PL3489211T3 - Ulepszone sposoby otrzymywania skwalenu - Google Patents

Ulepszone sposoby otrzymywania skwalenu

Info

Publication number: PL3489211T3
Authority: PL; Poland
Prior art keywords: improved methods; preparing squalene; squalene; preparing; methods
Prior art date: 2010-05-12

Application number

PL19151232T

Other languages

English (en)

Inventor

Maninder Hora

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2010-05-12

Filing date

2011-05-12

Publication date

2020-12-14

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44358794&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL3489211(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2011-05-12 Application filed by Novartis Ag filed Critical Novartis Ag

2020-12-14 Publication of PL3489211T3 publication Critical patent/PL3489211T3/pl

Links

YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 title 1
BHEOSNUKNHRBNM-UHFFFAOYSA-N Tetramethylsqualene Natural products CC(=C)C(C)CCC(=C)C(C)CCC(C)=CCCC=C(C)CCC(C)C(=C)CCC(C)C(C)=C BHEOSNUKNHRBNM-UHFFFAOYSA-N 0.000 title 1
PRAKJMSDJKAYCZ-UHFFFAOYSA-N dodecahydrosqualene Natural products CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 title 1
229940031439 squalene Drugs 0.000 title 1
TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C11/00—Aliphatic unsaturated hydrocarbons
- C07C11/21—Alkatrienes; Alkatetraenes; Other alkapolyenes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/01—Hydrocarbons
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D3/00—Distillation or related exchange processes in which liquids are contacted with gaseous media, e.g. stripping
- B01D3/10—Vacuum distillation
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D3/00—Distillation or related exchange processes in which liquids are contacted with gaseous media, e.g. stripping
- B01D3/14—Fractional distillation or use of a fractionation or rectification column
- B01D3/143—Fractional distillation or use of a fractionation or rectification column by two or more of a fractionation, separation or rectification step
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/10—Wash bottles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C7/00—Purification; Separation; Use of additives
- C07C7/04—Purification; Separation; Use of additives by distillation
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Virology (AREA)
Oil, Petroleum & Natural Gas (AREA)
Microbiology (AREA)
Immunology (AREA)
Mycology (AREA)
Bioinformatics & Cheminformatics (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Genetics & Genomics (AREA)
Analytical Chemistry (AREA)
Water Supply & Treatment (AREA)
Pulmonology (AREA)
Dispersion Chemistry (AREA)
Biotechnology (AREA)
Biomedical Technology (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
Communicable Diseases (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Oncology (AREA)
Molecular Biology (AREA)
Clinical Laboratory Science (AREA)
Biophysics (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicinal Preparation (AREA)

PL19151232T 2010-05-12 2011-05-12 Ulepszone sposoby otrzymywania skwalenu PL3489211T3 (pl)

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
US39544810P	2010-05-12	2010-05-12
EP19151232.6A EP3489211B1 (en)	2010-05-12	2011-05-12	Improved methods for preparing squalene
PCT/IB2011/001397 WO2011141819A1 (en)	2010-05-12	2011-05-12	Improved methods for preparing squalene
EP16176832.0A EP3103784B1 (en)	2010-05-12	2011-05-12	Manufacture of an oil-in-water emulsion comprising squalene
EP13164769.5A EP2620423B2 (en)	2010-05-12	2011-05-12	Improved methods for preparing squalene
EP11738802.5A EP2569267B2 (en)	2010-05-12	2011-05-12	Improved methods for preparing squalene

Publications (1)

Publication Number	Publication Date
PL3489211T3 true PL3489211T3 (pl)	2020-12-14

Family

ID=44358794

Family Applications (4)

Application Number	Title	Priority Date	Filing Date
PL13164769T PL2620423T5 (pl)	2010-05-12	2011-05-12	Ulepszone sposoby otrzymywania skwalenu
PL16176832T PL3103784T3 (pl)	2010-05-12	2011-05-12	Wytwarzanie emulsji typu olej w wodzie zawierającej skwalen
PL11738802T PL2569267T5 (pl)	2010-05-12	2011-05-12	Ulepszone sposoby otrzymywania skwalenu
PL19151232T PL3489211T3 (pl)	2010-05-12	2011-05-12	Ulepszone sposoby otrzymywania skwalenu

Family Applications Before (3)

Application Number	Title	Priority Date	Filing Date
PL13164769T PL2620423T5 (pl)	2010-05-12	2011-05-12	Ulepszone sposoby otrzymywania skwalenu
PL16176832T PL3103784T3 (pl)	2010-05-12	2011-05-12	Wytwarzanie emulsji typu olej w wodzie zawierającej skwalen
PL11738802T PL2569267T5 (pl)	2010-05-12	2011-05-12	Ulepszone sposoby otrzymywania skwalenu

Country Status (20)

