PL3507366T3 - Chemicznie modyfikowane jednoniciowe oligonukleotydy edytujące rna - Google Patents
Chemicznie modyfikowane jednoniciowe oligonukleotydy edytujące rnaInfo
- Publication number
- PL3507366T3 PL3507366T3 PL17771348T PL17771348T PL3507366T3 PL 3507366 T3 PL3507366 T3 PL 3507366T3 PL 17771348 T PL17771348 T PL 17771348T PL 17771348 T PL17771348 T PL 17771348T PL 3507366 T3 PL3507366 T3 PL 3507366T3
- Authority
- PL
- Poland
- Prior art keywords
- uniconious
- chemically modified
- rna editing
- editing oligonucleotides
- oligonucleotides
- Prior art date
Links
- 108091034117 Oligonucleotide Proteins 0.000 title 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
- C12Y305/04—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in cyclic amidines (3.5.4)
- C12Y305/04004—Adenosine deaminase (3.5.4.4)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/344—Position-specific modifications, e.g. on every purine, at the 3'-end
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/352—Nature of the modification linked to the nucleic acid via a carbon atom
- C12N2310/3521—Methyl
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
- C12N2310/533—Physical structure partially self-complementary or closed having a mismatch or nick in at least one of the strands
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/34—Allele or polymorphism specific uses
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Psychology (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Psychiatry (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1614858.7A GB201614858D0 (en) | 2016-09-01 | 2016-09-01 | Modified Bulgeomers |
| GBGB1616374.3A GB201616374D0 (en) | 2016-09-27 | 2016-09-27 | Modified bulgeomers |
| GBGB1621467.8A GB201621467D0 (en) | 2016-12-16 | 2016-12-16 | Modified bulgeomers |
| GBGB1703034.7A GB201703034D0 (en) | 2017-02-24 | 2017-02-24 | Modified bulgeomers |
| GBGB1707508.6A GB201707508D0 (en) | 2017-05-10 | 2017-05-10 | Modified bulgeomers |
| PCT/EP2017/071912 WO2018041973A1 (en) | 2016-09-01 | 2017-08-31 | Chemically modified single-stranded rna-editing oligonucleotides |
| EP17771348.4A EP3507366B1 (en) | 2016-09-01 | 2017-08-31 | Chemically modified single-stranded rna-editing oligonucleotides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3507366T3 true PL3507366T3 (pl) | 2021-05-04 |
Family
ID=59923385
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL17771348T PL3507366T3 (pl) | 2016-09-01 | 2017-08-31 | Chemicznie modyfikowane jednoniciowe oligonukleotydy edytujące rna |
Country Status (15)
| Country | Link |
|---|---|
| US (4) | US10941402B2 (pl) |
| EP (1) | EP3507366B1 (pl) |
| JP (1) | JP7244922B2 (pl) |
| KR (1) | KR102501980B1 (pl) |
| CN (1) | CN110352244B (pl) |
| AU (1) | AU2017320901C1 (pl) |
| CA (1) | CA3035293A1 (pl) |
| DK (1) | DK3507366T3 (pl) |
| ES (1) | ES2837076T3 (pl) |
| IL (1) | IL264923B2 (pl) |
| NZ (1) | NZ751483A (pl) |
| PL (1) | PL3507366T3 (pl) |
| PT (1) | PT3507366T (pl) |
| WO (1) | WO2018041973A1 (pl) |
| ZA (1) | ZA201901016B (pl) |
Families Citing this family (117)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12359197B2 (en) * | 2014-12-12 | 2025-07-15 | Etagen Pharma, Inc. | Compositions and methods for editing nucleic acids in cells utilizing oligonucleotides |
| ES2810375T3 (es) | 2014-12-17 | 2021-03-08 | Proqr Therapeutics Ii Bv | Edición direccionada de ARN |
| WO2016161388A1 (en) | 2015-04-03 | 2016-10-06 | University Of Massachusetts | Fully stabilized asymmetric sirna |
| WO2017030973A1 (en) | 2015-08-14 | 2017-02-23 | University Of Massachusetts | Bioactive conjugates for oligonucleotide delivery |
| US10478503B2 (en) | 2016-01-31 | 2019-11-19 | University Of Massachusetts | Branched oligonucleotides |
| EP3475424A1 (en) | 2016-06-22 | 2019-05-01 | ProQR Therapeutics II B.V. | Single-stranded rna-editing oligonucleotides |
| CA3035293A1 (en) * | 2016-09-01 | 2018-03-08 | Proqr Therapeutics Ii B.V. | Chemically modified single-stranded rna-editing oligonucleotides |
| EP3571300A1 (en) | 2017-01-19 | 2019-11-27 | ProQR Therapeutics II B.V. | Oligonucleotide complexes for use in rna editing |
| CN118416088A (zh) | 2017-03-03 | 2024-08-02 | 加利福尼亚大学董事会 | 经由抑制性tRNAs和脱氨酶对突变进行RNA靶向 |
| CA3064590A1 (en) | 2017-06-23 | 2018-12-27 | University Of Massachusetts | Two-tailed self-delivering sirna and related methods |
| US20200291383A1 (en) * | 2017-10-06 | 2020-09-17 | Oregon Health & Science University | Compositions and methods for editing rna |
| WO2019158475A1 (en) | 2018-02-14 | 2019-08-22 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for rna editing |
| AU2019265019B2 (en) | 2018-05-11 | 2025-11-06 | Beam Therapeutics Inc. | Methods of substituting pathogenic amino acids using programmable base editor systems |
| KR20250133482A (ko) * | 2018-05-11 | 2025-09-05 | 빔 테라퓨틱스, 인크. | 프로그래밍가능한 염기 편집기 시스템을 이용하여 단일 뉴클레오티드 다형성을 편집하는 방법 |
| EP3790964A4 (en) * | 2018-05-11 | 2022-06-08 | Beam Therapeutics, Inc. | METHODS FOR REMOVAL OF PATHOGENIC MUTATIONS USING PROGRAMMABLE BASE EDITOR SYSTEMS |
| GB201808146D0 (en) | 2018-05-18 | 2018-07-11 | Proqr Therapeutics Ii Bv | Stereospecific Linkages in RNA Editing Oligonucleotides |
| JP7347830B2 (ja) * | 2018-06-29 | 2023-09-20 | エバーハルト カール ウニヴェルジテート テュービンゲン | Ｒｎａ編集のための人工核酸 |
| WO2020033899A1 (en) | 2018-08-10 | 2020-02-13 | University Of Massachusetts | Modified oligonucleotides targeting snps |
| JP7627042B2 (ja) | 2018-08-23 | 2025-02-05 | ユニバーシティー オブ マサチューセッツ | Ｏ－メチルリッチ完全安定化オリゴヌクレオチド |
