (es) 2018-05-31
EP3375782B1 (en) 2020-07-29
JP6559894B2 (ja) 2019-08-14
BR112018009754A2 (pt) 2018-11-06
BR112018009754A8 (pt) 2019-02-26
PE20181301A1 (es) 2018-08-09
CN108349963B (zh) 2021-03-30
HK1251229A1 (zh) 2019-01-25
RU2705578C1 (ru) 2019-11-08
AU2016351526A1 (en) 2018-05-17
SI3375782T1 (sl) 2020-10-30
SA518391540B1 (ar) 2021-04-06
MX376469B (es) 2025-03-07
MA43231B1 (fr) 2020-08-31
RS60927B1 (sr) 2020-11-30
HUE052569T2 (hu) 2021-05-28
PH12018500999A1 (en) 2019-01-28
KR102245930B1 (ko) 2021-04-29
MY194015A (en) 2022-11-08
NZ742069A (en) 2019-08-30
BR112018009754B1 (pt) 2024-01-23
MX2018005940A (es) 2018-08-14
EP3375782A4 (en) 2019-05-15
AU2016351526B2 (en) 2019-02-21
HRP20201695T1 (hr) 2020-12-25
CA3003119A1 (en) 2017-05-18
US10227338B2 (en) 2019-03-12
CN108349963A (zh) 2018-07-31
US20180346459A1 (en) 2018-12-06
SG11201803867TA (en) 2018-06-28
KR20170056461A (ko) 2017-05-23

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