Country	Link
US (5)	US9199897B2 (pl)
EP (4)	EP2620423B2 (pl)
JP (2)	JP5946188B2 (pl)
KR (1)	KR101875894B1 (pl)
CN (2)	CN102892734B (pl)
AU (1)	AU2011251706B2 (pl)
BR (1)	BR112012028711B1 (pl)
CA (1)	CA2798924C (pl)
EA (1)	EA027142B1 (pl)
ES (4)	ES2453316T5 (pl)
IL (1)	IL222855A (pl)
MX (1)	MX352758B (pl)
NZ (1)	NZ603918A (pl)
PL (4)	PL2620423T5 (pl)
PT (3)	PT3103784T (pl)
SG (2)	SG185419A1 (pl)
SI (1)	SI2569267T1 (pl)
TR (1)	TR201905021T4 (pl)
WO (1)	WO2011141819A1 (pl)
ZA (1)	ZA201208381B (pl)

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JP2016502994A (ja)	2012-12-18	2016-02-01	グラクソスミスクラインバイオロジカルズソシエテアノニム	ジフテリア及び／又は破傷風から防御するためのコンジュゲート
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JP7555929B2 (ja) *	2018-12-24	2024-09-25	遠大賽威信生命科学（南京）有限公司	Ｂ型肝炎を治療するための薬物製剤、その製造方法及び用途
WO2023056089A1 (en)	2021-10-03	2023-04-06	Eisai R&D Management Co., Ltd.	Immunological adjuvant formulations comprising tlr4 agonist e6020
CN113956125B (zh) *	2021-11-11	2022-10-11	宜春大海龟生命科学有限公司	一种植物角鲨烷的组合物及其制备方法和应用
EP4544069A1 (en) *	2022-06-24	2025-04-30	Amyris, Inc.	Compositions and methods for the purification of squalene
EP4634144A1 (en)	2022-12-12	2025-10-22	Evonik Operations GmbH	Process for obtaining plant-based squalene
KR20260068101A (ko) *	2023-09-07	2026-05-13	아반토 퍼포먼스 머티리얼즈, 엘엘씨	합성 트리테르펜 조성물, 제조 방법 및 이의 용도
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EP2620423B2 (en)	2010-05-12	2019-07-31	Novartis AG	Improved methods for preparing squalene
CN101830770B (zh)	2010-06-02	2013-06-05	天津大学	从植物油脱臭馏出物中提取角鲨烯的方法
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2011
- 2011-05-12 EP EP13164769.5A patent/EP2620423B2/en active Active
- 2011-05-12 PT PT16176832T patent/PT3103784T/pt unknown
- 2011-05-12 KR KR1020127031750A patent/KR101875894B1/ko active Active
- 2011-05-12 PL PL13164769T patent/PL2620423T5/pl unknown
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Also Published As

Publication number	Publication date
IL222855A (en)	2015-11-30
PT3489211T (pt)	2020-09-22
BR112012028711B1 (pt)	2020-12-01
CA2798924A1 (en)	2011-11-17
ZA201208381B (en)	2014-04-30
EP3489211B1 (en)	2020-07-15
ES2597158T3 (es)	2017-01-16
AU2011251706B2 (en)	2015-10-22
EP2620423A1 (en)	2013-07-31
PL2569267T5 (pl)	2017-10-31
MX352758B (es)	2017-12-07
EP2569267B2 (en)	2017-03-22
US9199897B2 (en)	2015-12-01
US20180169225A1 (en)	2018-06-21
KR101875894B1 (ko)	2018-08-02
MX2012013027A (es)	2012-12-17
ES2717266T3 (es)	2019-06-20
PL2569267T3 (pl)	2014-05-30
JP2013530941A (ja)	2013-08-01
EP3103784B1 (en)	2019-02-06
EA027142B1 (ru)	2017-06-30
JP2015157858A (ja)	2015-09-03
US9545440B2 (en)	2017-01-17
CA2798924C (en)	2014-05-06
US9867877B2 (en)	2018-01-16
US20130209510A1 (en)	2013-08-15
PT2620423T (pt)	2016-09-23
ES2597158T5 (es)	2020-03-26
CN102892734B (zh)	2015-07-22
PL2620423T3 (pl)	2017-09-29
US20200061187A1 (en)	2020-02-27
IL222855A0 (en)	2012-12-31
SG10201503689TA (en)	2015-06-29
TR201905021T4 (tr)	2019-05-21
AU2011251706A1 (en)	2012-12-20
ES2817446T3 (es)	2021-04-07
US11077186B2 (en)	2021-08-03
EP2569267A1 (en)	2013-03-20
PT3103784T (pt)	2019-05-20
PL3103784T3 (pl)	2019-07-31
WO2011141819A1 (en)	2011-11-17
PL2620423T5 (pl)	2019-12-31
EP3103784A1 (en)	2016-12-14
EP2620423B1 (en)	2016-07-20
SG185419A1 (en)	2012-12-28
NZ603918A (en)	2015-04-24
SI2569267T1 (sl)	2014-03-31
US10517947B2 (en)	2019-12-31
BR112012028711A2 (pt)	2017-03-21
ES2453316T5 (es)	2017-07-18
EP2569267B1 (en)	2013-12-25
CN105125488A (zh)	2015-12-09
US20170072053A1 (en)	2017-03-16
JP5946188B2 (ja)	2016-07-05
EA201291225A1 (ru)	2013-06-28
KR20130103668A (ko)	2013-09-24
CN102892734A (zh)	2013-01-23
ES2453316T3 (es)	2014-04-07
US20160051670A1 (en)	2016-02-25
EP3489211A1 (en)	2019-05-29
EP2620423B2 (en)	2019-07-31

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