| EP3844274A1 (en) | 2018-08-28 | 2021-07-07 | Roche Innovation Center Copenhagen A/S | Neoantigen engineering using splice modulating compounds |
| EP3850088A4 (en) | 2018-09-07 | 2023-07-19 | Beam Therapeutics, Inc. | Compositions and methods for improving base editing |
| AU2019336245B2 (en) | 2018-09-07 | 2026-02-26 | Beam Therapeutics Inc. | Compositions and methods for delivering a nucleobase editing system |
| EP4527931A1 (en) * | 2018-10-12 | 2025-03-26 | Peking University | Methods and compositions for editing rnas |
| WO2020150636A1 (en) | 2019-01-18 | 2020-07-23 | University Of Massachusetts | Dynamic pharmacokinetic-modifying anchors |
| JP2022519184A (ja) | 2019-01-22 | 2022-03-22 | コロ バイオ， インコーポレイテッド | Ｒｎａ編集オリゴヌクレオチド及びその使用 |
| CA3127243A1 (en) | 2019-01-22 | 2020-07-30 | Korro Bio, Inc. | Rna-editing oligonucleotides and uses thereof |
| CA3126947A1 (en) * | 2019-01-22 | 2020-07-30 | Korro Bio, Inc. | Rna-editing oligonucleotides and uses thereof |
| WO2020157008A1 (en) | 2019-01-28 | 2020-08-06 | Proqr Therapeutics Ii B.V. | Rna-editing oligonucleotides for the treatment of usher syndrome |
| GB201901873D0 (en) | 2019-02-11 | 2019-04-03 | Proqr Therapeutics Ii Bv | Antisense oligonucleotides for nucleic acid editing |
| AU2020223314A1 (en) | 2019-02-13 | 2021-08-12 | Beam Therapeutics Inc. | Compositions and methods for treating alpha-1 antitrypsin deficiency |
| SG11202108346WA (en) | 2019-02-13 | 2021-08-30 | Beam Therapeutics Inc | Modified immune cells having adenosine deaminase base editors for modifying a nucleobase in a target sequence |
| US11820985B2 (en) | 2019-03-26 | 2023-11-21 | University Of Massachusetts | Modified oligonucleotides with increased stability |
| GB201904709D0 (en) | 2019-04-03 | 2019-05-15 | Proqr Therapeutics Ii Bv | Chemically modified oligonucleotides |
| PH12021552613A1 (en) | 2019-04-15 | 2022-06-27 | Edigene Therapeutics Beijing Inc | METHODS AND COMPOSITIONS FOR EDITING RNAs |
| GB201905732D0 (en) | 2019-04-24 | 2019-06-05 | Proqr Therapeutics Ii Bv | RNA editing inhibitors and methods of use |
| AU2020287787A1 (en) * | 2019-06-05 | 2022-01-20 | Daiichi Sankyo Company, Limited | Stable target-editing guide RNA having chemically modified nucleic acid introduced thereinto |
| AU2020290517B2 (en) * | 2019-06-13 | 2026-02-26 | Proqr Therapeutics Ii B.V. | Antisense RNA editing oligonucleotides comprising cytidine analogs |
| CN114269919B (zh) | 2019-07-12 | 2023-08-18 | 北京大学 | 采用工程化rna利用内源adar进行靶向的rna编辑 |
| US20220275359A1 (en) | 2019-08-01 | 2022-09-01 | Astellas Pharma Inc. | Guide rna for editing target, with functional nucleotide sequence added |
| CA3149835A1 (en) | 2019-08-09 | 2021-02-18 | University Of Massachusetts | Chemically modified oligonucleotides targeting snps |
| US12365894B2 (en) | 2019-09-16 | 2025-07-22 | University Of Massachusetts | Branched lipid conjugates of siRNA for specific tissue delivery |
| CN115279398B (zh) | 2019-09-27 | 2025-07-04 | 比姆医疗股份有限公司 | 治疗液态癌症的组合物和方法 |
| CA3154768A1 (en) * | 2019-10-06 | 2021-04-15 | Wave Life Sciences Ltd. | Oligonucleotide compositions and methods of use thereof |
| AU2020375040A1 (en) * | 2019-11-01 | 2022-05-19 | Tevard Biosciences, Inc. | Methods and compositions for treating a premature termination codon-mediated disorder |
| AU2020395113A1 (en) | 2019-12-02 | 2022-06-09 | Shape Therapeutics Inc. | Therapeutic editing |
| JP7754721B2 (ja) | 2019-12-09 | 2025-10-15 | アステラス製薬株式会社 | 標的ｒｎａを編集するための機能性領域を付加したアンチセンス型ガイドｒｎａ |
| JP7765837B2 (ja) | 2019-12-23 | 2025-11-07 | プロキューアール セラピューティクス ツー ベスローテン フェンノートシャップ | シュタルガルト病の処置におけるヌクレオチド脱アミノ化のためのアンチセンスオリゴヌクレオチド |
| PH12022551595A1 (en) * | 2019-12-30 | 2023-11-29 | Edigene Therapeutics Beijing Inc | Leaper technology based method for treating mps ih and composition |
| CN113122580A (zh) * | 2019-12-30 | 2021-07-16 | 博雅辑因（北京）生物科技有限公司 | 一种基于leaper技术治疗mps ih的方法和组合物 |
| CN114728080A (zh) * | 2019-12-31 | 2022-07-08 | 博雅辑因（北京）生物科技有限公司 | 一种靶向编辑rna的新方法 |
| US12146136B2 (en) | 2020-03-26 | 2024-11-19 | University Of Massachusetts | Synthesis of modified oligonucleotides with increased stability |
| CN113528582B (zh) * | 2020-04-15 | 2022-05-17 | 博雅辑因（北京）生物科技有限公司 | 基于leaper技术靶向编辑rna的方法和药物 |
| PH12022552687A1 (en) | 2020-04-15 | 2024-03-25 | Edigene Therapeutics Beijing Inc | Method and drug for treating hurler syndrome |
| WO2021231673A1 (en) * | 2020-05-15 | 2021-11-18 | Korro Bio, Inc. | Methods and compositions for the adar-mediated editing of leucine rich repeat kinase 2 (lrrk2) |
| EP4149518A4 (en) * | 2020-05-15 | 2024-08-21 | Korro Bio, Inc. | METHODS AND COMPOSITIONS FOR ADAR-MEDIATED PROCESSING OF ABCA4 |
| EP4150088A1 (en) * | 2020-05-15 | 2023-03-22 | Korro Bio, Inc. | Methods and compositions for the adar-mediated editing of argininosuccinate synthetase (ass1) |
| WO2021231691A1 (en) * | 2020-05-15 | 2021-11-18 | Korro Bio, Inc. | Methods and compositions for the adar-mediated editing of retinoschisin 1 (rsi) |
| WO2021231692A1 (en) * | 2020-05-15 | 2021-11-18 | Korro Bio, Inc. | Methods and compositions for the adar-mediated editing of otoferlin (otof) |
| WO2021231680A1 (en) * | 2020-05-15 | 2021-11-18 | Korro Bio, Inc. | Methods and compositions for the adar-mediated editing of methyl-cpg binding protein 2 (mecp2) |
| WO2021231679A1 (en) * | 2020-05-15 | 2021-11-18 | Korro Bio, Inc. | Methods and compositions for the adar-mediated editing of gap junction protein beta 2 (gjb2) |
| WO2021231698A1 (en) * | 2020-05-15 | 2021-11-18 | Korro Bio, Inc. | Methods and compositions for the adar-mediated editing of argininosuccinate lyase (asl) |
| EP4150077A1 (en) * | 2020-05-15 | 2023-03-22 | Korro Bio, Inc. | Methods and compositions for the adar-mediated editing of transmembrane channel-like protein 1 (tmc1) |
| WO2021242870A1 (en) * | 2020-05-26 | 2021-12-02 | Shape Therapeutics Inc. | Compositions and methods for genome editing |
| EP4157289A4 (en) | 2020-05-26 | 2024-06-26 | University Of Massachusetts | Synthetic oligonucleotides having regions of block and cluster modifications |
| KR20230033651A (ko) * | 2020-05-28 | 2023-03-08 | 코로 바이오, 인크. | Serpina1의 adar-매개 편집을 위한 방법 및 조성물 |
| GB202011428D0 (en) * | 2020-07-23 | 2020-09-09 | Proqr Therapeutics Ii Bv | Antisense oligonucleotides for RNA editing |
| US12576151B2 (en) | 2020-09-25 | 2026-03-17 | Beam Therapeutics Inc. | Fratricide resistant modified immune cells and methods of using the same |
| CN114380918B (zh) * | 2020-10-19 | 2023-03-31 | 上海交通大学 | 一种目标rna单碱基编辑的系统和方法 |
| KR20230118716A (ko) * | 2020-11-08 | 2023-08-11 | 웨이브 라이프 사이언시스 리미티드 | 올리고뉴클레오티드 조성물 및 이의 방법 |
| IL303533A (en) * | 2020-12-08 | 2023-08-01 | Univ Fukuoka | RNA is a stable guide for editing targets into which chemically modified nucleic acids are inserted |
| EP4098745A1 (en) | 2021-06-01 | 2022-12-07 | Eberhard-Karls-Universität Tübingen | Antisense oligonucleotides (aso) for efficient and precise rna editing with endogenous adenosine deaminase acting on rna (adar) |
| US20250034564A1 (en) * | 2021-06-29 | 2025-01-30 | Korro Bio, Inc. | Methods and Compositions for ADAR-Mediated Editing |
| JP7780172B2 (ja) * | 2021-07-30 | 2025-12-04 | 国立研究開発法人理化学研究所 | 筋萎縮性側索硬化症におけるｃｅｐ２９０遺伝子の変異 |
| EP4168581B1 (en) * | 2021-08-11 | 2023-09-13 | Hummingbird Diagnostics GmbH | Advanced dumbbell pcr for isomir detection |
| US20250001011A1 (en) * | 2021-08-18 | 2025-01-02 | Peking University | Engineered adar-recruiting rnas and methods of use thereof |
| EP4405478A1 (en) | 2021-09-20 | 2024-07-31 | Alnylam Pharmaceuticals, Inc. | Inhibin subunit beta e (inhbe) modulator compositions and methods of use thereof |
| EP4408999A1 (en) | 2021-09-29 | 2024-08-07 | F. Hoffmann-La Roche AG | Rna editing |
| CA3238033A1 (en) * | 2021-11-30 | 2023-06-08 | Eberhard Karls Universitat Tubingen | Antisense oligonucleotides (aso) for efficient and precise rna editing with endogenous adenosine deaminase acting on rna (adar) |
| WO2023143539A1 (en) * | 2022-01-28 | 2023-08-03 | Edigene Therapeutics (Beijing) Inc. | Engineered adar-recruiting rnas and methods of use thereof |
| US20250154504A1 (en) | 2022-02-14 | 2025-05-15 | Proqr Therapeutics Ii B.V. | Guide oligonucleotides for nucleic acid editing in the treatment of hypercholesterolemia |
| CN119452084A (zh) * | 2022-05-12 | 2025-02-14 | 波涛生命科学有限公司 | 寡核苷酸组合物及其方法 |
| CN115010794A (zh) * | 2022-06-30 | 2022-09-06 | 武汉瑞佶生物科技有限公司 | 蛋白质介导的mRNA靶向分子及其制备方法和应用 |
| EP4555085A1 (en) | 2022-07-15 | 2025-05-21 | ProQR Therapeutics II B.V. | Chemically modified oligonucleotides for adar-mediated rna editing |
| EP4555086A1 (en) | 2022-07-15 | 2025-05-21 | ProQR Therapeutics II B.V. | Oligonucleotides for adar-mediated rna editing and use thereof |
| GB202215614D0 (en) | 2022-10-21 | 2022-12-07 | Proqr Therapeutics Ii Bv | Heteroduplex rna editing oligonucleotide complexes |
| WO2024092189A2 (en) * | 2022-10-27 | 2024-05-02 | Arizona Board Of Regents On Behalf Of Arizona State University | Compositions and methods related to nucleic acid sensors |
| WO2024110565A1 (en) | 2022-11-24 | 2024-05-30 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for the treatment of hereditary hfe-hemochromatosis |
| US20250101418A1 (en) | 2022-11-30 | 2025-03-27 | Eberhard-Karls-Universität-Tübingen | Chemically modified antisense oligonucleotides (asos) and compositions comprising the same for rna editing |
| GB202218090D0 (en) | 2022-12-01 | 2023-01-18 | Proqr Therapeutics Ii Bv | Antisense oligonucleotides for the treatment of aldehyde dehydrogenase 2 deficiency |
| CN120322556A (zh) | 2022-12-09 | 2025-07-15 | ProQR治疗上市公司Ⅱ | 用于治疗心血管疾病的反义寡核苷酸 |
| GB202300865D0 (en) | 2023-01-20 | 2023-03-08 | Proqr Therapeutics Ii Bv | Delivery of oligonucleotides |
| WO2024175550A1 (en) | 2023-02-20 | 2024-08-29 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for the treatment of atherosclerotic cardiovascular disease |
| EP4432289A1 (en) | 2023-03-15 | 2024-09-18 | Shape Therapeutics Inc. | Generative sequence screening with conditional gans, diffusion models, and denoising diffusion conditional gans |
| GB202304363D0 (en) | 2023-03-24 | 2023-05-10 | Proqr Therapeutics Ii Bv | Chemically modified antisense oligonucleotides for use in RNA editing |
| JP2026510408A (ja) | 2023-03-24 | 2026-04-02 | プロキューアール セラピューティクス ツー ベスローテン フェンノートシャップ | 神経障害の処置のためのアンチセンスオリゴヌクレオチド |
| CN121002181A (zh) | 2023-03-27 | 2025-11-21 | ProQR治疗上市公司Ⅱ | 用于治疗肝脏疾病的反义寡核苷酸 |
| EP4698645A1 (en) | 2023-04-21 | 2026-02-25 | University of Rochester | Nucleic acid molecules for pseudouridylation |
| CN118853661A (zh) * | 2023-04-28 | 2024-10-29 | 时夕(广州)生物科技有限公司 | 编辑rna的方法、组合物及其应用 |
| AR132964A1 (es) | 2023-06-16 | 2025-08-13 | Proqr Therapeutics Ii Bv | Oligonucleótidos antisentido para el tratamiento de enfermedades neurodegenerativas |
| AU2024287308A1 (en) * | 2023-07-13 | 2025-12-18 | Korro Bio, Inc. | Rna-editing oligonucleotides and uses thereof |
| CN121794378A (zh) | 2023-08-15 | 2026-04-03 | 艾尔纳公司 | 用于rna编辑的化学修饰的反义寡核苷酸（aso）及组合物 |
| WO2025051946A1 (en) | 2023-09-07 | 2025-03-13 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for the treatment of metabolic disorders |
| WO2025073902A1 (en) | 2023-10-06 | 2025-04-10 | Eberhard Karls Universität Tübingen | Chemical and sequence optimisation of antisense oligonucleotides for adar-mediated rna editing |
| WO2025083268A1 (en) | 2023-10-20 | 2025-04-24 | Airna Corporation | Chemically modified antisense oligonucleotides (asos) and compositions comprising the same for rna editing |
| AU2024379264A1 (en) | 2023-11-16 | 2026-05-14 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for the treatment of classic galactosemia |
| WO2025128799A1 (en) * | 2023-12-12 | 2025-06-19 | Korro Bio, Inc. | Double-stranded rna-editing oligonucleotides and uses thereof |
| WO2025132708A1 (en) | 2023-12-20 | 2025-06-26 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for the treatment of huntington's disease |
| WO2025155911A1 (en) | 2024-01-18 | 2025-07-24 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for the treatment of hurler syndrome |
| GB202404661D0 (en) | 2024-04-02 | 2024-05-15 | Proqr Therapeutics Ii Bv | Antisense oligoncleotides for the treatment of liver disease |
| GB202405143D0 (en) | 2024-04-11 | 2024-05-29 | Proqr Therapeutics Ii Bv | Antisense oligonucleotides for the treatment of poly-q disease |
| WO2025224230A1 (en) | 2024-04-25 | 2025-10-30 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for the treatment of fatty liver disease |
| GB202410081D0 (en) | 2024-07-11 | 2024-08-28 | Proqr Therapeutics Ii Bv | Antisense oligonucleotides for the treatment of cardiovascular disease |
| WO2026022136A1 (en) | 2024-07-23 | 2026-01-29 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for the treatment of metabolic disorders |
| WO2026060374A2 (en) | 2024-09-16 | 2026-03-19 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for the treatment of neurological disorders |
| WO2026068781A1 (en) | 2024-09-30 | 2026-04-02 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for the treatment of liver disease |
| WO2026080897A1 (en) | 2024-10-11 | 2026-04-16 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for the treatment of chronic pain |
| WO2026093339A1 (en) | 2024-10-29 | 2026-05-07 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for the treatment of peroxisome biogenesis disorders in the zellweger spectrum (pbd-zsd) |
Family Cites Families (165)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0724447B1 (en) | 1991-10-24 | 2003-05-07 | Isis Pharmaceuticals, Inc. | Derivatized oligonucleotides having improved uptake |
| US5952221A (en) | 1996-03-06 | 1999-09-14 | Avigen, Inc. | Adeno-associated virus vectors comprising a first and second nucleic acid sequence |
| NZ514348A (en) | 1999-05-04 | 2004-05-28 | Exiqon As | L-ribo-LNA analogues |
| EP1191097A1 (en) | 2000-09-21 | 2002-03-27 | Leids Universitair Medisch Centrum | Induction of exon skipping in eukaryotic cells |
| WO2005007855A2 (en) | 2003-07-14 | 2005-01-27 | Sirna Therapeutics, Inc. | RNA INTERFERENCE MEDIATED INHIBITION OF B7-H1 GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
| US20060276422A1 (en) | 2001-05-18 | 2006-12-07 | Nassim Usman | RNA interference mediated inhibition of B7-H1 gene expression using short interfering nucleic acid (siNA) |
| CA2521464C (en) | 2003-04-09 | 2013-02-05 | Alnylam Pharmaceuticals, Inc. | Irna conjugates |
| US20050074801A1 (en) * | 2003-09-09 | 2005-04-07 | Monia Brett P. | Chimeric oligomeric compounds comprising alternating regions of northern and southern conformational geometry |
| WO2005087949A1 (en) | 2004-03-12 | 2005-09-22 | Compugen Ltd. | Systematic mapping of adenosine to inosine editing sites in the human transcriptome |
| WO2005094370A2 (en) | 2004-03-29 | 2005-10-13 | The General Hospital Corporation | Oligonucleotide complex compositions and methods of use as gene alteration tools |
| US8053212B1 (en) | 2004-08-28 | 2011-11-08 | Steven Albert Benner | Non-standard nucleoside analogs with reduced epimerization |
| US8389703B1 (en) | 2004-08-28 | 2013-03-05 | Steven A. Benner | Ribonucleoside analogs with novel hydrogen bonding patterns |
| DK3428191T3 (da) | 2004-10-06 | 2025-01-02 | Mayo Found Medical Education & Res | B7-h1 og pd-1 til behandling af renalcellekarcinom |
| WO2007031091A2 (en) | 2005-09-15 | 2007-03-22 | Santaris Pharma A/S | Rna antagonist compounds for the modulation of p21 ras expression |
| JP5252622B2 (ja) | 2007-01-17 | 2013-07-31 | 独立行政法人産業技術総合研究所 | 高いヌクレアーゼ耐性と優れたｒｎａ干渉効果を発現可能な二本鎖ｒｎａ |
| WO2008152146A1 (en) * | 2007-06-13 | 2008-12-18 | Biocortech | Peripherical tissue sample containing cells expressing the 5htr2c and/or adars as markers of the alteration of the mechanism of the 5htr2c mrna editing and its applications |
| US7625555B2 (en) * | 2007-06-18 | 2009-12-01 | Novagen Holding Corporation | Recombinant human interferon-like proteins |
| WO2010064231A1 (en) | 2008-12-02 | 2010-06-10 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Methods of analyzing a-i rna editing and nucleic acid constructs capable of same |
| SG171914A1 (en) | 2008-12-02 | 2011-07-28 | Chiralgen Ltd | Method for the synthesis of phosphorus atom modified nucleic acids |
| ES2628144T3 (es) | 2009-04-03 | 2017-08-01 | Dicerna Pharmaceuticals, Inc. | Métodos y composiciones para la inhibición específica de KRAS por RNA bicatenario asimétrico |
| EP2451461A4 (en) | 2009-07-06 | 2013-05-29 | Ontorii Inc | NOVEL NUCLEIC ACID PRODRUGS AND METHOD OF USE THEREOF |
| US9012421B2 (en) | 2009-08-06 | 2015-04-21 | Isis Pharmaceuticals, Inc. | Bicyclic cyclohexose nucleic acid analogs |
| JP5685267B2 (ja) | 2009-12-09 | 2015-03-18 | 日東電工株式会社 | Ｈｓｐ４７発現の調節 |
| CN111700901A (zh) | 2010-01-08 | 2020-09-25 | Ionis制药公司 | 血管生成素样3表达的调节 |
| BR112012024049A2 (pt) | 2010-03-24 | 2017-03-01 | Rxi Pharmaceuticals Corp | interferência de rna em indicações dérmicas e fibróticas |
| AU2011237630B2 (en) | 2010-04-06 | 2016-01-21 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of CD274/PD-L1 gene |
| CA2804210A1 (en) * | 2010-07-06 | 2012-01-12 | Dicerna Pharmaceuticals, Inc. | Methods and compositions for the specific inhibition of androgen receptor by double-stranded rna |
| US20140128449A1 (en) | 2011-04-07 | 2014-05-08 | The Board Of Regents Of The University Of Texas System | Oligonucleotide modulation of splicing |
| US9238814B2 (en) | 2011-05-20 | 2016-01-19 | Fukuoka University | Ribozyme for identifying modification on RNA sequence and RNA cleavage method using same |
| EP3640332A1 (en) | 2011-08-29 | 2020-04-22 | Ionis Pharmaceuticals, Inc. | Oligomer-conjugate complexes and their use |
| MY167390A (en) | 2011-11-18 | 2018-08-16 | Alnylam Pharmaceuticals Inc | Rnai agents, compositions and methods of use thereof for treating transthyretin (ttr) associated diseases |
| EP2850092B1 (en) | 2012-04-09 | 2017-03-01 | Ionis Pharmaceuticals, Inc. | Tricyclic nucleic acid analogs |
| US9605255B2 (en) | 2012-07-12 | 2017-03-28 | Proqr Therapeutics Ii B.V. | Oligonucleotides for making a change in the sequence of a target RNA molecule present in a living cell |
| CN112007045B (zh) | 2012-07-13 | 2026-01-06 | 波涛生命科学有限公司 | 手性控制 |
| DK2872485T3 (da) | 2012-07-13 | 2021-03-08 | Wave Life Sciences Ltd | Asymmetrisk hjælpegruppe |
| US9650627B1 (en) | 2012-07-19 | 2017-05-16 | University Of Puerto Rico | Site-directed RNA editing |
| SG10201804331TA (en) | 2012-11-15 | 2018-07-30 | Roche Innovation Ct Copenhagen As | Oligonucleotide conjugates |
| NZ627796A (en) | 2012-12-18 | 2017-07-28 | Icahn School Med Mount Sinai | Influenza virus vaccines and uses thereof |
| CA2921162A1 (en) | 2013-05-01 | 2014-11-06 | Ionis Pharmaceuticals, Inc. | Conjugated antisense compounds and their use |
| EP3010514B1 (en) | 2013-06-16 | 2021-01-20 | National University Corporation Tokyo Medical and Dental University | Double-stranded antisense nucleic acid with exon-skipping effect |
| AU2014300981B2 (en) | 2013-06-27 | 2017-08-10 | Ricc A/S | Antisense oligomers and conjugates targeting PCSK9 |
| KR102423317B1 (ko) | 2014-01-16 | 2022-07-22 | 웨이브 라이프 사이언시스 리미티드 | 키랄 디자인 |
| US10131910B2 (en) | 2014-07-10 | 2018-11-20 | Stichting Katholieke Universiteit | Antisense oligonucleotides for the treatment of Usher syndrome type 2 |
| GB201418892D0 (en) | 2014-10-23 | 2014-12-10 | Proqr Therapeutics B V | DNA editing |
| JP2017536119A (ja) | 2014-11-19 | 2017-12-07 | ロシュ イノベーション センター コペンハーゲン エーエス | キラルホスホロチオエート連結を含むｌｎａギャップマーオリゴヌクレオチド |
| WO2016089433A1 (en) | 2014-12-03 | 2016-06-09 | Agilent Technologies, Inc. | Guide rna with chemical modifications |
| US12359197B2 (en) * | 2014-12-12 | 2025-07-15 | Etagen Pharma, Inc. | Compositions and methods for editing nucleic acids in cells utilizing oligonucleotides |
| US10815481B2 (en) | 2014-12-16 | 2020-10-27 | Roche Innovation Center Copenhagen A/S | Chiral library screen |
| ES2810375T3 (es) * | 2014-12-17 | 2021-03-08 | Proqr Therapeutics Ii Bv | Edición direccionada de ARN |
| GB201503408D0 (en) | 2015-02-27 | 2015-04-15 | Proqr Therapeutics N V | Oligonucleotides |
| WO2016138278A2 (en) | 2015-02-27 | 2016-09-01 | Idera Pharmaceuticals, Inc. | Compositions for inhibiting checkpoint gene expression and uses thereof |
| JP6624743B2 (ja) | 2015-07-14 | 2019-12-25 | 学校法人福岡大学 | 部位特異的ｒｎａ変異導入方法およびそれに使用する標的編集ガイドｒｎａならびに標的ｒｎａ−標的編集ガイドｒｎａ複合体 |
| WO2017015575A1 (en) | 2015-07-22 | 2017-01-26 | Wave Life Sciences Ltd. | Oligonucleotide compositions and methods thereof |
| EP3353298B1 (en) | 2015-09-21 | 2023-09-13 | Arcturus Therapeutics, Inc. | Allele selective gene editing and uses thereof |
| DE102015012522B3 (de) | 2015-09-26 | 2016-06-02 | Eberhard Karls Universität Tübingen | Verfahren und Substanzen zur gerichteten RNA-Editierung |
| EP3359523A4 (en) | 2015-10-09 | 2019-07-24 | Wave Life Sciences Ltd. | OLIGONUCLEOTIDE COMPOSITIONS AND METHOD THEREFOR |
| EP3387131A4 (en) | 2015-12-09 | 2019-08-07 | Alnylam Pharmaceuticals, Inc. | AGAINST PROGRAMMED CELL DEOD 1 LIGAND 1 (PD-L1) POLYNUCLEOTIDE AGENT AND METHOD OF USE THEREOF |
| AU2017234150B2 (en) | 2016-03-13 | 2021-09-16 | Wave Life Sciences Ltd. | Compositions and methods for phosphoramidite and oligonucleotide synthesis |
| TWI794662B (zh) | 2016-03-14 | 2023-03-01 | 瑞士商赫孚孟拉羅股份公司 | 用於降低pd-l1表現之寡核苷酸 |
| CA3021899A1 (en) | 2016-04-25 | 2017-11-02 | Proqr Therapeutics Ii B.V. | Oligonucleotides to treat eye disease |
| JP2019516680A (ja) | 2016-05-04 | 2019-06-20 | ウェイブ ライフ サイエンシズ リミテッドＷａｖｅ Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ Ｌｔｄ． | オリゴヌクレオチド組成物およびその方法 |
| US20190249173A1 (en) | 2016-05-04 | 2019-08-15 | Chandra Vargeese | Methods and compositions of biologically active agents |
| EP3458464B1 (en) | 2016-05-18 | 2026-04-15 | ETH Zurich | Stereoselective synthesis of phosphorothioate oligoribonucleotides |
| US11013757B2 (en) | 2016-06-03 | 2021-05-25 | Wave Life Sciences Ltd. | Oligonucleotides, compositions and methods thereof |
| US10767175B2 (en) | 2016-06-08 | 2020-09-08 | Agilent Technologies, Inc. | High specificity genome editing using chemically modified guide RNAs |
| EP3475424A1 (en) * | 2016-06-22 | 2019-05-01 | ProQR Therapeutics II B.V. | Single-stranded rna-editing oligonucleotides |
| US20180028554A1 (en) | 2016-07-05 | 2018-02-01 | Biomarin Technologies B.V. | Oligomers Having Bicyclic Scaffold Moeities |
| KR20250103795A (ko) | 2016-08-03 | 2025-07-07 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 아데노신 핵염기 편집제 및 그의 용도 |
| CA3035293A1 (en) | 2016-09-01 | 2018-03-08 | Proqr Therapeutics Ii B.V. | Chemically modified single-stranded rna-editing oligonucleotides |
| GB201616202D0 (en) | 2016-09-23 | 2016-11-09 | Proqr Therapeutics Ii Bv | Antisense oligonucleotides for the treatment of eye deisease |
| JP7296882B2 (ja) | 2016-11-23 | 2023-06-23 | ウェイブ ライフ サイエンシズ リミテッド | ホスホラミダイト及びオリゴヌクレオチド合成のための組成物及び方法 |
| MX420023B (es) | 2016-12-30 | 2025-01-14 | Editas Medicine Inc | Moléculas guía sintéticas, composiciones y métodos relacionados con éstas. |
| EP3571300A1 (en) | 2017-01-19 | 2019-11-27 | ProQR Therapeutics II B.V. | Oligonucleotide complexes for use in rna editing |
| CN111050806A (zh) | 2017-06-02 | 2020-04-21 | 波涛生命科学有限公司 | 寡核苷酸组合物及其使用方法 |
| EP3630788A4 (en) | 2017-06-02 | 2021-04-28 | Wave Life Sciences Ltd. | OLIGONUCLEOTIDE COMPOSITIONS AND METHODS FOR THEIR USE |
| WO2018223081A1 (en) | 2017-06-02 | 2018-12-06 | Wave Life Sciences Ltd. | Oligonucleotide compositions and methods of use thereof |
| WO2018237194A1 (en) | 2017-06-21 | 2018-12-27 | Wave Life Sciences Ltd. | Compounds, compositions and methods for synthesis |
| CA3064601A1 (en) | 2017-06-26 | 2019-01-03 | President And Fellows Of Harvard College | Crispr/cas-adenine deaminase based compositions, systems, and methods for targeted nucleic acid editing |
| SG10201705285SA (en) | 2017-06-27 | 2019-01-30 | Agency Science Tech & Res | Antisense oligonucleotides |
| TW201920672A (zh) | 2017-08-08 | 2019-06-01 | 新加坡商波濤生命科學有限公司 | 寡核苷酸組合物及其使用方法 |
| GB201714027D0 (en) | 2017-09-01 | 2017-10-18 | Proqr Therapeutics Ii Bv | Antisense oligonucleotides for the treatment of huntington's disease |
| US11608355B2 (en) | 2017-09-18 | 2023-03-21 | Wave Life Sciences Ltd. | Technologies for oligonucleotide preparation |
| US20200291383A1 (en) | 2017-10-06 | 2020-09-17 | Oregon Health & Science University | Compositions and methods for editing rna |
| US11596646B2 (en) | 2017-10-12 | 2023-03-07 | Wave Life Sciences Ltd. | Oligonucleotide compositions and methods thereof |
| US11795443B2 (en) | 2017-10-16 | 2023-10-24 | The Broad Institute, Inc. | Uses of adenosine base editors |
| WO2019104094A2 (en) | 2017-11-21 | 2019-05-31 | The Regents Of The University Of California | Fusion proteins and methods for site-directed genome editing |
| JP7333508B2 (ja) | 2017-12-06 | 2023-08-25 | 学校法人福岡大学 | オリゴヌクレオチド、その製造方法及び標的ｒｎａの部位特異的編集方法 |
| WO2019111957A1 (ja) | 2017-12-06 | 2019-06-13 | 学校法人福岡大学 | オリゴヌクレオチド、その製造方法及び標的ｒｎａの部位特異的編集方法 |
| WO2019158475A1 (en) | 2018-02-14 | 2019-08-22 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for rna editing |
| CA3095311A1 (en) | 2018-03-27 | 2019-10-03 | University Of Rochester | Nucleic acid molecules for pseudouridylation |
| IL277889B2 (en) | 2018-04-12 | 2025-01-01 | Wave Life Sciences Ltd | Oligonucleotide preparations and methods of using them |
| SG11202010131QA (en) | 2018-05-11 | 2020-11-27 | Wave Life Sciences Ltd | Oligonucleotide compositions and methods of use thereof |
| GB201808146D0 (en) | 2018-05-18 | 2018-07-11 | Proqr Therapeutics Ii Bv | Stereospecific Linkages in RNA Editing Oligonucleotides |
| JP7347830B2 (ja) | 2018-06-29 | 2023-09-20 | エバーハルト カール ウニヴェルジテート テュービンゲン | Ｒｎａ編集のための人工核酸 |
| CN113383078A (zh) | 2018-12-06 | 2021-09-10 | 波涛生命科学有限公司 | 寡核苷酸组合物及其方法 |
| BR112021012222A8 (pt) | 2018-12-21 | 2023-04-25 | Univ Berlin Charite | Molécula de ligação direcionada à célula melhorada |
| JP2022519184A (ja) | 2019-01-22 | 2022-03-22 | コロ バイオ， インコーポレイテッド | Ｒｎａ編集オリゴヌクレオチド及びその使用 |
| CA3127243A1 (en) | 2019-01-22 | 2020-07-30 | Korro Bio, Inc. | Rna-editing oligonucleotides and uses thereof |
| CA3126947A1 (en) | 2019-01-22 | 2020-07-30 | Korro Bio, Inc. | Rna-editing oligonucleotides and uses thereof |
| WO2020157008A1 (en) | 2019-01-28 | 2020-08-06 | Proqr Therapeutics Ii B.V. | Rna-editing oligonucleotides for the treatment of usher syndrome |
| BR112021014940A2 (pt) | 2019-02-01 | 2021-09-28 | Wave Life Sciences Ltd. | Oligonucleotídeo, composição de oligonucleotídeo quiralmente controlada, composição farmacêutica, e método de tratamento, prevenção, atraso de início e/ou diminuição da gravidade de pelo menos um sintoma de doença de huntington |
| GB201901873D0 (en) | 2019-02-11 | 2019-04-03 | Proqr Therapeutics Ii Bv | Antisense oligonucleotides for nucleic acid editing |
| US12590115B2 (en) | 2019-03-20 | 2026-03-31 | Wave Life Sciences Ltd. | Technologies useful for oligonucleotide preparation |
| JPWO2020196662A1 (pl) | 2019-03-25 | 2020-10-01 | ||
| CA3132178A1 (en) | 2019-04-02 | 2020-10-08 | Aliye Seda Yilmaz-Elis | Antisense oligonucleotides for immunotherapy |
| GB201904709D0 (en) | 2019-04-03 | 2019-05-15 | Proqr Therapeutics Ii Bv | Chemically modified oligonucleotides |
| PH12021552613A1 (en) | 2019-04-15 | 2022-06-27 | Edigene Therapeutics Beijing Inc | METHODS AND COMPOSITIONS FOR EDITING RNAs |
| GB201905732D0 (en) | 2019-04-24 | 2019-06-05 | Proqr Therapeutics Ii Bv | RNA editing inhibitors and methods of use |
| AU2020262485A1 (en) | 2019-04-25 | 2021-11-11 | Wave Life Sciences Ltd. | Oligonucleotide compositions and methods of use thereof |
| EP3958872A4 (en) | 2019-04-25 | 2024-07-03 | Wave Life Sciences Ltd. | Oligonucleotide compositions and methods of use thereof |
| CN114502177A (zh) | 2019-05-09 | 2022-05-13 | 波涛生命科学有限公司 | 寡核苷酸组合物及其使用方法 |
| AU2020287787A1 (en) | 2019-06-05 | 2022-01-20 | Daiichi Sankyo Company, Limited | Stable target-editing guide RNA having chemically modified nucleic acid introduced thereinto |
| AU2020290517B2 (en) | 2019-06-13 | 2026-02-26 | Proqr Therapeutics Ii B.V. | Antisense RNA editing oligonucleotides comprising cytidine analogs |
| CN114269919B (zh) | 2019-07-12 | 2023-08-18 | 北京大学 | 采用工程化rna利用内源adar进行靶向的rna编辑 |
| US20220275359A1 (en) | 2019-08-01 | 2022-09-01 | Astellas Pharma Inc. | Guide rna for editing target, with functional nucleotide sequence added |
| CN114514318B (zh) | 2019-09-27 | 2025-01-10 | 弗雷斯特公司 | 寡核苷酸和靶rna的位点特异性编辑方法 |
| CA3154768A1 (en) | 2019-10-06 | 2021-04-15 | Wave Life Sciences Ltd. | Oligonucleotide compositions and methods of use thereof |
| CA3156176A1 (en) | 2019-10-06 | 2021-04-15 | Wave Life Sciences Ltd. | Oligonucleotide compositions and methods of use thereof |
| AU2020395113A1 (en) | 2019-12-02 | 2022-06-09 | Shape Therapeutics Inc. | Therapeutic editing |
| WO2021113390A1 (en) | 2019-12-02 | 2021-06-10 | Shape Therapeutics Inc. | Compositions for treatment of diseases |
| JP7754721B2 (ja) | 2019-12-09 | 2025-10-15 | アステラス製薬株式会社 | 標的ｒｎａを編集するための機能性領域を付加したアンチセンス型ガイドｒｎａ |
| EP3838910B1 (en) | 2019-12-18 | 2022-09-28 | Freie Universität Berlin | Efficient gene delivery tool with a wide therapeutic margin |
| JP7765837B2 (ja) | 2019-12-23 | 2025-11-07 | プロキューアール セラピューティクス ツー ベスローテン フェンノートシャップ | シュタルガルト病の処置におけるヌクレオチド脱アミノ化のためのアンチセンスオリゴヌクレオチド |
| EP4086346A4 (en) | 2019-12-30 | 2024-03-20 | EdiGene Therapeutics (Beijing) Inc. | METHOD FOR TREATMENT OF USHER SYNDROME AND ASSOCIATED COMPOSITION |
| PH12022551595A1 (en) | 2019-12-30 | 2023-11-29 | Edigene Therapeutics Beijing Inc | Leaper technology based method for treating mps ih and composition |
| EP4100519A2 (en) | 2020-02-05 | 2022-12-14 | The Broad Institute, Inc. | Adenine base editors and uses thereof |
| JP2023515862A (ja) | 2020-03-01 | 2023-04-14 | ウェイブ ライフ サイエンシズ リミテッド | オリゴヌクレオチド組成物及びその方法 |
| US20240247258A1 (en) | 2020-03-12 | 2024-07-25 | Frest Inc. | Oligonucleotide and target rna site-specific editing method |
| PH12022552687A1 (en) | 2020-04-15 | 2024-03-25 | Edigene Therapeutics Beijing Inc | Method and drug for treating hurler syndrome |
| WO2021216853A1 (en) | 2020-04-22 | 2021-10-28 | Shape Therapeutics Inc. | Compositions and methods using snrna components |
| WO2021231673A1 (en) | 2020-05-15 | 2021-11-18 | Korro Bio, Inc. | Methods and compositions for the adar-mediated editing of leucine rich repeat kinase 2 (lrrk2) |
| WO2021231679A1 (en) | 2020-05-15 | 2021-11-18 | Korro Bio, Inc. | Methods and compositions for the adar-mediated editing of gap junction protein beta 2 (gjb2) |
| EP4149518A4 (en) | 2020-05-15 | 2024-08-21 | Korro Bio, Inc. | METHODS AND COMPOSITIONS FOR ADAR-MEDIATED PROCESSING OF ABCA4 |
| EP4150077A1 (en) | 2020-05-15 | 2023-03-22 | Korro Bio, Inc. | Methods and compositions for the adar-mediated editing of transmembrane channel-like protein 1 (tmc1) |
| WO2021231692A1 (en) | 2020-05-15 | 2021-11-18 | Korro Bio, Inc. | Methods and compositions for the adar-mediated editing of otoferlin (otof) |
| WO2021231698A1 (en) | 2020-05-15 | 2021-11-18 | Korro Bio, Inc. | Methods and compositions for the adar-mediated editing of argininosuccinate lyase (asl) |
| WO2021231680A1 (en) | 2020-05-15 | 2021-11-18 | Korro Bio, Inc. | Methods and compositions for the adar-mediated editing of methyl-cpg binding protein 2 (mecp2) |
| WO2021231691A1 (en) | 2020-05-15 | 2021-11-18 | Korro Bio, Inc. | Methods and compositions for the adar-mediated editing of retinoschisin 1 (rsi) |
| EP4150088A1 (en) | 2020-05-15 | 2023-03-22 | Korro Bio, Inc. | Methods and compositions for the adar-mediated editing of argininosuccinate synthetase (ass1) |
| JP2023526533A (ja) | 2020-05-22 | 2023-06-21 | ウェイブ ライフ サイエンシズ リミテッド | 二本鎖オリゴヌクレオチド組成物及びそれに関連する方法 |
| EP4153604A4 (en) | 2020-05-22 | 2024-11-27 | Wave Life Sciences Ltd. | OLIGONUCLEOTIDE COMPOSITIONS AND RELATED METHODS |
| JP2023528039A (ja) | 2020-05-26 | 2023-07-03 | シェイプ セラピューティクス インコーポレイテッド | 改変環状ポリヌクレオチド |
| EP4158019A1 (en) | 2020-05-26 | 2023-04-05 | Shape Therapeutics Inc. | Methods and compositions relating to engineered guide systems for adenosine deaminase acting on rna editing |
| WO2021242870A1 (en) | 2020-05-26 | 2021-12-02 | Shape Therapeutics Inc. | Compositions and methods for genome editing |
| AU2021280283A1 (en) | 2020-05-26 | 2022-12-08 | Shape Therapeutics Inc. | Compositions and methods for modifying target RNAs |
| KR20230033651A (ko) | 2020-05-28 | 2023-03-08 | 코로 바이오, 인크. | Serpina1의 adar-매개 편집을 위한 방법 및 조성물 |
| JP2023532375A (ja) | 2020-07-06 | 2023-07-27 | 北京▲輯▼因医▲療▼科技有限公司 | 改良されたｒｎａ編集方法 |
| GB202011428D0 (en) | 2020-07-23 | 2020-09-09 | Proqr Therapeutics Ii Bv | Antisense oligonucleotides for RNA editing |
| CA3190477A1 (en) | 2020-07-30 | 2022-02-03 | Adarx Pharmaceuticals, Inc. | Adar dependent editing compositions and methods of use thereof |
| CN115989041A (zh) | 2020-08-24 | 2023-04-18 | 波涛生命科学有限公司 | 经工程化为表达adar1的细胞和非人动物及其用途 |
| WO2022078569A1 (en) | 2020-10-12 | 2022-04-21 | Eberhard Karls Universität Tübingen | Artificial nucleic acids for rna editing |
| CN116783296A (zh) | 2020-10-21 | 2023-09-19 | 小利兰·斯坦福大学托管委员会 | 用于募集adar的向导rna的筛选平台 |
| IL278401A (en) | 2020-10-29 | 2022-05-01 | Yeda Res & Dev | Polynucleotides for editing RNA and a method for using them |
| KR20230118716A (ko) | 2020-11-08 | 2023-08-11 | 웨이브 라이프 사이언시스 리미티드 | 올리고뉴클레오티드 조성물 및 이의 방법 |
| WO2022103852A1 (en) | 2020-11-11 | 2022-05-19 | Shape Therapeutics Inc. | Rna-editing compositions and methods of use |
| WO2022103839A1 (en) | 2020-11-11 | 2022-05-19 | Shape Therapeutics Inc. | Rna editing compositions and uses thereof |
| WO2022119975A2 (en) | 2020-12-01 | 2022-06-09 | Shape Therapeutics Inc. | High throughput rna-editing screening methods |
| IL303533A (en) | 2020-12-08 | 2023-08-01 | Univ Fukuoka | RNA is a stable guide for editing targets into which chemically modified nucleic acids are inserted |
| JP7756166B2 (ja) | 2020-12-23 | 2025-10-17 | イーライ リリー アンド カンパニー | Ｒｎａ治療薬及びその使用方法 |
| US20240150754A1 (en) | 2020-12-25 | 2024-05-09 | Astellas Pharma Inc. | Guide rna for editing polyadenylation signal sequence of target rna |
| US20250270543A1 (en) | 2021-01-04 | 2025-08-28 | The Regents Of The University Of California | Programmable rna editing in vivo via recruitment of endogenous adars |
| WO2022150974A1 (en) | 2021-01-12 | 2022-07-21 | Peking University | Targeted rna editing by leveraging endogenous adar using engineered rnas |
| US20220307027A1 (en) | 2021-03-26 | 2022-09-29 | Korro Bio, Inc. | RNA-Editing Enzyme-Recruiting Oligonucleotides and Uses Thereof |
| EP4098745A1 (en) | 2021-06-01 | 2022-12-07 | Eberhard-Karls-Universität Tübingen | Antisense oligonucleotides (aso) for efficient and precise rna editing with endogenous adenosine deaminase acting on rna (adar) |
| WO2022256283A2 (en) | 2021-06-01 | 2022-12-08 | Korro Bio, Inc. | Methods for restoring protein function using adar |
-
2017
- 2017-08-31 CA CA3035293A patent/CA3035293A1/en active Pending
- 2017-08-31 DK DK17771348.4T patent/DK3507366T3/da active
- 2017-08-31 EP EP17771348.4A patent/EP3507366B1/en active Active
- 2017-08-31 WO PCT/EP2017/071912 patent/WO2018041973A1/en not_active Ceased
- 2017-08-31 IL IL264923A patent/IL264923B2/en unknown
- 2017-08-31 NZ NZ751483A patent/NZ751483A/en unknown
- 2017-08-31 US US16/329,787 patent/US10941402B2/en active Active
- 2017-08-31 ES ES17771348T patent/ES2837076T3/es active Active
- 2017-08-31 KR KR1020197008525A patent/KR102501980B1/ko active Active
- 2017-08-31 AU AU2017320901A patent/AU2017320901C1/en active Active
- 2017-08-31 JP JP2019511856A patent/JP7244922B2/ja active Active
- 2017-08-31 CN CN201780068116.0A patent/CN110352244B/zh active Active
- 2017-08-31 PL PL17771348T patent/PL3507366T3/pl unknown
- 2017-08-31 PT PT177713484T patent/PT3507366T/pt unknown
-
2019
- 2019-02-18 ZA ZA2019/01016A patent/ZA201901016B/en unknown
-
2021
- 2021-01-20 US US17/152,982 patent/US11851656B2/en active Active
-
2023
- 2023-03-17 US US18/185,929 patent/US12203072B2/en active Active
-
2024
- 2024-12-12 US US18/978,669 patent/US20250223593A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| ES2837076T3 (es) | 2021-06-29 |
| PT3507366T (pt) | 2020-11-09 |
| IL264923A (pl) | 2019-04-30 |
| JP7244922B2 (ja) | 2023-03-23 |
| ZA201901016B (en) | 2021-06-30 |
| US12203072B2 (en) | 2025-01-21 |
| DK3507366T3 (da) | 2020-11-02 |
| WO2018041973A9 (en) | 2019-05-09 |
| US20250223593A1 (en) | 2025-07-10 |
| US11851656B2 (en) | 2023-12-26 |
| IL264923B2 (en) | 2025-07-01 |
| US20240271131A1 (en) | 2024-08-15 |
| EP3507366A1 (en) | 2019-07-10 |
| US20210238597A1 (en) | 2021-08-05 |
| US10941402B2 (en) | 2021-03-09 |
| IL264923B1 (en) | 2025-03-01 |
| NZ751483A (en) | 2022-07-01 |
| AU2017320901B2 (en) | 2023-11-09 |
| KR20190042660A (ko) | 2019-04-24 |
| US20190218552A1 (en) | 2019-07-18 |
| AU2017320901C1 (en) | 2026-04-02 |
| CN110352244B (zh) | 2023-03-21 |
| CN110352244A (zh) | 2019-10-18 |
| KR102501980B1 (ko) | 2023-02-20 |
| EP3507366B1 (en) | 2020-10-07 |
| CA3035293A1 (en) | 2018-03-08 |
| AU2017320901A1 (en) | 2019-04-04 |
| WO2018041973A1 (en) | 2018-03-08 |
| JP2019526260A (ja) | 2019-09-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK3433368T3 (da) | Transreplikerende rna | |
| EP3664817A4 (en) | CHEMICALLY MODIFIED OLIGONUCLEOTIDES | |
| EP3668998C0 (en) | RNA TEMPLATE LIGATION | |
| IL264966B (en) | De novo synthesized nucleic acid libraries | |
| DK3234134T3 (da) | Målrettet rna-redigering | |
| EP3642334C0 (en) | NUCLEIC ACID GUIDED NUCLEASES | |
| EP3307889A4 (en) | DEFINED MULTICONJUGATE OLIGONUCLEOTIDES | |
| EP3463386A4 (en) | OLIGONUCLEOTIDES, COMPOSITIONS AND ASSOCIATED METHODS | |
| EP3538557A4 (en) | ANTI-CD47 ANTIBODY | |
| EP3535566C0 (en) | BIOSENSOR | |
| EP3328873A4 (en) | TARGETED OLIGONUCLEOTIDES | |
| EP3408391A4 (en) | BRANCHED OLIGONUCLEOTIDES | |
| EP3792357C0 (en) | PREDETERMINED NUCLEOTIDE SUBSTITUTIONS | |
| EP3464313A4 (en) | MODIFIED NUCLEOTIDES 5 '-CYCLO-PHOSPHONATE | |
| IL247581B (en) | Genome editing without nucleases | |
| EP3411494A4 (en) | HIGH-RESOLUTION SEQUENCING | |
| IL249574B (en) | Antisense nucleic acids | |
| HUE051767T2 (hu) | Új eljárások oligonukleotidok elõállítására | |
| EP3341477A4 (en) | MANIPULATED CRISPR-CAS9 NUCLEASES | |
| IL247663A0 (en) | Antisense nucleic acids | |
| EP3286549A4 (en) | BIOSENSOR | |
| EP3156789C0 (en) | BIOSENSOR | |
| EP3409779A4 (en) | Single-stranded oligonucleotide | |
| DK3537878T3 (da) | Algedræbende organismer | |
| IL263852B (en) | Oligonucleotides comprising modified nucleosides |